In vitro differentiation of human bone marrow mesenchymal stem cells into hepatocyte-like cells

Archives of Iranian Medicine

Volumn 14, Issue 4, 2011, Pages 244-249

  Pournasr, Behshad ^a   Mohamadnejad, Mehdi ^b   Bagheri, Mohammad ^b   Aghdami, Naser ^a   Shahsavani, Mansoureh ^a   Malekzadeh, Reza ^b   Baharvand, Hossein ^a,c  

^a ROYAN INSTITUTE FOR REPRODUCTIVE BIOMEDICINE   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c UNIVERSITY OF SCIENCE AND CULTURE   (Iran)

Author keywords

Bone marrow stem cells; Differentiation; Hepatocyte

Indexed keywords

5' NUCLEOTIDASE; ALBUMIN; ALPHA 1 ANTITRYPSIN; AMMONIA; B7 ANTIGEN; CD11B ANTIGEN; CD146 ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; CD86 ANTIGEN; CELL MARKER; CYTOKERATIN 18; CYTOKERATIN 19; ENDOGLIN; GLUCOSE 6 PHOSPHATASE; GLYCOGEN; HERMES ANTIGEN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; STEM CELL FACTOR RECEPTOR; THY 1 ANTIGEN; TYROSINE AMINOTRANSFERASE; ALBUMINOID;

ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; COLONY FORMING UNIT F; CONTROLLED STUDY; FAMILIAL HYPERCHOLESTEROLEMIA; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; LIVER CELL; MALE; MESENCHYMAL STEM CELL; NORMAL HUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; BONE MARROW CELL; CYTOLOGY; GENE EXPRESSION; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SECRETION (PROCESS); TRANSPLANTATION;

ADULT; ALBUMINS; ALPHA 1-ANTITRYPSIN; AMMONIA; BONE MARROW CELLS; CELL DIFFERENTIATION; GENE EXPRESSION; GLUCOSE-6-PHOSPHATASE; GLYCOGEN; HEPATOCYTES; HUMANS; KERATIN-18; KERATIN-19; LIPOPROTEINS, LDL; MALE; MESENCHYMAL STROMAL CELLS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, LDL; RNA, MESSENGER; TYROSINE TRANSAMINASE;

EID: 84857659190     PISSN: 10292977     EISSN: 17353947     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Murray KF, Carithers RL, Jr. AASLD practice guidelines: Evaluation of the patient for liver transplantation. Hepatology. 2005; 41: 1407-1432
2. Fox IJ, Roy-Chowdhury J. Hepatocyte transplantation. J Hepatol. 2004; 40: 878-886
3. Strom SC, Fisher RA, Thompson MT, Sanyal AJ, Cole PE, Ham JM, et al. Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure. Transplantation. 1997; 63: 559-569
4. Bilir BM, Guinette D, Karrer F, Kumpe DA, Krysl J, Stephens J, et al. Hepatocyte transplantation in acute liver failure. Liver Transpl. 2000; 6: 32-40
5. Knight RL, Booth C, Wilcox HE, Fisher J, Ingham E. Tissue engineering of cardiac valves: re-seeding of acellular porcine aortic valve matrices with human mesenchymal progenitor cells. J Heart Valve Dis. 2005; 14: 806-813
6. Ott M, Schmidt HH, Cichon G, Manns MP. Emerging therapies in hepatology: liver-directed gene transfer and hepatocyte transplantation. Cells Tissues Organs. 2000; 167: 81-87
7. Horslen SP, Fox IJ. Hepatocyte transplantation. Transplantation. 2004; 77: 1481-1486
8. Hughes RD, Mitry RR, Dhawan A. Hepatocyte transplantation for metabolic liver disease: UK experience. J R Soc Med. 2005; 98: 341-345
9. Stephenne X, Najimi M, Sibille C, Nassogne MC, Smets F, Sokal EM. Sustained engraftment and tissue enzyme activity after liver cell transplantation for argininosuccinate lyase deficiency. Gastroenterology. 2006; 130: 1317-1323
10. Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osborne L, et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med. 2000; 6: 1229-1234
11. Park SM, Vo K, Lallier M, Cloutier AS, Brochu P, Alvarez F, et al. Hepatocyte transplantation in the Long Evans Cinnamon rat model of Wilson's disease. Cell Transplant. 2006; 15: 13-22
12. Overturf K, Al-Dhalimy M, Tanguay R, Brantly M, Ou CN, Finegold M, et al. Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I. Nat Genet. 1996; 12: 266-273
13. Gunsalus JR, Brady DA, Coulter SM, Gray BM, Edge AS. Reduction of serum cholesterol in Watanabe rabbits by xenogeneic hepatocellular transplantation. Nat Med. 1997; 3: 48-53
14. Fox IJ, Chowdhury JR, Kaufman SS, Goertzen TC, Chowdhury NR, Warkentin PI, et al. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N Engl J Med. 1998; 338: 1422-1426
15. Muraca M, Gerunda G, Neri D, Vilei MT, Granato A, Feltracco P, et al. Hepatocyte transplantation as a treatment for glycogen storage disease type 1a. Lancet. 2002; 359: 317-318
16. Dhawan A, Mitry RR, Hughes RD, Lehec S, Terry C, Bansal S, et al. Hepatocyte transplantation for inherited factor VII deficiency. Transplantation. 2004; 78: 1812-1814
17. Nussler A, Konig S, Ott M, Sokal E, Christ B, Thasler W, et al. Present status and perspectives of cell-based therapies for liver diseases. J Hepatol. 2006; 45: 144-159
18. Stieger B, Peters R, Sidler MA, Meier PJ. Hepatocyte transplantation: potential of hepatocyte progenitor cells and bone marrow derived stem cells. Swiss Med Wkly. 2006; 136: 552-556
19. Wexler SA, Donaldson C, Denning-Kendall P, Rice C, Bradley B, Hows JM. Adult bone marrow is a rich source of human mesenchymal 'stem' cells but umbilical cord and mobilized adult blood are not. Br J Haematol. 2003; 121: 368-374
20. Sotiropoulou PA, Perez SA, Salagianni M, Baxevanis CN, Papamichail M. Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells. Stem Cells. 2006; 24: 462-471
21. Shiota M, Heike T, Haruyama M, Baba S, Tsuchiya A, Fujino H, et al. Isolation and characterization of bone marrow-derived mesenchymal progenitor cells with myogenic and neuronal properties. Exp Cell Res. 2007; 313: 1008-1023
22. Alhadlaq A, Mao JJ. Mesenchymal stem cells: isolation and therapeutics. Stem Cells Dev. 2004; 13: 436-448
23. Pittenger MF, Kistler A, Helfman DM. Alternatively spliced exons of the beta tropomyosin gene exhibit different affinities for F-actin and effects with nonmuscle caldesmon. J Cell Sci. 1995; 108: 3253-3265
24. Snykers S, Vanhaecke T, Papeleu P, Luttun A, Jiang Y, Vander Heyden Y, et al. Sequential exposure to cytokines refiecting embryogenesis: the key for in vitro differentiation of adult bone marrow stem cells into functional hepatocyte-like cells. Toxicol Sci. 2006; 94: 330-341
25. Baharvand H, Hashemi SM, Kazemi Ashtiani S, Farrokhi A. Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro. Int J Dev Biol. 2006; 50: 645-652
26. Baharvand H, Hashemi SM, Shahsavani M. Differentiation of human embryonic stem cells into functional hepatocyte-like cells in a serumfree adherent culture condition. Differentiation. 2008; 76: 465-477
27. Mohamadnejad M, Pournasr B, Bagheri M, Aghdami N, Shahsavani M, Hosseini LA, et al. Transplantation of allogeneic bone marrow mesenchymal stromal cell-derived hepatocyte-like cells in homozygous familial hypercholesterolemia. Cytotherapy. 2010; 12: 566-568
28. Muraca M, Ferraresso C, Vilei MT, Granato A, Quarta M, Cozzi E, et al. Liver repopulation with bone marrow derived cells improves the metabolic disorder in the Gunn rat. Gut. 2007; 56: 1725-1735
29. Korbling M, Katz RL, Khanna A, Ruifrok AC, Rondon G, Albitar M, et al. Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. N Engl J Med. 2002; 346: 738-746
30. Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M, et al. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature. 2003; 422: 897-901
31. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007; 131: 861-872
32. Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, et al. Reprogramming of human somatic cells to pluripotency with defined factors. Nature. 2008; 451: 141-146
33. Schwartz RE, Reyes M, Koodie L, Jiang Y, Blackstad M, Lund T, et al. Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest. 2002; 109: 1291-302
34. Lee K-D, Kuo TK-C, Whang-Peng J, Chung Y-F, Lin C-T, Chou S-H, et al. In Vitro Hepatic Differentiation of Human Mesenchymal Stem Cells. Hepatology. 2004; 40: 1275-1284.