The elastic properties of valve interstitial cells undergoing pathological differentiation

Journal of Biomechanics

Volumn 45, Issue 5, 2012, Pages 882-887

  Wyss, Kristine ^a,b   Yip, Cindy Y Y ^b   Mirzaei, Zahra ^b   Jin, Xiaofan ^a   Chen, Jan Hung ^a,b   Simmons, Craig A ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Calcification; Cell mechanics; Heart valve; Micropipette aspiration; Myofibroblast

Indexed keywords

AORTIC VALVES; BIOMECHANICAL PROPERTIES; CELL MECHANICS; COLLAGEN GELS; ELASTIC PROPERTIES; EXPRESSION LEVELS; HEART VALVE; IN-VITRO; IN-VIVO; MATRIX; MECHANICAL FORCE; MECHANICAL STIMULUS; MICROPIPETTE ASPIRATION; MYOFIBROBLASTS; NATRIURETIC PEPTIDES; PHENOTYPIC PLASTICITY; SMOOTH MUSCLE ACTINS; STIFF TISSUES; VALVE INTERSTITIAL CELLS;

BIOMECHANICS; BIOMINERALIZATION; CALCIFICATION (BIOCHEMISTRY); ELASTIC MODULI; MUSCLE; PEPTIDES; POLYSTYRENES; TISSUE CULTURE;

ELASTICITY;

ALPHA SMOOTH MUSCLE ACTIN; NATRIURETIC PEPTIDE TYPE C;

ANIMAL CELL; AORTA VALVE DISEASE; ARTICLE; BIOMECHANICS; CALCIFICATION; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; DISEASE COURSE; ELASTICITY; FIBROBLAST; HEART VALVE; HISTOPATHOLOGY; IN VITRO STUDY; MECHANOTRANSDUCTION; MICROPIPETTE; MUSCLE STIFFNESS; MYOFIBROBLAST; NONHUMAN; OSTEOBLAST; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STIMULUS RESPONSE; SWINE; YOUNG MODULUS;

ACTINS; ANIMALS; AORTIC VALVE; BIOMECHANICS; CELL DIFFERENTIATION; CELLS, CULTURED; COLLAGEN; ELASTIC MODULUS; HEART VALVE DISEASES; MECHANICAL PHENOMENA; MYOFIBROBLASTS; NATRIURETIC PEPTIDE, C-TYPE; OSTEOBLASTS; STRESS, MECHANICAL; SWINE;

EID: 84857644134     PISSN: 00219290     EISSN: 18732380     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2011.11.030     Document Type: Article

References (34)

1. Chen J.-H., Simmons C.A. Cell-matrix interactions in the pathobiology of calcific aortic valve disease: Critical roles for matricellular, matricrine, and matrix mechanics cues. Circulation Research 2011, 108(12):1510-1524.
2. Chen J.H., Chen W.L., Sider K.L., Yip C.Y., Simmons C.A. {beta}-catenin mediates mechanically regulated, transforming growth factor-{beta}1-induced myofibroblast differentiation of aortic valve interstitial cells. Arteriosclerosis Thrombosis and Vascular Biology 2011, 31(3):590-597.
3. Chen J.H., Yip C.Y., Sone E.D., Simmons C.A. Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential. American Journal of Pathology 2009, 174(3):1109-1119.
4. Cimini M., Rogers K.A., Boughner D.R. Smoothelin-positive cells in human and porcine semilunar valves. Histochemistry and Cell Biology 2003, 120(4):307-317.
5. Glenister F.K., Coppel R.L., Cowman A.F., Mohandas N., Cooke B.M. Contribution of parasite proteins to altered mechanical properties of malaria-infected red blood cells. Blood 2002, 99(3):1060-1063.
6. Hinz B., Celetta G., Tomasek J.J., Gabbiani G., Chaponnier C. Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Molecular Biology of the Cell 2001, 12(9):2730-2741.
7. Hochmuth R.M. Micropipette aspiration of living cells. Journal of Biomechanics 2000, 33(1):15-22.
8. Imanaka K., Takamoto S., Ohtsuka T., Oka T., Furuse A., Omata S. The stiffness of normal and abnormal mitral valves. Annals of Thoracic and Cardiovascular Surgery 2007, 13(3):178-184.
9. Jones W.R., Ting-Beall H.P., Lee G.M., Kelley S.S., Hochmuth R.M., Guilak F. Alterations in the Young's modulus and volumetric properties of chondrocytes isolated from normal and osteoarthritic human cartilage. Journal of Biomechanics 1999, 32(2):119-127.
10. Kloxin A.M., Benton J.A., Anseth K.S. In situ elasticity modulation with dynamic substrates to direct cell phenotype. Biomaterials 2010, 31(1):1-8.
11. Lim C.T., Zhou E.H., Quek S.T. Mechanical models for living cells-a review. Journal of Biomechanics 2006, 39(2):195-216.
12. Merryman W.D., Bieniek P.D., Guilak F., Sacks M.S. Viscoelastic properties of the aortic valve interstitial cell. Journal of Biomechanical Engineering 2009, 131(4):041005.
13. Merryman W.D., Youn I., Lukoff H.D., Krueger P.M., Guilak F., Hopkins R.A., Sacks M.S. Correlation between heart valve interstitial cell stiffness and transvalvular pressure: implications for collagen biosynthesis. American Journal of Physiology. Heart and Circulatory Physiology 2006, 290(1):H224-H231.
14. Messier R.H., Bass B.L., Aly H.M., Jones J.L., Domkowski P.W., Wallace R.B., Hopkins R.A. Dual structural and functional phenotypes of the porcine aortic valve interstitial population: characteristics of the leaflet myofibroblast. Journal of Surgical Research 1994, 57(1):1-21.
15. Mohler E.R., Gannon F., Reynolds C., Zimmerman R., Keane M.G., Kaplan F.S. Bone formation and inflammation in cardiac valves. Circulation 2001, 103(11):1522-1528.
16. Peltonen T.O., Taskinen P., Soini Y., Rysa J., Ronkainen J., Ohtonen P., Satta J., Juvonen T., Ruskoaho H., Leskinen H. Distinct downregulation of C-type natriuretic peptide system in human aortic valve stenosis. Circulation 2007, 116(11):1283-1289.
17. Pho M., Lee W., Watt D.R., Laschinger C., Simmons C.A., McCulloch C.A. Cofilin is a marker of myofibroblast differentiation in cells from porcine aortic cardiac valves. American Journal of Physiology Heart and Circulatory Physiology 2008, 294(4):H1767-H1778.
18. Rabkin-Aikawa E., Farber M., Aikawa M., Schoen F.J. Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves. Journal of Heart Valve Disease 2004, 13(5):841-847.
19. Rajamannan N.M., Subramaniam M., Rickard D., Stock S.R., Donovan J., Springett M., Orszulak T., Fullerton D.A., Tajik A.J., Bonow R.O., Spelsberg T. Human aortic valve calcification is associated with an osteoblast phenotype. Circulation 2003, 107(17):2181-2184.
20. Simmons C.A., Grant G.R., Manduchi E., Davies P.F. Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves. Circulation Research 2005, 96(7):792-799.
21. Solon J., Levental I., Sengupta K., Georges P.C., Janmey P.A. Fibroblast adaptation and stiffness matching to soft elastic substrates. Biophysical Journal 2007, 93(12):4453-4461.
22. Taylor P.M., Allen S.P., Yacoub M.H. Phenotypic and functional characterization of interstitial cells from human heart valves, pericardium and skin. Journal of Heart Valve Disease 2000, 9(1):150-158.
23. Theret D.P., Levesque M.J., Sato M., Nerem R.M., Wheeler L.T. The application of a homogeneous half-space model in the analysis of endothelial cell micropipette measurements. Journal of Biomechanical Engineering 1988, 110(3):190-199.
24. Thubrikar M.J., Aouad J., Nolan S.P. Patterns of calcific deposits in operatively excised stenotic or purely regurgitant aortic valves and their relation to mechanical stress. American Journal of Cardiology 1986, 58(3):304-308.
25. Titushkin I., Cho M. Modulation of cellular mechanics during osteogenic differentiation of human mesenchymal stem cells. Biophysical Journal 2007, 93(10):3693-3702.
26. Trickey W.R., Baaijens F.P., Laursen T.A., Alexopoulos L.G., Guilak F. Determination of the Poisson's ratio of the cell: recovery properties of chondrocytes after release from complete micropipette aspiration. Journal of Biomechanics 2006, 39(1):78-87.
27. Trickey W.R., Vail T.P., Guilak F. The role of the cytoskeleton in the viscoelastic properties of human articular chondrocytes. Journal of orthopaedic research: official publication of the Orthopaedic research society 2004, 22(1):131-139.
28. Vesely I., Noseworthy R. Micromechanics of the fibrosa and the ventricularis in aortic valve leaflets. Journal of Biomechanics 1992, 25(1):101-113.
29. Walker G.A., Masters K.S., Shah D.N., Anseth K.S., Leinwand L.A. Valvular myofibroblast activation by transforming growth factor-beta: implications for pathological extracellular matrix remodeling in heart valve disease. Circulation Research 2004, 95(3):253-260.
30. Yip C.Y., Chen J.H., Zhao R., Simmons C.A. Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix. Arteriosclerosis Thrombosis Vascular Biology 2009, 29(6):936-942.
31. Yip C.Y.Y., Blaser M., Mirzaei Z., Zhong X., Simmons C.A. C-type natriuretic peptide inhibits the pathological differentiation of valve interstitial cells. Arteriosclerosis Thrombosis Vascular Biology 2011, 31(8):1881-1889.
32. Zhao R., Sider K.L., Simmons C.A. Measurement of layer-specific mechanical properties in multilayered biomaterials by micropipette aspiration. Acta Biomaterialia 2011, 7(3):1220-1227.
33. Zhao R., Wyss K., Simmons C.A. Comparison of analytical and inverse finite element approaches to estimate cell viscoelastic properties by micropipette aspiration. Journal of Biomechanics 2009, 42(16):2768-2773.
34. Zhou E., Lim C., Quek S. Finite element simulation of the micropipette aspiration of a living cell undergoing large viscoelastic deformation. Mechanics of Advanced Materials and Structures 2005, 12(6):501-512.