Relationship between expression of apoptosis-related proteins and the efficacy of postoperative chemotherapy in patients with T3 gastric cancer

Surgery Today

Volumn 42, Issue 3, 2012, Pages 225-232

  Tsujitani, Shunichi ^a   Saito, Hiroaki ^b   Wakatsuki, Toshiro ^b   Ikeguchi, Masahide ^b   Shirabe, Ken ^a   Morita, Masaru ^a   Kakeji, Yoshihiro ^a   Yano, Tokujiro ^a   Maehara, Yoshihiko ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

Author keywords

Apoptosis; Bcl 2 family; Chemotherapy; Gastric cancer; p53

Indexed keywords

PROTEIN BAX; PROTEIN MCL 1; PROTEIN P21; PROTEIN P53; UFT;

ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER PROGNOSIS; CANCER SURVIVAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; OVERALL SURVIVAL; POSTOPERATIVE PERIOD; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; STOMACH CANCER; SURVIVAL RATE; SURVIVAL TIME;

ADENOCARCINOMA; ADULT; AGED; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CHEMOTHERAPY, ADJUVANT; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FEMALE; GASTRECTOMY; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-BCL-2; RETROSPECTIVE STUDIES; STOMACH NEOPLASMS; TEGAFUR; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53; URACIL;

EID: 84857643621     PISSN: 09411291     EISSN: 14362813     Source Type: Journal    
DOI: 10.1007/s00595-011-0062-z     Document Type: Article

References (55)

1. Y Noguchi T Imada A Matsumoto DG Goit MF Brennan 1989 Radical surgery for gastric cancer. A review of the Japanese experience Cancer 64 2053 2062 2680049 10.1002/1097-0142(19891115)64:10<2053::AID-CNCR2820641014>3.0.CO;2-J 1:STN:280:DyaK3c%2FjtVSqtg%3D%3D (Pubitemid 19280403)
2. K Nakamura T Ueyama T Yao ZX Xuan K Ambe Y Adachi, et al. 1992 Pathology and prognosis of gastric carcinoma. Findings in 10,000 patients who underwent primary gastrectomy Cancer 70 1030 1037 1515980 10.1002/1097-0142(19920901)70: 5<1030::AID-CNCR2820700504>3.0.CO;2-C 1:STN:280:DyaK38zos1ekuw%3D%3D
3. S Otani M Maeta A Oka S Tsujitani M Ikeguchi R Hamazoe, et al. 1995 Long-term survival of 5 years following initial surgery for gastric cancer and simultaneous disseminated peritoneal metastasis; report of a case Surg Today 25 959 961 8640021 10.1007/BF00312381 1:STN:280:DyaK283ivFGgsA%3D%3D
4. N Kaibara H Nishidoi O Kimura M Makino K Sumi S Koga 1988 Analysis of results of surgical treatment of gastric cancer. Retrospective study of 1,215 curatively resected cases Dig Surg 5 124 127 10.1159/000171847
5. Y Maehara T Okuyama T Oshiro H Baba Y Adachi K Sugimachi 1994 Analysis of 390 patients surviving 10 years or longer after curative resection for gastric cancer Oncology 51 366 371 8208523 10.1159/000227367 1:STN:280: DyaK2c3mvVyisQ%3D%3D (Pubitemid 24185140)
6. J Deng H Liang D Wang D Sun Y Pan Y Liu 2011 Investigations of the recurrence patterns of gastric cancer following a curative resection Surg Today 41 210 215 21264756 10.1007/s00595-009-4251-y
7. WS El-Deiry JW Harper PM O'Connor VE Velculescu CE Canman J Jackman, et al. 1994 WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis Cancer Res 54 1169 1174 8118801 1:CAS:528:DyaK2cXivFCkuro%3D (Pubitemid 24108052)
8. MS Sheikh H Rochefort M Garcia 1995 Overexpression of p21waf1/cip1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines Oncogene 11 1899 1905 7478620 1:CAS:528:DyaK2MXptlOksLw%3D
9. Q Zhan I Bae MB Kastan AF Fornace Jr 1994 The p53-dependent gamma-ray response of GADD45 Cancer Res 54 2755 2760 8168107 1:CAS:528:DyaK2cXktVCjtL8%3D (Pubitemid 2087873)
10. Q Zhan S Fan I Bae C Guillouf DA Liebermann PM O'Connor, et al. 1994 Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis Oncogene 9 3743 3751 7970735 1:CAS:528:DyaK2MXisFWrtL4%3D (Pubitemid 24359416)
11. CA Finlay PW Hinds TH Tan D Eliyahu M Oren AJ Levine 1988 Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life Mol Cell Biol 8 531 539 2832726 1:CAS:528:DyaL1cXht12nsbg%3D
12. D Lane S Benchimol 1990 p53: oncogene or anti-oncogene Genes Dev 4 1 8 2137806 10.1101/gad.4.1.1 1:CAS:528:DyaK3cXhtFaru78%3D
13. T Starzynska M Blomley A Ghosh PL Stern 1992 Prognostic significance of p53 overexpression in gastric and colorectal carcinoma Br J Cancer 66 558 562 1520594 10.1038/bjc.1992.314 1:STN:280:DyaK38zpt1Ohsg%3D%3D
14. HM Martin MI Filipe RW Morris DP Lane F Silvestre 1992 p53 expression and prognosis in gastric carcinoma Int J Cancer 50 859 862 1555884 10.1002/ijc.2910500604 1:STN:280:DyaK383htVajuw%3D%3D
15. J Hurlimann EP Saraga 1994 Expression of p53 protein in gastric carcinoma Am J Surg Pathol 18 1247 1253 7977948 10.1097/00000478-199412000-00008 1:STN:280:DyaK2M%2FmvVGruw%3D%3D
16. SW Loewe HE Ruley T Jacks DE Housman 1993 p53-dependent apoptosis modulates the cytotoxicity of anticancer agents Cell 74 957 967 10.1016/0092-8674(93)90719-7 (Pubitemid 23289454)
17. K Yamashita S Sakuramoto M Watababe 2011 Genomic and epigenetic profiles of gastric cancer: potential diagnostic and therapeutic applications Surg Today 41 24 38 21191688 10.1007/s00595-010-4370-5
18. P Michieli M Chedid D Lin JH Pierce WE Mercer D Givol 1994 Induction of WAF1/CIP1 by a p53-independent pathway Cancer Res 54 3391 3395 8012956 1:CAS:528:DyaK2cXkslCmtrc%3D (Pubitemid 24225956)
19. JA Bond JP Blaydes J Rowson MF Haughton JR Smith TD Wynford, et al. 1995 Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1 Cancer Res 55 2404 2409 7538902 1:CAS:528: DyaK2MXlvFeqs7s%3D
20. N Barboule P Mazars V Baldin S Vidal S Jozan P Martel, et al. 1995 Expression of p21WAF1/CIP1 is heterogeneous and unrelated to proliferation index in human ovarian carcinoma Int J Cancer 63 611 615 7591274 10.1002/ijc. 2910630502 1:CAS:528:DyaK28XlvFGnsw%3D%3D
21. J Kerr A Wylle A Currie 1972 Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics Br J Cancer 26 239 257 4561027 10.1038/bjc.1972.33 1:STN:280:DyaE3s%2FgsFSksw%3D%3D
22. FC Manning SR Patienro 1996 Apoptosis: inhibitor or instigator of carcinogenesis? Cancer Invest 14 455 465 8816861 10.3109/07357909609018903 1:STN:280:DyaK28vhtlOjtQ%3D%3D (Pubitemid 26338210)
23. SJ Korsmeyer 1992 Bcl-2 initiates a new category of oncogene; regulators of cell death Blood 80 879 886 1498330 1:CAS:528:DyaK3sXnvVShsQ%3D%3D
24. G Kroemer 1997 The proto-oncogene Bcl-2 and its role in regulating apoptosis Nat Med 3 614 620 9176486 10.1038/nm0697-614 1:CAS:528: DyaK2sXjsFOisbs%3D (Pubitemid 27264969)
25. SJ Korsmeyer 1999 BCL-2 gene family and the regulation of programmed cell death Cancer Res 59 Suppl 1693s 1700s 10197582 1:CAS:528:DyaK1MXisVWrsrk%3D (Pubitemid 29165240)
26. JE Reynold J Li RW Craig A Eastman 1996 BCL-2 and Mcl-1 expression in Chinese hamster ovary cells inhibits intracellular acidification and apoptosis induced by staurosporine Exp Cell Res 225 430 436 10.1006/excr.1996.0194 (Pubitemid 26183961)
27. J Lomo EB Smeland S Krajewski JC Reed HK Blomhoff 1996 Expression of the Bcl-2 homologue Mcl-1 correlates with survival of peripheral blood B lymphocytes Cancer Res 56 40 43 8548771 1:STN:280:DyaK287isVyktg%3D%3D (Pubitemid 26010382)
28. P Zhou L Qian KM Kozopas RW Craig 1997 Mcl-1, a Bcl-2 family member, delays the death of hematopoietic cells under a variety of apoptosis-inducing conditions Blood 89 630 643 9002967 1:CAS:528:DyaK2sXlt1GrsQ%3D%3D (Pubitemid 27051700)
29. E Yang SJ Korsmeyer 1996 Molecular thanatopsis: a discourse on the Bcl-2 family and cell death Blood 88 386 401 8695785 1:CAS:528:DyaK28XktFSrtLc%3D (Pubitemid 26240369)
30. K Shigemasa O Katoh Y Shiroyama 2002 Increased MCL-1expression is associated with poor prognosis in ovarian cancer Jpn J Cancer Res 93 542 550 12036450 10.1111/j.1349-7006.2002.tb01289.x 1:CAS:528:DC%2BD38XlsVGht7Y%3D (Pubitemid 34752911)
31. MG Dole R Jasty MJ Cooper CB Thompson G Nunez VP Castle 1995 Bcl-XL is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis Cancer Res 55 2576 2582 7780971 1:CAS:528:DyaK2MXmtlWrtr4%3D
32. M Baekeland R Horm JM Neslannd CG Trope GB Kristensen 2000 Expression of apoptosis-related proteins is an independent determinant of patient prognosis in advanced ovarian cancer J Clin Oncol 18 3775 3781
33. M Rieger M Weller A Bornemann M Schabet J Dichgans R Meyermann 1998 Bcl-2 family protein expression in human malignant glioma: a clinical-pathological correlative study J Neurol Sci 155 68 75 9562325 10.1016/S0022-510X(97)00277-3 1:CAS:528:DyaK1cXhtlOltb8%3D (Pubitemid 28141061)
34. J Erenpreisa MS Cragg 2001 Mitotic death: a mechanism of survival? A review Cancer Cell Int 1 1 7 11983025 10.1186/1475-2867-1-1 (Pubitemid 38751048)
35. S Kubicka C Claas S Staab F Kühnel L Zender C Trautwein, et al. 2002 p53 mutation pattern and expression of c-erbB2 and c-met in gastric cancer: relation to histological subtypes, Helicobacter pylori infection, and prognosis Dig Dis Sci 47 114 121 11837710 10.1023/A:1013275706401 1:CAS:528: DC%2BD38XhsVGmsLs%3D (Pubitemid 34075026)
36. RJ Cote D Esrig S Groshen PA Jones DG Skinner 1997 p53 and treatment of bladder cancer Nature 358 123 125 10.1038/385123b0
37. M Tada R Matsumoto RD Iggo R Onimaru H Shirato Y Sawamura, et al. 1998 Selective sensitivity to radiation of cerebral glioblastomas harboring p53 mutations Cancer Res 58 1793 1797 9581814 1:CAS:528:DyaK1cXislensbw%3D (Pubitemid 28217448)
38. T Hashimoto Y Tokuchi M Hayashi Y Kaobayashi K Nishida S Hayashi, et al. 1999 p53 null mutations undetected by immunohistochemical staining predict a poor outcome with early-stage non-small cell lung carcinomas Cancer Res 59 5572 5577 10554037 1:CAS:528:DyaK1MXnt1Gisrk%3D (Pubitemid 29526476)
39. A Hartmann H Blaszyk RM McGovern JJ Schroeder J Cunningham EM De Vries, et al. 1995 p53 gene mutations inside and outside of exons 5-8: the patterns differ in breast and other cancers Oncogene 16 681 688
40. F Bataille P Rümmele W Dietmaier D Gaag F Klebi A Reichle, et al. 2003 Alterations in p53 predict response to preoperative high dose chemotherapy in patients with gastric cancer J Clin Pathol Mol Pathol 56 286 292 10.1136/mp.56.5.286 1:CAS:528:DC%2BD3sXptVCht7g%3D (Pubitemid 37243921)
41. M Ikeguchi S Tatebe N Kaibara H Ito 1997 Changes in levels of expression of p53 and the product of the bcl-2 in lines of gastric cancer cells during cisplatin-induced apoptosis Eur Surg Res 29 396 402 9323493 10.1159/000129549 1:CAS:528:DyaK2sXmt1Gru7g%3D (Pubitemid 27420344)
42. T Grundei H Vogelsang K Ott J Mueller M Scholz K Becker, et al. 2000 Loss of heterozygosity and microsatellite instability as predictive markers for neoadjuvant treatment in gastric carcinoma Clin Cancer Res 6 4782 4788 11156235 1:STN:280:DC%2BD3M3htFaruw%3D%3D (Pubitemid 32110420)
43. AV Gudkov EA Komarova 2003 The role of p53 in determining sensitivity to radiotherapy Nat Rev Cancer 3 117 129 12563311 10.1038/nrc992 1:CAS:528:DC%2BD3sXisVCqsrs%3D (Pubitemid 37328879)
44. Y Gomyo M Ikeda M Osaki S Tatebe S Tsujitani M Ikeguchi, et al. 1997 Expression of p21 (waf1/cip1/sdi1), but not p53 protein, is a factor in the survival of patients with advanced gastric carcinoma Cancer 79 2067 2072 9179052 10.1002/(SICI)1097-0142(19970601)79:11<2067::AID-CNCR3>3.0.CO;2-M 1:CAS:528:DyaK2sXjs1yksL4%3D (Pubitemid 27227370)
45. M Krajewska S Krajewski JI Epstein A Shabaik J Sauvagoet K Song, et al. 1996 Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancer Am J Pathol 148 1567 1576 8623925 1:STN:280:DyaK283gvVWgsA%3D%3D (Pubitemid 26135897)
46. M Krajewska SF Moss S Krajewski PR Holt K Song PR Holt, et al. 1996 Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas Cancer Res 56 2422 2427 8625322 1:CAS:528:DyaK28XivF2qsrg%3D (Pubitemid 26154093)
47. M Krajewska CM Fenoglio Preiser S Krajewski K Song JS Macdonald G Stemmerman, et al. 1996 Immunohistochemical analysis of Bcl-2 family proteins in adenocarcinoma of the stomach Am J Pathol 149 1449 1457 8909234 1:STN:280:DyaK2s%2FmsFOmsQ%3D%3D (Pubitemid 26363951)
48. Y Maeta S Tsujitani K Yamaguchi S Tatebe A Kondo M Ikeguchi, et al. 2004 Expression of Mcl-1 and p53 proteins predicts the survival of patients with T3 gastric carcinoma Gastric Cancer 7 78 84 15224193 10.1007/s10120-004-0272-9 1:CAS:528:DC%2BD2cXlt1Glurs%3D (Pubitemid 38899657)
49. D Puthier R Bataille M Amiot 1999 IL-6 up-regulates Mcl-1 in human myeloma cells through JAK/STAT rather than ras/MAP kinase pathway Eur J Immunol 29 3945 3950 10602002 10.1002/(SICI)1521-4141(199912)29:12<3945::AID- IMMU3945>3.0.CO;2-O 1:CAS:528:DyaK1MXotVehs74%3D
50. LH Wei ML Kuo CA Chen CH Chou WF Cheng MC Chang, et al. 2001 The anti-apoptotic role of interleukin-6 in human cervical cancer is mediated by up-regulation of Mcl-1 through a PI3-K/Akt pathway Oncogene 20 5799 5809 11593385 10.1038/sj.onc.1204733 1:CAS:528:DC%2BD3MXntlSgtrs%3D (Pubitemid 32937949)
51. HM Huang CJ Huang JJ Yen 2000 Mcl-1 is a common target stem cell factor and interleukin-5 for apoptosis prevention activity via MEK/MAPK and a PI3-K/Akt pathways Blood 96 1764 1771 10961875 1:CAS:528:DC%2BD3cXmt1Omtb0%3D (Pubitemid 30661060)
52. L Li S Krajewski JC Reed YS Choi 1997 The apoptosis and proliferation of SAC-activated B cell by IL-10 are associated with change in Bcl-2, Bcl-xL, and Mcl-1 expression Cell Immunol 178 33 41 9184696 10.1006/cimm.1997.1129 1:CAS:528:DyaK2sXjvVWmu7s%3D (Pubitemid 27250278)
53. J Lomo HK Blomhoff SE Jacobcen S Krajewski JC Reed EB Smeland 1997 Interleukin 13 in combination with CD40 ligand potently inhibits apoptosis in human B lymphocytes: upregulation of Bcl-xL and Mcl-1 expression Blood 89 4415 4424 9192766 1:CAS:528:DyaK2sXjvFCltrc%3D (Pubitemid 27260252)
54. ML Kuo SE Chuang MT Lin SY Yang 2001 The involvement of PI3-K/Akt-dependent up-regulation of Mcl-1 in the prevention of apoptosis of Her3B cells by Interleukin-6 Oncogene 20 677 685 11314001 10.1038/sj.onc.1204140 1:CAS:528:DC%2BD3MXhs1Shsbw%3D (Pubitemid 32179336)
55. JM Wang JR Chao W Chen ML Kuo JJ Yen HF Yang-Yen 1999 The apoptotic gene Mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB Mol Cell Biol 19 6195 6206 10454566 1:CAS:528:DyaK1MXlslWjsbs%3D (Pubitemid 29399324)