Catalytic activity and acyl-chain selectivity of diacylglycerol kinaseεare modulated by residues in and near the lipoxygenase-like motif

Journal of Molecular Biology

Volumn 416, Issue 5, 2012, Pages 619-628

  D'Souza, Kenneth ^a   Epand, Richard M ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

CRAC motif; LOX motif; PI cycle; polyunsaturated acyl chains; substrate specificity

Indexed keywords

DIACYLGLYCEROL; DIACYLGLYCEROL KINASE; DIACYLGLYCEROL KINASE EPSILON; LIPOXYGENASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CATALYSIS; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; MICHAELIS CONSTANT; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; SEQUENCE ALIGNMENT;

MAMMALIA;

EID: 84857627615     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2012.01.008     Document Type: Article

References (34)

1. Di Paolo G., and De Camilli P. Phosphoinositides in cell regulation and membrane dynamics Nature 433 2006 651 657 (Pubitemid 44564702)
2. Eberhard D.A., Cooper C.L., Low M.G., and Holz R.W. Evidence that the inositol phospholipids are necessary for exocytosis. Loss of inositol phospholipids and inhibition of secretion in permeabilized cells caused by a bacterial phospholipase C and removal of ATP Biochem. J. 268 1990 15 25 (Pubitemid 20166644)
3. Carrasco S., and Merida I. Diacylglycerol, when simplicity becomes complex Trends Biochem. Sci. 32 2007 27 36 (Pubitemid 46038735)
4. Wakelam M.J. Diacylglycerol-when is it an intracellular messenger? Biochim. Biophys. Acta 1436 1998 117 126
5. Garcia-Bermejo M.L., Leskow F.C., Fujii T., Wang Q., Blumberg P.M., and Ohba M. Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha J. Biol. Chem. 277 2002 645 655 (Pubitemid 34952103)
6. Parekh D.B., Ziegler W., and Parker P.J. Multiple pathways control protein kinase C phosphorylation EMBO J. 19 2000 496 503 (Pubitemid 30093722)
7. Caloca M.J., Wang H., and Kazanietz M.G. Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor Biochem. J. 375 2003 313 321 (Pubitemid 37315439)
8. Caloca M.J., Wang H., Delemos A., Wang S., and Kazaneitz M.G. Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor J. Biol. Chem. 276 2001 18303 18312
9. Madani S., Hichami A., Legrand A., Belleville J., and Khan N.A. Implication of acyl chain of diacylglycerols in activation of different isoforms of protein kinase C FASEB J. 15 2001 2595 2601 (Pubitemid 33131086)
10. Cai J., Abramovici H., Gee S.H., and Topham M.K. Diacylglycerol kinases as sources of phosphatidic acid Biochim. Biophys. Acta 1791 2009 942 948
11. Shulga Y.V., Topham M.K., and Epand R.M. Regulation and functions of diacylglycerol kinases Chem. Rev. 111 2011 6186 6208
12. Tang W., Bunting M., Zimmerman G.A., McIntyre T.M., and Prescott S.M. Molecular cloning of a novel human diacylglycerol kinase highly selective for arachidonate-containing substrates J. Biol. Chem. 271 1996 10237 10241 (Pubitemid 26131591)
13. Sakane F., and Kanoh H. Molecules in focus: diacylglycerol kinase Int. J. Biochem. Cell Biol. 10 1997 1139 1143
14. Lung M., Shulga Y.V., Ivanova P.V., Myers D.S., Milne S.B., and Brown H.A. Diacylglycerol kinase epsilon is selective for both acyl chains of phosphatidic acid or diacylglycerol J. Biol. Chem. 284 2009 31062 31073
15. Postle A.D., Dombrowsky H., Clarke H., Pynn C.J., Koster G., and Hunt A.N. Mass spectroscopic analysis of phosphatidylinositol synthesis using 6-deuteriated-myo-inositol: comparison of the molecular specificities and acyl remodelling mechanisms in mouse tissues and cultured cells Biochem. Soc. Trans. 32 2004 1057 1059 (Pubitemid 39655542)
16. Milne S.B., Ivanova P.T., Armstrong M.D., Myers D.S., Lubarda J., and Shulga Y.V. Dramatic differences in the roles in lipid metabolism of two isoforms of diacylglycerol kinase Biochemistry 47 2008 9372 9379
17. Rodriquez de Turco E.B., Tang W., Topham M.K., Sakane F., Marcheselli V.L., and Chen C. Diacylglycerol kinase epsilon regulates seizure susceptibility and long-term potentiation through arachidonoyl-inositol lipid signaling Proc. Natl Acad. Sci. USA 98 2001 4740 4745 (Pubitemid 32295046)
18. Shulga Y.V., Topham M.K., and Epand R.M. Study of arachidonoyl specificity in two enzymes of the PI cycle J. Mol. Biol. 409 2011 101 112
19. Epand R.M. Recognition of polyunsaturated acyl chains by enzymes acting on membrane lipids Biochim. Biophys. Acta 1818 2011 957 961
20. Neau D.B., Gilbert N.C., Bartlett S.G., Boeglin W., Brash A.R., and Newcomer M.E. The 1.85 Å structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity Biochemistry 48 2009 7906 7915
21. Gilbert N.C., Bartlett S.G., Waight M.T., Neau D.B., Boeglin W.E., Brash A.R., and Newcomer M.E. The structure of human 5-lipoxygenase Science 331 2011 217 219
22. Li H., and Papadopoulos V. Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern Endocrinology 139 1998 4991 4997 (Pubitemid 28533447)
23. Epand R.M. Cholesterol and the interaction of proteins with membrane domains Prog. Lipid Res. 45 2006 279 294 (Pubitemid 43818129)
24. Martínez-Abundis E., Correa F., Rodríguez E., Soria-Castro E., Rodríguez-Zavala J.S., Pacheco-Alvarez D., and Zazueta C. A CRAC-like motif in BAX sequence: relationship with protein insertion and pore activity in liposomes Biochim. Biophys. Acta 1808 2011 1888 1895
25. Jamin N., Neumann J.M., Ostuni M.A., Vu T.K., Yao Z.X., and Murail S. Characterization of the cholesterol recognition amino acid consensus sequence of the peripheral-type benzodiazepine receptor Mol. Endocrinol. 19 2005 588 594 (Pubitemid 40349433)
26. Li H., Yao Z., Degenhardt B., Teper G., and Papadopoulos V. Cholesterol binding at the cholesterol recognition/interaction amino acid consensus (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptide Proc. Natl Acad. Sci. USA 98 2001 1267 1272 (Pubitemid 32121221)
27. Langhorst M.F., Reuter A., Jaeger F.A., Wippich F.M., Luxenhofer G., Plattner H., and Stuermer C.A. Trafficking of the microdomain scaffolding protein reggie-1/flotillin-2 Eur. J. Cell Biol. 87 2008 211 226
28. Epand R.M., Sayer B.G., and Epand R.F. Caveolin scaffolding region and cholesterol-rich domains in membranes J. Mol. Biol. 345 2005 339 350 (Pubitemid 39574855)
29. Vishwanathan S.A., Thomas A., Brasseur R., Epand R.F., Hunter E., and Epand R.M. Hydrophobic substitutions in the first residue of the CRAC segment of the gp41 protein of HIV Biochemistry 47 2008 11869 11876
30. Batarseh A., and Papadopoulos V. Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states Mol. Cell. Endocrinol. 327 2010 1 12
31. Le Lan C., Gallay J., Vincent M., Neumann J.M., de Foresta B., and Jamin N. Structural and dynamic properties of juxta-membrane segments of caveolin-1 and caveolin-2 at the membrane interface Eur. Biophys. J. 39 2010 307 325
32. Shulga Y.V., Topham M.K., and Epand R.M. Substrate specificity of diacylglycerol kinase-epsilon and the phosphatidylinositol cycle FEBS Lett. 585 2011 4025 4028
33. Dicu A.O., Topham M.K., Ottaway L., and Epand R.M. Role of the hydrophobic segment of diacylglycerol kinase epsilon Biochemistry 46 2007 6109 6117 (Pubitemid 46804907)
34. Walsh J.P., Suen R., Lemaitre R.N., and Glomset J.A. Arachidonoyl- diacylglycerol kinase from bovine testis. Purification and properties J. Biol. Chem. 269 1994 21155 21164