Large changes in the CRAC segment of gp41 of HIV do not destroy fusion activity if the segment interacts with cholesterol

Biochemistry

Volumn 47, Issue 45, 2008, Pages 11869-11876

  Vishwanathan, Sundaram A ^a   Thomas, Annick ^c   Brasseur, Robert ^c   Epand, Raquel F ^b   Hunter, Eric ^a   Epand, Richard M ^b  

^a EMORY UNIVERSITY   (United States)

^b MCMASTER UNIVERSITY   (Canada)

^c UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; AMINES; AMINO ACIDS; CHOLESTEROL; FLOW INTERACTIONS; FUSION REACTIONS; ORGANIC ACIDS; PEPTIDES; PROTEINS; VIRUSES;

AMINO ACID SUBSTITUTIONS; CARBOXYL TERMINUSES; CELL SURFACES; CONFORMATIONAL FLEXIBILITIES; DO-MAINS; EXTERNAL-; FUSION ACTIVITIES; FUSION PROTEINS; MEMBRANE FUSIONS; MUTANT PROTEINS; PEPTIDE AMIDES; VACCINE DEVELOPMENTS;

CELL MEMBRANES;

AMIDE; CHOLESTEROL; GLYCINE; GLYCOPROTEIN GP 41; HYBRID PROTEIN; LEUCINE; LYSINE; MUTANT PROTEIN; TYROSINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CONTROLLED STUDY; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; MEMBRANE FUSION; MUTATION; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FAMILY; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; CELL LINE; CERCOPITHECUS AETHIOPS; CHOLESTEROL; COS CELLS; HIV ENVELOPE PROTEIN GP41; HUMANS; MEMBRANE FUSION; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS;

EID: 55849097339     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi8014828     Document Type: Article

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