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Volumn 9, Issue 24, 2011, Pages 8328-8339

One-pot near-ambient temperature syntheses of aryl(difluoroenol) derivatives from trifluoroethanol

Author keywords

[No Author keywords available]

Indexed keywords

ARYL HALIDES; BATH TEMPERATURES; COUPLING PROCEDURE; METHOXY; NEAR-AMBIENT TEMPERATURES; NEGISHI COUPLING; ONE POT; ONE-POT PROCEDURES; TRIFLUOROETHANOL;

EID: 84857571861     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/c1ob06372c     Document Type: Article
Times cited : (8)

References (65)
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    • A 0.5 eq excess of LDA provided 100% conversion while stoichiometric amounts did not. The sensitive difluorinated carbon generated from this reaction tolerates an excess of the non-nucleophilic amido base but undergoes an addition/elimination reaction when an excess of the more nucleophilic tert-butyllithium is used
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  • 46
  • 52
    • 57549099215 scopus 로고    scopus 로고
    • We are considering a standard mechanism for couplings of this type in which transmetallation and reductive elimination are usually the key events: see ref. 39
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    • Martin, R.1    Buchwald, S.L.2
  • 54
    • 31144444766 scopus 로고    scopus 로고
    • 1-Iodo-4-nitrobenzene was used instead of bromide as it was available in our laboratory Katz and co-workers also identified HF addition products, including 14, when generating styrenes bearing a strong EWG in the para position
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    • Gaussian 09, Revision A.1, M. J. Frisch et al., Gaussian, Inc., Wallingford CT, 2009.
    • (2009) Gaussian 09
    • Frisch, M.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.