Enhancement of felodipine dissolution rate through its incorporation into eudragit® E-PHB polymeric microparticles: In vitro characterization and investigation of absorption in rats

Journal of Pharmaceutical Sciences

Volumn 101, Issue 4, 2012, Pages 1518-1523

  Bazzo, Giovana C ^a   Caetano, Daniela B ^a   Boch, Maura L T ^a   Mosca, Mileine ^a   Branco, Luiza C ^a   Zétola, Melissa ^a   Pereira, Eduardo M ^a   Pezzini, Bianca R ^a  

^a UNIVERSITY OF JOINVILLE REGION   (Brazil)

Author keywords

Bioavailability; Eudragit E; Felodipine; Microencapsulation; Microparticles; Oral drug delivery; PHB; Solubility

Indexed keywords

EUDRAGIT; FELODIPINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG SOLUBILITY; ENCAPSULATION; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; RAT; SCANNING ELECTRON MICROSCOPY; X RAY DIFFRACTION;

EID: 84857503302     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23044     Document Type: Article

References (17)

1. Kim E, Chun M, Jang J, Lee I, Lee K, Choi H. 2006. Preparation of a solid dispersion of felodipine using a solvent wetting method. Eur J Pharm Biopharm 64:200-205.
2. Won DH, Kim MS, Lee S, Park JS, Wang SJ. 2005. Improved physicochemical characteristics of felodipine solid dispersion particles by supercritical anti-solvent precipitation process. Int J Pharm 30:199-208.
3. Karavas E, Georgarakis E, Sigalas MP, Avgoustakis K, Bikiaris D. 2007. Investigation of the release mechanism of a sparingly water-soluble drug from solid dispersions in hydrophilic carriers based on physical state of drug, particle size distribution and drug-polymer interactions. Eur J Pharm Biopharm 66:334-347.
4. Konno H, Handa T, Alonzo DE, Taylor LS. 2008. Effect of polymer type on the dissolution profile of amorphous solid dispersions containing felodipine. Eur J Pharm Biopharm 70:493-499.
5. Kerc J, Srcic S, Knez Z, Sencar-Bozic P. 1999. Micronization of drugs using supercritical carbon dioxide. Int J Pharm 182:33-39.
6. Vogt M, Kunath K, Dressman JB. 2008. Dissolution improvement of four poorly water soluble drugs by cogrinding with commonly used excipients. Eur J Pharm Biopharm 68:330-337.
7. Shaikh J, Ankola DD, Beniwal V, Singh D, Ravi Kumar MNV. 2009. Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. Eur J Pharm Sci 37:223-230.
8. Woo JS, Piao MG, Li DX, Ryu DS, Choi JY, Kim JA, Kim JH, Jin SG, Kim DD, Lyoo WS, Yong CS, Choi HG. 2007. Development of cyclosporin A-loaded hyaluronic microsphere with enhanced oral bioavailability. Int J Pharm 345:134-141.
9. Alhnan MA, Murdan S, Basit AW. 2011. Encapsulation of poorly soluble basic drugs into enteric microparticles: A novel approach to enhance their oral bioavailability. Int J Pharm 416:55-60.
10. Zang Z, Bu H, Gao Z, Huang Y, Gao F, Li Y. 2010. The characteristics and mechanism of simvastatin loaded lipid nanoparticles to increase oral bioavailability in rats. Int J Pharm 394:147-153.
11. Martin MA, Miguens FC, Rieumont J, Sanchez R. 2000. Tailoring of the external and internal morphology of poly-3-hydroxybutyrate microparticles. Colloids Surf B 17:111-116.
12. Wong SM, Kellaway IW, Murdan S. 2006. Enhancement of the dissolution rate and oral absorption of a poorly water soluble drug by formation of surfactant-containing microparticles. Int J Pharm 317:61-68.
13. Sudesh K, Abe H, Doi Y. 2000. Synthesis, structure and properties of polyhydroxyalkanoates: Biological polyesters. Prog Polym Sci 25:1503-1555.
14. Pouton CW, Akhtar S. 1996. Biosynthetic polyhydroxyalkanoates and their potential in drug delivery. Adv Drug Deliv Rev 18:133-162.
15. Passerini N, Albertini B, Perissutti B, Rodriguez L. 2006. Evaluation of melt granulation and ultrasonic spray congealing as techniques to enhance the dissolution of praziquantel. Int J Pharm 318:92-102.
16. Modi A, Tayade P. 2006. Enhancement of dissolution profile by solid dispersion (kneading) technique. AAPS PharmSciTech 7:E1-E6.
17. Quinteros DA, Rigo VR, Kairuz J, Oliveira ME, Manzo RH, Allemandi DA. 2008. Interaction between a cationic polymethacrylate (Eudragit E100) and anionic drugs. Eur J Pharm Sci 33:72-79.