Granulocyte colony-stimulating factor improves cerebrovascular reserve capacity by enhancing collateral growth in the circle of willis

Cerebrovascular Diseases

Volumn 33, Issue 5, 2012, Pages 419-429

  Duelsner, André ^a   Gatzke, Nora ^a   Glaser, Johanna ^a   Hillmeister, Philipp ^a   Li, Meijing ^a   Lee, Eun Ji ^a   Lehmann, Kerstin ^a   Urban, Daniel ^b   Meyborg, Heike ^b   Stawowy, Philipp ^b   Busjahn, Andreas ^c   Nagorka, Stephanie ^a   Bondke Persson, Anja ^a   Buschmann, Ivo R ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b DEUTSCHES HERZZENTRUM BERLIN   (Germany)

^c HealthTwist GmbH   (Germany)

Author keywords

Arteriogenesis; Brain ischemia; Cerebral blood flow; Cerebrovascular disease; Chemokines; Colony stimulating factor; Granulocyte colony stimulating factor; Granulocyte macrophage colony stimulating factor; Macrophages; Stroke

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; TRIPHENYLTETRAZOLIUM;

ANGIOGENESIS; ANGIOGRAPHY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CIRCULUS ARTERIOSUS; BRAIN PERFUSION; CAROTID ARTERY OBSTRUCTION; CELL COUNT; CELL MIGRATION; CEREBROVASCULAR RESERVE CAPACITY; CONTROLLED STUDY; DRUG EFFECT; HEART STROKE VOLUME; HEMODYNAMIC PARAMETERS; IN VITRO STUDY; IN VIVO STUDY; MALE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; STROKE;

ANIMALS; ARTERIAL OCCLUSIVE DISEASES; CAROTID STENOSIS; CELL MOVEMENT; CEREBROVASCULAR CIRCULATION; CEREBROVASCULAR DISORDERS; CIRCLE OF WILLIS; COLLATERAL CIRCULATION; DATA INTERPRETATION, STATISTICAL; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMODYNAMICS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MICE; MICE, INBRED C57BL; MONOCYTES; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; RECOVERY OF FUNCTION;

EID: 84857484642     PISSN: 10159770     EISSN: 14219786     Source Type: Journal    
DOI: 10.1159/000335869     Document Type: Article

References (42)

1. Piepgras A, Schmiedek P, Leinsinger G, Haberl RL, Kirsch CM, Einhaupl KM: A simple test to assess cerebrovascular reserve capacity using transcranial doppler sonography and acetazolamide. Stroke 1990; 21: 1306-1311. (Pubitemid 20301787)
2. Stoll M, Hamann GF: Cerebrovascular reserve capacity (in German). Nervenarzt 2002; 73: 711-718.
3. van Oers CA, Manschot SM, van Huffelen AC, Kappelle LJ, Biessels GJ: Cerebrovascular reserve capacity is preserved in a population-based sample of patients with type 2 diabetes mellitus. Cerebrovasc Dis 2006; 22: 46-50. (Pubitemid 43875160)
4. Coyle P, Jokelainen PT: Dorsal cerebral arterial collaterals of the rat. Anat Rec 1982; 203: 397-404. (Pubitemid 12097167)
5. Busch HJ, Buschmann IR, Mies G, Bode C, Hossmann KA: Arteriogenesis in hypoperfused rat brain. J Cereb Blood Flow Metab 2003; 23: 621-628. (Pubitemid 36566139)
6. Busch HJ, Schirmer SH, Jost M, van Stijn S, Peters SL, Piek JJ, Bode C, Buschmann IR, Mies G: Leptin augments cerebral hemodynamic reserve after three-vessel occlusion: Distinct effects on cerebrovascular tone and proliferation in a nonlethal model of hypoperfused rat brain. J Cereb Blood Flow Metab 2010.
7. Buschmann IR, Busch HJ, Mies G, Hossmann KA: Therapeutic induction of arteriogenesis in hypoperfused rat brain via granulocyte-macrophage colony-stimulating factor. Circulation 2003; 108: 610-615. (Pubitemid 36961178)
8. Schneeloch E, Mies G, Busch HJ, Buschmann IR, Hossmann KA: Granulocyte-macrophage colony-stimulating factor-induced arteriogenesis reduces energy failure in hemodynamic stroke. Proc Natl Acad Sci USA 2004; 101: 12730-12735. (Pubitemid 39122091)
9. Eitenmuller I, Volger O, Kluge A, Troidl K, Barancik M, Cai WJ, Heil M, Pipp F, Fischer S, Horrevoets AJ, Schmitz-Rixen T, Schaper W: The range of adaptation by collateral vessels after femoral artery occlusion. Circ Res 2006; 99: 656-662. (Pubitemid 44401457)
10. Buschmann I, Pries A, Styp-Rekowska B, Hillmeister P, Loufrani L, Henrion D, Shi Y, Duelsner A, Hoefer I, Gatzke N, Wang H, Lehmann K, Ulm L, Ritter Z, Hauff P, Hlushchuk R, Djonov V, van Veen T, le Noble F: Pulsatile shear and Gja5 modulate arterial identity and remodeling events during flowdriven arteriogenesis. Development 2010; 137: 2187-2196.
11. Bergmann CE, Hoefer IE, Meder B, Roth H, van Royen N, Breit SM, Jost MM, Aharinejad S, Hartmann S, Buschmann IR: Arteriogenesis depends on circulating monocytes and macrophage accumulation and is severely depressed in op/op mice. J Leukoc Biol 2006; 80: 59-65. (Pubitemid 44835526)
12. Heil M, Ziegelhoeffer T, Pipp F, Kostin S, Martin S, Clauss M, Schaper W: Blood monocyte concentration is critical for enhancement of collateral artery growth. Am J Physiol Heart Circ Physiol 2002; 283:H2411-H2419. (Pubitemid 35345945)
13. Buschmann IR, Hoefer IE, van Royen N, Katzer E, Braun-Dulleaus R, Heil M, Kostin S, Bode C, Schaper W: GM-CSF: A strong arteriogenic factor acting by amplification of monocyte function. Atherosclerosis 2001; 159: 343-356. (Pubitemid 33127248)
14. Deindl E, Zaruba MM, Brunner S, Huber B, Mehl U, Assmann G, Hoefer IE, Mueller-Hoecker J, Franz WM: G-csf administration after myocardial infarction in mice attenuates late ischemic cardiomyopathy by enhanced arteriogenesis. FASEB J 2006; 20: 956-958.
15. Schabitz WR, Kollmar R, Schwaninger M, Juettler E, Bardutzky J, Scholzke MN, Sommer C, Schwab S: Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia. Stroke 2003; 34: 745-751. (Pubitemid 36307405)
16. Schneider A, Wysocki R, Pitzer C, Kruger C, Laage R, Schwab S, Bach A, Schabitz WR: An extended window of opportunity for G-CSF treatment in cerebral ischemia. BMC Biol 2006; 4: 36.
17. Shyu WC, Lin SZ, Lee CC, Liu DD, Li H: Granulocyte colony-stimulating factor for acute ischemic stroke: A randomized controlled trial. CMAJ 2006; 174: 927-933.
18. Hillmeister P, Gatzke N, Dulsner A, Bader M, Schadock I, Hoefer I, Hamann I, Infante-Duarte C, Jung G, Troidl K, Urban D, Stawowy P, Frentsch M, Li M, Nagorka S, Wang H, Shi Y, le Noble F, Buschmann I: Arteriogenesis is modulated on bradykinin receptor signaling. Circ Res 2011; 109: 524-533.
19. Clayton JA, Chalothorn D, Faber JE: Vascular endothelial growth factor-A specifies formation of native collaterals and regulates collateral growth in ischemia. Circ Res 2008; 103: 1027-1036.
20. Jongen LM, Hendrikse J, Moll FL, Mali WP, van der Worp HB: Cerebral perfusion affects the risk of ischemia during carotid artery stenting. Cerebrovasc Dis 2010; 29: 538-545.
21. Hillmeister P, Lehmann KE, Bondke A, Witt H, Duelsner A, Gruber C, Busch HJ, Jankowski J, Ruiz-Noppinger P, Hossmann KA, Buschmann IR: Induction of cerebral arteriogenesis leads to early-phase expression of protease inhibitors in growing collaterals of the brain. J Cereb Blood Flow Metab 2008.
22. Sugiyama Y, Yagita Y, Oyama N, Terasaki Y, Omura-Matsuoka E, Sasaki T, Kitagawa K: Granulocyte colony-stimulating factor enhances arteriogenesis and ameliorates cerebral damage in a mouse model of ischemic stroke. Stroke 2011; 42: 770-775.
23. Jungehuelsing GJ, Liman TG, Brunecker P, Ebel A, Endres M, Buschmann I, Pagonas N, Buschmann EE: Does external counterpulsation augment mean cerebral blood flow in the healthy brain? Effects of external counterpulsation on middle cerebral artery flow velocity and cerebrovascular regulatory response in healthy subjects. Cerebrovasc Dis 2010; 30: 612-617.
24. Thoma R: Untersuchungen über die Histogenese und Histomechanik des Gefässsystems. Stuttgart, Enke, 1893.
25. Ujihara M, Nomura K, Yamada O, Shibata N, Kobayashi M, Takano K: Granulocyte-macrophage colony-stimulating factor ensures macrophage survival and generation of the superoxide anion: A study using a monocytic-differentiated HL60 subline. Free Radic Biol Med 2001; 31: 1396-1404. (Pubitemid 33145309)
26. Hoefer IE, van Royen N, Rectenwald JE, Deindl E, Hua J, Jost M, Grundmann S, Voskuil M, Ozaki CK, Piek JJ, Buschmann IR: Arteriogenesis proceeds via ICAM-1/Mac-1-mediated mechanisms. Circ Res 2004; 94: 1179-1185. (Pubitemid 38656404)
27. Gurleyik G, Yanikkaya G, Gurleyik E, Ozturk E, Dulundu E, Saglam A: Effects of granulocyte-colony stimulating factor on the polymorphonuclear leukocyte activity and the course of sepsis in rats with experimental peritonitis. Surg Today 2007; 37: 401-405. (Pubitemid 46684514)
28. Gutschalk CM, Herold-Mende CC, Fusenig NE, Mueller MM: Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor promote malignant growth of cells from head and neck squamous cell carcinomas in vivo. Cancer Res 2006; 66: 8026-8036. (Pubitemid 44299167)
29. Kreider BL, Phillips PD, Prystowsky MB, Shirsat N, Pierce JH, Tushinski R, Rovera G: Induction of the granulocyte-macrophage colony-stimulating factor (CSF) receptor by granulocyte CSF increases the differentiative options of a murine hematopoietic progenitor cell. Mol Cell Biol 1990; 10: 4846-4853.
30. Aapro MS, Cameron DA, Pettengell R, Bohlius J, Crawford J, Ellis M, Kearney N, Lyman GH, Tjan-Heijnen VC, Walewski J, Weber DC, Zielinski C: EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphomas and solid tumours. Eur J Cancer 2006; 42: 2433-2453. (Pubitemid 44442936)
31. Welte K, Gabrilove J, Bronchud MH, Platzer E, Morstyn G: Filgrastim (r-metHuG-CSF): The first 10 years. Blood 1996; 88: 1907-1929. (Pubitemid 26307891)
32. Marino VJ, Roguin LP: The granulocyte colony stimulating factor (G-CSF) activates Jak/STAT and MAPK pathways in a trophoblastic cell line. J Cell Biochem 2008; 103: 1512-1523. (Pubitemid 351490719)
33. Valdembri D, Serini G, Vacca A, Ribatti D, Bussolino F: In vivo activation of JAK2/STAT-3 pathway during angiogenesis induced by GM-CSF. FASEB J 2002; 16: 225-227.
34. Carrao AC, Chilian WM, Yun J, Kolz C, Rocic P, Lehmann K, van den Wijngaard JP, van Horssen P, Spaan JA, Ohanyan V, Pung YF, Buschmann I: Stimulation of coronary collateral growth by granulocyte stimulating factor: Role of reactive oxygen species. Arterioscler Thromb Vasc Biol 2009; 29: 1817-1822.
35. Li D, Mehta JL: Antisense to LOX-1 inhibits oxidized LDL-mediated upregulation of monocyte chemoattractant protein-1 and monocyte adhesion to human coronary artery endothelial cells. Circulation 2000; 101: 2889-2895. (Pubitemid 30415877)
36. Konishi Y, Chui DH, Hirose H, Kunishita T, Tabira T: Trophic effect of erythropoietin and other hematopoietic factors on central cholinergic neurons in vitro and in vivo. Brain Res 1993; 609: 29-35. (Pubitemid 23136796)
37. van Royen N, Hoefer I, Bottinger M, Hua J, Grundmann S, Voskuil M, Bode C, Schaper W, Buschmann I, Piek JJ: Local monocyte chemoattractant protein-1 therapy increases collateral artery formation in apolipoprotein E-deficient mice but induces systemic monocytic CD11b expression, neointimal formation, and plaque progression. Circ Res 2003; 92: 218-225. (Pubitemid 36254278)
38. Schaper W: Collateral circulation: Past and present. Basic Res Cardiol 2009; 104: 5-21.
39. Deindl E: Arteriogenesis: A focus on signal transduction cascades and transcription factors. Thromb Haemost 2007; 98: 940-943.
40. Persson AB, Buschmann IR: Vascular growth in health and disease. Front Mol Neurosci 2011; 4: 14.
41. Wilson RF, Henry TD: Granulocyte colonystimulating factor and granulocyte-macrophage colony-stimulating factor: Doubleedged swords. J Am Coll Cardiol 2005; 46: 1649-1650. (Pubitemid 41531617)
42. Eckman PM, Bertog SC, Wilson RF, Henry TD: Ischemic cardiac complications following G-CSF. Catheter Cardiovasc Interv 2010; 76: 98-101.