Different in vitro and in vivo profiles of substituted 3- aminopropylphosphinate and 3-aminopropyl(methyl)phosphinate GABA B receptor agonists as inhibitors of transient lower oesophageal sphincter relaxation

British Journal of Pharmacology

Volumn 165, Issue 6, 2012, Pages 1757-1772

  Lehmann, A ^a   Antonsson, M ^a   Aurell Holmberg, A ^a   Blackshaw, L A ^b,f   Branden L ^a   Elebring, T ^a   Jensen, J ^a   Karrberg L ^a   Mattsson, J P ^a,e   Nilsson, K ^a   Oja, S S ^c   Saransaari, P ^d   Von Unge, S ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

^d TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^e Albireo AB   (Sweden)

^f QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

GABA transporter; GABA B receptor; gastro oesophageal reflux disease; hypothermia; transient lower oesophageal sphincter relaxation

Indexed keywords

3 AMINOPROPYL(METHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B1 RECEPTOR; 4 AMINOBUTYRIC ACID B2 RECEPTOR; LESOGABERAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG UPTAKE; FEMALE; HYPOTHERMIA; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; LOWER ESOPHAGUS SPHINCTER; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; SPECIES COMPARISON; STRUCTURE ACTIVITY RELATION;

ANIMALS; BRAIN; CEREBRAL CORTEX; CHO CELLS; CRICETINAE; CRICETULUS; DOGS; ESOPHAGEAL SPHINCTER, LOWER; FEMALE; GABA-B RECEPTOR AGONISTS; HUMANS; HYPOTHERMIA; MICE; MICE, INBRED C57BL; MUSCLE RELAXATION; ORGANOPHOSPHORUS COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, GABA-A; RECEPTORS, GABA-B;

EID: 84857463153     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01682.x     Document Type: Article

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