The novel, peripherally restricted GABAB receptor agonist lesogaberan (AZD3355) inhibits acid reflux and reduces esophageal acid exposure as measured with 24-h pHmetry in dogs

European Journal of Pharmacology

Volumn 634, Issue 1-3, 2010, Pages 138-141

  Brändén, Lena ^a   Fredriksson, Anita ^a   Harring, Emelie ^a   Jensen, Jörgen ^a   Lehmann, Anders ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

24 h acid exposure; Baclofen; GABAB receptor; Gastroesophageal reflux; Lesogaberan (AZD3355)

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; AZD 3355; BACLOFEN; LESOGABERAN; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; PHOSPHINIC ACID DERIVATIVE; PROPYLAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; EXPERIMENTAL DOG; GASTRIC PH MONITORING; GASTROESOPHAGEAL REFLUX; MALE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; STOMACH ACID SECRETION; TREATMENT RESPONSE; ANIMAL; COMPARATIVE STUDY; DOG; DRUG EFFECTS; ESOPHAGUS; FEMALE; MANOMETRY; METABOLISM; PATHOPHYSIOLOGY; PH; PHYSIOLOGY; PILOT STUDY; PROCEDURES; SECRETION (PROCESS); STOMACH ACID; TIME;

ANIMALS; BACLOFEN; DOGS; ESOPHAGUS; FEMALE; GABA AGONISTS; GASTRIC ACID; GASTROESOPHAGEAL REFLUX; HYDROGEN-ION CONCENTRATION; MALE; MANOMETRY; PHOSPHINIC ACIDS; PILOT PROJECTS; PROPYLAMINES; RECEPTORS, GABA-B; TIME FACTORS; GABA-B RECEPTOR AGONISTS;

EID: 77951205836     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.02.015     Document Type: Article

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