Giardia duodenalis: Dendritic cell defects in IL-6 deficient mice contribute to susceptibility to intestinal infection

Experimental Parasitology

Volumn 130, Issue 3, 2012, Pages 288-291

  Kamda, Joel D ^a   Nash, Theodore E ^b   Singer, Steven M ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b National Institute for Allergy and Infectious Disease   (United States)

Author keywords

Dendritic cells; Giardia; Interleukin 6; Mucosal immunity

Indexed keywords

CYTOKINE; INTERLEUKIN 6;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BONE MARROW; CELL TYPE; CHIMERA; CONTROLLED STUDY; DENDRITIC CELL; DIARRHEA; DISEASE PREDISPOSITION; FEMALE; GIARDIA DUODENALIS; GIARDIASIS; GROWTH RETARDATION; INFECTION CONTROL; INTESTINE INFECTION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOPOIESIS; MOUSE; MUSCLE CRAMP; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL; T LYMPHOCYTE; TH17 CELL;

ANIMALS; BONE MARROW CELLS; CHIMERA; DENDRITIC CELLS; FEMALE; GIARDIA LAMBLIA; GIARDIASIS; INTERLEUKIN-6; MICE; MICE, INBRED C57BL;

GIARDIA; GIARDIA INTESTINALIS; MAMMALIA; MUS; PROTOZOA;

EID: 84857457510     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2012.01.003     Document Type: Article

References (26)

1. Adam R.D. The Biology of Giardia spp. Microbiological Reviews 1991, 55:706-732.
2. Aggarwal A., Nash T.E. Antigenic variation of Giardia lamblia in vivo. Infection and Immunity 1988, 56:1420-1423.
3. Bienz M., Dai W.J., Welle M., Gottstein B., Muller N. Interleukin-6-deficient mice are highly susceptible to Giardia lamblia infection but exhibit normal intestinal immunoglobulin A responses against the parasite. Infection and Immunity 2003, 71:1569-1573.
4. Bleier J.I., Pillarisetty V.G., Shah A.B., DeMatteo R.P. Increased and long-term generation of dendritic cells with reduced function from IL-6-deficient bone marrow. The Journal of Immunology 2004, 172:7408-7416.
5. Cotton J.A., Beatty J.K., Buret A.G. Host parasite interactions and pathophysiology in Giardia infections. International Journal for Parasitology 2011, 41:925-933.
6. Draube A., Klein-Gonzalez N., Mattheus S., Brillant C., Hellmich M., Engert A., von Bergwelt-Baildon M. Dendritic cell based tumor vaccination in prostate and renal cell cancer: a systematic review and meta-analysis. PLoS One 2011, 6:e18801.
7. Faubert G. Immune response to Giardia duodenalis. Clinical Microbiology Reviews 2000, 13:35-54.
8. Gilman R.H., Marquis G.S., Miranda E., Vestegui M., Martinez H. Rapid reinfection by Giardia lamblia after treatment in a hyperendemic Third World community. Lancet 1988, 1:343-345.
9. Heyworth M.F., Carlson J.R., Ermak T.H. Clearance of Giardia muris infection requires helper/inducer T lymphocytes. The Journal of Experimental Medicine 1987, 165:1743-1748.
10. Isaac-Renton J.L., Lewis L.F., Ong C.S., Nulsen M.F. A second community outbreak of waterborne giardiasis in Canada and serological investigation of patients. Transactions of the Royal Society of Tropical Medicine and Hygiene 1994, 88:395-399.
11. Istre G.R., Dunlop T.S., Gaspard G.B., Hopkins R.S. Waterborne giardiasis at a mountain resort: evidence for acquired immunity. American Journal of Public Health 1984, 74:602-604.
12. Jones S.A. Directing transition from innate to acquired immunity: defining a role for IL-6. The Journal of Immunology 2005, 175:3463-3468.
13. Kamda J.D., Singer S.M. Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia. Infection and Immunity 2009, 77:685-693.
14. Keister D.B. Axenic culture of Giardia lamblia in TYI-S-33 medium supplemented with bile. Transactions of the Royal Society of Tropical Medicine and Hygiene 1983, 77:487-488.
15. Kimura A., Naka T., Kishimoto T. IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells. Proceedings of the National Academy of Sciences USA 2007, 104:12099-12104.
16. Li E., Zhou P., Petrin Z., Singer S.M. Mast cell-dependent control of Giardia lamblia infections in mice. Infection and Immunity 2004, 72:6642-6649.
17. Lutz M.B., Kukutsch N., Ogilvie A.L., Rossner S., Koch F., Romani N., Schuler G. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. Journal of Immunological Methods 1999, 223:77-92.
18. Matowicka-Karna J., Dymicka-Piekarska V., Kemona H. IFN-gamma, IL-5, IL-6 and IgE in patients infected with Giardia intestinalis. Folia Histochemica et Cytobiologica 2009, 47:93-97.
19. Muraguchi A., Hirano T., Tang B., Matsuda T., Horii Y., Nakajima K., Kishimoto T. The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. The Journal of Experimental Medicine 1988, 167:332-344.
20. Park S.J., Nakagawa T., Kitamura H., Atsumi T., Kamon H., Sawa S., Kamimura D., Ueda N., Iwakura Y., Ishihara K., Murakami M., Hirano T. IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation. The Journal of Immunology 2004, 173:3844-3854.
21. Remer K.A., Apetrei C., Schwarz T., Linden C., Moll H. Vaccination with plasmacytoid dendritic cells induces protection against infection with Leishmania major in mice. European Journal of Immunology 2007, 37:2463-2473.
22. Singer S.M., Nash T.E. T-cell-dependent control of acute Giardia lamblia infections in mice. Infection and Immunity 2000, 68:170-175.
23. Su H., Messer R., Whitmire W., Fischer E., Portis J.C., Caldwell H.D. Vaccination against chlamydial genital tract infection after immunization with dendritic cells pulsed ex vivo with nonviable Chlamydiae. The Journal of Experimental Medicine 1998, 188:809-818.
24. von Allmen N., Christen S., Forster U., Gottstein B., Welle M., Muller N. Acute trichinellosis increases susceptibility to Giardia lamblia infection in the mouse model. Parasitology 2006, 133:139-149.
25. Weaver C.T., Harrington L.E., Mangan P.R., Gavrieli M., Murphy K.M. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 2006, 24:677-688.
26. Zhou P., Li E., Zhu N., Robertson J., Nash T., Singer S.M. Role of interleukin-6 in the control of acute and chronic Giardia lamblia infections in mice. Infection and Immunity 2003, 71:1566-1568.