Carbamazepine (CBZ) induced enzymatic stress in gill, liver and muscle of a common carp, Cyprinus carpio

Journal of King Saud University - Science

Volumn 24, Issue 2, 2012, Pages 179-186

  Malarvizhi, Annamalai ^a   Kavitha, Chokkalingam ^a   Saravanan, Manoharan ^a   Ramesh, Mathan ^a  

^a BHARATHIAR UNIVERSITY   (India)

Author keywords

Acute; Carbamazepine; Cyprinus carpio; LDH; Sublethal toxicity; Transaminases

Indexed keywords

EID: 84857444293     PISSN: 10183647     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jksus.2011.01.001     Document Type: Article

References (75)

1. Abston P.A., Yarbrough J.D. The in vivo effect of mirex on soluble hepatic enzymes in the rat. Pestic. Biochem. Physiol. 1976, 6:192-199.
2. Agrahari S., Pandey K.C., Gopal K. Biochemical alteration induced by monocrotophos in the blood plasma of fish, Channa punctatus (Bloch). Pestic. Biochem. Physiol. 2007, 88:268-272.
3. APHA Standard Method for the Examination of Water and Wastewater 1971, American Public Health Association, New York, USA, p. 874. 13th ed.
4. APHA Standard Methods for the Examination of Water and Wastewater 1998, American Public Health Association, Washington, DC. 20th ed.
5. Ayscough, N.J., Fawell, J., Franklin, G., Young, W., 2000. Review of Human Pharmaceuticals in the Environment. Technical Report, Environment Agency, Bristol, p. 390.
6. Bernet D., Schmidt H., Wahli T., Burkhardt-Holm P. Effluent from a sewage treatment works causes changes in serum biochemistry of brown trout (Salmo trutta L.). Ecotoxicol. Environ. Saf. 2001, 48:140-147.
7. Canesi L., Ciacci C., Lorusso L.C., Betti M., Gallo G., Poiana G., Marcomini A. Effects of Triclosan on Mytilus galloprovincialis hemocyte function and digestive gland enzyme activities: possible modes of action on non target organisms. Comp. Biochem. Physiol. Part C 2007, 145:464-472.
8. Choi K., Kim Y., Jung J., Kim M.H., Kim C.S., Kim N.H., Park J. Occurrences and ecological risks of roxithromycin, trimethoprim, and chloramphenicol in the Han River, Korea. Environ. Toxicol. Chem. 2008, 27:711-719.
9. Clara M., Strenn B., Kreuzinger N. Carbamazepine as a possible anthropogenic marker in the aquatic environment: investigations on the behaviour of carbamazepine in wastewater treatment and during groundwater infiltration. Water Res. 2004, 38:947-954.
10. Daughton, C.G., Jones-Lepp, T., 2001. Pharmaceuticals and personal care products in the environment- scientific and regulatory issues. ACS Symposium Series, vol. 791. American Chemical Society, Washington, DC.
11. Daughton C.G., Ternes T.A. Pharmaceuticals and personal care products in the environment: agents of subtle change?. Environ. Health Perspect. 1999, 107(6):907-938.
12. Diamantino T.C., Almeida E., Soares A.M.V.M., Guilhermino L. Lactate dehydrogenase activity as an effect criterion in toxicity tests with Daphnia magna straus. Chemosphere 2001, 45:553-560.
13. Drewes J.E., Heberer T., Reddersen K. Fate of pharmaceuticals during indirect potable reuse. Water Sci. Technol. 2002, 46:73-80.
14. El-Sayed Y.S., Saad T.T., El-Bahr S.M. Acute intoxication of deltamethrin in monosex Nile tilapia, Oreochromis niloticus with special reference to the clinical, biochemical and haematological effects. Environ. Toxicol. Pharmacol. 2007, 24:212-217.
15. Fent K., Weston A.A., Caminada D. Ecotoxicology of human pharmaceuticals. Aquat. Toxicol. 2006, 76:22-159.
16. Finney D.J. Statistical Methods in Biological Assay 1978, Springer, Berlin, p. 508. third ed.
17. Gagne F., Blaise C., André C. Occurrence of pharmaceutical products in a municipal effluent and toxicity to rainbow trout (Oncorhynchus mykiss) hepatocytes. Ecotoxicol. Environ. Saf. 2006, 64(3):329-336.
18. Gagnon M.M. Metabolic enzymes as biochemical markers of effect following exposure of fish to sodium pentachlorophenate (Na-PCP). Bull. Environ. Contam. Toxicol. 2002, 69:570-575.
19. Galina J., Nemcsok J., Jeney Z.S., Olah J. Acute effect of sublethal ammonia concentration on common carp, Cyprinus carpio L. II. Effect of ammonia on blood plasma transaminases (GOT, GPT), GIDH enzyme activity, and ATP value. Aquaculture 1992, 104:149-156.
20. Gill T.S., Tewari H., Pande J. Use of the fish enzyme system in monitoring water quality. Effects of mercury on tissue enzymes. Comp. Biochem. Physiol. Part C 1990, 97:287-292.
21. Gomez M.J., Martínez Bueno M.J., Lacorte S., Fernández-Alba A.R., Agüera A. Pilot survey monitoring pharmaceuticals and related compounds in a sewage treatment plant located on the Mediterranean coast. Chemosphere 2007, 66(6):993-1002.
22. Gravel A., Vijayan M.M. Salicylate impacts the physiological responses to an acute handling disturbance in rainbow trout. Aquat. Toxicol. 2007, 85:87-95.
23. Gros M., Petrovic M., Barcelo D. Development of a multi-residue analytical methodology based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for screening and trace level determination of pharmaceuticals in surface and wastewaters. Talanta 2006, 70(4):678-690.
24. Haap T., Triebskorn R., Hohler H.R. Acute effects of diclofenac and DMSO to Daphnia magna: immobilization and hsp70-induction. Chemosphere 2008, 73:353-359.
25. Halling-Sørensen B., Nors Nielsen S., Lanzky P.F., Ingerslev F., Holtzen Lutzhøft H.C., Jørgensen S.E. Occurrence, fate and effects of pharmaceutical substances in the environment - a review. Chemosphere 1998, 36:357-393.
26. Hoeger B., Köllner B., Dietrich D.R., Hitzfeld B. Water-borne diclofenac affects kidney and gill integrity and selected immune parameters in brown trout (Salmo trutta f. fario). Aquat. Toxicol. 2005, 75(1):53-64.
27. Hoeger B., Dietrich D.R., Schmid D., Hartmann A., Hitzfeld B. Distribution of intraperitoneally injected diclofenac in brown trout (Salmo trutta f. Fario). Ecotoxicol. Environ. Saf. 2008, 71:412-418.
28. Hogeboom G.H., Schneider W.C., Pallade G.E. Cytochemical studies of mammalian tissues: 1. Isolation of intact mitochondria from rat liver; some biochemical properties of mitochondria and submicroscopic particulate material. J. Biol. Chem. 1948, 172:619-635.
29. Huggett D.B., Cook J.C., Ericson J.F., Williams R.T. A theoretical model for utilizing mammalian pharmacology and safety data to prioritize potential impacts of human pharmaceuticals to fish. Hum. Ecol. Risk Assess. 2003, 9:1789-1799.
30. Isidori M., Lavorgna M., Nardelli A., Pascarella L., Parrella A. Toxic and genotoxic evaluation of six antibiotics on non-target organisms. Sci. Total Environ. 2005, 346:87-98.
31. Jones O.A.H., Volvoulis N., Lester J.N. Aquatic environmental assessment of the top 25 English prescription pharmaceuticals. Water Res. 2002, 36:5013-5022.
32. Jos A., Repetto G., Riosc J.C., Hazend M.J., Molerod M.L., Del Pesoa A., Salgueroa M., Fernandez-Freired P., Perez-Marti{dotless}nd J.M., Cameanb A. Ecotoxicological evaluation of carbamazepine using six different model systems with eighteen endpoints. Toxicol. In Vitro 2003, 17:525-532.
33. Kasprzyk-Hordern B., Dinsdale R.M., Guwy A.J. Illicit drugs and pharmaceuticals in the environment-forensic applications of environmental data, Part 2: pharmaceuticals as chemical markers of faecal water contamination. Environ. Pollut. 2009, 157:1778-1786.
34. Kim Y., Choi K., Jung J., Park S., Kim P., Park J. Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea. Environ. Int. 2007, 33:370-375.
35. Laura Martín-Díaz M., Gagnéc F., Blaise C. The use of biochemical responses to assess ecotoxicological effects of pharmaceutical and personal care products (PPCPs) after injection in the mussel Elliptio complanata. Environ. Toxicol. Pharmacol. 2009, 28(2):237-242.
36. Letzel M., Metzner G., Letzel T. Exposure assessment of the pharmaceutical diclofenac based on long-term measurements of the aquatic input. Environ. Int. 2009, 35:363-368.
37. +-ATPase activity in gill of rainbow trout, Oncorhynchus mykiss, chronically treated with carbamazepine. Chemosphere 2009, 77(11):1476-1481.
38. Li Z., Zlabek V., Velisek J., Grabic R., Machova J., Randak T. Modulation of antioxidant defence system in brain of rainbow trout (Oncorhynchus mykiss) after chronic carbamazepine treatment. Comp. Biochem. Physiol. Part C: Toxicol. Pharmacol. 2010, 151(1):137-141.
39. Muralidharan S., Dhananjayan V. Diclofenac residues in blood plasma and tissues of vultures collected from Ahmedabad, India. Bull. Environ. Contam. Toxicol. 2010, 85:377-380.
40. Nemcsok J., Boross L. Comparative studies on the sensitivity of different fish species to metal pollution. Acta Biol. Hung. 1982, 33:23-27.
41. Nemcsok J., Benedeczky I., Boross L., Asztalos B., Orban L. Sub cellular localization of transaminase enzyme in fishes and their significance in the detection of water pollution. Acta Biol. Szeged. 1981, 27:9-15.
42. Nemcsok J., Nemeth A., Buzas Z., Botorr L. Effect of copper, zinc and paraquat on acetylcholinesterase activity in carp, Cyprinus carpio (L). Aquat. Toxicol. 1984, 5:23-31.
43. Nunes B., Carvalho F., Guilhermino L. Acute and chronic effects of clofibrate and clofibric acid on the enzymes acetylcholinesterase, lactate dehydrogenase and catalase of the mosquitofish, Gambusia holbrooki. Chemosphere 2004, 57:1581-1589.
44. Oaks J.L., Gilbert M., Virani M.Z., Watson R.T., Meteyer C.U., Rideout B.A., Shivaprasad H.L., Ahmed S., Chauddry M.J.I., Arshad M., Mahmood S., Ali A., Khan A.A. Diclofenac residues as the cause of population decline of vultures in Pakistan. Nature 2004, 427:630-633.
45. Pacheco M., Santos M.A. Biotransformation, ecotoxic and histopathological effects of environmental contaminants in European eel, Anguilla anguilla (L). Ecotoxicol. Environ. Saf. 2002, 53:331-347.
46. Pfluger P., Dietrich D.R. Effects on pharmaceuticals in the environment-an overview and principle considerations. Pharmaceuticals in the Environment-Sources, Fate, Effects and Risks 2001, 11-17. Springer, Berlin. K. Kummerer (Ed.).
47. Pomati F., Netting A.G., Clamari D., Neilan B.A. Effects of erythromycin, tetracycline and ibuprofen on the growth of Synechocystis sp. and Lemna minor. Aquat. Toxicol. 2004, 67:387-396.
48. Reddy S.L.N., Venugopal N.B.R.K. In vivo effects of cadmium chloride on certain aspects of protein metabolism in tissues of a freshwater field crab, Barytelphusa guerini. Bull. Environ. Contam. Toxicol. 1991, 46:583-590.
49. Reitmen S., Franckel S. A colorimetric method for the determination of serum glutamic oxalo acetic and glutamic pyruvic transaminase. Am. J. Clin. Pathol. 1957, 28-56.
50. Rendon-von Osten J., Orti{dotless}z-Arana A., Guilhermino L., Soares A.M.V.M. In vivo evaluation of three biomarkers in the mosquito fish, Gambusia yucatana exposed to pesticides. Chemosphere 2005, 58:627-636.
51. Richardson M.L., Bowron J.M. The fate of pharmaceutical chemicals in the aquatic environment. J. Pharm. Pharmacol. 1985, 37:1-12.
52. Rosal R., Gonzalo M.S., Boltes K., Letón P., Vaquero J.J., García-Calvo E. Identification of intermediates and assessment of ecotoxicity in the oxidation products generated during the ozonation of clofibric acid. J. Hazard. Mater. 2009, 172(2-3):1061-1068.
53. RxList, 2006. The Internet Drug Index. <>. http://www.rxlist.com.
54. Sanderson H., Johnson D.J., Reitsma T., Brain R.A., Wilson C.J., Solomon K.R. Ranking and prioritization of environmental risks of pharmaceuticals in surface waters. Regul. Toxicol. Pharmacol. 2004, 39:158-183.
55. Sastry K.V., Siddiqui A.A. Some haematological, biochemical and enzymological parameters of a freshwater teleost fish, Channa punctatus, exposed to sublethal concentration of quinalphos. Pestic. Biochem. Physiol. 1984, 22:8-13.
56. Schwaiger J., Ferling H., Mallowa U., Wintermayr H., Negele R.D. Toxic effects of the non-steroidal anti-inflammatory drug diclofenac. Part I: histopathological alterations and bioaccumulation in rainbow trout. Aquat. Toxicol. 2004, 68:141-150.
57. Shultz S., Baral H.S., Charman S., Cunningha A.A., Das D., Ghalsasi G.R., Goudar M.S., Green R.E., Jones A., Nigot P., Plain D.J., Prakash V. Diclofenac poisoning is widespread in decline vulture populations across the Indian subcontinent. Proc. R. Soc. London B 2004, 271(6):S458-S460. doi: 10.1098/rsbl.2004.0223.
58. Sprague J.B. Measurement of pollutant toxicity to fish. III. Sublethal effects and 'safe' concentrations. Water Res. 1971, 5:245-266.
59. Svoboda M., Luskova V., Drastichova J., Zlabek V. The effect of diazinon on haematological indices of common carp (Cyprinus carpio L.). Acta Vet. BRNO. 2001, 70:457-465.
60. Szegletes T., Polyhos C.S., Balint T., Reddy A.A., Lang G., Kufesak O., Nemcsok J. In vivo effects of deltamethrin on some biochemical parameters of carp, Cyprinus carpio (L.). Environ. Monit. Assess. 1995, 35:97-111.
61. Ternes T.A. Occurrence of drugs in German sewage treatment, plants and rivers. Water Res. 1998, 32(11):3245-3260.
62. Thaker P.D. Pharmaceutical data elude researchers. Environ. Sci. Technol. 2005, 139(9):193A-194A.
63. Thibaut R., Porte C. Effects of fibrates, anti-inflammatory drugs and antidepressants in the fish hepatoma cell line PLHC-1: cytotoxicity and interactions with cytochrome P450 1A. Toxicol. In Vitro 2008, 22:1128-1135.
64. Thomas K.V., Hilton M.J. The occurrence of selected human pharmaceutical compounds in UK estuaries. Mar. Pollut. Bull. 2004, 49:436-444.
65. Tietz N.W. Fundamentals of Clinical Chemistry 1976, W.B. Saunders Co., Philadelphia, PA, p. 652.
66. Triebskorn R., Casper H., Heyd A., Eikemper R., Kohler H.R., Schwaiger J. Toxic effects of the nonsterodial anti-inflammatory drug diclofenac: Part II. Cytological effects in liver, kidney, gills and intestine of rainbow trout (Oncorhynchus mykiss). Aquat. Toxicol. 2004, 68:151-166.
67. Triebskorn R., Casper H., Scheil V., Schwaiger J. Ultrastructural effects of pharmaceuticals (carbamazepine, clofibric acid, metoprolol, diclofenac) in rainbow trout (Oncorhynchus mykiss) and common carp (Cyprinus carpio). Anal. Bioanal. Chem. 2007, 387:1405-1416.
68. Tu H.T., Silvestre F., Scippo M.L., Thome J.P., Phuong N.T., Kestemont P. Acetylcholinesterase activity as a biomarker of exposure to antibiotics and pesticides in the black tiger shrimp (Penaeus monodon). Ecotoxicol. Environ. Saf. 2009, 72(5):1463-1470.
69. Van der R.O., Jonny B., Vermeulen N.P.E. Fish bioaccumulation and biomarkers in environmental risk assessment, a review. Environ. Toxicol. Pharmacol. 2003, 13:57-149.
70. Webb D., Gagnon M.M., Rose T. Metabolic enzyme activities in black bream, Acanthopagrus butcheri from the swan canning estuary, Western Australia. Comp. Biochem. Physiol. Part C 2005, 141:356-365.
71. Yadav A., Gopesh A., Pandey R.S., Rai D.K., Sharma B. Fertilizer Industry Effluent Induced Biochemical Changes in Fresh water Teleost, Channa striatus (Bloch). Bull. Environ. Contam. Toxicol. 2007, 79:588-595.
72. Yamamoto H., Nakamura Y., Moriguchi S., Nakamura Y., Honda Y., Tamura I., Hirata Y., Hayashi A., Sekizawa J. Persistence and partitioning of eight selected pharmaceuticals in the aquatic environment: laboratory photolysis, biodegradation, and sorption experiments. Water Res. 2009, 43:351-362.
73. Yang L.H., Ying G.G., Su H.C., Stauber J.L., Adams M.S., Binet M.T. Growth inhibiting effects of 12 antibacterial agents and their mixtures on the freshwater micro alga Pseudokirchneriella subcapitata. Environ. Toxicol. Chem. 2008, 27(5):1201-1208.
74. Zuccato E., Calamari D., Natangelo M., Fanelli R. Presence of therapeutic drugs in the environment. Lancet 2000, 355:1789-1790.
75. Zuccato E., Castiglioni S., Fanelli R. Identification of the pharmaceuticals for human use contaminating the Italian aquatic environment. J. Hazard. Mater. 2005, 122:205-209.