A multidisciplinary approach to characterise exposure risk and toxicological effects of PM 10 and PM 2.5 samples in urban environments

Ecotoxicology and Environmental Safety

Volumn 78, Issue , 2012, Pages 327-335

  Reche, Cristina ^a,b   Moreno, Teresa ^a   Amato, Fulvio ^a,c   Viana, Mar ^a   van Drooge, Barend L ^a   Chuang, Hsiao Chi ^d   Bérubé, Kelly ^d   Jones, Tim ^e   Alastuey, Andrés ^a   Querol, Xavier ^a  

^a INSTITUTE OF ENVIRONMENTAL ASSESSMENT AND WATER RESEARCH   (Spain)

^b INSTITUT DE CIÈNCIA I TECNOLOGIA AMBIENTALS   (Spain)

^c TNO   (Netherlands)

^d CARDIFF UNIVERSITY   (United Kingdom)

^e CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

PM; Risk assessment; ROS; Source apportionment; Toxicology

Indexed keywords

ANTHRACENE; BENZ[A]ANTHRACENE; BENZO[A]PYRENE; BENZO[E]PYRENE; BENZO[GHI]PERYLENE; BENZO[K]FLUORANTHENE; CHRYSENE; DIBENZ[A,H]ANTHRACENE; DICHLORODIHYDROFLUORESCEIN; FLUORANTHENE; FUEL OIL; INDENO[1,2,3 CD]PYRENE; PHENANTHRENE; PLASMID DNA; POLYCYCLIC AROMATIC HYDROCARBON; PYRENE;

AEROSOL; AEROSOL COMPOSITION; CANCER; COMBUSTION; DNA; HEALTH IMPACT; HEALTH RISK; INDUSTRIAL EMISSION; OXIDATION; PAH; PARTICLE SIZE; PLASMID; POLLUTANT SOURCE; POLLUTION EFFECT; POLLUTION EXPOSURE; REACTION KINETICS; RISK ASSESSMENT; RISK FACTOR; SIZE DISTRIBUTION; TRAFFIC EMISSION; URBAN ATMOSPHERE; URBAN POLLUTION;

AIR POLLUTANT; ARTICLE; CANCER RISK; COMBUSTION; COMPUTER PROGRAM; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; ENVIRONMENTAL EXPOSURE; HEALTH HAZARD; OXIDATIVE STRESS; PARTICULATE MATTER; RISK ASSESSMENT; SECONDARY ORGANIC AEROSOL; SPAIN; URBAN AREA;

AEROSOLS; AIR POLLUTANTS; CITIES; DUST; ENVIRONMENTAL EXPOSURE; HUMANS; MODELS, CHEMICAL; NEOPLASMS; OXIDATIVE STRESS; PARTICLE SIZE; POLYCYCLIC HYDROCARBONS, AROMATIC; RISK ASSESSMENT;

BARCELONA [BARCELONA (PRV)]; BARCELONA [CATALONIA]; CATALONIA; SPAIN;

EID: 84857440655     PISSN: 01476513     EISSN: 10902414     Source Type: Journal    
DOI: 10.1016/j.ecoenv.2011.11.043     Document Type: Article

References (62)

1. Aiken A.C., DeCarlo P.F., Kroll J.H., Worsnop D.R., Huffman J.A., Docherty K.S., Ulbrich K.S., Mohr C., Kimmel J.R., Sueper D., Sun Y., Zhang Q., Trimborn A., Northway M., Ziemann P.J., Canagaratna M.R., Onasch T.B., Alfarra M.R., Prevot A.S.H., Dommen J., Duplissy J., Metzger A., Baltensperger U., Jimenez J.L. O/C and OM/OC ratios of primary, secondary, and ambient organic aerosols with high-resolution Time-of-Flight Aerosol Mass Spectrometry. Environ. Sci. Technol. 2008, 42:4478-4485.
2. Amato F., Pondolfi M., Escrig A., Querol X., Alastuey A., Pey J., Pérez N., Hopke P.K. Quantifying road dust resuspension in urban environment by multilinear engine: a comparison with PMF2. Atmos. Environ. 2009, 43:2770-2780.
3. Aust A.E., Ball J.C., Hu A.A., Lighty J.S., Smith K.R., Straccia A.M., Veranth J.M., Young W.C. Particle characteristics responsible for effects on human lung epithelial cells. Res. Rep. Health Eff. Inst. 2002, 110:1-76.
4. Becker S.D., Dailey L.A., Soukup J.M., Grambow S.C., Devlin R.B., Huang Y. Seasonal variations in air pollution particle induced inflammatory mediator release and oxidative stress. Environ. Health Perspect. 2005, 113:1032-1038.
5. Birch M.E., Cary R.A. Elemental carbon-based method for monitoring occupational exposures to particulate diesel exhaust. Aerosol Sci. Technol. 1996, 25:221-241.
6. Burczynski M.E., Penning T.M. Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductase induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor. Cancer Res. 2000, 60:908-915.
7. Cahill T.A., Barnes D.E., Spada N.J., Lawton J.A., Cahill T.M. Very fine and ultrafine metals and ischemic heart disease in the California Central Valley 1: 2003-2007. Aerosol Sci. Technol. 2011, 45:1123-1134.
8. Cahill T.A., Barnes D.E., Withycombe E., Watnik M. Very fine and ultrafine metals and ischemic heart disease in the California Central Valley 2: 1974-1991. Aerosol Sci. Technol. 2011, 45:1135-1142.
9. 10 samples and assessment of the energy generation impact. Fuel Process. Technol. 2011, 92:176-182.
10. Clarke R.W., Catalano P.J., Koutrakis P., Murthy G.G., Sioutas C., Paulauskis J., Coull B., Ferguson S., Godleski J.J. Urban air particulate inhalation alters pulmonary function and induces pulmonary inflammation in a rodent model of chronic bronchitis. Inhal. Toxicol. 1999, 11:637-656.
11. Dachs J., Eisenreich S.J. Adsorption onto aerosol soot carbon dominates gas-particle partitioning of polycyclic aromatic hydrocarbons. Environ. Sci. Technol. 2000, 34:3690-3697.
12. Demokritou P., Gupta T., Ferguson S., Koutrakis P. Development of laboratory characterization of a prototype coarse particle concentrator for toxicological studies. J. Aerosol Sci. 2002, 33:1111-1123.
13. Draxler, R.R., Rolph, G.D., 2003. HYSPLIT (HYbrid Single-Particle Lagrangian Integrated Trajectory) Model access via NOAA ARL READY Website. NOAA Air Resources Laboratory, Silver Spring, MD. http://www.arl.noaa.gov/ready/hysplit4.html.
14. Dvosrká A., Lammel G., Klánová J. Use of diagnostic ratios for studying source apportionment and reactivity of ambient polycyclic aromatic hydrocarbons over Central Europe. Atmos. Environ. 2011, 45:420-427.
15. EPA Cancer Risk Guidelines, 2011. (last accessed on 9th September 2011). http://www.epa.gov/cancerguidelines.
16. 2 and OH radicals with polycyclic aromatic hydrocarbons adsorbed on carbonaceous particles. Part 2: PAHs adsorbed on diesel particulate exhaust. Atmos. Environ. 2006, 40:201-211.
17. Galarneau E. Source specificity and atmospheric processing of airborne PAHs: implications for source apportionment. Atmos. Environ. 2008, 42:8139-8149.
18. Goldberg M.S., Burnett R.T., Valois M.F., Flegel J.C., Brooks J., et al. Associations between ambient air pollution and daily mortality among persons with congestive heart failure. Environ. Res. 2003, 91:8-20.
19. Gomes A., Fernandes E., Lima J.L.F.C. Fluorescence probes used for detection of reactive oxygen species. J. Biochem. Biophys. Methods 2005, 65:45-80.
20. Greenwell L.L., Moreno T., Jones T.P., Richards R.J. Particle-induced oxidative damage is ameliorated by pulmonary antioxidants. Free Radical Bio. Med. 2002, 32:898-905.
21. Huang Y.C., Stonehuerner A.J., McGree J., Carter J.D., Grambow S.C., Devlin R.B. The role of soluble components in ambient fine particles-induced changes in human lungs and blood. Inhal. Toxicol. 2003, 15:327-342.
22. Integrated Risk Information System (IRIS). 〈www.epa.gov/iris〉 (last accessed on 26th July 2011).
23. Knaapen M., Borm P.J.A., Albrecht C., Schins R.P.F. Inhaled particles and lung cancer. Part A: mechanisms. Int. J. Cancer. 2004, 109:799-809.
24. Koshy L., Jones T., Bérubé K. Bioreactivity of municipal solid waste landfill leachates-hormesis and DNA damage. Water Res. 2007, 42:2177-2183.
25. Koshy L., Jones T.P., BéruBé K.A. Characterisation and bioreactivity of respirable airborne particles from a municipal landfill. Biomarkers 2009, 14:49-53.
26. Møller P., Folkmann J.K., Forchhammer L., Bräuner E.V., Danielsen P.H., Risom L., et al. Air pollution, oxidative damage to DNA, and carcinogenesis. Cancer Lett. 2008, 266:84-89.
27. Moreno T., Merolla L., Gibbons W., Greenwell L., Jones T., Richards R. Variations in the source, metal content and bioreactivity of technogenic aerosols: a case study from Port Talbot, Wales, UK. Sci. Total Environ. 2004, 333:59-73.
28. Mukerjee S., Biswas P. A concept of risk apportionment of air emission sources for risk reduction considerations. Environ. Technol. 1992, 13:635-646.
29. 2.5 and elemental composition: heterogeneous associations in 19 European cities. Atmos. Environ. 2009, 43:4595-4606.
30. Noether G.E., Dueker M. Introduction to Statistics-The Nonparametric Way 1991, Springer-Velag.
31. Olivares A., van Dooge B.L., Pérez-Ballesta P., Grimalt J.O., Piña B. Assessment of dioxin-like activity in ambient air particulate matter using recombinant yeast assays. Atmos. Environ. 2011, 45:271-274.
32. Onoue S., Kawamura K., Igarashi N., Zhou Y., Fujikawa M., Yamada H., Tsuda Y., Seto Y., Yamada S. Reactive oxygen species assay-based risk assessment of drug-induced phototoxicity: classification criteria and application to drug candidates. J. Pharm. Biomed. Anal. 2008, 47:967-972.
33. Ostro B., Tobias A., Querol X., Alastuey A., Amato A., Pey J., Pérez N., Sunyer J. The effects of particulate matter sources on daily mortality: a case-crossover study of Barcelona, Spain. Environ. Health Perspect. 2011.
34. Paatero P. The multilinear engine: a table-driven least squares program for solving multilinear problems, including the n-way parallel factor analysis model. J. Comput. Graphical Stat. 1999, 8:1-35.
35. 1 at an urban site in Southern Europe. Atmos. Environ. 2008, 42:1677-1691.
36. Pey J., Rodríguez S., Querol X., Alastuey A., Moreno T., Putaud J.P., Van Dingenen R. Events and cycles of urban aerosols in the western Mediterranean. Atmos. Environ. 2008, 42:9052-9062.
37. Pope C.A., Renlund D.G., Kfouy A.G., May H.T., Horne B.D. Relation of heart failure hospitalization to exposure to fine particulate air pollution. J. Cardiol. 2008, 102:1230-1234.
38. Querol X., Viana M., Alastuey A., Amato F., Moreno T., Castillo S., Pey J., de la Rosa J., Sánchez de la Campa A., Artíñano B., Salvador P., García dos Santos S., Fernández-Patier R., Moreno-Grau S., Negral L., Minguillón M.C., Monfort E., Gil J.I., Izna A., Ortega L.A., Santamaría J.M., Zabalza J. Source origin of trace elements in PM from regional background, urban and industrial sites of Spain. Atmos. Environ. 2007, 41:7219-7231.
39. Reche C., Viana M., Moreno T., Querol X., Alastuey A., Pey J., Pandolfi M., PrévÔt A., Mohr C., Richard A., Artiñano B., Gomez-Moreno F.J., Cots N. Peculiarities in atmospheric particle number and size-resolved speciation in an urban area in the western Mediterranean: results from the DAURE campaign. Atmos. Environ. 2011, 10.1016/j.atmosenv.2011.06.059.
40. Risom L., Møller P., Loft S. Oxidative stress-induced DNA damage by particulate air pollution. Mutat. Res. 2005, 592:119-137.
41. Rogge W.F., Mazurek M.A., Hildemann L.M., Cass G.R., Simoneit B.R.T. Quantification of urban organic aerosols at a molecular-level-identification, abundance and seasonal-variation. Atmos. Environ. 1993, 27:1309-1330.
42. Sax S.N., Bennett D.H., Chillrud S.N., Ross J., Kinney P.L., Spengler J.D. A cancer risk assessment of inner-city teenagers living in New York City and Los Angeles. Environ. Health Perspect. 2006, 114:1558-1566.
43. Schoeny R., Poirier K. Provisional Guidance for Quantitative Risk Assessment of Polycyclic Aromatic Hydrocarbons 1993, U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Washington, DC, (EPA/600/R-93/089).
44. See S.W., Balasubramanian R. Risk assessment of exposure to indoor aerosols associated with Chinese cooking. Environ. Res. 2005, 102:197-204.
45. 2.5) in Shanghai atmosphere. Atmos. Environ. 2008, 42:7205-7214.
46. 10 study in Beijing, China. Atmos. Environ. 2007, 41:5316-5326.
47. Shao L., Shi Z., Jones T.P., Li J., Whittaker A.G., Bérubé K.A. Bioreactivity of particulate matter in Beijing air: results from plasmid DNA assay. Sci. Total Environ. 2006, 367:261-272.
48. Stanek L.W., Sacks J.D., Dutton S.J., Dubois J.-J.B. Attributing health effects to apportioned components and sources of particulate matter: an evaluation of collective results. Atmos. Environ. 2011, 10.1016/j.atmosenv.2011.07.023.
49. Stieb D.M., Judek S., Burnett R.T. Meta-analysis of time-series studies of air pollution and mortality: effects of gases and particles and the influence of cause of death, age, and season. J. Air Waste Manage. Assoc. 2002, 52:470-484.
50. The California Environmental Protection Agency (CalEPA). (last accessed on 26th July 2011). http://www.oehha.ca.gov/air/hot_spots/tsd052909.html.
51. The USEPA Regional Screening Level. (last accessed on 26th July 2011). http://www.epa.gov/epahome/quickfinder.hti.
52. Terzi E., Samara C. Polycyclic aromatic hydrocarbons in urban, adjacent coastal, and continental background sites of Western Greece. Environ. Sci. Technol. 2004, 38:4973-4978.
53. 2.5 in an acellular assay. Toxicol. Lett. 2011, 10.1016/j.toxlet.2011.02.005.
54. UNE-EN 12341, 1999. Air quality-determination of the PM10 fraction of suspended particulate matter-reference method and field test procedure to demonstrate reference equivalent of measurements methods.
55. USEPA, 2005. Integrated risk information system. Available from: (last accessed on April 2011). http://www.epa.
56. Valavanidis A., Salikam A., Theodoropoulou A. Generation of hydroxyl radicals by urban suspended particulate air matter. The role of iron ions. Atmos. Environ. 2000, 34:2379-2386.
57. 10 in a semirural European area. Environ. Sci. Technol. 2009, 43:7310-7316.
58. Viana M., Querol X., Alastuey A. Chemical characterisation of PM episodes in NE Spain. Chemosphere 2006, 62:947-956.
59. Wang T., Chiang E.T., Moreno-Vinasco L., Lang G.D., Pendyala S., Samet J.M., Geyh A.S., Breysse P.N., Chillrud S.N., Natarajan V. Garcia JGN. Particulate matter disrupts human lung endothelial barrier integrity via ROS- and p38 MAPK-dependent pathways. Am. J. Respir. Cell Mol. Biol. 2010, 42:442-449.
60. Wei H., Wei D., Yi S., Zhang F., Ding W. Oxidative stress induced by urban fine particles in cultured EA.hy926 cells. Hum. Exp. Toxicol. 2011, 30:579-590.
61. Whittaker A., Bérubé K., Jones T., Maynard R., Richards R. Killer smog of London, 50 years on: particle properties and oxidative capacity. Sci. Total Environ. 2005, 334-335:435-445.
62. Wu C., Wu S., Wu Y., Cullen A.C., Larson T.V., Williamson J., Li L.J.S. Cancer risk assessment of selected hazardous air pollutants in Seattle. Environ. Int. 2009, 35:516-522.