Dopamine receptor D4 gene variation predicts preschoolers' developing theory of mind

Developmental Science

Volumn 15, Issue 2, 2012, Pages 272-280

  Lackner, Christine ^a   Sabbagh, Mark A ^a   Hallinan, Elizabeth ^a   Liu, Xudong ^a   Holden, Jeanette J A ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE 4 RECEPTOR; DOPAMINE TRANSPORTER; DRD4 PROTEIN, HUMAN; PRIMER DNA; SLC6A3 PROTEIN, HUMAN;

ANALYSIS OF VARIANCE; ARTICLE; CANADA; CHILD DEVELOPMENT; EXECUTIVE FUNCTION; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HUMAN; MALE; NEUROPSYCHOLOGICAL TEST; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; THEORY OF MIND;

ANALYSIS OF VARIANCE; CATECHOL O-METHYLTRANSFERASE; CHILD DEVELOPMENT; CHILD, PRESCHOOL; DNA PRIMERS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; EXECUTIVE FUNCTION; FEMALE; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; ONTARIO; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RECEPTORS, DOPAMINE D4; THEORY OF MIND;

EID: 84857439881     PISSN: 1363755X     EISSN: 14677687     Source Type: Journal    
DOI: 10.1111/j.1467-7687.2011.01124.x     Document Type: Article

References (50)

1. Anckarsater, H., Stahlberg, O., Larson, T., Hakansson, C., Jutblad, S.B., Niklasson, L., Nydén, A., Wentz, E., Westergren, S., Cloninger, C.R., Gillberg, C., & Rastam, M. (2006). The impact of ADHD and autism spectrum disorders on temperament, character, and personality development. American Journal of Psychiatry, 163 (7), 1239-1244.
2. Asghari, V., Sanyal, S., Buchwaldt, S., Paterson, A., Jovanovic, V., & Van Tol, H.H.M. (1995). Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. Journal of Neurochemistry, 65, 1157-1165.
3. Bakermans-Kranenburg, M.J., & van Ijzendoorn, M.H. (2006). Gene-environment interaction of the dopamine D4 receptor (DRD4) and observed maternal insensitivity predicting externalizing behavior in preschoolers. Developmental Psychobiology, 48 (5), 406-409.
4. Bhaduri, N., Das, M., Sinha, S., Chattopadhyay, A., Gangopadhyay, P.K., Chaudhuri, K., Singh, M., & Mukhopadhyay, K. (2006). Association of dopamine D4 receptor (DRD4) polymorphisms with attention deficit hyperactivity disorder in Indian population. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 141B (1), 61-66.
5. Brieber, S., Neufang, S., Bruning, N., Kamp-Becker, I., Remschmidt, H., Herpertz-Dahlmann, B., Fink, G.R., & Konrad, K. (2007). Structural brain abnormalities in adolescents with autism spectrum disorder and patients with attention deficit/hyperactivity disorder. Journal of Child Psychology and Psychiatry, 48, 1251-1258.
6. Carlson, S.M., Davis, A.C., & Leach, J.G. (2005). Less is more: executive function and symbolic representation in preschool children. Psychological Science, 16, 609-616.
7. Carlson, S.M., & Moses, L. (2001). Individual differences in inhibitory control and children's theory of mind. Child Development, 72, 1032-1053.
8. Carlson, S.M., Moses, L.J., & Hix, H.R. (1998). The role of inhibitory processes in young children's difficulties with deception and false belief. Child Development, 69, 672-691.
9. Cassimjee, N., & Murphy, R. (2010). Temperament and character correlates of neuropsychological performance. South African Journal of Psychology, 40 (2), 125-138.
10. Diamond, A., Briand, L., Fossella, J., & Gehlbach, L. (2004). Genetic and neurochemical modulation of prefrontal cognitive functions in children. American Journal of Psychiatry, 161, 125-132.
11. Ebstein, R.P., Novick, O., Umansky, R., Priel, B., Osher, Y., Blaine, D., Bennett, E.R., Nemanov, L., Katz, M., & Belmaker, R.H. (1996). Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking. Nature Genetics, 12 (1), 78-80.
12. Egan, M.F., Goldberg, T.E., Kolachana, B.S., Callicott, J.H., Mazzanti, C.M., Straub, R.E., Goldman, D., & Weinberger, D.R. (2001). Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proceedings of the National Academy of Sciences, USA, 98, 6917-6922.
13. Frye, D., Zelazo, P.D., & Palfai, T. (1995). Theory of mind and rule-based reasoning. Cognitive Development, 10, 483-527.
14. Girgis, R.R., Minshew, N.J., Melhem, N.M., Nutche, J.J., Keshavan, M.S., & Hardan, A.Y. (2007). Volumetric alterations of the orbitofrontal cortex in autism. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 31, 41-45.
15. Gopnik, A., & Astington, J.W. (1988). Children's understanding of representational change and its relation to the understanding of false belief and the appearance-reality distinction. Child Development, 59, 26-37.
16. Gopnik, A., & Wellman, H.M. (1994). The theory theory. In L.A. Hirschfeld & S.A. Gelman (Eds.), Mapping the mind: Domain specificity in cognition and culture (pp. 257-293). New York: Cambridge University Press.
17. Heidbreder, C.A., Foxton, R., Cilia, J., Hughes, Z.A., Shah, A.J., Atkins, A., Hunter, A.J., Hagan, J.J., & Jones, D.N. (2001). Increased responsiveness of dopamine to atypical, but not typical antipsychotics in the medial prefrontal cortex of rats reared in isolation. Psychopharmacology, 156, 338-351.
18. Hettinger, J.A., Liu, X., Schwartz, C.E., Michaelis, R.C., & Holden, J.J. (2008). A DRD1 haplotype is associated with risk for autism spectrum disorders in male-only affected sib-pair families. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B (5), 628-636.
19. Hughes, C. (1998). Finding your marbles: does preschoolers' strategic behavior predict later understanding of mind? Developmental Psychology, 34, 1326-1339.
20. Hughes, C., & Cutting, A.L. (1999). Nature, nurture, and individual differences in early understanding of mind. Psychological Science, 10, 429-432.
21. Jacobs, B.L., & Azmitia, E.C. (1992). Structure and function of the brain serotonin system. Physiological Reviews, 72 (1), 165-229.
22. Kalsbeek, A., Buijs, R.M., Hofman, M.A., Matthijssen, M.A., Pool, C.W., & Uylings, H.B. (1987). Effects of neonatal thermal lesioning of the mesocortical dopaminergic projection on the development of the rat prefrontal cortex. Brain Research, 429 (1), 123-132.
23. Karama, S., Grizenko, N., Sonuga-Barke, E., Doyle, A., Biederman, J., Mbekou, V., Polotsjaia, A., Ter-Stepanian, M., De Guzman, R., Bellingham, J., Sengupta, S., & Joober, R. (2008). Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD. Biomedical Psychiatry, 8, 45.
24. Lachman, H.M., Papolos, D.F., Saito, T., Yu, Y. M., Szumlanski, C.L., & Weinshilboum, R.M. (1996). Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics, 6 (3), 243-250.
25. Lackner, C.L., Bowman, L.C., & Sabbagh, M.A. (2010). Dopaminergic functioning and preschoolers' theory of mind. Neuropsychologia, 48 (6), 1767-1774.
26. Lam, K.S.L., Aman, M.G., & Arnold, L.E. (2006). Neurochemical correlates of autistic disorder: a review of the literature. Research in Developmental Disabilities, 27 (3), 254-289.
27. Lichter, J.B., Barr, C.L., Kennedy, J.L., Van Tol, H.H., Kidd, K.K., & Livak, K.J. (1993). A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Human Molecular Genetics, 2 (6), 767-773.
28. Lipsky, R.H., Sparling, M.B., Ryan, L.M., Xu, K., Salazar, A.M., Goldman, D., & Warden, D.L. (2005). Association of COMT Val158Met genotype with executive functioning following traumatic brain injury. Journal of Neuropsychiatry Clinical Neuroscience, 17, 465-471.
29. Liu, D., Sabbagh, M., Gehring, W., & Wellman, H. (2009). Neural correlates of children's theory of mind development. Child Development, 80, 318-326.
30. Liu, X., Novosedlik, N., Wang, A., Hudson, M.L., Cohen, I.L., Chudley, A.E., Forster-Gibson, C.J., Lewis, S.M., & Holden, J.J. (2009). The DLX1and DLX2 genes and susceptibility to autism spectrum disorders. European Journal of Human Genetics, 17 (2), 228-235.
31. McAlonan, G.M., Suckling, J., Wong, N., Cheung, V., Lienenkaemper, N., Cheung, C., & Chua, S.E. (2008). Distinct patterns of grey matter abnormality in high-functioning autism and Asperger's syndrome. Journal of Child Psychology and Psychiatry, 49, 1287-1295.
32. Matsumoto, M., Weickert, C.S., Akil, M., Lipska, B.K., Hyde, T.M., Herman, M., Kleinman, J.E., & Weinberger, D.R. (2003). Catechol O-methyltransterase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function. Neuroscience, 116, 127-137.
33. Miller, G.M., & Madras, B.K. (2002). Polymorphisms in the 3'-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression. Molecular Psychiatry, 7, 44-55.
34. Moron, J.A., Brockington, A., Wise, R.A., Rocha, B.A., & Hope, B.T. (2002). Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. Journal of Neuroscience, 22, 389-395.
35. Onishi, K., & Baillargeon, R. (2005). Do 15-month-old infants understand false beliefs? Science, 308, 255-258.
36. Peterson, C.C., Wellman, H.M., & Liu, D. (2005). Steps in theory of mind development for children with deafness or autism. Child Development, 76, 523-541.
37. Popolo, M., McCarthy, D.M., & Bhide, P.G. (2004). Influence of dopamine on precursor cell proliferation and differentiation in the embryonic mouse telencephalon. Developmental Neuroscience, 26, 229-244.
38. 3H]NGD 94-1. Journal of Pharmacology and Experimental Therapeutics, 282, 1020-1027.
39. Rybakowski, J.K., Borkowska, A., Czerski, P.M., Dmitrzak-Weglarz, M., Skibinska, M., Kapelski, P., & Hauser, J. (2006). Performance on the Wisconsin Card Sorting Test in schizophrenia and genes of dopaminergic inactivation (COMT, DAT, NET). Psychiatry Research, 143, 13-19.
40. Sabbagh, M.A., Bowman, L.C., Evraire, L., & Ito, J.M.B. (2009). Neurodevelopmental correlates of theory of mind in preschool children. Child Development, 80, 1147-1162.
41. Sabbagh, M.A., Moses, L., & Shiverick, S. (2006). Executive functioning and preschoolers' understanding of false beliefs, false photographs, and false signs. Child Development, 77, 1034-1049.
42. Schoots, O., & Van Tol, H.H. (2003). The human dopamine D4 receptor repeat sequences modulate expression. Pharmacogenomics Journal, 3 (6), 343-348.
43. Schultz, W. (2000). Multiple reward signals in the brain. Nature Reviews Neuroscience, 1, 199-207.
44. Schultz, W. (2007). Behavioral dopamine signals. Trends in Neurosciences, 30, 203-210.
45. Van Ness, S.H., Owens, M.J., & Kilts, C.D. (2005). The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density. Biomedical Genetics, 6, 55.
46. Wellman, H.M. (1990). The child's theory of mind. Cambridge, MA: MIT Press.
47. Wellman, H.M., Cross, D., & Watson, J. (2001). Meta-analysis of theory-of-mind development: the truth about false belief. Child Development, 72 (3), 655-684.
48. Wimmer, H., & Perner, J. (1983). Beliefs about beliefs: representation and constraining function of wrong beliefs in young children's understanding of deception. Cognition, 13, 41-68.
49. Yirmiya, N., Pilowsky, T., Nemanov, L., Arbelle, S., Feinsilver, T., Fried, I., & Ebstein, R.P. (2001). Evidence for an association with the serotonin transporter promoter region polymorphism and autism. American Journal of Medical Genetics, 105 (4), 381-386.
50. Zelazo, P., Muller, U., Frye, D., & Marcovitch, S. (2003). The development of executive function in early childhood. Monographs for the Society for Research in Child Development, 68 (3 Serial No. 274).