Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 8, 2012, Pages 3101-3106

  Grieder, Taryn E ^a   George, Olivier ^b   Tan, Huibing ^c   George, Susan R ^d   Le Foll, Bernard ^a,d   Laviolette, Steven R ^c   Van Der Kooy, Derek ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c WESTERN UNIVERSITY   (Canada)

^d CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

Burst firing; Negative reinforcement; Osmotic minipumps; Place conditioning; Population activity

Indexed keywords

ADENOSINE A2A RECEPTOR; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; NICOTINE;

ACUTE NICOTINE WITHDRAWAL; ANIMAL EXPERIMENT; ARTICLE; AVERSION; BEHAVIOR; CHRONIC NICOTINE WITHDRAWAL; CONDITIONING; CONTROLLED STUDY; DNA MODIFICATION; DOPAMINERGIC ACTIVITY; DOPAMINERGIC NERVE CELL; DRUG WITHDRAWAL; MALE; MOTIVATION; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NONHUMAN; PHARMACOLOGICAL PROCEDURES; PHASIC DOPAMINERGIC ACTIVITY; PRIORITY JOURNAL; RAT; TONIC DOPAMINERGIC ACTIVITY; VENTRAL TEGMENTUM;

ANIMALS; DISSOCIATIVE DISORDERS; GENE DELETION; MALE; MICE; MICE, INBRED C57BL; MOTIVATION; NICOTINE; RATS; RATS, WISTAR; RECEPTOR, ADENOSINE A2A; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; SIGNAL TRANSDUCTION; SUBSTANCE WITHDRAWAL SYNDROME; VENTRAL TEGMENTAL AREA;

EID: 84857422417     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1114422109     Document Type: Article

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