Transcription factor AP2 regulates human inhibin α subunit gene expression during in vitro trophoblast differentiation

Molecular Human Reproduction

Volumn 17, Issue 11, 2011, Pages 702-709

  Debieve F ^a   Depoix, C ^a   Hubinont, C ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

AP2; Inhibin A; Placenta; Syncytiotrophoblast; Trophoblast differentiation

Indexed keywords

AP2 ALPHA TRANSCRIPTION FACTOR; AP2 GAMMA TRANSCRIPTION FACTOR; DNA; INHIBIN A; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; INHIBIN; INHIBIN ALPHA SUBUNIT; INHIBIN-ALPHA SUBUNIT; TRANSCRIPTION FACTOR AP 2;

AFFINITY CHROMATOGRAPHY; ARTICLE; CONTROLLED STUDY; CYTOTROPHOBLAST; DNA BINDING; EMBRYO GROWTH; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN PURIFICATION; REAL TIME POLYMERASE CHAIN REACTION; TROPHOBLAST; WESTERN BLOTTING; CELL DIFFERENTIATION; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION;

BASE SEQUENCE; BLOTTING, WESTERN; CELL DIFFERENTIATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE EXPRESSION REGULATION; HUMANS; INHIBINS; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTOR AP-2; TROPHOBLASTS;

EID: 84857412196     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gar045     Document Type: Article

References (26)

1. Auman HJ, Nottoli T, Lakiza O, Winger Q, Donaldson S, Williams T. Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development. Development 2002; 129:2733-2747.
2. Brown LM, Lacey HA, Baker PN, Crocker IP. E-cadherin in the assessment of aberrant placental cytotrophoblast turnover in pregnancies complicated by pre-eclampsia. Histochem Cell Biol 2005;124:499-506.
3. Cheng YH, Aronow BJ, Hossain S, Trapnell B, Kong S, Handwerger S. Critical role for transcription factor AP-2alpha in human trophoblast differentiation. Physiol Genomics 2004;18:99-107.
4. Coutifaris C, Kao LC, Sehdev HM, Chin U, Babalola GO, Blaschuk OW, Strauss JF III. E-cadherin expression during the differentiation of human trophoblasts. Development 1991;113:767-777.
5. Dalgliesh GL, Aitken DA, Lyall F, Howatson AG, Connor JM. Placental and maternal serum inhibin-A and activin-A levels in Down's syndrome pregnancies. Placenta 2001;22:227-234.
6. Debieve F, Thomas K. Control of the human inhibin alpha chain promoter in cytotrophoblast cells differentiating into syncytium. Mol Hum Reprod 2002;8:262-270.
7. Debieve F, Pampfer S, Thomas K. Inhibin and activin production and subunit expression in human placental cells cultured in vitro. Mol Hum Reprod 2000;6:743-749.
8. Depoix CL, Taylor RN. Placental angiogenesis. In Pijnenborg R, Brosens I, Romero R (eds). Placental Bed Disorders-Basic Science and its Translation to Obstetrics. Cambridge: Cambridge University Press, 2010, 52-62.
9. Eckert D, Buhl S, Weber S, Jager R, Schorle H. The AP-2 family of transcription factors. Genome Biol 2005;6:246.
10. Florio P, Cobellis L, Luisi S, Ciarmela P, Severi FM, Bocchi C, Petraglia F. Changes in inhibins and activin secretion in healthy and pathological pregnancies. Mol Cell Endocrinol 2001;180:123-130.
11. Fowler PA, Evans LW, Groome NP, Templeton A, Knight PG. A longitudinal study of maternal serum inhibin-A, inhibin-B, activin-A, activin-AB, pro-alphaC and follistatin during pregnancy. Hum Reprod 1998;13:3530-3536.
12. Hilger-Eversheim K, Moser M, Schorle H, Buettner R. Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control. Gene 2000;260:1-12.
13. Johnson W, Albanese C, Handwerger S, Williams T, Pestell RG, Jameson JL. Regulation of the human chorionic gonadotropin alpha-and beta-subunit promoters by AP-2. J Biol Chem 1997;272:15405-15412.
14. Jones RL, Stoikos C, Findlay JK, Salamonsen LA. TGF-beta superfamily expression and actions in the endometrium and placenta. Reproduction 2006;132:217-232.
15. Langbein M, Strick R, Strissel PL, Vogt N, Parsch H, Beckmann MW, Schild RL. Impaired cytotrophoblast cell-cell fusion is associated with reduced Syncytin and increased apoptosis in patients with placental dysfunction. Mol Reprod Dev 2008;75:175-183.
16. Massin N, Frendo JL, Guibourdenche J, Luton D, Giovangrandi Y, Muller F, Vidaud M, Evain-Brion D. Defect of syncytiotrophoblast formation and human chorionic gonadotropin expression in Down's syndrome. Placenta 2001;22(Suppl. A):S93-S97.
17. McPherson LA, Weigel RJ. AP2alpha and AP2gamma: a comparison of binding site specificity and trans-activation of the estrogen receptor promoter and single site promoter constructs. Nucleic Acids Res 1999; 27:4040-4049.
18. Muttukrishna S, Child TJ, Groome NP, Ledger WL. Source of circulating levels of inhibin A, pro alpha C-containing inhibins and activin A in early pregnancy. Hum Reprod 1997;12:1089-1093.
19. Muttukrishna S, Bearfield C, Johns J, Jauniaux E. Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the villous tissue of miscarriage patients. Mol Hum Reprod 2004;10:793-798.
20. Radonic A, Thulke S, Mackay IM, Landt O, Siegert W, Nitsche A. Guideline to reference gene selection for quantitative real-time PCR. Biochem Biophys Res Commun 2004;313:856-862.
21. Remacle JE, Kraft H, Lerchner W, Wuytens G, Collart C, Verschueren K, Smith JC, Huylebroeck D. New mode of DNA binding of multi-zinc finger transcription factors: deltaEF1 family members bind with two hands to two target sites. EMBO J 1999;18:5073-5084.
22. Richardson BD, Cheng YH, Langland RA, Handwerger S. Differential expression of AP-2gamma and AP-2alpha during human trophoblast differentiation. Life Sci 2001;69:2157-2165.
23. Schorle H, Meier P, Buchert M, Jaenisch R, Mitchell PJ. Transcription factor AP-2 essential for cranial closure and craniofacial development. Nature 1996;381:235-238.
24. Williams T, Tjian R. Analysis of the DNA-binding and activation properties of the human transcription factor AP-2. Genes Dev 1991;5: 670-682.
25. Ying SY. Inhibins, activins, and follistatins: gonadal proteins modulating the secretion of follicle-stimulating hormone. Endocr Rev 1988; 9:267-293.
26. Zhang J, Hagopian-Donaldson S, Serbedzija G, Elsemore J, Plehn-Dujowich D, McMahon AP, Flavell RA, Williams T. Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature 1996;381:238-241.