Extinction of Tumor Antigen Expression by SF2/ASF in JCV-Transformed Cells

Genes and Cancer

Volumn 2, Issue 7, 2011, Pages 728-736

  Uleri, Elena ^a,b   Beltrami, Sarah ^a   Gordon, Jennifer ^a   Dolei, Antonina ^b   Sariyer, Ilker Kudret ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SASSARI   (Italy)

Author keywords

JC virus; SF2 ASF; transcription; tumor antigen

Indexed keywords

AGNOPROTEIN; PROTEIN VP1; PROTEIN VP2; PROTEIN VP3; REGULATOR PROTEIN; SPLICING FACTOR 2 ALTERNATIVE SPLICING FACTOR; TUMOR ANTIGEN; UNCLASSIFIED DRUG; VIRUS LARGE T ANTIGEN; VIRUS SMALL T ANTIGEN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CELL PROLIFERATION; CELL TRANSFORMATION; CELL VIABILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; JC VIRUS; MITOSIS INHIBITION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION;

EID: 84857400632     PISSN: 19476019     EISSN: 19476027     Source Type: Journal    
DOI: 10.1177/1947601911424578     Document Type: Article

References (22)

1. Mandl C,Walker DL,Frisque RJ.Derivation and characterization of POJ cells transformed human fetal glial cells that retain their permissivity for JC virus.J Virol. 1987;61 (3): 755-63.
2. Major EO,Miller AE,Mourrain P,Traub RG,de Widt E,Sever J.Establishment of a line of human fetal glial cells that supports JC virus multiplication.Proc Natl Acad Sci U S A. 1985;82 (4): 1257-61.
3. Gallia GL,Gordon J,Khalili K.Tumor pathogenesis of human neurotropic JC virus in the CNS.J Neurovirol. 1998;4 (2): 175-81.
4. London WT,Houff SA,Madden DL, et al.Brain tumors in owl monkeys inoculated with a human polyomavirus (JC virus).Science. 1978;201:1246-9.
5. London WT,Houff SA,McKeever PE, et al.Viral-induced astrocytomas in squirrel monkeys.Prog Clin Biol Res. 1983;105:227-37.
6. Franks RR,Rencic A,Gordon J, et al.Formation of undifferentiated mesenteric tumors in transgenic mice expressing human neurotropic polymavirus early protein.Oncogene. 1996;12:2573-8.
7. Shollar D,Del Valle L,Khalili K,Otte J,Gordon J.JCV T-antigen interacts with the neurofibromatosis type 2 gene product in a transgenic mouse model of malignant peripheral nerve sheath tumors.Oncogene. 2004;23 (32): 5459-67.
8. Krynska B,Otte J,Franks R,Khalili K,Croul S.Human ubiquitous JCV (CY) T-antigen gene induces brain tumors in experimental animals.Oncogene. 1999;18 (1): 39-46.
9. Gordon J,Del Valle L,Otte J,Khalili K.Pituitary neoplasia induced by expression of human neurotropic polyomavirus, JCV, early genome in transgenic mice.Oncogene. 2000;19:4840-6.
10. Manley JL,Tacke R.SR proteins and splicing control.Genes Dev. 1996;10:1569-79.
11. Michlewski G,Sanford JR,Caceres JF.The splicing factor SF2/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1.Mol Cell. 2008;30 (2): 179-89.
12. Sariyer IK,Khalili K.Regulation of human neurotropic JC virus replication by alternative splicing factor SF2/ASF in glial cells.PLoS One. 2011;6 (1): e14630.
13. Wold WS,Green M,Mackey JK,Martin JD,Padgett BL,Walker DL.Integration pattern of human JC virus sequences in two clones of a cell line established from a JC virus-induced hamster brain tumor.J Virol. 1980;33 (3): 1225-8.
14. Raj G,Gordon J,Logan T, et al.Characterization of glioma-cells derived from human polyomavirus-induced brain-tumors in hamsters.Int J Oncol. 1995;7 (4): 801-8.
15. Krynska B,Del Valle L,Gordon J,Otte J,Croul S,Khalili K.Identification of a novel p53 mutation in JCV-induced mouse medulloblastoma.Virology. 2000;274 (1): 65-74.
16. Karni R,de Stanchina E,Lowe SW,Sinha R,Mu D,Krainer AR.The gene encoding the splicing factor SF2/ASF is a proto-oncogene.Nat Struct Mol Biol. 2007;14 (3): 185-93.
17. Graveley BR.Sorting out the complexity of SR protein functions.RNA. 2000;6:1197-211.
18. Sanford SR,Ellis JD,Cazalla D,Caceres JF.Reversible phosphorylation differentially affects nuclear and cytoplasmic functions of splicing factor 2/alternative splicing factor.PNAS. 2005;102 (42): 15042-7.
19. Walker DL,Padgett BL,ZuRhein GM,Albert AE,Marsh RF.Human papovavirus (JC): induction of brain tumors in hamsters.Science. 1973;181:674-6.
20. Song Y,Wilkins P,Hu W, et al.Inhibition of calcium-independent phospholipase A2 suppresses proliferation and tumorigenicity of ovarian carcinoma cells.Biochem J. 2007;406 (3): 427-36.
21. Rubinson DA,Dillon CP,Kwiatkowski AV, et al.A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference.Nat Genet. 2003;33 (3): 401-6.
22. Akan I,Sariyer IK,Biffi R, et al.Human polyomavirus JCV late leader peptide region contains important regulatory elements.Virology. 2006;349 (1): 66-78.