Regulation of neuronal apl-1 expression by cholesterol starvation

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Wiese, Mary ^a   Antebi, Adam ^a,b   Zheng, Hui ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MAX PLANCK INSTITUTE FOR BIOLOGY OF AGEING   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALDICARB; AMYLOID PRECURSOR LIKE PROTEIN 1; AMYLOID PRECURSOR PROTEIN; CHOLESTEROL; GREEN FLUORESCENT PROTEIN; LIPOPROTEIN RECEPTOR; LIPOPROTEIN RECEPTOR RELATED PROTEIN 1; UNCLASSIFIED DRUG; APL 1 PROTEIN, C ELEGANS; APL-1 PROTEIN, C ELEGANS; CAENORHABDITIS ELEGANS PROTEIN; MEMBRANE PROTEIN;

ARTICLE; CAENORHABDITIS ELEGANS; CHOLESTEROL METABOLISM; CONTROLLED STUDY; GENE SILENCING; GENETIC TRANSCRIPTION; NEUROMODULATION; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; REGULATORY MECHANISM; RNA INTERFERENCE; STARVATION; SYNAPTIC TRANSMISSION; WESTERN BLOTTING; ANIMAL; CYTOLOGY; DIET; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLTING; NERVE CELL;

ALDICARB; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CHOLESTEROL; DIET; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GREEN FLUORESCENT PROTEINS; MEMBRANE PROTEINS; MOLTING; NEURONS; RNA INTERFERENCE; SYNAPTIC TRANSMISSION; TRANSCRIPTION, GENETIC;

EID: 84857399067     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032038     Document Type: Article

References (30)

1. Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance MA, et al. (1993) Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43: 1467-1472.
2. Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, et al. (1993) Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A 90: 1977-1981.
3. Yochem J, Tuck S, Greenwald I, Han M, (1999) A gp330/megalin-related protein is required in the major epidermis of Caenorhabditis elegans for completion of molting. Development 126: 597-606.
4. Gerisch B, Weitzel C, Kober-Eisermann C, Rottiers V, Antebi A, (2001) A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span. Dev Cell 1: 841-851.
5. Hieb WF, Rothstein M, (1968) Sterol requirement for reproduction of a free-living nematode. Science 160: 778-780.
6. Saito A, Pietromonaco S, Loo AK, Farquhar MG, (1994) Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family. Proc Natl Acad Sci U S A 91: 9725-9729.
7. Cam JA, Bu G, (2006) Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family. Mol Neurodegener 1: 8.
8. Hornsten A, Lieberthal J, Fadia S, Malins R, Ha L, et al. (2007) APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability. Proc Natl Acad Sci U S A 104: 1971-1976.
9. Wiese M, Antebi A, Zheng H, (2010) Intracellular trafficking and synaptic function of APL-1 in Caenorhabditis elegans. PLoS One 5 (9): e12790 doi:10.1371/journal.pone.0012790.
10. Merris M, Wadsworth WG, Khamrai U, Bittman R, Chitwood DJ, et al. (2003) Sterol effects and sites of sterol accumulation in Caenorhabditis elegans: developmental requirement for 4alpha-methyl sterols. J Lipid Res 44: 172-181.
11. Grigorenko AP, Moliaka YK, Soto MC, Mello CC, Rogaev EI, (2004) The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins. Proc Natl Acad Sci U S A 101: 14955-14960.
12. Frand AR, Russel S, Ruvkun G, (2005) Functional genomic analysis of C. elegans molting. PLoS Biol 3: e312.
13. Brenner S, (1974) The genetics of Caenorhabditis elegans. Genetics 77: 71-94.
14. Miller KG, Alfonso A, Nguyen M, Crowell JA, Johnson CD, et al. (1996) A genetic selection for Caenorhabditis elegans synaptic transmission mutants. Proc Natl Acad Sci U S A 93: 12593-12598.
15. Carstea ED, Morris JA, Coleman KG, Loftus SK, Zhang D, et al. (1997) Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. Science 277: 228-231.
16. Sym M, Basson M, Johnson C, (2000) A model for niemann-pick type C disease in the nematode Caenorhabditis elegans. Curr Biol 10: 527-530.
17. Li J, Brown G, Ailion M, Lee S, Thomas JH, (2004) NCR-1 and NCR-2, the C. elegans homologs of the human Niemann-Pick type C1 disease protein, function upstream of DAF-9 in the dauer formation pathways. Development 131: 5741-5752.
18. Wustner D, Landt Larsen A, Faergeman NJ, Brewer JR, Sage D, (2010) Selective visualization of fluorescent sterols in Caenorhabditis elegans by bleach-rate-based image segmentation. Traffic 11: 440-454.
19. Kurzchalia TV, Ward S, (2003) Why do worms need cholesterol? Nat Cell Biol 5: 684-688.
20. Sluder AE, Mathews SW, Hough D, Yin VP, Maina CV, (1999) The nuclear receptor superfamily has undergone extensive proliferation and diversification in nematodes. Genome Res 9: 103-120.
21. Sluder AE, Maina CV, (2001) Nuclear receptors in nematodes: themes and variations. Trends Genet 17: 206-213.
22. Antebi A, (2006) Nuclear hormone receptors in C. elegans. WormBook pp. 1-13.
23. Motola DL, Cummins CL, Rottiers V, Sharma KK, Li T, et al. (2006) Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans. Cell 124: 1209-1223.
24. Hada K, Asahina M, Hasegawa H, Kanaho Y, Slack FJ, et al. (2010) The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition. Dev Biol 344: 1100-1109.
25. Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, et al. (2005) Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell 120: 343-355.
26. Urs AN, Dammer E, Kelly S, Wang E, Merrill AH Jr, et al. (2007) Steroidogenic factor-1 is a sphingolipid binding protein. Mol Cell Endocrinol 265-266: 174-178.
27. Asahina M, Ishihara T, Jindra M, Kohara Y, Katsura I, et al. (2000) The conserved nuclear receptor Ftz-F1 is required for embryogenesis, moulting and reproduction in Caenorhabditis elegans. Genes Cells 5: 711-723.
28. Kamath RS, Martinez-Campos M, Zipperlen P, Fraser AG, Ahringer J, (2001) Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Genome Biol 2: RESEARCH0002.
29. Edwards SL, Charlie NK, Richmond JE, Hegermann J, Eimer S, et al. (2009) Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2. J Cell Biol 186: 881-895.
30. Wood WB, (1988) The Nematode Caenorhabditis elegans Cold Spring Harbor, N.Y. Cold Spring Harbor Laboratory pp. xiii, 667.