Should the treatment of anal carcinoma be adapted in the elderly? A retrospective analysis of acute toxicities in a French centre and a review of the literature;Faut-il adapter le traitement du carcinome du canal anal pour les patients âgés ? Analyse rétrospective de la toxicité dans un centre français et revue de la littérature

Cancer/Radiotherapie

Volumn 16, Issue 1, 2012, Pages 52-57

  De Bari, B ^a,b   Lestrade, L ^a,b   Chekrine, T ^a,b   Shakir Shakir, I ^a,b   Ardiet, J M ^a,b   Chapet, O ^a,b   Mornex, F ^a,b  

^a CENTRE HOSPITALIER LYON SUD   (France)

^b UNIVERSITÉ LYON 1   (France)

Author keywords

Anal carcinoma; Brachytherapy; Elderly patients; Radiochemotherapy; Radiotherapy

Indexed keywords

ANTINEOPLASTIC AGENT;

ACUTE TOXICITY; AGED; ANUS CARCINOMA; ARTICLE; BRACHYTHERAPY; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CHEMORADIOTHERAPY; COMORBIDITY; EXTERNAL BEAM RADIOTHERAPY; FOLLOW UP; HUMAN; LEUKOPENIA; PRIORITY JOURNAL; RADIATION SICKNESS; RECTUM HEMORRHAGE; RETROSPECTIVE STUDY; TUMOR VOLUME;

AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ANUS NEOPLASMS; BRACHYTHERAPY; CARCINOMA, SQUAMOUS CELL; CARCINOMA, TRANSITIONAL CELL; CHEMORADIOTHERAPY; CISPLATIN; DOSE FRACTIONATION; FEMALE; FLUOROURACIL; FRANCE; GASTROINTESTINAL HEMORRHAGE; HUMANS; LEUKOPENIA; MALE; RADIOTHERAPY; RETROSPECTIVE STUDIES;

EID: 84857397183     PISSN: 12783218     EISSN: 17696658     Source Type: Journal    
DOI: 10.1016/j.canrad.2011.05.015     Document Type: Article

References (42)

1. International agency for research on cancer World cancer report 2008, World Health Organization, Genève, p. 495.
2. Halperin E.C., Perez C.A., Brady L.W., Wazer D.E., Freeman C., Prosnitz L.R. Anal Cancer. Perez and Brady's principles and practice of radiation oncology, 5th Edition 2007, Lippincott Williams & Wilkins, Philadelphia, PA, p. 1386.
3. UKCCCR Anal canal cancer trial working party Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil and mitomycin C. Lancet 1996, 348:1049-1054.
4. Bartelink H., Roelofsen F., Eschwège F., Rougier P., Bosset J.F., Gonzalez D.G. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European organization for research and treatment of cancer radiotherapy and gastrointestinal cooperative groups. J Clin Oncol 1997, 15:2040-2049.
5. Yancik R. Cancer burden in the aged: an epidemiologic and demographic overview. Cancer 1997, 80:1273-1283.
6. Yancik R., Ries L.A. Cancer in older persons: an international issue in an aging world. Semin Oncol 2004, 31:128-136.
7. Valentini V., Morganti A.G., Luzi S., Mantello G., Mantini G., Salvi G., et al. Is chemoradiation feasible in elderly patients?. Cancer 1997, 80:1387-1392.
8. Allal A.S., Obradovic M., Laurencet F., Roth A.D., Spada A., Marti M.C., et al. Treatment of anal carcinoma in the elderly feasibility and outcome of radical radiotherapy with or without concomitant chemotherapy. Cancer 1999, 85:26-31.
9. Goodwin J.S., Hunt W.C., Humble C.G., Key C.R., Somet J.M. Cancer treatment protocols: who gets chosen?. Arch Intern Med 1988, 148:2258-2260.
10. Audisio R.A., Bozzetti F., Gennari R., Jaklitsch M.T., Koperna T., Longo W.E., et al. The surgical management of elderly cancer patients; recommendations of the SIOG surgical task force. Eur J Cancer 2004, 40:926-938.
11. Zachariah B., Balducci L., Venkattaramanabalaji G.V., Casey L., Greenberg H.M., DelRegado J.A. Radiotherapy for cancer patients aged 80 and older: study of effectiveness and side effects. Int J Rad Oncol Biol Phys 1997, 39:1125-1129.
12. Mitsuhashi N., Hayakawa K., Yamakawa M., Sakurai H., Saito Y., Hasegawa M., et al. Cancers in patients aged 90 years and older: radiation therapy. Radiology 1999, 211:829-833.
13. Wasil T., Lichtman S.M., Gupta V., Rush S. Radiation therapy in cancers patients 80 years of age and older. Am J Clin Oncol 2000, 5:526-530.
14. Extermann M., Aapro M., Bernabei R., Cohen H.J., Droz J.P., Lichtman S., et al. Use of comprehensive geriatric assessment in older cancer patients: Recommendations from the task force on CGA of the International society of geriatric oncology (SIOG). Crit Rev Oncol Hematol 2005, 55:241-252.
15. Extermann M. Measurement and impact of comorbidity in older cancer patients. Crit Rev Oncol Hematol 2000, 35:181-200.
16. Satariano W.A., Ragland D.A. The effect of comorbidity on 3-year survival of women with primary breast cancer. Ann Intern Med 1994, 120:104-110.
17. Newschaffer C.J., Bush T.L., Penberthy L.E., Bellantoni M., Helzlsour K., Diener-West M. Does comorbid disease interact with cancer? An epidemiologic analysis of mortality in a cohort of elderly breast cancer patients. J Gerontol A Biol Sci Med Sci 1998, 53:M372-M378.
18. Frasci G., D'Aiuto G., Comella P., Thomas R., Capasso I., Di Bonito M., et al. Cisplatin-epirubicin-paclitaxel weekly administration with G-CSF support in advanced breast cancer. A southern Italy cooperative oncology group (SICOG) phase II study. Breast Cancer Res Treat 2000, 62:87-97.
19. Firat S., Bousamra M., Gore E., Byhardt R.W. Comorbidity and KPS are independent prognostic factors in stage I non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 2002, 52:1047-1057.
20. Rochon P.A., Katz J.N., Morrow L.A., McGlinchey-Berroth R., Ahlquist M.M., Sarkarati M., et al. Comorbid illness is associated with survival and length of hospital stay in patients with chronic disability. A prospective comparison of three comorbidity indices. Med Care 1996, 34:1093-1101.
21. Piccirillo J.F. Inclusion of comorbidity in a staging system for head and neck cancer. Oncology (Huntingt) 1995, 9:831-836.
22. Fried L.P., Bandeen-Roche K., Kasper J.D., Guralnik J.M. Association of comorbidity with disability in older women: the women's health and aging study. J Clin Epidemiol 1999, 52:27-37.
23. Wilcoxon F. Individual comparisons by ranking methods. Biometrics Bull 1945, 1:80-83.
24. Philadelphia, PA: Radiation therapy oncology group (RTOG). Disponible à l'adresse: http://www.rtog.org. [accès le 1/11/11].
25. Flam M.S., John M., Lovalvo L.J., Mills R.J., Ramalho L.D., Prather C., et al. Definitive non-surgical therapy of epithelial malignancies of the anal canal. A report of 12 cases. Cancer 1983, 51:1378-1387.
26. Nigro N.D., Vaitkevicius V.K., Considine B. Combined therapy for cancer of the anal canal: a preliminary report. Dis Colon Rectum 1974, 17:354-356.
27. Benhamiche A.M., Faivre J., Tazi A.M., Couillault C., Villing A.L., Rat P. Time trends in diagnostic strategy, treatment, and prognosis of gastric cancer in the elderly: a population based study. Eur J Cancer Prev 1997, 6:71-77.
28. Karl R.C., Smith S.K., Fabri P.J. Validity of major cancer operations in elderly patients. Ann Surg Oncol 1995, 2:107-113.
29. Giovanazzi-Bannon S., Rademaker A., Lai G., Benson A.B. Treatment tolerance of elderly cancer patients entered onto phase II clinical trials: an Illinois cancer center study. J Clin Oncol 1994, 12:2447-2452.
30. Chin R., Fisher R.J., Smee R.I., Barton M.B. Oropharyngeal cancer in the elderly. Int J Radiat Oncol Biol Phys 1995, 32:1007-1016.
31. Irvin T.T. Prognosis of colorectal cancer in the elderly. Br J Surg 1988, 75:419-421.
32. Busch E., Kemeny M., Fremgen A., Osteen R.T., Winchester D.P., Clive R.E. Patterns of breast cancer care in the elderly. Cancer 1996, 78:101-111.
33. Barzan L., Veronesi A., Caruso G., Serraino D., Magri D., Zagonel V., et al. Head and neck cancer and aging: a retrospective study in 438 patients. J Laryngol Otol 1990, 104:634-640.
34. Pignon T., Horiot J.C., Bolla M., van Poppel H., Bartelink H., Roelofsen F., et al. Age is not a limiting factor for radical radiotherapy in pelvic malignancies. Radiother Oncol 1997, 42:107-120.
35. Charnley N., Choudhury A., Chesser P., Cooper R.A., Sebag-Montefiore D. Effective treatment of anal cancer in the elderly with low-dose chemoradiotherapy. Br J Cancer 2005, 92:1221-1225.
36. Buroker T.R., Nigro N., Bradley G., Pelok L., Chomchai C., Considine B., et al. Combined therapy for cancer of the anal canal: a follow-up report. Dis Colon Rectum 1977, 20:677-678.
37. Smith D.E., Shah K.H., Rao A.R., Frost D.B., Latino F., Anderson P.J., et al. Cancer of the anal canal: treatment with chemotherapy and low-dose radiation therapy. Radiology 1994, 191:569-572.
38. Peddada A.V., Smith D.E., Rao A.R., Frost D.B., Kagan A.R. Chemotherapy and low-dose radiotherapy in the treatment of HIV-infected patients with carcinoma of the anal canal. Int J Radiat Oncol Biol Phys 1997, 37:1101-1105.
39. Crowley C., Winship A.Z., Hawkins M.A., Morris S.L., Leslie M.D. Size does matter: can we reduce the radiotherapy field size for selected cases of anal canal cancer undergoing chemoradiation?. Clin Oncol (R Coll Radiol) 2009, 21:376-379. [Epub 2009 Mar 17].
40. Fiorino C., Valdagni R., Rancati T., Sanguineti G. Dose-volume effects for normal tissues in external radiotherapy: pelvis. Radiother Oncol 2009, 93:153-167.
41. Milano M.T., Jani A.B., Farrey K.J., Rash C., Heimann R., Chmura S.J. Intensity-modulated radiation therapy (IMRT) in the treatment of anal cancer: toxicity and clinical outcome. Int J Radiat Oncol Biol Phys 2005, 63:354-361.
42. Saarilahti K., Arponen P., Vaalavirta L., Tenhunen M. The effect of intensity-modulated radiotherapy and high dose rate brachytherapy on acute and late radiotherapy-related adverse events following chemoradiotherapy of anal cancer. Radiother Oncol 2008, 87:383-390. [Epub 2008 May 22].