Is chemoradiation feasible in elderly patients?: A study of 17 patients with anorectal carcinoma

Cancer

Volumn 80, Issue 8, 1997, Pages 1387-1392

  Valentini, Vincenzo ^a,b   Morganti, Alessio G ^a   Luzi, Stefano ^a   Mantello, Giovanna ^a   Mantini, Giovanna ^a   Salvi, Giovanna ^a   Cellini, Numa ^a  

^a FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

Author keywords

5 fluorouracil; Aged; Anal neoplasms; Combined modality therapy; Continuous infusion; External radiation therapy; Mitomycin C; Rectal neoplasms

Indexed keywords

FLUOROURACIL; MITOMYCIN C;

AGED; ANTINEOPLASTIC ACTIVITY; ANUS CARCINOMA; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CLINICAL ARTICLE; FEMALE; HUMAN; MALE; MULTIMODALITY CANCER THERAPY; PRIORITY JOURNAL; RECTUM CARCINOMA;

AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ANUS NEOPLASMS; COMBINED MODALITY THERAPY; FEASIBILITY STUDIES; FEMALE; FLUOROURACIL; FOLLOW-UP STUDIES; HUMANS; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAVENOUS; MALE; MITOMYCIN; RECTAL NEOPLASMS;

EID: 0030783112     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1387::AID-CNCR4>3.0.CO;2-C     Document Type: Article

References (34)

1. Decarli A, La Vecchia C. Cancer mortality in Italy, 1990. Tumori 1994;80:12-8.
2. Exton Smith AN. Epidemiological studies in the elderly: methodological considerations. Am J Clin Nutr 1982; 35:1273-9.
3. New South Wales Central Cancer Registry. Cancer in New South Wales. Incidence and Mortality 1980-85.
4. Fentiman IS, Tirelli U, Monfardini S, Schneider M, Festen J, Cognetti F, et al. Cancer in the elderly: why so badly treated? Lancet 1990;335:1020-2.
5. Goodwin JS, Hunt WC, Humble CG, Key CR, Somet JM. Cancer treatment protocols: who gets chosen ? Arch Intern Med 1988;148:2258-60.
6. Monfardini S, Yancik R. Cancer in the elderly: meeting the challenge of an aging population. J Natl Cancer Inst 1993;85: 532-8.
7. Greenberg HM, Trotti AM. Radiotherapy of cancer in the older aged person. In: Balducci L, Lyman GH, Ershler WB, editors. Geriatric oncology. Philadelphia: J. B. Lippincott Company, 1992:160-8.
8. Schonwetter RS. Quality of life in older cancer patients. In: Balducci L, Lyman GH, Ershler WB, editors. Geriatric oncology. Philadelphia: J. B. Lippincott Company, 1992:320-5.
9. Goodwin JS, Samet JM, Key CR. Stage at diagnosis of cancer varies with the age of the patient. J Am Geriatr Soc 1986;34: 20-6.
10. Holmes FF, Hearne E. Cancer stage-to-age relationship: implications for cancer screening in the elderly. J Am Geriatr Soc 1981;29:55-7.
11. Suen KC, Lau LL, Yermakov V. Cancer and old age. An autopsy study of 3,535 patients over 65 years old. Cancer 1974;33:1164-8.
12. Holmes FF. Clinical evidence for change in tumor aggressiveness with age. In: Balducci L, Lyman GH, Ershler WB, editors. Geriatric oncology. Philadelphia: J. B. Lippincott Company, 1992:86-91.
13. Morganti AG, Valentini V, De Franco A, Luzi S, Mantini G, Marmiroli L, et al. Tolleranza e risposta al trattamento radiochemioterapico concomitante modulato del ca. del retto: analisi di uno studio prospettico su 97 pazienti. In: Proceedings of the IV Congresso Nazionale A.I.R.O., Taormina, September 12-15, 1994:619-21.
14. Goodwin JS, Hunt WC, Samet JM. A population based study of functional status and social support of elderly patients newly diagnosed with cancer. Arch Intern Med 1991; 151:366-70.
15. Hermanek P, Sobin LH, editors. UICC TNM classification of malignant tumors. 4th edition. 2nd revision. Berlin: Springer-Verlag, 1992.
16. Nigro N, Vaitkevicius VK, Considine B Jr. Combined therapy for cancer of the anal canal: a preliminary report. Dis Colon Rectum 1974;17:354-7.
17. International Commission on Radiation Units and Measurements. Report 50. Prescribing, recording and reporting photon beam therapy., Bethesda, MD: International Commission on Radiation Units and Measurements, 1993:1-71.
18. Perez CA, Brady LW. Overview. In: Perez CA, Brady LW, editors. Principles and practices of radiation oncology. Philadelphia: J. B. Lippincott Company, 1992:1-63.
19. Lyman GH. Decision analysis: a way of thinking about health care in the elderly. In: Balducci L, Lyman GH, Ershler WB, editors. Geriatric oncology. Philadelphia: J. B. Lippincott Company, 1992:18-9.
20. Chin R, Fisher RJ, Smee RI, Barton MB. Oropharyngeal cancer in the elderly. Int J Radiat Oncol Biol Phys 1995;32:1007-16.
21. Mitsuhashi N, Takahashi M, Nozaki M, Yamakawa M, Takahashi T, Sakurai H, et al. Squamous cell carcinoma of the uterine cervix: radiation therapy for patients aged 70 years and older. Radiology 1995;194:141-5.
22. Hanks IGE, Hanlon A, Owen JB, Schultheiss TE. Patterns of radiation treatment of elderly patients with prostate cancer. Cancer 1994;74(7 Suppl):2174-7.
23. Farniok KE, Levitt SH. The role of radiation therapy in the treatment of colorectal cancer. Implications for the older patient. Cancer 1994;74:2154-9.
24. Valentini V, Luzi S, Mantini G, Turriziani A, Cellini N. Concomitant radiochemotherapy in rectal cancer: methodology and indications. Rays 1995;20:77-95.
25. Byfield JE. Theoretical basis and clinical applications of 5-fluorouracil as a radiosensitizer: an overview. In: Rotman M, Rosenthal CJ, editors. Concomitant continuous infusion chemotherapy and radiation. Berlin: Springer-Verlag, 1991:115-27.
26. Rockwell S. Effects of Mitomycin C alone and in combination with X-rays on EMT6 mouse mammary tumors in vivo. J Natl Cancer Inst 1983;71:765-71.
27. Rockwell S. Tumor radiation response and tumor oxygenation in aging mice. Exp Gerontol 1989;24:37-48.
28. Balducci L, Mowrey K, Parker M. Pharmacology of antineoplastic agents in older patients. In: Balducci L, Lyman GH, Ershler WB, editors. Geriatric oncology. Philadelphia: J. B. Lippincott Company, 1992:169-80.
29. Veronesi A, Lo Re G, Carbone A, Trovo MG, Dal Bo V, Talamini R, et al. Multimodal treatment of locally advanced transitional cell bladder carcinoma in elderly patients. Eur J Cancer 1994;30A(7):918-20.
30. Saito I, Yoshikawa T, Takashio T, Hayasaka K, Mineta M, Aburano T, et al. Non-Hodgkin's lymphoma of stage I and II in elderly patients: a retrospective study in comparison with younger patients. Nippon Igaku Hoshasen Gakkai Zasshi 1995;55(8):576-81.
31. McGuirt WF, Davis SP III. Demographic portrayal and outcome analysis of head and neck cancer surgery in the elderly. Arch Otolaryngol Head Neck Surg 1995;121(2):150-4.
32. Greenfield S, Blanco DM, Klashoff RM, Ganz PA. Patterns of care related to age of breast cancer patients. JAMA 1987;257:2766-70.
33. Samet J, Key C, Hunt C. Choice of cancer therapy varies with the age of the patients. J Am Geriatr Soc 1986;34:20-6.
34. Begg CB, Cohen GL, Elletron J. Are the elderly predisposed to toxicity from cancer chemotherapy? Cancer Clin Trials 1980;3:369-74.