Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs

Drug Metabolism and Disposition

Volumn 40, Issue 3, 2012, Pages 625-634

  Sharma, Raman ^a   Strelevitz, Timothy J ^a   Gao, Hongying ^a   Clark, Alan J ^a   Schildknegt, Klaas ^a   Obach, R Scott ^a   Ripp, Sharon L ^a   Spracklin, Douglas K ^a   Tremaine, Larry M ^a   Vaz, Alfin D N ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE OXIDASE; CARBAZERAN; DEUTERIUM; PHTHALAZINE DERIVATIVE; QUINOLINE; QUINOXALINE; ZONIPORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG METABOLISM; ENZYME MECHANISM; EX VIVO STUDY; FIRST PASS EFFECT; GUINEA PIG; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER CYTOSOL; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; RAT;

ALDEHYDE OXIDASE; ANIMALS; CARBAMATES; CYTOSOL; DEUTERIUM; GUANIDINES; GUINEA PIGS; HEPATOCYTES; HUMANS; KINETICS; LIVER; MALE; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84857383845     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.042770     Document Type: Article

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