The bacterial preparation OK432 induces IL-12p70 secretion in human dendritic cells in a TLR3 dependent manner

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Hovden, Arnt Ove ^a,b   Karlsen, Marie ^a   Jonsson, Roland ^a   Appel, Silke ^a  

^a UNIVERSITY OF BERGEN   (Norway)

^b Bionor Pharma   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 12P70; PICIBANIL; PROTEINASE; RIBONUCLEASE; TOLL LIKE RECEPTOR 3; CHLOROQUINE; INTERLEUKIN 12; LIGAND; MYELOID DIFFERENTIATION FACTOR 88; RNA; SMALL INTERFERING RNA; TICAM1 PROTEIN, HUMAN; TLR3 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 4; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ARTICLE; CANCER IMMUNOTHERAPY; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNOREGULATION; LYMPHOCYTE ACTIVATION; SIGNAL TRANSDUCTION; BIOSYNTHESIS; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GENE SILENCING; METABOLISM; SECRETION; STREPTOCOCCUS PYOGENES;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; CHLOROQUINE; DENDRITIC CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTERLEUKIN-12; LIGANDS; MYELOID DIFFERENTIATION FACTOR 88; PICIBANIL; RNA; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STREPTOCOCCUS PYOGENES; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4;

EID: 84857377661     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031217     Document Type: Article

References (40)

1. Schuler G, (2010) Dendritic cells in cancer immunotherapy. Eur J Immunol 40: 2123-2130.
2. Rescigno M, (2010) Dendritic cells in tolerance induction for the treatment of autoimmune diseases. Eur J Immunol 40: 2119-2123.
3. Jonuleit H, Kuhn U, Muller G, Steinbrink K, Paragnik L, et al. (1997) Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol 27: 3135-3142.
4. Osada T, Clay TM, Woo CY, Morse MA, Lyerly HK, (2006) Dendritic cell-based immunotherapy. Int Rev Immunol 25: 377-413.
5. Okamoto H, Shoin S, Koshimura S, Shimizu R, (1967) Studies on the anticancer and streptolysin S-forming abilities of hemolytic streptococci. Jpn J Microbiol 11: 323-326.
6. Kim SY, Park HC, Yoon C, Yoon HJ, Choi YM, et al. (1998) OK-432 and 5-fluorouracil, doxorubicin, and mitomycin C (FAM-P) versus FAM chemotherapy in patients with curatively resected gastric carcinoma: a randomized Phase III trial. Cancer 83: 2054-2059.
7. Okazaki T, Iwatani S, Yanai T, Kobayashi H, Kato Y, et al. (2007) Treatment of lymphangioma in children: our experience of 128 cases. J Pediatr Surg 42: 386-389.
8. Sakamoto J, Teramukai S, Nakazato H, Sato Y, Uchino J, et al. (2002) Efficacy of adjuvant immunochemotherapy with OK-432 for patients with curatively resected gastric cancer: a meta-analysis of centrally randomized controlled clinical trials. J Immunother 25: 405-412.
9. Hovden AO, Karlsen M, Jonsson R, Aarstad HJ, Appel S, (2011) Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses. BMC Immunol 12: 2.
10. Ahmed SU, Okamoto M, Oshikawa T, Tano T, Sasai A, et al. (2004) Anti-tumor effect of an intratumoral administration of dendritic cells in combination with TS-1, an oral fluoropyrimidine anti-cancer drug, and OK-432, a streptococcal immunopotentiator: involvement of toll-like receptor 4. J Immunother 27: 432-441.
11. Nakahara S, Tsunoda T, Baba T, Asabe S, Tahara H, (2003) Dendritic cells stimulated with a bacterial product, OK-432, efficiently induce cytotoxic T lymphocytes specific to tumor rejection peptide. Cancer Res 63: 4112-4118.
12. Pan K, Wang H, Liu WL, Zhang HK, Zhou J, et al. (2009) The pivotal role of p38 and NF-kappaB signal pathways in the maturation of human monocyte-derived dendritic cells stimulated by streptococcal agent OK-432. Immunobiology 214: 350-358.
13. Okamoto M, Oshikawa T, Tano T, Ohe G, Furuichi S, et al. (2003) Involvement of Toll-like receptor 4 signaling in interferon-gamma production and antitumor effect by streptococcal agent OK-432. J Natl Cancer Inst 95: 316-326.
14. Okamoto M, Furuichi S, Nishioka Y, Oshikawa T, Tano T, et al. (2004) Expression of toll-like receptor 4 on dendritic cells is significant for anticancer effect of dendritic cell-based immunotherapy in combination with an active component of OK-432, a streptococcal preparation. Cancer Res 64: 5461-5470.
15. Scott MJ, Billiar TR, (2008) Beta2-integrin-induced p38 MAPK activation is a key mediator in the CD14/TLR4/MD2-dependent uptake of lipopolysaccharide by hepatocytes. J Biol Chem 283: 29433-29446.
16. Okamoto M, Kaji R, Kasetani H, Yoshida H, Moriya Y, et al. (1993) Purification and characterization of interferon-gamma-inducing molecule of OK-432, a penicillin-killed streptococcal preparation, by monoclonal antibody neutralizing interferon-gamma-inducing activity of OK-432. J Immunother Emphasis Tumor Immunol 13: 232-242.
17. Nilsen NJ, Deininger S, Nonstad U, Skjeldal F, Husebye H, et al. (2008) Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling: role of CD14 and CD36. J Leukoc Biol 84: 280-291.
18. Beutler B, (2004) Inferences, questions and possibilities in Toll-like receptor signalling. Nature 430: 257-263.
19. Kuznik A, Bencina M, Svajger U, Jeras M, Rozman B, et al. (2011) Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines. J Immunol 186: 4794-4804.
20. Woolley SL, Smith DR, Quine S, (2008) Adult cystic hygroma: successful use of OK-432 (Picibanil(R)). J Laryngol Otol 1-5.
21. Itoh T, Ueda Y, Okugawa K, Fujiwara H, Fuji N, et al. (2003) Streptococcal preparation OK432 promotes functional maturation of human monocyte-derived dendritic cells. Cancer Immunol Immunother 52: 207-214.
22. Naito K, Ueda Y, Itoh T, Fuji N, Shimizu K, et al. (2006) Mature dendritic cells generated from patient-derived peripheral blood monocytes in one-step culture using streptococcal preparation OK-432 exert an enhanced antigen-presenting capacity. Int J Oncol 28: 1481-1489.
23. Nakamoto Y, Mizukoshi E, Kitahara M, Arihara F, Sakai Y, et al. (2011) Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization. Clin Exp Immunol 163: 165-177.
24. Kontani K, Teramoto K, Ozaki Y, Sawai S, Tezuka N, et al. (2007) Preparation of fully activated dendritic cells capable of priming tumor-specific cytotoxic T lymphocytes in patients with metastatic cancer using penicillin-killed streptococcus pyogenes (OK432) and anti-CD40 antibody. Oncol Rep 17: 895-902.
25. Ueta M, Mizushima K, Yokoi N, Naito Y, Kinoshita S, (2010) Gene-expression analysis of polyI:C-stimulated primary human conjunctival epithelial cells. Br J Ophthalmol 94: 1528-1532.
26. Palucka AK, Ueno H, Fay JW, Banchereau J, (2007) Taming cancer by inducing immunity via dendritic cells. Immunol Rev 220: 129-150.
27. Rothenfusser S, Goutagny N, DiPerna G, Gong M, Monks BG, et al. (2005) The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J Immunol 175: 5260-5268.
28. Cristina GM, Del CM, Gessani S, (2010) Dissecting TLR3 signalling in dendritic cells. Immunobiology 215: 713-723.
29. Tada H, Aiba S, Shibata K, Ohteki T, Takada H, (2005) Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells. Infect Immun 73: 7967-7976.
30. Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, et al. (2003) IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 4: 491-496.
31. Sharma S, tenOever BR, Grandvaux N, Zhou GP, Lin R, et al. (2003) Triggering the interferon antiviral response through an IKK-related pathway. Science 300: 1148-1151.
32. Sabbah A, Chang TH, Harnack R, Frohlich V, Tominaga K, et al. (2009) Activation of innate immune antiviral responses by Nod2. Nat Immunol 10: 1073-1080.
33. Kawai T, Akira S, (2007) Antiviral signaling through pattern recognition receptors. J Biochem 141: 137-145.
34. Leonard JN, Ghirlando R, Askins J, Bell JK, Margulies DH, et al. (2008) The TLR3 signaling complex forms by cooperative receptor dimerization. Proc Natl Acad Sci U S A 105: 258-263.
35. Jin MS, Lee JO, (2008) Structures of the toll-like receptor family and its ligand complexes. Immunity 29: 182-191.
36. Edy VG, Szekely M, Loviny T, Dreyer C, (1976) Action of nucleases on double-stranded RNA. Eur J Biochem 61: 563-572.
37. Kariko K, Ni H, Capodici J, Lamphier M, Weissman D, (2004) mRNA is an endogenous ligand for Toll-like receptor 3. J Biol Chem 279: 12542-12550.
38. Marshall-Clarke S, Downes JE, Haga IR, Bowie AG, Borrow P, et al. (2007) Polyinosinic acid is a ligand for toll-like receptor 3. J Biol Chem 282: 24759-24766.
39. Derbigny WA, Johnson RM, Toomey KS, Ofner S, Jayarapu K, (2010) The Chlamydia muridarum-Induced IFN-{beta} Response Is TLR3-Dependent in Murine Oviduct Epithelial Cells. J Immunol.
40. Aksoy E, Zouain CS, Vanhoutte F, Fontaine J, Pavelka N, et al. (2005) Double-stranded RNAs from the helminth parasite Schistosoma activate TLR3 in dendritic cells. J Biol Chem 280: 277-283.