Anti-leukemic therapies induce cytogenetic changes of human bone marrow-derived mesenchymal stem cells

Annals of Hematology

Volumn 91, Issue 2, 2012, Pages 163-172

  Yeh, Su Peng ^a,b   Lo, Wen Jyi ^a   Lin, Chiao Lin ^a   Liao, Yu Min ^a   Lin, Chen Yuan ^a   Bai, Li Yuan ^a   Liang, Ji An ^a,b   Chiu, Chang Fang ^a,b  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Chemotherapy; Chromosome; Leukemia; Mesenchymal stem cell; Total body irradiation

Indexed keywords

ANTHRACYCLINE; ANTILEUKEMIC AGENT; ASPARAGINASE; BUSULFAN; CYCLOPHOSPHAMIDE; CYTARABINE; DOXORUBICIN; HYDROXYUREA; IDARUBICIN; PREDNISOLONE; RETINOIC ACID; VINCRISTINE;

ADULT; AGED; ALLOTRANSPLANTATION; ARTICLE; BONE MARROW; CANCER CHEMOTHERAPY; CLINICAL ARTICLE; CYTOGENETICS; DRUG MEGADOSE; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA; MALE; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; RADIATION DOSE; THERAPY EFFECT; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; WHOLE BODY RADIATION;

ADOLESCENT; ADULT; ANTINEOPLASTIC AGENTS; BONE MARROW CELLS; CELL DIFFERENTIATION; CHROMOSOME ABERRATIONS; CYTOGENETICS; FEMALE; HEMATOPOIETIC STEM CELLS; HUMANS; KARYOTYPE; LEUKEMIA; MALE; MESENCHYMAL STEM CELLS; MIDDLE AGED; REMISSION INDUCTION; TRANSPLANTATION, HOMOLOGOUS; WHOLE-BODY IRRADIATION; YOUNG ADULT;

EID: 84857367469     PISSN: 09395555     EISSN: 14320584     Source Type: Journal    
DOI: 10.1007/s00277-011-1254-8     Document Type: Article

References (36)

1. R Kalluri M Zeisberg 2006 Fibroblasts in cancer Nat Rev Cancer 6 392 401 16572188 10.1038/nrc1877 1:CAS:528:DC%2BD28XjslGitLw%3D
2. J Marx 2008 Cancer biology. All in the stroma: cancer's Cosa Nostra Science 320 38 41 18388269 10.1126/science.320.5872.38 1:CAS:528: DC%2BD1cXksFCqtLw%3D (Pubitemid 351490738)
3. A Albini MB Sporn 2007 The tumour microenvironment as a target for chemoprevention Nat Rev Cancer 7 139 147 17218951 10.1038/nrc2067 1:CAS:528:DC%2BD2sXotFOjuw%3D%3D (Pubitemid 46160989)
4. X Guo H Oshima T Kitmura MM Taketo M Oshima 2008 Stromal fibroblasts activated by tumor cells promote angiogenesis in mouse gastric cancer J Biol Chem 283 19864 19871 18495668 10.1074/jbc.M800798200 1:CAS:528: DC%2BD1cXotF2ktLk%3D
5. K Kurose K Gilley S Matsumoto PH Watson XP Zhou C Eng 2002 Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas Nat Genet 32 355 357 12379854 10.1038/ng1013 1:CAS:528:DC%2BD38Xot1Kls7o%3D [Erratum, Nat Genetics 2002 32:681] (Pubitemid 35266108)
6. F Moinfar YG Man L Arnould GL Bratthauer M Ratschek FA Tavassoli 2000 Concurrent and independent genetic alternations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis Cancer Res 60 2562 2566 10811140 1:CAS:528:DC%2BD3cXjtV2qtb0%3D (Pubitemid 30262453)
7. E Gunsillius HC Duba AL Petzer 2000 Evidence from a leukaemia model for maintenance of vascular endothelium by bone-marrow-derived endothelial cells Lancet 355 1688 1691 10.1016/S0140-6736(00)02241-8 (Pubitemid 30248482)
8. B Streubel A Chott D Huber M Exner U Jager O Wagner I Schwarzinger 2004 Lymphoma-specific genetic aberrations in microvascular endothelial cells in B-cell lymphomas New Eng J Med 351 250 259 15254283 10.1056/NEJMoa033153 1:CAS:528:DC%2BD2cXlslKrurg%3D (Pubitemid 38916042)
9. J Corre K Mahtouk M Attal M Gadelorge A Huynh S Fleury-Cappellesso C Danho P Laharrague B Klein T Rème P Bourin 2007 Bone marrow mesenchymal stem cells are abnormal in multiple myeloma Leukemia 21 1079 1088 17344918 1:CAS:528:DC%2BD2sXksFeltb8%3D (Pubitemid 46672085)
10. O Lopez-Villar JL Garcia FM Sanchez-Guijo, et al. 2009 Both expanded and uncultured mesenchymal stem cells from MDS patients are genomically abnormal, showing a specific genetic profile for the 5q-syndrome Leukemia 23 664 672 19151777 10.1038/leu.2008.361 1:CAS:528:DC%2BD1MXks1SitLo%3D
11. E Flores-Figueroa RM Arana-Trejo G Gutiérrez-Espíndola A Pérez-Cabrera H Mayani 2005 Mesenchymal stem cells in myelodysplastic syndromes: phenotypic and cytogenetic characterization Leuk Res 29 215 224 15607371 10.1016/j.leukres.2004.06.011 1:CAS:528:DC%2BD2cXhtVyktb%2FK (Pubitemid 39647516)
12. O Blau WK Hofmann CD Baldus G Thiel V Serbent E Schümann E Thiel IW Blau 2007 Chromosomal aberrations in bone marrow mesenchymal stroma cells from patients with myelodysplastic syndrome and acute myeloblastic leukemia Exp Hematol 35 221 229 17258071 10.1016/j.exphem.2006.10.012 1:CAS:528: DC%2BD2sXhtVarsrs%3D (Pubitemid 46135819)
13. M Czader A Orazi 2009 Therapy-related myeloid neoplasms Am J Clin Pathol 132 410 425 19687318 10.1309/AJCPD85MCOHHCOMQ 1:CAS:528:DC%2BD1MXhtFOisLrF
14. LB Travis M Gospodarowicz RE Curtis, et al. 2002 Lung cancer following chemotherapy and radiotherapy for Hodgkin's disease J Natl Cancer Inst 94 182 192 11830608 10.1093/jnci/94.3.182 (Pubitemid 34162752)
15. TO Henderson J Whitton M Stovall AC Mertens P Mitby D Friedman LC Strong S Hammond JP Neglia AT Meadows L Robison L Diller 2007 Secondary sarcomas in childhood cancer survivors: a report from the childhood cancer survivor study J Natl Cancer Inst 99 300 308 17312307 10.1093/jnci/djk052 (Pubitemid 47073493)
16. AK Chaturvedi EA Engels ES Gilbert, et al. 2007 Second cancers among 104,760 survivors of cervical cancer: evaluation of long-term risk J Natl Cancer Inst 99 21 1634 1643 17971527 10.1093/jnci/djm201
17. DJ Brenner RE Curtis EJ Hall E Ron 2000 Second malignancies in prostate carcinoma patients after radiotherapy compared with surgery Cancer 88 2 398 406 10640974 10.1002/(SICI)1097-0142(20000115)88:2<398::AID-CNCR22>3.0.CO;2-V 1:STN:280:DC%2BD3c7gvVOmsg%3D%3D (Pubitemid 30051826)
18. KM Thijssens RJ van Ginkel AJ Suurmeijer E Pras WT van der Graaf M Hollander HJ Hoekstra 2005 Radiation-induced sarcoma: a challenge for the surgeon Ann Surg Oncol 12 3 237 245 15827816 10.1245/ASO.2005.03.041 (Pubitemid 40568911)
19. MF Pittenger AM Mackay SC Beck, et al. 1999 Multilineage potential of adult human mesenchymal stem cells Science 284 143 147 10102814 10.1126/science.284.5411.143 1:CAS:528:DyaK1MXitlCnu7o%3D (Pubitemid 29282067)
20. Shaffer LG, Slovak ML, Campbell LJ (eds) (2009) ISCN 2009. An international system for human cytogenetic nomenclature. S. Karger, Basel
21. D Pinkel J Landegent C Collins J Fuscoe R Segraves J Lucas J Gray 1988 Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4 Proc Natl Acad Sci USA 85 23 9138 9142 2973607 10.1073/pnas.85.23.9138 1:CAS:528: DyaL1MXovFykuw%3D%3D (Pubitemid 19001853)
22. SP Yeh JG Chang CL Lin WJ Lo CC Lee CY Lin CF Chiu 2005 Mesenchymal stem cells can be easily isolated from bone marrow of patients with various hematological malignancies but the surface antigens expression may be changed after prolonged ex vivo culture Leukemia 19 1505 1507 15902289 10.1038/sj.leu.2403795 1:CAS:528:DC%2BD2MXmt12qu7o%3D (Pubitemid 41136354)
23. D Rubio J Garcia-Castro MC Martin, et al. 2005 Spontaneous human adult stem cell transformation Cancer Res 65 3035 3039 15833829 1:CAS:528: DC%2BD2MXjt1yks78%3D (Pubitemid 40524580)
24. A Ramakrishnan B Torok-Storb 2006 The stromal component of the marrow microenvironment is not derived from the malignant clone in MDS [redux] Blood 108 3948 3949 10.1182/blood-2006-02-001479 1:CAS:528:DC%2BD28Xht1Kgs7rF (Pubitemid 44061386)
25. MH Raaijmakers S Mukherjee S Guo, et al. 2010 Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia Nature 464 7290 852 857 20305640 10.1038/nature08851 1:CAS:528:DC%2BC3cXjs1egsr0%3D
26. A Taghian F de Vathaire P Terrier M Le A Auquier H Mouriesse E Grimaud D Sarrazin M Tubiana 1991 Long-term risk of sarcoma following radiation treatment for breast cancer Int J Radiat Oncol Biol Phys 21 2 361 367 1648044 10.1016/0360-3016(91)90783-Z 1:STN:280:DyaK3M3osF2gtQ%3D%3D
27. RJ Mark J Poen LM Tran YS Fu MT Selch RG Parker 1994 Postirradiation sarcomas. A single-institution study and review of the literature Cancer 73 10 2653 2662 8174066 10.1002/1097-0142(19940515)73:10<2653::AID- CNCR2820731030>3.0.CO;2-G 1:STN:280:DyaK2c3ivVCmtg%3D%3D (Pubitemid 24155546)
28. N Gonin-Laurent NS Hadj-Hamou N Vogt C Houdayer M Gauthiers-Villars C Dehainault X Sastre-Garau S Chevillard B Malfoy 2007 RB1 and TP53 pathways in radiation-induced sarcomas Oncogene 26 6106 6112 17369843 10.1038/sj.onc.1210404 1:CAS:528:DC%2BD2sXpvFWmtb4%3D (Pubitemid 47373799)
29. RE Curtis PA Rowlings HJ Deeg DA Shriner G Socíe LB Travis MM Horowitz RP Witherspoon RN Hoover KA Sobocinski JF Fraumeni Jr JD Boice Jr 1997 Solid cancers after bone marrow transplantation N Engl J Med 336 13 897 904 9070469 10.1056/NEJM199703273361301 1:STN:280:DyaK2s3gvFCrtg%3D%3D (Pubitemid 27137189)
30. G Socié RE Curtis HJ Deeg, et al. 2000 Solid cancers after bone marrow transplantation J Clin Oncol 18 2 348 357 10637249
31. JD Rizzo RE Curtis G Socié, et al. 2009 Solid cancers after allogeneic hematopoietic cell transplantation Blood 113 5 1175 1183 18971419 10.1182/blood-2008-05-158782 1:CAS:528:DC%2BD1MXhvVajtr8%3D
32. I Matushansky E Hernando ND Socci JE Mills TA Matos MA Edgar S Singer RG Maki C Cordon-Cardo 2007 Derivation of sarcomas from mesenchymal stem cell via inactivation of the Wnt pathway J Clin Invest 117 3248 3257 17948129 10.1172/JCI31377 1:CAS:528:DC%2BD2sXht12isrrN (Pubitemid 350096982)
33. J Tolar AJ Nauta MJ Osborn, et al. 2007 Sarcoma derived from cultured mesenchymal stem cells Stem Cells 25 371 379 17038675 10.1634/stemcells.2005- 0620 1:CAS:528:DC%2BD2sXivVOltrk%3D (Pubitemid 46232791)
34. N Li R Yang W Zhang H Dorfman P Rao R Gorlick 2009 Genetically transforming human mesenchymal stem cells to sarcomas: changes in cellular phenotype and multilineage differentiation potential Cancer 115 20 4795 4806 19593798 10.1002/cncr.24519 1:CAS:528:DC%2BD1MXhtlGns7nL
35. R Rubio J García-Castro I Gutiérrez-Aranda J Paramio M Santos P Catalina PE Leone P Menendez R Rodríguez 2010 Deficiency in p53 but not retinoblastoma induces the transformation of mesenchymal stem cells in vitro and initiates leiomyosarcoma in vivo Cancer Res 70 10 4185 4194 20442289 10.1158/0008-5472.CAN-09-4640 1:CAS:528:DC%2BC3cXlvFyqsbo%3D
36. K Kemp R Morse K Sanders J Hows C Donaldson 2011 Alkylating chemotherapeutic agents cyclophosphamide and melphalan cause functional injury to human bone marrow-derived mesenchymal stem cells Ann Hematol 10.1007/s00277-010-1141-8 21234567