Quantified tracking and monitoring of diazepam treated socially housed cynomolgus monkeys

Regulatory Toxicology and Pharmacology

Volumn 62, Issue 2, 2012, Pages 292-301

  Rose, C ^a   De Heer, R C ^b   Korte, S ^a   Van der Harst, J E ^b   Weinbauer, G F ^a   Spruijt, B M ^b  

^a Developmental and Reproductive Toxicology   (Germany)

^b Delta Phenomics BV   (Netherlands)

Author keywords

Automation of patterns of moving; Behaviour; Cynomolgus monkey; Group housed nonhuman primates; Locomotor activity; Long tailed macaque; Quantitative; Video tracking

Indexed keywords

DIAZEPAM;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL HOUSING; ANIMAL MODEL; ARTICLE; AUTOANALYSIS; BALANCE DISORDER; BEHAVIOR CHANGE; COMPUTER ANALYSIS; COMPUTER PROGRAM; COMPUTER SYSTEM; CONTROLLED STUDY; CYNOMOLGUS MONKEY; DRUG EXPOSURE; DRUG MONITORING; FEMALE; HAPLORHINI; IMAGE ANALYSIS; LOCOMOTION; MALE; MOTOR DYSFUNCTION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SEX DIFFERENCE; TOXICITY TESTING; VIDEORECORDING;

ANIMALS; BEHAVIOR, ANIMAL; DIAZEPAM; FEMALE; MACACA FASCICULARIS; MALE; MOTOR ACTIVITY;

ANIMALIA; MACACA FASCICULARIS; PRIMATES; RODENTIA;

EID: 84857366921     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2011.10.008     Document Type: Article

References (28)

1. Bayne K.A., Hurst J.K., Dexter S.L. Evaluation of the preference to and behavioral effects of an enriched environment on male rhesus monkeys. Lab. Anim. Sci. 1992, 42:38-45.
2. Burbacher T.M., Grant K.S. Methods for studying nonhuman primates in neurobehavioral toxicology and teratology. Neurotoxicol. Teratol. 2000, 22:475-486.
3. Cleveland W.S. Robust locally weighted regression and smoothing scatterplots. J. Am. Stat. Assoc. 1977, 74:829-836.
4. Delgado J.M., Grau C., Delgado-Garcia J.M., Rodero J.M. Effects of diazepam related to social hierarchy in thesus monkeys. Neuropharmacology 1976, 15:409-414.
5. Drai D., Golani I. SEE: a tool for the visualization and analysis of rodent exploratory behavior. Neurosci. Biobehav. Rev. 2001, 25:409-426.
6. Drai D., Benjamini Y., Golani I. Statistical discrimination of natural modes of motion in rat exploratory behaviour. J. Neurosci. Methods 2000, 96:119-131.
7. Everitt B.S. Finite Mixture Distributions 1981, Chapman and Hall, London.
8. Fujiwara A., Iino M., Sasaki M., Hironaka N., Wakasa Y. A new behavioral test for assessment of drug effects on attentional performance and its validity in cynomolgus monkeys. J. Toxicol. Sci. 2009, 34:183-190.
9. Gauvin D.V., Baird T.J. A functional observational battery in non-human primates for regulatory-required neurobehavioral assessments. J. Pharmacol. Toxicol. Methods 2008, 58:88-93.
10. Hauty G.T., Yellin A.M. Activity cycles of the monkey (Macaca Mulatta) under different environmental conditions. J. Interdiscrip. Cyclic Res. 1970, 1:181-191.
11. Hen I., Sakov A., Kafkafi N., Golani I., Benjamini Y. The dynamics of spatial behavior: how can robust smoothing techniques help?. J. Neurosci. Methods 2004, 133(1/2):161-172.
12. Honess P.E., Marin C.M. Enrichment and aggression in primates. Neurosci. Biobehav. Rev. 2006, 30:413-436.
13. Kafkafi N., Elmer G.I. Texture of locomotor path: a replicable characterization of a complex behavioral phenotype. Genes Brain Behav. 2005, 4:431-443.
14. Korte S., Fuchs A., Weinbauer G.F., Moscardo E., Giarola A. Modified Irwin test as diagnostic tool to monitor neurobehavioural changes in monkeys. J. Pharmacol. Toxicol. Methods 2007, 56:47.
15. Kumar R., Palit G., Singh J.R., Dhawan B.N. Comparative behavioural effects of benzodiazepine and non-benzodiazepine anxiolytics in rhesus monkeys. Pharmacol. Res. 1999, 39:437-444.
16. Márquez-Arias A., Santillán-Doherty A.M., Arenas Rosas R.V., Gasca-Matias M.P., Munoz-Delgado J. Environmental enrichment for captive stumptail macaques (Macaca arctoides). J. Med. Primatol. 2010, 39:32-40.
17. Moscardo E., McPhie G., Fasdelli N., Dorigatti R., Meecham K. An integrated cardiovascular and neurobehavioural functional assessment in the conscious telemetered cynomolgus monkey. J. Pharmacol. Toxicol. Methods 2010, 62:95-106.
18. Müller W. The new European housing regulations for nonhuman primates: opportunities and challenges. Critical Contributions of Primate Models for Biopharmaceutical Drug Development 2008, 53-74. Waxmann Verlag GmbH, Münster. G.F. Weinbauer, F. Vogel (Eds.).
19. Noldus L.P.J.J., Spink A.J., Tegelenbosch R.A.J. EthoVision: a versatile video-tracking system for automation of behavioral experiments. Behav. Res. Methods Instrum. Comput. 2001, 33:398-414.
20. Novak M.F., Kenney C., Suomi S.J., Ruppenthal G.C. Use of animal-operated folding perches by rhesus macaques. J. Am. Lab. Anim. Sci. 2007, 46:35-43.
21. Sibal L.R., Samson K.J. Nonhuman primates: a critical role in current disease research. ILAR J. 2001, 42:78-84.
22. Silverman B.W. Density Estimation for Statistics and Data Analysis 1980, Chapman and Hall, London.
23. Spink A.J., Tegelenbosch R.A., Buma M.O., Noldus L.P. The EthoVision video-tracking system - a tool for behavioral phenotyping of transgenic mice. Physiol. Behav. 2001, 73:731-744.
24. Spruijt B.M., DeVisser L. Advanced behavioural screening: automated home cage ethology. Drug Disc. Today: Technol. 2006, 3:231-237.
25. Spruijt B.M., Hol T., Rousseau J. Approach, avoidance and contact behavior of individually recognized animals automatically quantified with an imaging technique. Physiol. Behav. 1992, 51:747-752.
26. Tricklebank M.D., Honoré T., Iversen S.D., Kemp J.A., Knight A.R., Marshall G.R., Rupniak N.M.J., Tye L.S.S., Watjen F., Wong E.H.F. The pharmacological properties of the imidazobenzodiazepine, FG 8205, a novel partial agonist of the benzodiazepine receptor. Br. J. Pharmacol. 1990, 101:753-761.
27. Turner P.V., Grantham L.E. Short-term effects of an environmental enrichment program for adult cynomolgus monkeys. Contemp. Top. Lab. Anim. Sci. 2002, 41:13-17.
28. Walton A., Branham A., Gash D.M., Grondin R. Automated video analysis of age-related motor deficits in monkeys using EthoVison. Neurobiol. Aging 2006, 10:1477-1483.