메뉴 건너뛰기




Volumn 164, Issue 1-2, 2012, Pages 68-77

Genetic variation of porcine circovirus type 2 (PCV2) and its relevance to vaccination, pathogenesis and diagnosis

Author keywords

PCV2; PCV2 genetic variation; PCV2 pathogenesis

Indexed keywords

PORCINE CIRCOVIRUS TYPE 2 VACCINE; UNCLASSIFIED DRUG; VIRUS VACCINE;

EID: 84857360606     PISSN: 01681702     EISSN: 18727492     Source Type: Journal    
DOI: 10.1016/j.virusres.2011.11.018     Document Type: Review
Times cited : (68)

References (87)
  • 2
    • 0028964740 scopus 로고
    • Pathogenesis of porcine circovirus; experimental infections of colostrum deprived piglets and examination of pig foetal material
    • Allan G.M., McNeilly F., Cassidy J.P., Reilly G.A., Adair B., Ellis W.A., McNulty M.S. Pathogenesis of porcine circovirus; experimental infections of colostrum deprived piglets and examination of pig foetal material. Vet. Microbiol. 1995, 44(1):49-64.
    • (1995) Vet. Microbiol. , vol.44 , Issue.1 , pp. 49-64
    • Allan, G.M.1    McNeilly, F.2    Cassidy, J.P.3    Reilly, G.A.4    Adair, B.5    Ellis, W.A.6    McNulty, M.S.7
  • 3
    • 79955403919 scopus 로고    scopus 로고
    • Chimeric porcine circoviruses (PCV) containing amino acid epitope tags in the C terminus of the capsid gene are infectious and elicit both anti-epitope tag antibodies and anti-PCV type 2 neutralizing antibodies in pigs
    • Beach N.M., Smith S.M., Ramamoorthy S., Meng X.-J. Chimeric porcine circoviruses (PCV) containing amino acid epitope tags in the C terminus of the capsid gene are infectious and elicit both anti-epitope tag antibodies and anti-PCV type 2 neutralizing antibodies in pigs. J. Virol. 2011, 85(9):4591-4595.
    • (2011) J. Virol. , vol.85 , Issue.9 , pp. 4591-4595
    • Beach, N.M.1    Smith, S.M.2    Ramamoorthy, S.3    Meng, X.-J.4
  • 5
    • 79956312599 scopus 로고    scopus 로고
    • Natural recombinants derived from different patterns of recombination between two PCV2b parental strains
    • Cai L., Han X., Ni J., Yu X., Zhou Z., Zhai X., Chen X., Tian K. Natural recombinants derived from different patterns of recombination between two PCV2b parental strains. Virus Res. 2011, 158(1-2):281-288.
    • (2011) Virus Res. , vol.158 , Issue.1-2 , pp. 281-288
    • Cai, L.1    Han, X.2    Ni, J.3    Yu, X.4    Zhou, Z.5    Zhai, X.6    Chen, X.7    Tian, K.8
  • 7
    • 2542497046 scopus 로고    scopus 로고
    • Postweaning multisystemic wasting syndrome: a review of aetiology, diagnosis and pathology
    • Chae C. Postweaning multisystemic wasting syndrome: a review of aetiology, diagnosis and pathology. Vet. J. 2004, 168(1):41-49.
    • (2004) Vet. J. , vol.168 , Issue.1 , pp. 41-49
    • Chae, C.1
  • 8
    • 14044274588 scopus 로고    scopus 로고
    • A review of porcine circovirus 2-associated syndromes and diseases
    • Chae C. A review of porcine circovirus 2-associated syndromes and diseases. Vet. J. 2005, 169:326-336.
    • (2005) Vet. J. , vol.169 , pp. 326-336
    • Chae, C.1
  • 10
    • 62149134559 scopus 로고    scopus 로고
    • Homologous recombination within the capsid gene of porcine circovirus type 2 subgroup viruses via natural co-infection
    • Cheung A.K. Homologous recombination within the capsid gene of porcine circovirus type 2 subgroup viruses via natural co-infection. Arch. Virol. 2009, 154(3):531-534.
    • (2009) Arch. Virol. , vol.154 , Issue.3 , pp. 531-534
    • Cheung, A.K.1
  • 11
    • 79955535615 scopus 로고    scopus 로고
    • Characterization of a new disease syndrome associated with porcine circovirus type 2 (PCV2) in previously vaccinated herds
    • Cino-Ozuna A.G., Henry S., Hesse R., Nietfeld J.C., Bai J., Scott H.M., Rowland R.R.R. Characterization of a new disease syndrome associated with porcine circovirus type 2 (PCV2) in previously vaccinated herds. J. Clin. Microbiol. 2011, 49(5):2012-2016.
    • (2011) J. Clin. Microbiol. , vol.49 , Issue.5 , pp. 2012-2016
    • Cino-Ozuna, A.G.1    Henry, S.2    Hesse, R.3    Nietfeld, J.C.4    Bai, J.5    Scott, H.M.6    Rowland, R.R.R.7
  • 13
    • 79953042329 scopus 로고    scopus 로고
    • Further comments on porcine circovirus type 2 (PCV2) genotype definition and nomenclature
    • Cortey M., Olvera A., Grau-Roma L., Segalés J. Further comments on porcine circovirus type 2 (PCV2) genotype definition and nomenclature. Vet. Microbiol. 2011, 149(3-4):522-523.
    • (2011) Vet. Microbiol. , vol.149 , Issue.3-4 , pp. 522-523
    • Cortey, M.1    Olvera, A.2    Grau-Roma, L.3    Segalés, J.4
  • 14
    • 1342289077 scopus 로고    scopus 로고
    • Molecular characterization of porcine circovirus type 2 isolates from post-weaning multisystemic wasting syndrome-affected and non-affected pigs
    • de Boisséson C., Béven V., Bigarré L., Thiéry R., Rose N., Eveno E., Madec F., Jestin A. Molecular characterization of porcine circovirus type 2 isolates from post-weaning multisystemic wasting syndrome-affected and non-affected pigs. J. Gen. Virol. 2004, 85:293-304.
    • (2004) J. Gen. Virol. , vol.85 , pp. 293-304
    • de Boisséson, C.1    Béven, V.2    Bigarré, L.3    Thiéry, R.4    Rose, N.5    Eveno, E.6    Madec, F.7    Jestin, A.8
  • 15
    • 40849097775 scopus 로고    scopus 로고
    • Rates of evolutionary change in viruses: patterns and determinants
    • Duffy S., Shackelton L.A., Holmes E.C. Rates of evolutionary change in viruses: patterns and determinants. Nat. Rev. Genet. 2008, 9(4):267-276.
    • (2008) Nat. Rev. Genet. , vol.9 , Issue.4 , pp. 267-276
    • Duffy, S.1    Shackelton, L.A.2    Holmes, E.C.3
  • 16
    • 38849118996 scopus 로고    scopus 로고
    • Genomic analysis of PCV2 isolates from Danish archives and a current PMWS case-control study supports a shift in genotypes with time
    • Dupont K., Nielsen E.O., Baekbo P., Larsen L.E. Genomic analysis of PCV2 isolates from Danish archives and a current PMWS case-control study supports a shift in genotypes with time. Vet. Microbiol. 2008, 128(1-2):56-64.
    • (2008) Vet. Microbiol. , vol.128 , Issue.1-2 , pp. 56-64
    • Dupont, K.1    Nielsen, E.O.2    Baekbo, P.3    Larsen, L.E.4
  • 17
    • 70349913720 scopus 로고    scopus 로고
    • Transmission of different variants of PCV2 and viral dynamics in a research facility with pigs mingled from PMWS-affected herds and non-affected herds
    • Dupont K., Hjulsager C.K., Kristensen C.S., Baekbo P., Larsen L.E. Transmission of different variants of PCV2 and viral dynamics in a research facility with pigs mingled from PMWS-affected herds and non-affected herds. Vet. Microbiol. 2009, 139(3-4):219-226.
    • (2009) Vet. Microbiol. , vol.139 , Issue.3-4 , pp. 219-226
    • Dupont, K.1    Hjulsager, C.K.2    Kristensen, C.S.3    Baekbo, P.4    Larsen, L.E.5
  • 18
    • 39949085072 scopus 로고    scopus 로고
    • The effect of vaccination against porcine circovirus type 2 in pigs suffering from porcine respiratory disease complex
    • Fachinger V., Bischoff R., Jedidia S.B., Saalmüller A., Elbers K. The effect of vaccination against porcine circovirus type 2 in pigs suffering from porcine respiratory disease complex. Vaccine 2008, 26(11):1488-1499.
    • (2008) Vaccine , vol.26 , Issue.11 , pp. 1488-1499
    • Fachinger, V.1    Bischoff, R.2    Jedidia, S.B.3    Saalmüller, A.4    Elbers, K.5
  • 19
    • 0033944713 scopus 로고    scopus 로고
    • Genetic characterization of type 2 porcine circovirus (PCV-2) from pigs with postweaning multisystemic wasting syndrome in different geographic regions of North America and development of a differential PCR-restriction fragment length polymorphism assay to detect and differentiate between infections with PCV-1 and PCV-2
    • Fenaux M., Halbur P.G., Gill M., Toth T.E., Meng X.J. Genetic characterization of type 2 porcine circovirus (PCV-2) from pigs with postweaning multisystemic wasting syndrome in different geographic regions of North America and development of a differential PCR-restriction fragment length polymorphism assay to detect and differentiate between infections with PCV-1 and PCV-2. J. Clin. Microbiol. 2000, 38(7):2494-2503.
    • (2000) J. Clin. Microbiol. , vol.38 , Issue.7 , pp. 2494-2503
    • Fenaux, M.1    Halbur, P.G.2    Gill, M.3    Toth, T.E.4    Meng, X.J.5
  • 20
    • 7444259508 scopus 로고    scopus 로고
    • Two amino acid mutations in the capsid protein of type 2 porcine circovirus (PCV2) enhanced PCV2 replication in vitro and attenuated the virus in vivo
    • Fenaux M., Opriessnig T., Halbur P.G., Elvinger F., Meng X.J. Two amino acid mutations in the capsid protein of type 2 porcine circovirus (PCV2) enhanced PCV2 replication in vitro and attenuated the virus in vivo. J. Virol. 2004, 78(24):13440-13446.
    • (2004) J. Virol. , vol.78 , Issue.24 , pp. 13440-13446
    • Fenaux, M.1    Opriessnig, T.2    Halbur, P.G.3    Elvinger, F.4    Meng, X.J.5
  • 21
    • 0141788497 scopus 로고    scopus 로고
    • Immunogenicity and pathogenicity of chimeric infectious DNA clones of pathogenic porcine circovirus type 2 (PCV2) and nonpathogenic PCV1 in weanling pigs
    • Fenaux M., Opriessnig T., Halbur P.G., Meng X.J. Immunogenicity and pathogenicity of chimeric infectious DNA clones of pathogenic porcine circovirus type 2 (PCV2) and nonpathogenic PCV1 in weanling pigs. J. Virol. 2003, 77(20):11232-11243.
    • (2003) J. Virol. , vol.77 , Issue.20 , pp. 11232-11243
    • Fenaux, M.1    Opriessnig, T.2    Halbur, P.G.3    Meng, X.J.4
  • 22
    • 72849121997 scopus 로고    scopus 로고
    • Insights into the evolutionary history of an emerging livestock pathogen: porcine circovirus 2
    • Firth C., Charleston M.A., Duffy S., Shapiro B., Holmes E.C. Insights into the evolutionary history of an emerging livestock pathogen: porcine circovirus 2. J. Virol. 2009, 83(24):12813-12821.
    • (2009) J. Virol. , vol.83 , Issue.24 , pp. 12813-12821
    • Firth, C.1    Charleston, M.A.2    Duffy, S.3    Shapiro, B.4    Holmes, E.C.5
  • 23
    • 39149102499 scopus 로고    scopus 로고
    • Porcine circovirus type 2 (PCV2) vaccination of conventional pigs prevents viremia against PCV2 isolates of different genotypes and geographic origins
    • Fort M., Sibila M., Allepuz A., Mateu E., Roerink F., Segalés J. Porcine circovirus type 2 (PCV2) vaccination of conventional pigs prevents viremia against PCV2 isolates of different genotypes and geographic origins. Vaccine 2008, 26(8):1063-1071.
    • (2008) Vaccine , vol.26 , Issue.8 , pp. 1063-1071
    • Fort, M.1    Sibila, M.2    Allepuz, A.3    Mateu, E.4    Roerink, F.5    Segalés, J.6
  • 24
    • 67349110424 scopus 로고    scopus 로고
    • One dose of a porcine circovirus 2 (PCV2) sub-unit vaccine administered to 3-week-old conventional piglets elicits cell-mediated immunity and significantly reduces PCV2 viremia in an experimental model
    • Fort M., Sibila M., Pérez-Martín E., Nofrarías M., Mateu E., Segalés J. One dose of a porcine circovirus 2 (PCV2) sub-unit vaccine administered to 3-week-old conventional piglets elicits cell-mediated immunity and significantly reduces PCV2 viremia in an experimental model. Vaccine 2009, 27(30):4031-4037.
    • (2009) Vaccine , vol.27 , Issue.30 , pp. 4031-4037
    • Fort, M.1    Sibila, M.2    Pérez-Martín, E.3    Nofrarías, M.4    Mateu, E.5    Segalés, J.6
  • 25
    • 77954815934 scopus 로고    scopus 로고
    • Emergence of a new type of porcine circovirus in swine (PCV): a type 1 and type 2 PCV recombinant
    • Gagnon C.A., Music N., Fontaine G., Tremblay D., Harel J. Emergence of a new type of porcine circovirus in swine (PCV): a type 1 and type 2 PCV recombinant. Vet. Microbiol. 2010, 144(1-2):18-23.
    • (2010) Vet. Microbiol. , vol.144 , Issue.1-2 , pp. 18-23
    • Gagnon, C.A.1    Music, N.2    Fontaine, G.3    Tremblay, D.4    Harel, J.5
  • 26
    • 0033529321 scopus 로고    scopus 로고
    • Evidence that a plant virus switched hosts to infect a vertebrate and then recombined with a vertebrate-infecting virus
    • Gibbs M.J., Weiller G.F. Evidence that a plant virus switched hosts to infect a vertebrate and then recombined with a vertebrate-infecting virus. Proc. Natl. Acad. Sci. U. S. A. 1999, 96(14):8022-8027.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , Issue.14 , pp. 8022-8027
    • Gibbs, M.J.1    Weiller, G.F.2
  • 28
    • 38849205711 scopus 로고    scopus 로고
    • A proposal on porcine circovirus type 2 (PCV2) genotype definition and their relation with postweaning multisystemic wasting syndrome (PMWS) occurrence
    • Grau-Roma L., Crisci E., Sibila M., López-Soria S., Nofrarias M., Cortey M., Fraile L., Olvera A., Segalés J. A proposal on porcine circovirus type 2 (PCV2) genotype definition and their relation with postweaning multisystemic wasting syndrome (PMWS) occurrence. Vet. Microbiol. 2008, 128(1-2):23-35.
    • (2008) Vet. Microbiol. , vol.128 , Issue.1-2 , pp. 23-35
    • Grau-Roma, L.1    Crisci, E.2    Sibila, M.3    López-Soria, S.4    Nofrarias, M.5    Cortey, M.6    Fraile, L.7    Olvera, A.8    Segalés, J.9
  • 29
    • 2942739286 scopus 로고    scopus 로고
    • Detection and genetic typing of type 2 porcine circoviruses in archived pig tissues from the UK
    • Grierson S.S., King D.P., Sandvik T., Hicks D., Spencer Y., Drew T.W., Banks M. Detection and genetic typing of type 2 porcine circoviruses in archived pig tissues from the UK. Arch. Virol. 2004, 149(6):1171-1183.
    • (2004) Arch. Virol. , vol.149 , Issue.6 , pp. 1171-1183
    • Grierson, S.S.1    King, D.P.2    Sandvik, T.3    Hicks, D.4    Spencer, Y.5    Drew, T.W.6    Banks, M.7
  • 30
    • 77957894555 scopus 로고    scopus 로고
    • Porcine circovirus type 2 (PCV2): genetic variation and newly emerging genotypes in China
    • Guo L.J., Lu Y.H., Wei Y.W., Huang L.P., Liu C.M. Porcine circovirus type 2 (PCV2): genetic variation and newly emerging genotypes in China. Virol. J. 2010, 7:273.
    • (2010) Virol. J. , vol.7 , pp. 273
    • Guo, L.J.1    Lu, Y.H.2    Wei, Y.W.3    Huang, L.P.4    Liu, C.M.5
  • 32
    • 77957286941 scopus 로고    scopus 로고
    • Dual heterologous porcine circovirus genogroup 2a/2b infection induces severe disease in germ-free pigs
    • Harding J.C.S., Ellis J.A., McIntosh K.A., Krakowka S. Dual heterologous porcine circovirus genogroup 2a/2b infection induces severe disease in germ-free pigs. Vet. Microbiol. 2010, 145(3-4):209-219.
    • (2010) Vet. Microbiol. , vol.145 , Issue.3-4 , pp. 209-219
    • Harding, J.C.S.1    Ellis, J.A.2    McIntosh, K.A.3    Krakowka, S.4
  • 33
    • 0000447349 scopus 로고    scopus 로고
    • Post-weaning multisystemic wasting syndrome (PMWS): preliminary epidemiology and clinical presentation
    • Harding J.C.S. Post-weaning multisystemic wasting syndrome (PMWS): preliminary epidemiology and clinical presentation. Proc. Am. Assoc. Swine Pract. 1997, 28:503.
    • (1997) Proc. Am. Assoc. Swine Pract. , vol.28 , pp. 503
    • Harding, J.C.S.1
  • 34
    • 38949186001 scopus 로고    scopus 로고
    • Evidence for recombination between PCV2a and PCV2b in the field
    • Hesse R., Kerrigan M., Rowland R.R.R. Evidence for recombination between PCV2a and PCV2b in the field. Virus Res. 2008, 132(1-2):201-207.
    • (2008) Virus Res. , vol.132 , Issue.1-2 , pp. 201-207
    • Hesse, R.1    Kerrigan, M.2    Rowland, R.R.R.3
  • 36
    • 34548840862 scopus 로고    scopus 로고
    • A cluster of farms experiencing severe porcine circovirus associated disease: clinical features and association with the PCV2b genotype
    • Horlen K.P., Schneider P., Anderson J., Nietfeld J.C., Henry S.C., Tokach L.M., Rowland R.R.R. A cluster of farms experiencing severe porcine circovirus associated disease: clinical features and association with the PCV2b genotype. J. Swine Health Prod. 2007, 15(5):270-278.
    • (2007) J. Swine Health Prod. , vol.15 , Issue.5 , pp. 270-278
    • Horlen, K.P.1    Schneider, P.2    Anderson, J.3    Nietfeld, J.C.4    Henry, S.C.5    Tokach, L.M.6    Rowland, R.R.R.7
  • 37
    • 80053131129 scopus 로고    scopus 로고
    • Construction and biological characterisation of recombinant porcine circovirus type 2 expressing the V5 epitope tag
    • Huang L., Lu Y., Wei Y., Guo L., Wu H., Zhang F., Fu Y., Liu C. Construction and biological characterisation of recombinant porcine circovirus type 2 expressing the V5 epitope tag. Virus Res. 2011, 161(2):115-123.
    • (2011) Virus Res. , vol.161 , Issue.2 , pp. 115-123
    • Huang, L.1    Lu, Y.2    Wei, Y.3    Guo, L.4    Wu, H.5    Zhang, F.6    Fu, Y.7    Liu, C.8
  • 38
    • 39649090739 scopus 로고    scopus 로고
    • Nucleotide sequence polymorphism in circoviruses
    • Hughes A.L., Piontkivska H. Nucleotide sequence polymorphism in circoviruses. Infect. Genet. Evol. 2008, 8(2):130-138.
    • (2008) Infect. Genet. Evol. , vol.8 , Issue.2 , pp. 130-138
    • Hughes, A.L.1    Piontkivska, H.2
  • 39
    • 67349227125 scopus 로고    scopus 로고
    • Retrospective study on the occurrence of porcine circovirus 2 infection and associated entities in Northern Germany
    • Jacobsen B., Krueger L., Seeliger F., Bruegmann M., Segalés J., Baumgaertner W. Retrospective study on the occurrence of porcine circovirus 2 infection and associated entities in Northern Germany. Vet. Microbiol. 2009, 138(1-2):27-33.
    • (2009) Vet. Microbiol. , vol.138 , Issue.1-2 , pp. 27-33
    • Jacobsen, B.1    Krueger, L.2    Seeliger, F.3    Bruegmann, M.4    Segalés, J.5    Baumgaertner, W.6
  • 40
    • 79952064172 scopus 로고    scopus 로고
    • Genetic characterization of porcine circovirus type 2 in piglets from PMWS-affected and -negative farms in Thailand
    • Jantafong T., Boonsoongnern A., Poolperm P., Urairong K., Lekcharoensuk C., Lekcharoensuk P. Genetic characterization of porcine circovirus type 2 in piglets from PMWS-affected and -negative farms in Thailand. Virol. J. 2011, 8:88.
    • (2011) Virol. J. , vol.8 , pp. 88
    • Jantafong, T.1    Boonsoongnern, A.2    Poolperm, P.3    Urairong, K.4    Lekcharoensuk, C.5    Lekcharoensuk, P.6
  • 41
    • 80155158126 scopus 로고    scopus 로고
    • Porcine circovirus 2 major genotype group members' co-replication as a prerequisite to co-evolution that may explain the variable disease manifestations
    • Khaiseb S., Sydler T., Zimmermann D., Pospischil A., Sidler X., Brugnera E. Porcine circovirus 2 major genotype group members' co-replication as a prerequisite to co-evolution that may explain the variable disease manifestations. J. Virol. 2011, 85(21):11111-11120.
    • (2011) J. Virol. , vol.85 , Issue.21 , pp. 11111-11120
    • Khaiseb, S.1    Sydler, T.2    Zimmermann, D.3    Pospischil, A.4    Sidler, X.5    Brugnera, E.6
  • 43
    • 0347075715 scopus 로고    scopus 로고
    • Double in situ hybridization for simultaneous detection and differentiation of porcine circovirus 1 and 2 in pigs with postweaning multisystemic wasting syndrome
    • Kim J., Chae C. Double in situ hybridization for simultaneous detection and differentiation of porcine circovirus 1 and 2 in pigs with postweaning multisystemic wasting syndrome. Vet. J. 2002, 164(3):247-253.
    • (2002) Vet. J. , vol.164 , Issue.3 , pp. 247-253
    • Kim, J.1    Chae, C.2
  • 44
    • 70350344071 scopus 로고    scopus 로고
    • Phylogenetic and recombination analysis of genomic sequences of PCV2 isolated in Korea
    • Kim H.K., Luo Y., Moon H.J., Park S.J., Keum H.O., Rho S., Park B.K. Phylogenetic and recombination analysis of genomic sequences of PCV2 isolated in Korea. Virus Genes 2009, 39(3):352-358.
    • (2009) Virus Genes , vol.39 , Issue.3 , pp. 352-358
    • Kim, H.K.1    Luo, Y.2    Moon, H.J.3    Park, S.J.4    Keum, H.O.5    Rho, S.6    Park, B.K.7
  • 45
    • 44749089050 scopus 로고    scopus 로고
    • Reduction of PMWS-associated clinical signs and co-infections by vaccination against PCV2
    • Kixmöller M., Ritzmann M., Eddicks M., Saalmüller A., Elbers K., Fachinger V. Reduction of PMWS-associated clinical signs and co-infections by vaccination against PCV2. Vaccine 2008, 26(27-28):3443-3451.
    • (2008) Vaccine , vol.26 , Issue.27-28 , pp. 3443-3451
    • Kixmöller, M.1    Ritzmann, M.2    Eddicks, M.3    Saalmüller, A.4    Elbers, K.5    Fachinger, V.6
  • 46
    • 57849165064 scopus 로고    scopus 로고
    • Evaluation of induction of porcine dermatitis and nephropathy syndrome in gnotobiotic pigs with negative results for porcine circovirus type 2
    • Krakowka S., Hartunian C., Hamberg A., Shoup D., Rings M., Zhang Y., Allan G., Ellis J.A. Evaluation of induction of porcine dermatitis and nephropathy syndrome in gnotobiotic pigs with negative results for porcine circovirus type 2. Am. J. Vet. Res. 2008, 69:1615-1622.
    • (2008) Am. J. Vet. Res. , vol.69 , pp. 1615-1622
    • Krakowka, S.1    Hartunian, C.2    Hamberg, A.3    Shoup, D.4    Rings, M.5    Zhang, Y.6    Allan, G.7    Ellis, J.A.8
  • 47
    • 34948845594 scopus 로고    scopus 로고
    • Mortality in pigs given porcine circovirus type 2 subgroup 1 and 2 viruses derived from DNA clones
    • Lager K.M., Gauger P.C., Vincent A.L., Opriessnig T., Kehrli M.E., Cheung A.K. Mortality in pigs given porcine circovirus type 2 subgroup 1 and 2 viruses derived from DNA clones. Vet. Rec. 2007, 161(12):428-429.
    • (2007) Vet. Rec. , vol.161 , Issue.12 , pp. 428-429
    • Lager, K.M.1    Gauger, P.C.2    Vincent, A.L.3    Opriessnig, T.4    Kehrli, M.E.5    Cheung, A.K.6
  • 48
    • 0033066831 scopus 로고    scopus 로고
    • Typing of porcine circovirus in clinical specimens by multiplex PCR
    • Larochelle R., Antaya M., Morin M., Magar R. Typing of porcine circovirus in clinical specimens by multiplex PCR. J. Virol. Methods 1999, 80(1):69-75.
    • (1999) J. Virol. Methods , vol.80 , Issue.1 , pp. 69-75
    • Larochelle, R.1    Antaya, M.2    Morin, M.3    Magar, R.4
  • 49
    • 0036891235 scopus 로고    scopus 로고
    • Genetic characterization and phylogenetic analysis of porcine circovirus type 2 (PCV2) strains from cases presenting various clinical conditions
    • Larochelle R., Magar R., D'Allaire S. Genetic characterization and phylogenetic analysis of porcine circovirus type 2 (PCV2) strains from cases presenting various clinical conditions. Virus Res. 2002, 90(1-2):101-112.
    • (2002) Virus Res. , vol.90 , Issue.1-2 , pp. 101-112
    • Larochelle, R.1    Magar, R.2    D'Allaire, S.3
  • 50
    • 3242723069 scopus 로고    scopus 로고
    • Epitope mapping of the major capsid protein of type 2 porcine circovirus (PCV2) by using chimeric PCV1 and PCV2
    • Lekcharoensuk P., Morozov I., Paul P.S., Thangthumniyom N., Wajjawalku W., Meng X.J. Epitope mapping of the major capsid protein of type 2 porcine circovirus (PCV2) by using chimeric PCV1 and PCV2. J. Virol. 2004, 78(15):8135-8145.
    • (2004) J. Virol. , vol.78 , Issue.15 , pp. 8135-8145
    • Lekcharoensuk, P.1    Morozov, I.2    Paul, P.S.3    Thangthumniyom, N.4    Wajjawalku, W.5    Meng, X.J.6
  • 51
    • 38349076012 scopus 로고    scopus 로고
    • Antigenic differences among porcine circovirus type 2 strains, as demonstrated by the use of monoclonal antibodies
    • Lefebvre D.J., Costers S., Van Doorsselaere J., Misinzo G., Delputte P.L., Nauwynck H.J. Antigenic differences among porcine circovirus type 2 strains, as demonstrated by the use of monoclonal antibodies. J. Gen. Virol. 2008, 89(Pt 1):177-187.
    • (2008) J. Gen. Virol. , vol.89 , Issue.PART 1 , pp. 177-187
    • Lefebvre, D.J.1    Costers, S.2    Van Doorsselaere, J.3    Misinzo, G.4    Delputte, P.L.5    Nauwynck, H.J.6
  • 53
    • 0035918992 scopus 로고    scopus 로고
    • Nuclear localization of the ORF2 protein encoded by porcine circovirus type 2
    • Liu Q., Tikoo S.K., Babiuk L.A. Nuclear localization of the ORF2 protein encoded by porcine circovirus type 2. Virology 2001, 285(1):91-99.
    • (2001) Virology , vol.285 , Issue.1 , pp. 91-99
    • Liu, Q.1    Tikoo, S.K.2    Babiuk, L.A.3
  • 54
    • 34249787861 scopus 로고    scopus 로고
    • Evidence for recombination in natural populations of porcine circovirus type 2 in Hong Kong and mainland China
    • Ma C.-M., Hon C.-C., Lam T.-Y., Li V.Y.-Y., Wong C.K.-W., de Oliveira T., Leung F.C.-C. Evidence for recombination in natural populations of porcine circovirus type 2 in Hong Kong and mainland China. J. Gen. Virol. 2007, 88(Pt 6):1733-1737.
    • (2007) J. Gen. Virol. , vol.88 , Issue.PART 6 , pp. 1733-1737
    • Ma, C.-M.1    Hon, C.-C.2    Lam, T.-Y.3    Li, V.Y.-Y.4    Wong, C.K.-W.5    de Oliveira, T.6    Leung, F.C.-C.7
  • 55
    • 0033918124 scopus 로고    scopus 로고
    • Differential recognition of ORF2 protein from type 1 and type 2 porcine circoviruses and identification of immunorelevant epitopes
    • Mahé D., Blanchard P., Truong C., Arnauld C., Le Cann P., Cariolet R., Madec F., Albina E., Jestin A. Differential recognition of ORF2 protein from type 1 and type 2 porcine circoviruses and identification of immunorelevant epitopes. J. Gen. Virol. 2000, 81(Pt 7):1815-1824.
    • (2000) J. Gen. Virol. , vol.81 , Issue.PART 7 , pp. 1815-1824
    • Mahé, D.1    Blanchard, P.2    Truong, C.3    Arnauld, C.4    Le Cann, P.5    Cariolet, R.6    Madec, F.7    Albina, E.8    Jestin, A.9
  • 57
    • 0035864282 scopus 로고    scopus 로고
    • Replication of porcine circovirus type 1 requires two proteins encoded by the viral rep gene
    • Mankertz A., Hillenbrand B. Replication of porcine circovirus type 1 requires two proteins encoded by the viral rep gene. Virology 2001, 279(2):429-438.
    • (2001) Virology , vol.279 , Issue.2 , pp. 429-438
    • Mankertz, A.1    Hillenbrand, B.2
  • 58
    • 79953065578 scopus 로고    scopus 로고
    • One dose of a porcine circovirus 2 subunit vaccine induces humoral and cell-mediated immunity and protects against porcine circovirus-associated disease under field conditions
    • Martelli P., Ferrari L., Morganti M., De Angelis E., Bonilauri P., Guazzetti S., Caleffi A., Borghetti P. One dose of a porcine circovirus 2 subunit vaccine induces humoral and cell-mediated immunity and protects against porcine circovirus-associated disease under field conditions. Vet. Microbiol. 2011, 149(3-4):339-351.
    • (2011) Vet. Microbiol. , vol.149 , Issue.3-4 , pp. 339-351
    • Martelli, P.1    Ferrari, L.2    Morganti, M.3    De Angelis, E.4    Bonilauri, P.5    Guazzetti, S.6    Caleffi, A.7    Borghetti, P.8
  • 59
    • 34547379196 scopus 로고    scopus 로고
    • Genetic diversity of Brazilian strains of porcine circovirus type 2 (PCV-2) revealed by analysis of the cap gene (ORF-2)
    • Martins Gomes de Castro A.M., Cortez A., Heinemann M.B., Brandão P.E., Richtzenhain L.J. Genetic diversity of Brazilian strains of porcine circovirus type 2 (PCV-2) revealed by analysis of the cap gene (ORF-2). Arch. Virol. 2007, 152(8):1435-1445.
    • (2007) Arch. Virol. , vol.152 , Issue.8 , pp. 1435-1445
    • Martins Gomes de Castro, A.M.1    Cortez, A.2    Heinemann, M.B.3    Brandão, P.E.4    Richtzenhain, L.J.5
  • 61
    • 33645229143 scopus 로고    scopus 로고
    • Porcine circovirus 2 uses heparan sulfate and chondroitin sulfate B glycosaminoglycans as receptors for its attachment to host cells
    • Misinzo G., Delputte P.L., Meerts P., Lefebvre D.J., Nauwynck H.J. Porcine circovirus 2 uses heparan sulfate and chondroitin sulfate B glycosaminoglycans as receptors for its attachment to host cells. J. Virol. 2006, 80:3487-3494.
    • (2006) J. Virol. , vol.80 , pp. 3487-3494
    • Misinzo, G.1    Delputte, P.L.2    Meerts, P.3    Lefebvre, D.J.4    Nauwynck, H.J.5
  • 62
    • 0033833402 scopus 로고    scopus 로고
    • Open reading frame 2 of porcine circovirus type 2 encodes a major capsid protein
    • Nawagitgul P., Morozov I., Bolin S.R., Harms P.A., Sorden S.D., Paul P.S. Open reading frame 2 of porcine circovirus type 2 encodes a major capsid protein. J. Gen. Virol. 2000, 81(Pt 9):2281-2287.
    • (2000) J. Gen. Virol. , vol.81 , Issue.PART 9 , pp. 2281-2287
    • Nawagitgul, P.1    Morozov, I.2    Bolin, S.R.3    Harms, P.A.4    Sorden, S.D.5    Paul, P.S.6
  • 63
    • 33751514317 scopus 로고    scopus 로고
    • Molecular evolution of porcine circovirus type 2 genomes: phylogeny and clonality
    • Olvera A., Cortey M., Segalés J. Molecular evolution of porcine circovirus type 2 genomes: phylogeny and clonality. Virology 2007, 357(2):175-185.
    • (2007) Virology , vol.357 , Issue.2 , pp. 175-185
    • Olvera, A.1    Cortey, M.2    Segalés, J.3
  • 64
    • 48849102562 scopus 로고    scopus 로고
    • Effect of porcine circovirus type 2 (PCV2) vaccination on porcine reproductive and respiratory syndrome virus (PRRSV) and PCV2 coinfection
    • Opriessnig T., Madson D.M., Prickett J.R., Kuhar D., Lunney J.K., Elsener J., Halbur P.G. Effect of porcine circovirus type 2 (PCV2) vaccination on porcine reproductive and respiratory syndrome virus (PRRSV) and PCV2 coinfection. Vet. Microbiol. 2008, 131(1-2):103-114.
    • (2008) Vet. Microbiol. , vol.131 , Issue.1-2 , pp. 103-114
    • Opriessnig, T.1    Madson, D.M.2    Prickett, J.R.3    Kuhar, D.4    Lunney, J.K.5    Elsener, J.6    Halbur, P.G.7
  • 65
    • 79958789722 scopus 로고    scopus 로고
    • Porcine circovirus type 2 (PCV2) vaccination is effective in reducing disease and PCV2 shedding in semen of boars concurrently infected with PCV2 and Mycoplasma hyopneumoniae
    • Opriessnig T., Madson D.M., Schalk S., Brockmeier S., Shen H.G., Beach N.M., Meng X.J., Baker R.B., Zanella E.L., Halbur P.G. Porcine circovirus type 2 (PCV2) vaccination is effective in reducing disease and PCV2 shedding in semen of boars concurrently infected with PCV2 and Mycoplasma hyopneumoniae. Theriogenology 2011, 76(2):351-360.
    • (2011) Theriogenology , vol.76 , Issue.2 , pp. 351-360
    • Opriessnig, T.1    Madson, D.M.2    Schalk, S.3    Brockmeier, S.4    Shen, H.G.5    Beach, N.M.6    Meng, X.J.7    Baker, R.B.8    Zanella, E.L.9    Halbur, P.G.10
  • 66
    • 58549100979 scopus 로고    scopus 로고
    • Comparison of efficacy of commercial one dose and two dose PCV2 vaccines using a mixed PRRSV-PCV2-SIV clinical infection model 2-3-months post vaccination
    • Opriessnig T., Patterson A.R., Madson D.M., Pal N., Halbur P.G. Comparison of efficacy of commercial one dose and two dose PCV2 vaccines using a mixed PRRSV-PCV2-SIV clinical infection model 2-3-months post vaccination. Vaccine 2009, 27(7):1002-1007.
    • (2009) Vaccine , vol.27 , Issue.7 , pp. 1002-1007
    • Opriessnig, T.1    Patterson, A.R.2    Madson, D.M.3    Pal, N.4    Halbur, P.G.5
  • 67
    • 54449084635 scopus 로고    scopus 로고
    • Differences in virulence among porcine circovirus type 2 isolates are unrelated to cluster type 2a or 2b and prior infection provides heterologous protection
    • Opriessnig T., Ramamoorthy S., Madson D.M., Patterson A.R., Pal N., Carman S., Meng X.J., Halbur P.G. Differences in virulence among porcine circovirus type 2 isolates are unrelated to cluster type 2a or 2b and prior infection provides heterologous protection. J. Gen. Virol. 2008, 89(Pt 10):2482-2491.
    • (2008) J. Gen. Virol. , vol.89 , Issue.PART 10 , pp. 2482-2491
    • Opriessnig, T.1    Ramamoorthy, S.2    Madson, D.M.3    Patterson, A.R.4    Pal, N.5    Carman, S.6    Meng, X.J.7    Halbur, P.G.8
  • 68
    • 38449105591 scopus 로고    scopus 로고
    • Porcine circovirus type 2 associated disease: update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies
    • Opriessnig T., Meng X.-J., Halbur P.G. Porcine circovirus type 2 associated disease: update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies. J. Vet. Diagn. Invest. 2007, 19(6):591-615.
    • (2007) J. Vet. Diagn. Invest. , vol.19 , Issue.6 , pp. 591-615
    • Opriessnig, T.1    Meng, X.-J.2    Halbur, P.G.3
  • 69
    • 0032752155 scopus 로고    scopus 로고
    • Multiplex PCR for detection and typing of porcine circoviruses
    • Ouardani M., Wilson L., Jetté R., Montpetit C., Dea S. Multiplex PCR for detection and typing of porcine circoviruses. J. Clin. Microbiol. 1999, 37(12):3917-3924.
    • (1999) J. Clin. Microbiol. , vol.37 , Issue.12 , pp. 3917-3924
    • Ouardani, M.1    Wilson, L.2    Jetté, R.3    Montpetit, C.4    Dea, S.5
  • 70
    • 79952688735 scopus 로고    scopus 로고
    • Epidemiology and horizontal transmission of porcine circovirus type 2 (PCV2)
    • Patterson A.R., Opriessnig T. Epidemiology and horizontal transmission of porcine circovirus type 2 (PCV2). Anim. Health Res. Rev. 2010, 11(2):217-234.
    • (2010) Anim. Health Res. Rev. , vol.11 , Issue.2 , pp. 217-234
    • Patterson, A.R.1    Opriessnig, T.2
  • 73
    • 70349245662 scopus 로고    scopus 로고
    • Porcine circoviruses: a minuscule yet mammoth paradox
    • Ramamoorthy S., Meng X.-J. Porcine circoviruses: a minuscule yet mammoth paradox. Anim. Health Res. Rev. 2009, 10(1):1-20.
    • (2009) Anim. Health Res. Rev. , vol.10 , Issue.1 , pp. 1-20
    • Ramamoorthy, S.1    Meng, X.-J.2
  • 74
    • 80054758807 scopus 로고    scopus 로고
    • Outcome of experimental porcine circovirus type 1 infections in mid-gestational porcine foetuses
    • Saha D., Lefebvre D.J., Ducatelle R., Doorsselaere J.V., Nauwynck H.J. Outcome of experimental porcine circovirus type 1 infections in mid-gestational porcine foetuses. BMC Vet. Res. 2011, 7(1):64.
    • (2011) BMC Vet. Res. , vol.7 , Issue.1 , pp. 64
    • Saha, D.1    Lefebvre, D.J.2    Ducatelle, R.3    Doorsselaere, J.V.4    Nauwynck, H.J.5
  • 76
    • 80051826383 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome virus (PRRSV) influences infection dynamics of porcine circovirus type 2 (PCV2) subtypes PCV2a and PCV2b by prolonging PCV2 viremia and shedding
    • Sinha A., Shen H.G., Schalk S., Beach N.M., Huang Y.W., Meng X.J., Halbur P.G., Opriessnig T. Porcine reproductive and respiratory syndrome virus (PRRSV) influences infection dynamics of porcine circovirus type 2 (PCV2) subtypes PCV2a and PCV2b by prolonging PCV2 viremia and shedding. Vet. Microbiol. 2011, 152(3-4):235-246.
    • (2011) Vet. Microbiol. , vol.152 , Issue.3-4 , pp. 235-246
    • Sinha, A.1    Shen, H.G.2    Schalk, S.3    Beach, N.M.4    Huang, Y.W.5    Meng, X.J.6    Halbur, P.G.7    Opriessnig, T.8
  • 77
    • 79957613599 scopus 로고    scopus 로고
    • MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods
    • (Epub August 18)
    • Tamura K., Peterson D., Peterson N., Stecher G., Nei M., Kumar S. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol. Biol. Evol. 2011, (Epub August 18).
    • (2011) Mol. Biol. Evol.
    • Tamura, K.1    Peterson, D.2    Peterson, N.3    Stecher, G.4    Nei, M.5    Kumar, S.6
  • 78
    • 0036777851 scopus 로고    scopus 로고
    • Porcine dermatitis and nephropathy syndrome: clinical and pathological features of cases in the United Kingdom (1993-1998)
    • Thomson J.R., Higgins R.J., Smith W.J., Done S.H. Porcine dermatitis and nephropathy syndrome: clinical and pathological features of cases in the United Kingdom (1993-1998). J. Vet. Med. A: Physiol. Pathol. Clin. Med. 2002, 49:430-437.
    • (2002) J. Vet. Med. A: Physiol. Pathol. Clin. Med. , vol.49 , pp. 430-437
    • Thomson, J.R.1    Higgins, R.J.2    Smith, W.J.3    Done, S.H.4
  • 80
    • 0020057449 scopus 로고
    • A very small porcine virus with circular single-stranded DNA
    • Tischer I., Gelderblom H., Vettermann W., Koch M.A. A very small porcine virus with circular single-stranded DNA. Nature 1982, 295(5844):64-66.
    • (1982) Nature , vol.295 , Issue.5844 , pp. 64-66
    • Tischer, I.1    Gelderblom, H.2    Vettermann, W.3    Koch, M.A.4
  • 81
    • 0022494051 scopus 로고
    • Studies on epidemiology and pathogenicity of porcine circovirus
    • Tischer I., Mields W., Wolff D., Vagt M., Griem W. Studies on epidemiology and pathogenicity of porcine circovirus. Arch. Virol. 1986, 91(3-4):271-276.
    • (1986) Arch. Virol. , vol.91 , Issue.3-4 , pp. 271-276
    • Tischer, I.1    Mields, W.2    Wolff, D.3    Vagt, M.4    Griem, W.5
  • 82
    • 0015949192 scopus 로고
    • Characterization of papovavirus- and picornavirus-like particles in permanent pig kidney cell lines
    • Tischer I., Rasch R., Tochtermann G. Characterization of papovavirus- and picornavirus-like particles in permanent pig kidney cell lines. Zentralbl. Bakteriol. Orig. A 1974, 226(2):153-167.
    • (1974) Zentralbl. Bakteriol. Orig. A , vol.226 , Issue.2 , pp. 153-167
    • Tischer, I.1    Rasch, R.2    Tochtermann, G.3
  • 83
    • 79955733278 scopus 로고    scopus 로고
    • Antibody recognition of porcine circovirus type 2 capsid protein epitopes after vaccination, infection, and disease
    • Trible B.R., Kerrigan M., Crossland N., Potter M., Faaberg K., Hesse R., Rowland R.R.R. Antibody recognition of porcine circovirus type 2 capsid protein epitopes after vaccination, infection, and disease. Clin. Vaccine Immunol. 2011, 18(5):749-757.
    • (2011) Clin. Vaccine Immunol. , vol.18 , Issue.5 , pp. 749-757
    • Trible, B.R.1    Kerrigan, M.2    Crossland, N.3    Potter, M.4    Faaberg, K.5    Hesse, R.6    Rowland, R.R.R.7
  • 84
    • 69449098660 scopus 로고    scopus 로고
    • Genetic variation analysis of Chinese strains of porcine circovirus type 2
    • Wang F., Guo X., Ge X., Wang Z., Chen Y., Cha Z., Yang H. Genetic variation analysis of Chinese strains of porcine circovirus type 2. Virus Res. 2009, 145(1):151-156.
    • (2009) Virus Res. , vol.145 , Issue.1 , pp. 151-156
    • Wang, F.1    Guo, X.2    Ge, X.3    Wang, Z.4    Chen, Y.5    Cha, Z.6    Yang, H.7
  • 85
    • 1842788531 scopus 로고    scopus 로고
    • Excessive porcine circovirus type 2 antibody titres may trigger the development of porcine dermatitis and nephropathy syndrome: a case-control study
    • Wellenberg G.J., Stockhofe-Zurwieden N., de Jong M.F., Boersma W.J.A., Elbers A.R.W. Excessive porcine circovirus type 2 antibody titres may trigger the development of porcine dermatitis and nephropathy syndrome: a case-control study. Vet. Microbiol. 2004, 99(3-4):203-214.
    • (2004) Vet. Microbiol. , vol.99 , Issue.3-4 , pp. 203-214
    • Wellenberg, G.J.1    Stockhofe-Zurwieden, N.2    de Jong, M.F.3    Boersma, W.J.A.4    Elbers, A.R.W.5
  • 86
    • 24644494725 scopus 로고    scopus 로고
    • Genotyping of porcine circovirus type 2 from a variety of clinical conditions in China
    • Wen L., Guo X., Yang H. Genotyping of porcine circovirus type 2 from a variety of clinical conditions in China. Vet. Microbiol. 2005, 110(1-2):141-146.
    • (2005) Vet. Microbiol. , vol.110 , Issue.1-2 , pp. 141-146
    • Wen, L.1    Guo, X.2    Yang, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.