Characterization of a new disease syndrome associated with porcine circovirus type 2 in previously vaccinated herds

Journal of Clinical Microbiology

Volumn 49, Issue 5, 2011, Pages 2012-2016

  Cino Ozuna, Ada G ^a   Henry, Steven ^b   Hesse, Richard ^a   Nietfeld, Jerome C ^a   Bai, Jianfa ^a   Scott, H Morgan ^a   Rowland, Raymond R R ^a  

^a KANSAS STATE UNIVERSITY   (United States)

^b Abilene Animal Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS DNA; VIRUS VACCINE;

ARTICLE; CIRCOVIRIDAE INFECTION; CIRCOVIRUS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; HERD IMMUNITY; LUNG EDEMA; MICROSCOPY; NECROSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RESPIRATORY DISTRESS; SWINE; TORQUE TENO VIRUS; VACCINATION; VIRUS REPLICATION;

ANIMALS; CIRCOVIRIDAE INFECTIONS; CIRCOVIRUS; PULMONARY EDEMA; SWINE DISEASES; VIRAL VACCINES;

PORCINE CIRCOVIRUS; PORCINE CIRCOVIRUS 2;

EID: 79955535615     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.02543-10     Document Type: Article

References (32)

1. Allan, G. M., and J. A. Ellis. 2000. Porcine circovirus: a review. J. Vet. Diagn. Invest. 12:3-14.
2. Allan, G. M., et al. 1999. Experimental reproduction of severe wasting disease by co-infection of pigs with porcine circovirus and porcine parvovirus. J. Comp. Pathol. 121:1-11.
3. Chae, C. 2005. A review of porcine circovirus 2-associated syndromes and diseases. Vet. J. 169:326-336. (Pubitemid 40542908)
4. Cheung, A. K., et al. 2007. Detection of two porcine circovirus type 2 genotypic groups in United States swine herds. Arch. Virol. 152:1035-1044.
5. Darwich, L., J. Segales, and E. Mateu. 2004. Pathogenesis of postweaning multisystemic wasting syndrome caused by porcine circovirus 2: an immune riddle. Arch. Virol. 149:857-874.
6. Dorr, P. M., R. B. Baker, G. W. Almond, S. R. Wayne, and W. A. Gebreyes. 2007. Epidemiologic assessment of porcine circovirus type 2 coinfection with other pathogens in swine. J. Am. Vet. Med. Assoc. 230:244-250.
7. Ellis, J. A., G. Allan, and S. Krakowka. 2008. Effect of coinfection with genogroup 1 porcine torque teno virus on provine circovirus type 2-associated postweaning multisystemic wasting syndrome in gnotobiotic pigs. Am. J. Vet. Res. 69:1608-1614.
8. Fenaux, M., P. G. Halbur, M. Gill, T. E. Toth, and X. J. Meng. 2000. Genetic characterization of type 2 porcine circovirus (PCV-2) from pigs with postweaning multisystemic wasting syndrome in different geographic regions of North America and development of a differential PCR-restriction fragment length polymorphism assay to detect and differentiate between infections with PCV-1 and PCV-2. J. Clin. Microbiol. 38:2494-2503.
9. Hamel, A. L., L. Lin, C. Sachvie, E. Grudeski, and G. P. S. Nayar. 1999. PCR assay for detecting porcine cytomegalovirus. J. Clin. Microbiol. 37:3767-3768.
10. Hansen, M. S., et al. 2001. An investigation of the pathology and pathogens associated with porcine respiratory disease complex in Denmark. J. Comp. Pathol. 143:120-131.
11. Harding, J. C. S., J. A. Ellis, K. A. McIntosh, and S. Krakowka. 2010. Dual heterologous porcine circovirus genogroup 2a/2b infection induces severe disease in germ-free pigs. Vet. Microbiol. 145:209-219.
12. Harms, P. A., et al. 2001. Experimental reproduction of severe disease in CD/CD pigs concurrently infected with type 2 porcine circovirus and porcine reproductive and respiratory syndrome virus. Vet. Pathol. 38:528-539.
13. Hesse, R. A., M. Kerrigan, and R. R. R. Rowland. 2008. Evidence for recombination between PCV2a and PCV2b in the field. Virus Res. 132:201-207.
14. Horlen, K. P., et al. 2007. A cluster of farms experiencing severe porcine circovirus associated disease (PCVAD): clinical features and association with the PCV2b genotype. J. Swine Health Prod. 15:270-278. (Pubitemid 47441363)
15. Horlen, K. P., et al. 2008. A field evaluation of pig mortality, performance and infection following commercial vaccination against porcine circovirus type 2. J. Am. Vet. Med. Assoc. 232:906-912.
16. Krakowka, S., et al. 2000. Viral wasting syndrome of swine: experimental porcine circovirus diseases: reproduction of postweaning multisystemic wasting syndrome in gnotobiotic swine by coinfection with porcine circovirus 2 and porcine parvovirus. Vet. Pathol. 37:254-263.
17. Krakowka, S., et al. 2001. Activation of the immune system is the pivotal event in the production of wasting disease in pigs infected with porcine circovirus-2 (PCV-2). Vet. Pathol. 38:31-42. (Pubitemid 33621670)
18. Krakowka, S., et al. 2008. Evaluation of induction of porcine dermatitis and nephropathy syndrome in gnotobiotic pigs with negative results for porcine circovirus type 2. J. Vet. Res. 12:1615-1622.
19. Nawagitgul, P., et al. 2000. Open reading frame 2 of porcine circovirus type 2 encodes a major capsid protein. J. Gen. Virol. 81:2281-2287.
20. Opriessnig, T., et al. 2004. Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2. Vet. Pathol. 41:624-640.
21. Opriessnig, T., et al. 2006. Evidence of breed-dependent differences in susceptibility to porcine circovirus type-2-associated disease and lesions. Vet. Pathol. 43:281-293.
22. Opriessnig, T., N. E. McKeown, E. M. Zhou, X. J. Meng, and P. G. Halbur. 2006. Genetic and experimental comparison of porcine circovirus type 2 (PCV2) isolates from cases with and without PCV2-assocated lesions provides evidence for differences in virulence. J. Gen. Virol. 87:2923-2932.
23. Opriessnig, T., X. J. Meng, and P. G. Halbur. 2007. Porcine circovirus type 2-associated disease: update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies. J. Vet. Diagn. Invest. 19:591-615.
24. Segales, J., G. M. Allan, and M. Domingo. 2006. Porcine circovirus disease, p. 299-308. In B. E. Straw, J. J. Zimmerman, S. D'Allaire, and D. J. Taylor (ed.), Diseases of swine, 9th ed. Blackwell Publishing Ltd., Oxford, United Kingdom.
25. Segalés, J., et al. 2008. PCV-2 genotype definition and nomenclature. Vet. Rec. 162:867-868.
26. Segalés, J., et al. 2009. Retrospective study on swine torque teno virus genogroups 1 and 2 infection from 1985 to 2005 in Spain. Vet. Microbiol. 134:199-207.
27. Sorden, S. D. 2000. Update on porcine circovirus and postweaning multisystemic wasting syndrome (PMWS). J. Swine Health Prod. 8:133-136.
28. Staczek, J. 1990. Animal cytomegaloviruses. Microbiol. Rev. 54:247-265.
29. Taira, O., et al. 2009. Prevalence of swine torque teno virus genogroups 1 and 2 in Japanese swine with suspected post-weaning multisystemic wasting syndrome and porcine respiratory disease complex. Vet. Microbiol. 139:347-350.
30. Thompson, J. D., T. J. Gibson, F. Plewniak, F. Jeanmougin, and D. G. Higgins. 1997. The CLUSTAL X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res. 25:4876-4882.
31. Wellenberg, G. J., N. Stockhofe-Zerwieden, M. F. de Jong, and W. J. A. Boersma. 2004. Excessive porcine circovirus type 2 antibody titres may trigger the development of porcine dermatitis and nephropathy syndrome: a case control study. Vet. Microbiol. 99:203-214.
32. Yoon, K. J., S. C. Henry, J. J. Zimmerman, and K. B. Platt. 1996. Isolation of porcine cytomegalovirus from a swine herd with PRRS. Vet. Med. 91:779-784.