Immunoglobulin E-binding autoantigens: Biochemical characterization and clinical relevance

Clinical and Experimental Allergy

Volumn 42, Issue 3, 2012, Pages 343-351

  Crameri, R ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Autoantigens; Autoimmunity; Autoreactivity; Clinical relevance; IgE

Indexed keywords

ALLERGEN; AUTOANTIGEN; COMPLEMENTARY DNA; CROSS REACTING ANTIBODY; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN E BINDING AUTOANTIGEN; IMMUNOGLOBULIN G ANTIBODY; PROTEIN C; SUPEROXIDE DISMUTASE; THIOREDOXIN; UNCLASSIFIED DRUG;

ALLERGY; ASPERGILLUS FUMIGATUS; ASTHMA; ATOPIC DERMATITIS; ATOPY; AUTOIMMUNITY; BIOCHEMISTRY; CROSS REACTION; HUMAN; IMMUNITY; IMMUNOTHERAPY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVIEW; SEQUENCE HOMOLOGY; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; AUTOANTIGENS; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; MOLECULAR MIMICRY;

EID: 84857346675     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2011.03878.x     Document Type: Review

References (94)

1. Hamilton RG. Clinical laboratory assessment of immediate-type hypersensitivity. J Allergy Clin Immunol 2010; 125(2 Suppl. 2):S284-96.
2. Achatz G, Achatz-Straussberger G, Luger E, Lamers R, Crameri R. Regulation of the IgE response at the molecular level: impact on the development of systemic anti IgE therapeutic strategies. Chem Immunol Allergy 2006; 91:204-17.
3. Hakim-Rad K, Metz M, Maurer M. Mast cells: makers and breakers of allergic inflammation. Curr Opin Allergy Clin Immunol 2009; 9:427-30.
4. Kraft S, Novak N. Fc receptors as determinants of allergic reactions. Trends Immunol 2006; 27:88-95.
5. Hampton S, Cooke R. The sensitivity of man to human dander, with particular reference to eczema (allergic dermatitis). J Allergy 1941; 13:63-76.
6. Valenta R, Duchêne M, Pettenburger K et al. Identification of profilin as a novel pollen allergen; IgE autoreactivity in sensitized individuals. Science 1991; 253:557-60.
7. Appenzeller U, Meyer C, Menz G, Blaser K, Crameri R. IgE-mediated reactions to autoantigens in allergic diseases. Int Arch Allergy Immunol 1999; 118:193-6.
8. Aalberse RC. Structural biology of allergens. J Allergy Clin Immunol 2000; 106:228-38.
9. Aalberse RC, Kleine Budde I, Stapel SO, van Ree R. Structural aspects of cross-reactivity and its relation to antibody affinity. Allergy 2001; 56(Suppl. 67):27-9.
10. Christensen LH, Holm J, Lund G, Riise E, Lund K. Several distinct properties of the IgE repertoire determine effector cell degranulation in response to allergen challenge. J Allergy Clin Immunol 2008; 122:298-304.
11. Crameri R, Hemmann S, Ismail C, Menz G, Blaser K. Disease-specific recombinant allergens for the diagnosis of allergic bronchopulmonary aspergillosis. Int Immunol 1998; 10:1211-6.
12. Hemmann S, Nikolaizik WH, Schöni MH, Blaser K, Crameri R. Differential IgE recognition of recombinant Aspergillus fumigatus allergens by cystic fibrosis patients with allergic bronchopulmonary aspergillosis or Aspergillus allergy. Eur J Immunol 1998; 28:1155-60.
13. Crameri R, Faith A, Hemmann S et al. Humoral and cell-mediated autoimmunity in allergy to Aspergillus fumigatus. J Exp Med 1996; 184:265-70.
14. Mayer C, Hemmann S, Faith A, Blaser K, Crameri R. Cloning, production, characterization and IgE cross-reactivity of different manganese superoxide dismutases in individuals sensitized to Aspergillus fumigatus. Int Arch Allergy Immunol 1997; 113:213-5.
15. Flückiger S, Scapozza L, Mayer C, Blaser K, Folkers G, Crameri R. Immunological and structural analysis of IgE-mediated cross-reactivity between manganese superoxide dismutases. Int Arch Allergy Immunol 2002; 128:292-303.
16. Schmid-Grendelmeier P, Flückiger S, Disch R et al. IgE-mediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis. J Allergy Clin Immunol 2005; 115:1068-75.
17. Schmid-Grendelmeier P, Scheynius A, Crameri R. The role of sensitization to Malassezia sympodialis in atopic eczema. Chem Immunol Allergy 2006; 91:98-109.
18. 2 protein. J Exp Med 1999; 189:1507-12.
19. Flückiger S, Fijten H, Whitley P, Blaser K, Crameri R. Cyclophilins, a new family of cross-reactive allergens. Eur J Immunol 2002; 32:10-7.
20. Glaser AG, Limacher A, Flückiger S, Scheynius A, Scapozza L, Crameri R. Analysis of the cross-reactivity and of the 1.5 Å structure of the Malassezia sympodialis Mala s 6 allergen, a member of the cyclophilin pan-allergen family. Biochem J 2006; 396:41-9.
21. Limacher A, Glaser AG, Meier C et al. Cross-reactivity and 1.4-Å crystal structure of Malassezia sympodialis thioredoxin (Mala s 13), a member of a new pan-allergen family. J Immunol 2007; 178:389-96.
22. Flückiger S, Mittl PR, Scapozza L et al. Comparison of the crystal structures of the human manganese superoxide dismutase and the homologous Aspergillus fumigatus allergen at 2-Å resolution. J Immunol 2002; 168:1267-72.
23. Limacher A, Kloer DP, Flückiger S, Folkers G, Crameri R, Scapozza L. The crystal structure of Aspergillus fumigatus cyclophilin reveals 3D domain swapping of a central element. Structure 2006; 14:185-95.
24. Casagrande BF, Flückiger S, Linder MT et al. Sensitization to the yeast Malassezia sympodialis is specific for extrinsic and intrinsic atopic eczema. J Invest Dermatol 2006; 126:2414-21.
25. Aalberse RC, Crameri R. IgE-binding epitopes: a reappraisal. Allergy 2011; 66:1261-74.
26. Vilhelmsson M, Glaser AG, Martinez DB et al. Mutational analysis of amino acid residues involved in IgE-binding to Malassezia sympodialis allergen Mala s 11. Mol Immunol 2008; 46:294-303.
27. Glaser AG, Menz G, Kirsch AI, Zeller S, Crameri R, Rhyner C. Auto- and cross-reactivity to thioredoxin allergens in allergic bronchopulmonary aspergillosis. Allergy 2008; 63:1617-23.
28. Balaji H, Heratizadeh A, Wichmann K et al. Malassezia sympodialis thioredoxin-specific T cells are highly cross-reactive to human thioredoxin in atopic dermatitis. J Allergy Clin Immunol 2011; 128:92-9.e4.
29. Weichel M, Vergossen NJ, Bonomi S et al. Screening the allergenic repertoires of wheat and maize with sera from double-blind, placebo-controlled food challenge positive patients. Allergy 2006; 61:128-35.
30. Weichel M, Glaser AG, Ballmer-Weber BK, Schmid-Grendelmeier P, Crameri R. Wheat and maize thioredoxins: a novel cross-reactive cereal allergen family related to baker's asthma. J Allergy Clin Immunol 2006; 117:676-81.
31. Zeller S, Glaser AG, Vilhelmsson M, Rhyner C, Crameri R. Immunoglobulin-E-mediated reactivity to self antigens: a controversial issue. Int Arch Allergy Clin Immunol 2008; 145:87-93.
32. Mittermann I, Aichberger KJ, Bünder R, Mothes N, Renz H, Valenta R. Autoimmunity in atopic dermatitis. Curr Opin Allergy Clin Immunol 2004; 4:367-71.
33. Altrichter S, Kriehuber E, Moser J, Valenta R, Kopp T, Stingl G. Serum IgE autoantibodies target keratinocytes in patients with atopic dermatitis. J Invest Dermatol 2008; 128:2232-9.
34. 2LEN project. Allergy 2006; 61:671-80.
35. Natter S, Seiberler S, Haufnagl P et al. Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients. FASEB J 1998; 12:1559-69.
36. Rhyner C, Weichel M, Flückiger S, Hemmann S, Kleber-Janke T, Crameri R. Cloning allergens via phage display. Methods 2004; 32:212-8.
37. Zeller S, Rhyner C, Meyer N, Schmid-Grendelmeier P, Akdis CA, Crameri R. Exploring the repertoire of IgE-binding self-antigens associated with atopic eczema. J Allergy Clin Immunol 2009; 124: 278-85, 285.e1-7.
38. Valenta R, Mittermann I, Werfel T, Garn H, Renz H. Linking allergy to autoimmune disease. Trends Immunol 2009; 30:109-16.
39. Rosen A, Casiola-Rosen L. Autoantigens in systemic autoimmunity: critical partner in pathogenesis. J Intern Med 2009; 265:625-31.
40. Achatz G, Oberkofler H, Lechnauer E et al. Molecular cloning of major and minor allergens of Alternaria alternata and Cladosporium herbarum. Mol Immunol 1995; 32:213-27.
41. 2 protein in systemic lupus erythematosus. Allergy 2011; 66:1127-9.
42. Wüthrich B, Schindler C, Leuenberger P, Ackermann-Liebrich U. Prevalence of atopy and pollinosis in the adult population of Switzerland (SAPALDIA study). Swiss study on Air Pollution and Lung Diseases in Adults. Int Arch Allergy Immunol 1995; 106:149-56.
43. Charles N, Hardwick D, Daugas E, Illei GG, Rivera J. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med 2010; 16:701-8.
44. Stadler BM, Stadler MB. Allergenicity prediction by protein sequence. FASEB J 2003; 9:1141-3.
45. Radauer C, Bublin M, Wagner S, Mari A, Breiteneder H. Allergens are distributed into few protein families and possess a restricted number of biochemical functions. J Allergy Clin Immunol 2008; 121:847-52.
46. Aichberger KJ, Mittermann I, Reiniger R et al. Hom s 4, an IgE-reactive autoantigen belonging to a new subfamily of calcium-binding proteins, can induce Th cell type 1-mediated autoreactivity. J Immunol 2005; 175:1286-94.
47. Wopfer N, Dissertore O, Ferreira F, Lackner P. Calcium-binding proteins and their role in allergic diseases. Immunol Allergy Clin N Am 2007; 27:29-44.
48. Dreborg S. Skin tests in the diagnosis of food allergy. Pediatr Allergy Immunol 1995; 6(Suppl.8):38-43.
49. Kerschenlohr K, Darsow U, Burgdorf WH, Ring J, Wollenberg A. Lessons from atopy patch testing in atopic dermatitis. Curr Allergy Asthma Rep 2004; 4:285-9.
50. Ebo DG, Bridts CH, Hagendorens MM, Aerts NE, De Clerck LS, Stevens WJ. Basophil activation test by flow cytometry: present and future applications in allergology. Cytometry B Clin Cytom 2008; 74:201-10.
51. Knol F, Mul FP, Lie WJ, Verhoeven AJ, Roos D. The role of basophils in allergic disease. Eur Respir J 1996; 22(Suppl.):126s-31s.
52. Heratizadeh A, Mittermann I, Balaji H et al. The role of T-cell reactivity towards tha autoantigen α-NCA in atopic dermatitis. Br J Dermatol 2011; 164:316-24.
53. Rhyner C, Zeller S, Johansson C, Scheynius A, Crameri R. The IgE-binding self-antigens tubulin-α and HLA-DR-α are overexpressed in lesional skin of atopic eczema patients. J Clin Cell Immunol 2011; 2:109. DOI: 10.4172/2155-9899.1000109.
54. Kinaciyan T, Natter S, Kraft D, Stingl G, Valenta R. IgE autoantibodies monitored in a patient with atopic dermatitis under cyclosporine A treatment reflect tissue damage. J Allergy Clin Immunol 2002; 109:717-9.
55. Yamada Y, Nakamura H, Adachi T et al. Elevated serum levels of thioredoxin in patients with acute exacerbation of asthma. Immunol Lett 2003; 86:199-205.
56. Bertini R, Howard OM, Dong HF et al. Thioredoxin, a redox enzyme released in infection and inflammation, is a unique chemoattractant for neutrophils, monocytes, and T cells. J Exp Med 1999; 189:1783-9.
57. Niederberger V, Ring J, Rakoski J et al. Antigens drive memory IgE responses in human allergy vial the nasal mucosa. Int Arch Allergy Immunol 2007; 142:576-84.
58. Kaplan AP, Greaves M. Pathogenesis of chronic urticaria. Clin Exp Allergy 2009; 39:777-87.
59. Lourenco F, Azor MH, Santos JC et al. Activated status of basophils in chronic urticatia leads to interlukin-3 hyper-responsiveness and enhancement of histamine release induced by anti-IgE stimulus. Brit J Dermatol 2008; 158:979-86.
60. Zauli D, Deleonardi G, Foderaro S et al. Thiroid autoimmunity in chronic urticaria. Allergy Asthma Proc 2001; 22:93-5.
61. Dreskin SC, Andrews KY. The thyroid and urticaria. Curr Opin Allergy Clin Immunol 2005; 5:408-12.
62. Altrichter S, Peter HJ, Pisarevskaja D, Metz M, Martus P, Maurer M. IgE-mediated autoallergy against thiroid peroxidase - a novel pathomechanism of chronic spontaneous urticaria? PLoS One 2011; 6:e14794.
63. Groffik A, Mitzel-Kaoukhov H, Magerl M, Maurer M, Staubach P. Omalizumab - an effective and safe treatment of therapy-resistant chronic spontaneous urticaria. Allergy 2011; 66:303-5.
64. Schuerwegh AJ, Ioan-Facsinay A, Dorjée AL et al. Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis. Proc Natl Acad Sci USA 2010; 107:2586-91.
65. Lohmann T, Hawa M, Leslie RD, Lane R, Picard J, Londei M. Immune reactivity to glutamic acid decarbosylase 65 in stiffman syndrome and type 1 diabetes mellitus. Lancet 2000; 356:31-5.
66. Schilling J, Speikerdotter U, Wohlrab U, Wendel U, Seissler J. Immunoglobulin isotype profile of tissue transglutaminase autoantibodies is correlated with the clinical presentation of coeliac disease. Scand J Immunol 2005; 61:207-12.
67. Nagel A, Lang A, Engel D et al. Clinical activity of pemphigus vulgaris relates to IgE autoantibodies against desmoglein 3. Clin Immunol 2010; 134:320-30.
68. Dimson OB, Giudice GJ, Fu CL et al. Identification of a potential effector function for IgE autoantibodies in the organ-specific autoimmune disease bullous pemphigoid. J Invest Dermatol 2003; 120:784-8.
69. Zone JJ, Taylor T, Hull C, Schmidt L, Meyer L. IgE basement membrane zone antibodies induce eosinophil infiltration and histological blister in engrafted human skin on SCID mice. J Invest Dermatol 2007; 127:1167-74.
70. Fairley JA, Burnett CT, Fu CL, Larson DL, Fleming MG, Giudice GJ. A pathogenic role for IgE in autoimmunity: bullous pemphigoid IgE reproduces the early phase of lesion development in human skin grafted to nu/nu mice. J Invest Dermatol 2007; 127:2605-11.
71. Fairley JA, Baum CL, Brandt DS, Messingham KAN. Pathoginicity of IgE in autoimmunity: successful treatment of bullous pemphigoid with omalizumab. J Allergy Clin Immunol 2009; 123:704-5.
72. Holgate ST, Djukananovic R, Casale T, Bousquet J. Anti-immunoglobulin E treatment with omalizumab in allergic diseases: an update on anti-inflammatory activity and clinical efficacy. Clin Exp Allergy 2005; 35:408-16.
73. Arkins JA, Engbring NH, Lennon ER. The incidence of skin reactivity to insulin in diabetic patients. J Allergy 1962; 33:69-72.
74. Radermecker RP, Scheen AJ. Allergic reactions to insulin: effects of continuous subcutaneous insulin infusion and insulin analogues. Diabetes Metab Res Rev 2007; 23:348-55.
75. Patterson R, Roberts M, Grammer LC. Insulin allergy; re-evaluation after two decades. Ann Allergy 1990; 64:459-62.
76. Henzerling L, Raile K, Rochlitz H, Zuberbier T, Worm M. Insulin allergy: clinical manfestations and managment strategies. Allergy 2008; 63:148-55.
77. Ratner RE, Phillips TM, Steiner M. Persistent cutaneous insulin allergy resulting from high-molecular-weight insulin aggregates. Diabetes 1990; 39:728-33.
78. Brange J, Andersen L, Laursen ED, Meyn G, Rasmussen E. Towerd understanding insulin fibrillation. J Pharmacol Sci 1997; 86:517-25.
79. Yokoyoma H, Fukumoto S, Koyama H, Emoto M, Kitagawa Y, Nishizawa Y. Insulin allergy: desensitization with crystalline zinc-insulin and steroid tapering. Diab Res Clin Pract 2003; 61:161-6.
80. Blaser K, Heusser C. The IgE antibody response to the phosphorylcholine hapten. Int Rev Immunol 1987; 2:93-115.
81. Wetzien HU, Moulon C, Martin S, Padovan E, Hartmann U, Kohler J. T cell immune responses to haptens. Structural models for allergic and autoimmune reactions. Toxicology 1996; 107:141-51.
82. McFadden JP, White JM, Basketter DA, Kimber I. Does hapten exposure predispose to atopic disease? The hapten-atopy hypothesis. Trends Immunol 2009; 30:67-74.
83. Wisnewski AV, Redlich CA. Recent developments in diisocyanate asthma. Curr Opin Allergy Clin Immunol 2001; 1:169-75.
84. Pronk A, Preller L, Raulf-Heimsoth M et al. Respiratory symptoms, sensitization, and exposure-response relationship in spray painters exposed to isocyanates. Am J Respir Crit Care Med 2007; 176:1090-7.
85. Ulrich H. chemistry and technology of isocyanates. West Sussex, UK: Wiley, 1996.
86. Wisnewski AV, Stowe MH, Cartier A et al. Isocyanate vapor-induced antigenicity of human albumin. J Allergy Clin Immunol 2004; 113:1178-84.
87. Baur X. Immunologic cross-reactivity between different albumin-bound isocyanates. J Allergy Clin Immunol 1993; 71:197-2005.
88. Wisnewski AV, Srivastava R, Erick C et al. Identification of human lung and skin proteins conjugated with hexamethylene diisocyanate in vitro and in vivo. Am J Respir Crit Care med 2000; 162:2330-6.
89. Park JW, Kim CW, Kim KS et al. Role of skin prick test and serological measurement of specific IgE in the diagnosis of occupational asthma resulting from exposure to vinyl sulphone reactive dyes. Occup Environ Med 2001; 58:411-6.
90. Helaskoski E, Kuuliala O, Aalto-Korte K. Occupational contact urticaria caused by cyclic acid anhydirdes. Contact Derm 2009; 60:214-21.
91. Crameri R. Allergy vaccines: dreams and reality. Expert Rev Vaccines 2007; 6:991-9.
92. Valenta R, Natter S, Seiberler S et al. Molecular characterization of an autoallergen, Hom s 1, identified by serum IgE from atopic dermatitis patients. J Invest Dermatol 1998; 111:1178-83.
93. Mossabeb R, Seiberler S, Mittermann I et al. Characterization of a novel isoform of α-nascent polypeptide-associated complex as IgE-defined autoantigen. J Invest Dermatol 2002; 119:820-9.
94. Si K, Chaudhuri J, Chevesich J, Maitra U. Molecular cloning and functional expression of a human cDNA encoding translation initiation factor 6. Proc Natl Acad Sci USA 1997; 94:14285-90.