Time for a neurorestorative therapy in stroke

Expert Opinion on Biological Therapy

Volumn 12, Issue 3, 2012, Pages 267-270

  Jkl, Pekka ^a,b,c   Jolkkonen, Jukka ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b Brain Research and Rehabilitation Center Neuron   (Finland)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Brain repair; Neuronal restoration; Neuroprotection; Stroke; Trafermin

Indexed keywords

ERYTHROPOIETIN; FLUOXETINE; GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT BASIC FIBROBLAST GROWTH FACTOR;

ANGIOGENESIS; BLOOD BRAIN BARRIER; BRAIN ISCHEMIA; DRUG EFFECT; DRUG INDUSTRY; HUMAN; MOTOR PERFORMANCE; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NONHUMAN; PHYSIOTHERAPY; REVIEW; STROKE PATIENT; SYNAPTOGENESIS; TREATMENT OUTCOME;

BRAIN ISCHEMIA; HUMANS; NEUROPROTECTIVE AGENTS; STROKE;

EID: 84857261825     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.2012.656086     Document Type: Review

References (28)

1. Sivenius J, Tuomilehto J, Immonen-Raiha P, et al. Continuous 15-year decrease in incidence and mortality of stroke in Finland: the FINSTROKE study. Stroke 2004;35:420-5 (Pubitemid 38174423)
2. Baigent C, Blackwell L, Collins R, et al. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet 2009;30:1849-60
3. Diener HC, Cunha L, Forbes C; European Stroke Prevention Study. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci 1996;143:1-13 (Pubitemid 26402780)
4. Diener HC, Sacco RL, Yusuf S, et al. Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study. Lancet Neurol 2008;7:875-84
5. Bousser MG, Amarenco P, Chamorro A, et al. Terutroban versus aspirin in patients with cerebral ischaemic events (PERFORM): a randomised, double-blind, parallel-group trial. Lancet 2011;377:2013-22
6. Diener HC, Connolly SJ, Ezekowitz MD, et al. Dabigatran compared with warfarin in patients with atrial fibrillation and previous transient ischaemic attack or stroke: a subgroup analysis of the RE-LY trial. Lancet Neurol 2010;9:1157-63
7. Patel MR, Mahaffey KW, Garg J, et al. Rivaroxaban versus Warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011;365:883-91
8. Granger CB, Alexander JH, McMurray JJ, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2011;365:981-92
9. Lees KR, Bluhmki E, von Kummer R, et al. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet 2010;3751:695-703
10. Amaro S, Chamorro A. Translational stroke research of the combination of thrombolysis and antioxidant therapy. Stroke 2011;42:1495-9
11. Jahan R, Vinuela F. Treatment of acute ischemic stroke: intravenous and endovascular therapies. Expert Rev Cardiovasc Ther 2009;7:375-87
12. OCollins VE, Macleod MR, Donnan GA, et al. 1,026 experimental treatments in acute stroke. Ann Neurol 2006;59:467-77 (Pubitemid 43358067)
13. Sahota P, Savitz S. Investigational therapies for ischemic stroke: neuroprotection and neurorecovery. Neurotherapeutics 2011;8:434-51
14. Ginsberg MD, Palesch YY, Martin RH, et al. The albumin in acute stroke (ALIAS) multicenter clinical trial: safety analysis of part 1 and rationale and design of part 2. Stroke 2011;42:119-27. Available from www.clinicaltrials.com
15. Zhang ZG, Chopp M. Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic. Lancet Neurol 2009;8:491-500
16. Font MA, Arboix A, Krupinski J. Angiogenesis, neurogenesis and neuroplasticity in ischemic stroke. Curr Cardiol Rev 2010;6:238-44
17. Chollet F, Tardy J, Albucher JF, et al. Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial. Lancet Neurol 2011;10:123-30
18. Paciaroni M, Bogousslavsky J. Trafermin for stroke recovery: is it time for another randomized clinical trial? Expert Opin Biol Ther 2011;11:1533-41
19. Clark WM, Wechsler LR, Sabounjian LA, Schwiderski UE; Citicoline Stroke Study Group. A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients. Neurology 2001;57:1595-602 (Pubitemid 33055476)
20. Bogousslavsky J, Victor SJ, Salinas EO, et al. Fiblast (trafermin) in acute stroke: results of the European-Australian Phase II/III safety and efficacy trial. Cerebrovasc Dis 2002;14:239-51 (Pubitemid 36151425)
21. Stroke Therapy Academic Industry Roundtable. Recommendations for standards regarding preclinical neuroprotective and restorative drugs. Stroke 1999;30:2752-8
22. Chen HH, Chien CH, Liu HM. Correlation between angiogenesis and basic fibroblast growth factor expression in experimental brain infarct. Stroke 1994;25:1651-7 (Pubitemid 24233974)
23. Kawamata T, Alexis NE, Dietrich WD, Finklestein SP. Intracisternal basic fibroblast growth factor (bFGF) enhances behavioral recovery following focal cerebral infarction in the rat. J Cereb Blood Flow Metab 1996;16:542-7 (Pubitemid 26227062)
24. Kawamata T, Dietrich WD, Schallert T, et al. Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction. Proc Natl Acad Sci USA 1997;94:8179-84 (Pubitemid 27343797)
25. Won SJ, Xie L, Kim SH, et al. Influence of age on the response to fibroblast growth factor-2 treatment in a rat model of stroke. Brain Res 2006;1123:237-44
26. Wang ZL, Cheng SM, Ma MM, et al. Intranasally delivered bFGF enhances neurogenesis in adult rats following cerebral ischemia. Neurosci Lett 2008;446:30-5
27. Matsuse D, Kitada M, Ogura F, et al. Combined transplantation of bone marrow stromal cell-derived neural progenitor cells with a collagen sponge and basic fibroblast growth factor releasing microspheres enhances recovery after cerebral ischemia in rats. Tissue Eng Part A 2011;17:1993-2004
28. Levin MF, Kleim JA, Wolf SL. What do motor "recovery" and "compensation" mean in patients following stroke? Neurorehabil Neural Repair 2009;23:313-19