An algorithm for 353 odor detection thresholds in humans

Chemical Senses

Volumn 37, Issue 3, 2012, Pages 207-218

  Abraham, Michael H ^a   Sánchez moreno, Ricardo ^a   Cometto muñiz, J Enrique ^b   Cain, William S ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Linear free energy relationships; Psychometric odor functions; Sensory irritation; Volatile organic compounds

Indexed keywords

ACID; ALDEHYDE; ESTER DERIVATIVE; THIOL DERIVATIVE; VOLATILE AGENT;

ALGORITHM; ARTICLE; CHEMESTHETIC THRESHOLD; HUMAN; MATHEMATICAL COMPUTING; ODOR DETECTION THRESHOLD; OLFACTORY DISCRIMINATION; PERCEPTIVE THRESHOLD; PREDICTION; PRIORITY JOURNAL; PSYCHOMETRY;

EID: 84857213189     PISSN: 0379864X     EISSN: 14643553     Source Type: Journal    
DOI: 10.1093/chemse/bjr094     Document Type: Article

References (58)

1. Abraham MH. 1993. Scales of hydrogen bonding: their construction and application to physicochemical and biochemical processes. Chem Soc Rev. 22:73-83.
2. Abraham MH, Acree WE Jr., Cometto-Muñiz JE. 2009. Partition of compounds from water and air into amides. New J Chem. 33:2034-2043.
3. Abraham MH, Acree WE Jr., Leo AJ, Hoekman D. 2009. The partition of compounds from water and from air into wet and dry ketones. New J Chem. 33:568-573.
4. Abraham MH, Andonian-Haftvan J, Cometto-Muñiz JE, Cain WS. 1996. An analysis of nasal irritation thresholds using a new solvation equation. Fundam Appl Toxicol. 31:71-76.
5. Abraham MH, Gola JRM, Cometto-Muñiz JE, Cain WS. 2001. The correlation and prediction of VOC thresholds for nasal pungency, eye irritation and odour in humans. Indoor Built Environ. 10:252-257.
6. Abraham MH, Gola JRM, Cometto-Muñiz JE, Cain WS. 2002. A model for odor thresholds. Chem Senses. 27:95-104.
7. Abraham MH, Ibrahim A. 2006. Gas to olive oil partition coefficients: a linear free energy analysis. J Chem Inf Model. 46:1735-1741.
8. Abraham MH, Ibrahim A, Acree WE Jr. 2005. Air-to blood distribution of volatile organic compounds: a linear free energy analysis. Chem Res Toxicol. 18:904-911.
9. Abraham MH, Ibrahim A, Acree WE Jr. 2006a. Air to brain, blood to brain and plasma to brain distribution of volatile organic compounds: linear free energy analysis. Eur J Med Chem. 41:494-502.
10. Abraham MH, Ibrahim A, Acree WE Jr. 2006b. Air to muscle, and blood/ plasma to muscle, distribution of volatile organic compounds and drugs: linear free energy analyses. Chem Res Toxicol. 19:801-808.
11. Abraham MH, Ibrahim A, Zissimos AM. 2004. The determination of sets of solute descriptors from chromatographic measurements. J Chromatogr A. 1037:29-47.
12. Abraham MH, Kumarsingh R, Cometto-Muñiz JE, Cain WS. 1998. Draize eye scores and eye irritation thresholds in man can be combined into one quantitative structure-activity relationship. Toxicol In Vitro. 12:403-408.
13. Abraham MH, Kumarsingh R, Cometto-Muñiz JE, Cain WS, Roses M, Bosch E, Diaz ML. 1998. The determination of solvation descriptors for terpenes, and the prediction of nasal pungency thresholds. J Chem Soc Perkin Trans 2. 2405-2411.
14. Abraham MH, McGowan JC. 1987. The use of characteristic volumes to measure cavity terms in reversed-phase liquid chromatography. Chromatographia. 23:243-246.
15. ADME Suite. 2010. Version 5.0. Toronto (Canada): Advanced Chemistry Development, Inc.
16. Alarie Y, Nielsen GD, Abraham MH. 1998. A theoretical approach to the Ferguson principle and its use with non-reactive and reactive airborne chemicals. Pharmacol Toxicol. 83:270-279.
17. Alarie Y, Schaper M, Nielsen GD, Abraham MH. 1998. Structure-activity relationships of volatile organic chemicals as sensory irritants. Arch Toxicol. 72:125-140.
18. American Industrial Hygiene Association (AIHA). 1989. Odor thresholds for chemicals with established occupational standards. Akron (NY): AIHA.
19. Bandell M, Macpherson LJ, Patapoutian A. 2007. From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs. Curr Opin Neurobiol. 17:490-497.
20. Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D. 2006. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell. 124:1269-1282.
21. Cain WS. 1989. Testing olfaction in clinical setting. Ear Nose Throat J. 68:322-328.
22. Cain WS, de Wijk RA, Jalowayski AA, Pilla Caminha G, Schmidt R. 2005. Odor and chemesthesis from brief exposures to TXIB. Indoor Air. 15:445-457.
23. Cain WS, Schmidt R. 2009. Can we trust odor databases? Example of t- and n-butyl acetate. Atmos Environ. 43:2591-2601.
24. Cain WS, Schmidt R, Jalowayski AA. 2007. Odor and chemesthesis from exposures to glutaraldehyde vapor. Int Arch Occup Environ Health. 80:721-731.
25. Cometto-Muñiz JE. 2001. Physicochemical basis for odor and irritation potency of VOCs. In: Spengler JD, Samet J, McCarthy JF, editors. Indoor air quality handbook. New York: Mcgraw-Hill. p. 20.1-20.21.
26. Cometto-Muñiz JE, Abraham MH. 2008a. Human olfactory detection of homologous n-alcohols measured via concentration-response functions. Pharmacol Biochem Behav. 89:279-291.
27. Cometto-Muñiz JE, Abraham MH. 2008b. A cut-off in ocular chemesthesis from vapors of homologous alkylbenzenes and 2-ketones as revealed by concentration-detection functions. Toxicol Appl Pharmacol. 230:298-303.
28. Cometto-Muñiz JE, Abraham MH. 2009a. Olfactory detectability of homologous n-alkylbenzenes as reflected by concentration-detection functions in humans. Neuroscience. 161:236-248.
29. Cometto-Muñiz JE, Abraham MH. 2009b. Olfactory psychometric functions for homologous 2-ketones. Behav Brain Res. 201:207-215.
30. Cometto-Muñiz JE, Abraham MH. 2010a. Odor detection by humans of lineal aliphatic aldehydes and helional as gauged by dose-response functions. Chem Senses. 35:289-299.
31. Cometto-Muñiz JE, Abraham MH. 2010b. Structure-activity relationships on the odor detectability of homologous carboxylic acids by humans. Exp Brain Res. 207:75-84.
32. Cometto-Muñiz JE, Cain WS. 1990. Thresholds for odor and nasal pungency. Physiol Behav. 48:719-725.
33. Cometto-Muñiz JE, Cain WS. 1991. Nasal pungency, odor, and eye irritation thresholds for homologous acetates. Pharmacol Biochem Behav. 39:983-989.
34. Cometto-Muñiz JE, Cain WS. 1993. Efficacy of volatile organic compounds in evoking nasal pungency and odor. Arch Environ Health. 48:309-314.
35. Cometto-Muñiz JE, Cain WS. 1994. Sensory reactions of nasal pungency and odor to volatile organic compounds. The alkylbenzenes. Am Ind Hyg Assoc J. 55:811-817.
36. Cometto-Muñiz JE, Cain WS, Abraham MH. 1998. Nasal pungency and odor of homologous aldehydes and carboxylic acids. Exp Brain Res. 118:180-188.
37. Cometto-Muñiz JE, Cain WS, Abraham MH. 2005a. Determinants for nasal trigeminal detection of volatile organic compounds. Chem Senses. 30:627-642.
38. Cometto-Muñiz JE, Cain WS, Abraham MH. 2005b. Molecular restrictions for human eye irritation by chemical vapors. Toxicol Appl Pharmacol. 207:232-243.
39. Cometto-Muñiz JE, Cain WS, Abraham MH, Gil-Lostes J. 2008. Concentration-detection functions for the odor of homologous n-acetate esters. Physiol Behav. 95:658-667.
40. Cometto-Muñiz JE, Cain WS, Abraham MH, Kumarsingh R. 1998. Trigeminal and olfactory chemosensory impact of selected terpenes. Pharmacol Biochem Behav. 60:765-770.
41. Cometto-Muñiz JE, Cain WS, Abraham MH, Sánchez-Moreno R. 2006. Chemical boundaries for detection of eye irritation in humans from homologous vapors. Toxicol Sci. 91:600-609.
42. Cometto-Muñiz JE, Cain WS, Abraham MH, Sánchez-Moreno R. 2007a. Concentration-detection functions for eye irritation evoked by homologous n-alcohols and acetates approaching a cut-off point. Exp Brain Res. 182:71-79.
43. Cometto-Muñiz JE, Cain WS, Abraham MH, Sánchez-Moreno R. 2007b. Cutoff in detection of eye irritation from vapors of homologous carboxylic acids and aliphatic aldehydes. Neuroscience. 145:1130-1137.
44. Devos M, Patte F, Rouault J, Laffort P, Van Gemert LJ. 1990. Standardized human olfactory thresholds. Oxford: IRL Press at Oxford University Press.
45. Dube MF, Green CR. 1982. Methods of collection of smoke for analytical purposes. Rec Adv Tob Sci. 8:42-102.
46. Environmental Protection Agency (US EPA). 1992. Reference guide to odor thresholds for hazardous air pollutants listed in the clean air act amendments of 1990. EPA600/R-92/047, March 1992. Washington (DC): U.S. Environmental Protection Agency.
47. Hellman TM, Small FH. 1974. Characterization of the odor properties of 101 petrochemicals using sensory methods. J Air Pollut Control Assoc. 24:979-982.
48. Iwasaki Y. 2003. The history of odor measurement in Japan and triangle odor bag method. In: Odor measurement review. Tokyo (Japan): Office of Odor, Noise and Vibration, Environmental Management Bureau, Ministry of Environment. p. 37-47.
49. Julius D. 2005. From peppers to peppermints: natural products as probes of the pain pathway. Harvey Lect. 101:89-115.
50. Macpherson LJ, Geierstanger BH, Viswanath V, Bandell M, Eid SR, Hwang S, Patapoutian A. 2005. The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr Biol. 15:929-934.
51. Minitab. 2003. Version 14. State College (PA): Minitab Inc.
52. Nagata Y. 2003. Measurement of odor threshold by triangle odor bag method. Odor measurement review. Tokyo (Japan): Office of Odor, Noise and Vibration, Environmental Management Bureau, Ministry of Environment. p. 118-127.
53. Owsianik G, D'Hoedt D, Voets T, Nilius B. 2006. Structure-function relationship of the TRP channel superfamily. Rev Physiol Biochem Pharmacol. 156:61-90.
54. Peier AM, Moqrich A, Hergarden AC, Reeve AJ, Andersson DA, Story GM, Earley TJ, Dragoni I, McIntyre P, Bevan S, et al. 2002. A TRP channel that senses cold stimuli and menthol. Cell. 108:705-715.
55. Pierce JD, Doty RL, Amoore JE. 1996. Analysis of position of trial sequence and type of diluent on the detection threshold for phenyl ethyl alcohol using a single staircase method. Percept Mot Skills. 82:451-458.
56. Platts JA, Butina D, Abraham MH, Hersey A. 1999. Estimation of molecular linear free energy relation descriptors using a group contribution approach. J Chem Inf Comp Sci. 39:835-845.
57. Schmidt R, Cain WS. 2006. The credibility of measured odor thresholds. Presented at the 28th Annual Meeting of the Association for Chemoreception Sciences; 2006 April 28. Sarasota (FL): AChemS.
58. van Gemert LJ. 2003. Odour thresholds. Compilations of odour threshold values in air, water and other media. Utrecht (the Netherlands): Oliemans Punter & Partners BV.