Rhos and Rho kinases in the rat prostate: Their possible functional roles and distributions

Molecular and Cellular Biochemistry

Volumn 358, Issue 1-2, 2011, Pages 207-213

  Saito, Motoaki ^a   Ohmasa, Fumiya ^a   Shomori, Kohei ^a   Dimitriadis, Fotios ^a   Ohiwa, Harunori ^a   Shimizu, Shogo ^a   Tsounapi, Panagiota ^a   Kinoshita, Yukako ^a   Satoh, Keisuke ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

Fasudil; Prostate; Rat; Rho; Rho kinase

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; CARBACHOL; DRUG DERIVATIVE; FASUDIL; NORADRENALIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO KINASE;

ANIMAL; ARTICLE; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; METABOLISM; MUSCLE CONTRACTION; PROSTATE; RAT; SPRAGUE DAWLEY RAT;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; CARBACHOL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MUSCLE CONTRACTION; NOREPINEPHRINE; PROSTATE; RATS; RATS, SPRAGUE-DAWLEY; RHO GTP-BINDING PROTEINS; RHO-ASSOCIATED KINASES;

EID: 84857164773     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-011-0936-9     Document Type: Article

References (14)

1. Riento K, Ridley AJ (2003) Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol 4:446-456
2. Rikitake Y, Liao JK (2005) Rho GTPases, statin, and nitric oxide. Circ Res 97:1232-1235
3. Schwartz M (2004) Rho signalling at a glance. J Cell Sci 117:5457-5458
4. Liao JK, Seto M, Noma K (2007) Rho kinase (ROCK) inhibitors. J Cardiovasc Pharmacol 50:17-24
5. Wheeler AP, Ridley AJ (2004) Why three proteins? RhoA, RhoB, RhoC, and cell motility. Exp Cell Res 301:43-49
6. Christ GJ, Andersson KE (2007) Rho-kinase and effects of Rhokinase inhibition on the lower urinary tract. Neurourol Urodyn 26(6 Suppl):948-954
7. Rees RW, Foxwell NA, Ralph DJ, Kell PD, Moncada S, Cellek S (2003) Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells. J Urol 170:2517-2522
8. Takahashi R, Nishimura J, Seki N, Yunoki T, Tomoda T, Kanaide H, Naito S (2007) RhoA/Rho kinase-mediated Ca2? sensitization in the contraction of human prostate. Neurourol Urodyn 26:547-551
9. Saito M, Kinoshita Y, Satoh I, Shinbori C, Suzuki H, Yamada M, Satoh K (2007) Ability of cyclohexenonic long-chain fatty alcohol to reverse diabetes-induced cystopathy in the rat. Eur Urol 51:479-488
10. Saito M, Okada S, Kazuyama E, Satoh I, Kinoshita Y, Watanabe T, Satoh K (2008) Pharmacological properties, functional alterations and gene expression of muscarinic receptors in young and old type 2 Goto-Kakizaki diabetic rat bladders. J Urol 180:2701-2705
11. Masago T, Watanabe T, Saito M, Kinoshita Y, Sato K, Miyagawa I (2009) Effect of the rho-kinase inhibitor hydroxyfasudil on bladder overactivity: an experimental rat model. Int J Urol 16:842-847
12. Ohmasa F, Saito M, Tsounapi P, Dimitriadis F, Inoue S, Shomori K, Shimizu S, Kinoshita Y, Satoh K (2011) Edaravone ameliorates diabetes-induced dysfunction of NO-induced relaxation in corpus cavernosum smooth muscle in the rat. J Sex Med (in press)
13. Erschbamer MK, Hofstetter CP, Olson L (2005) RhoA, RhoB, RhoC, Rac1, Cdc42, and Tc10 mRNA levels in spinal cord, sensory ganglia, and corticospinal tract neurons and long-lasting specific changes following spinal cord injury. J Comp Neurol 484:224-233
14. Rattan S, Phillips BR, Maxwell PJ 4th (2010) RhoA/Rho-kinase: pathophysiologic and therapeutic implications in gastrointestinal smooth muscle tone and relaxation. Gastroenterology 138:13-18