Ca 2+ signaling amplification by oligomerization of L-type Ca v1.2 channels

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 5, 2012, Pages 1749-1754

  Dixon, Rose E ^a   Yuan, Can ^a   Cheng, Edward P ^a   Navedo, Manuel F ^a,b   Santana, Luis F ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Calcium sparklets; Coupled gating; EC coupling; Voltage gated calcium channels

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM ION; BIOPOLYMER; L TYPE CALCIUM CHANNEL ALPHA(1C); L-TYPE CALCIUM CHANNEL ALPHA(1C);

ANIMAL CELL; ARRHYTHMOGENESIS; ARTICLE; AUTISM; CALCIUM CURRENT; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; DIASTOLE; EXCITATION CONTRACTION COUPLING; GAIN OF FUNCTION MUTATION; HEART ARRHYTHMIA; HEART MUSCLE CONTRACTILITY; MOUSE; MUSCLE CELL; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYSTOLE; WILD TYPE; ANIMAL; CALCIUM SIGNALING; CHANNEL GATING; GENETICS; HEART VENTRICLE; METABOLISM; MUTATION;

PHLEUM PRATENSE;

ANIMALS; BIOPOLYMERS; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; HEART VENTRICLES; ION CHANNEL GATING; MUTATION;

EID: 84857132094     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1116731109     Document Type: Article

References (23)

1. 2+ channels and ryanodine receptors in heart cells. Nature 410:592-596.
2. Cheng H, Lederer WJ, Cannell MB (1993) Calcium sparks: Elementary events underlying excitation-contraction coupling in heart muscle. Science 262:740-744. (Pubitemid 23350693)
3. 2+ channels. Circ Res 92:532-538.
4. Sobie EA, Ramay HR (2009) Excitation-contraction coupling gain in ventricular myocytes: insights from a parsimonious model. J Physiol 587:1293-1299.
5. Cheng EP, et al. (2011) Restoration of normal L-type Ca2+ channel function during Timothy syndrome by ablation of an anchoring protein. Circ Res 109:255-261.
6. 2+ channels during hypertension and Timothy syndrome. Circ Res 106:748-756.
7. Hymel L, Striessnig J, Glossmann H, Schindler H (1988) Purified skeletal muscle 1,4- dihydropyridine receptor forms phosphorylation-dependent oligomeric calcium channels in planar bilayers. Proc Natl Acad Sci USA 85:4290-4294.
8. 2+-calmodulins. Proc Natl Acad Sci USA 106:5135-5140.
9. Wang MC, et al. (2004) The three-dimensional structure of the cardiac L-type voltagegated calcium channel: Comparison with the skeletal muscle form reveals a common architectural motif. J Biol Chem 279:7159-7168.
10. Kim EY, et al. (2010) Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization. EMBO J 29:3924-3938.
11. Digman MA, Dalal R, Horwitz AF, Gratton E (2008) Mapping the number of molecules and brightness in the laser scanning microscope. Biophys J 94:2320-2332.
12. Merzlyak EM, et al. (2007) Bright monomeric red fluorescent protein with an extended fluorescence lifetime. Nat Methods 4:555-557. (Pubitemid 47214772)
13. Yazawa M, Sadaghiani AM, Hsueh B, Dolmetsch RE (2009) Induction of protein-protein interactions in live cells using light. Nat Biotechnol 27:941-945.
14. Sinnegger-Brauns MJ, et al. (2004) Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca2+ channels. J Clin Invest 113:1430-1439. (Pubitemid 39071698)
15. Saffman PG, Delbrück M (1975) Brownian motion in biological membranes. Proc Natl Acad Sci USA 72:3111-3113.
16. Rossow MJ, Sasaki JM, Digman MA, Gratton E (2010) Raster image correlation spectroscopy in live cells. Nat Protoc 5:1761-1774.
17. McDonald TF, Pelzer S, Trautwein W, Pelzer DJ (1994) Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells. Physiol Rev 74:365-507. (Pubitemid 24127646)
18. Wei X, et al. (1994) Modification of Ca2+ channel activity by deletions at the carboxyl terminus of the cardiac alpha 1 subunit. J Biol Chem 269:1635-1640.
19. Splawski I, et al. (2004) Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell 119:19-31. (Pubitemid 39349317)
20. Barrett CF, Tsien RW (2008) The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels. Proc Natl Acad Sci USA 105:2157-2162. (Pubitemid 351439481)
21. 2+) release units and couplons in skeletal and cardiac muscles. Biophys J 77:1528-1539.
22. 2+ sparks and local control theories for cardiac excitation-contraction coupling. Circ Res 78:166-171.
23. 2+ channel activity and nuclear signaling. Neuron 55:261-275.