Th17-related genes and celiac disease susceptibility

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Medrano, Luz María ^a   García Magariños, Manuel ^b,c   Dema, Bárbara ^a   Espino, Laura ^a   Maluenda, Carlos ^a   Polanco, Isabel ^d   Figueredo, M Ángeles ^a   Fernández Arquero, Miguel ^a   Núñez, Concepción ^a  

^a HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c PUBLIC UNIVERSITY OF NAVARRE   (Spain)

^d HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; C C CHEMOKINE RECEPTOR TYPE 6 GENE; CELIAC DISEASE; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENE; GENE FUNCTION; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC RISK; HAPLOTYPE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INTERLEUKIN 11 RECEPTOR ALPHA GENE; INTERLEUKIN 12 RECEPTOR BETA1 GENE; INTERLEUKIN 17A GENE; INTERLEUKIN 17F GENE; INTERLEUKIN 22 GENE; INTERLEUKIN 23 RECEPTOR GENE; INTERLEUKIN 23A GENE; INTERLEUKIN 6 GENE; INTERLEUKIN 6 RECEPTOR GENE; JAK2 GENE; MOLECULAR PATHOLOGY; RAR RELATED ORPHAN RECEPTOR C GENE; SINGLE NUCLEOTIDE POLYMORPHISM; SOCS3 GENE; STAT3 GENE; TBX21 GENE; TH17 CELL; TNFSF15 GENE; GENETIC EPISTASIS; GENETICS; IMMUNOLOGY;

CELIAC DISEASE; EPISTASIS, GENETIC; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; TH17 CELLS;

EID: 84857129670     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031244     Document Type: Article

References (26)

1. Oukka M, (2008) Th17 cells in immunity and autoimmunity. Ann Rheum Dis 67 (Suppl 3): iii26-29.
2. Volpe E, Servant N, Zollinger R, Bogiatzi SI, Hupe P, et al. (2008) A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol 9: 650-657.
3. Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, et al. (2003) Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421: 744-748.
4. Yen D, Cheung J, Scheerens H, Poulet F, McClanahan T, et al. (2006) IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 116: 1310-1316.
5. Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, et al. (2006) A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314: 1461-1463.
6. Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, et al. (2007) Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 39: 1329-1337.
7. Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, et al. (2007) A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet 80: 273-290.
8. Steinman L, (2007) A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat Med 13: 139-145.
9. Lees CW, Barrett JC, Parkes M, Satsangi J, (2011) New IBD genetics: common pathways with other diseases. Gut Epub ahead of print.
10. Glas J, Stallhofer J, Ripke S, Wetzke M, Pfennig S, et al. (2009) Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease. Am J Gastroenterol 104: 1737-1744.
11. McGovern DP, Rotter JI, Mei L, Haritunians T, Landers C, et al. (2009) Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease. Inflamm Bowel Dis 15: 883-889.
12. Nunez C, Dema B, Cenit MC, Polanco I, Maluenda C, et al. (2008) IL23R: a susceptibility locus for celiac disease and multiple sclerosis? Genes Immun 9: 289-293.
13. Harris KM, Fasano A, Mann DL, (2008) Cutting edge: IL-1 controls the IL-23 response induced by gliadin, the etiologic agent in celiac disease. J Immunol 181: 4457-4460.
14. Einarsdottir E, Koskinen LL, Dukes E, Kainu K, Suomela S, et al. (2009) IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease. BMC Med Genet 10: 8.
15. Monteleone I, Sarra M, Del Vecchio Blanco G, Paoluzi OA, Franze E, et al. (2011) Characterization of IL-17A-producing cells in celiac disease mucosa. J Immunol 184: 2211-2218.
16. Castellanos-Rubio A, Santin I, Irastorza I, Castano L, Carlos Vitoria J, et al. (2009) TH17 (and TH1) signatures of intestinal biopsies of CD patients in response to gliadin. Autoimmunity 42: 69-73.
17. Fernandez S, Molina IJ, Romero P, Gonzalez R, Pena J, et al. (2011) Characterization of gliadin-specific Th17 cells from the mucosa of celiac disease patients. Am J Gastroenterol 106: 528-538.
18. van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, et al. (2007) A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Genet 39: 827-829.
19. Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, et al. (2008) Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet 40: 395-402.
20. Dubois PC, Trynka G, Franke L, Hunt KA, Romanos J, et al. (2010) Multiple common variants for celiac disease influencing immune gene expression. Nat Genet 42: 295-302.
21. Bush WS, McCauley JL, DeJager PL, Dudek SM, Hafler DA, et al. (2011) A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility. Genes Immun 12: 335-340.
22. Torok HP, Glas J, Endres I, Tonenchi L, Teshome MY, et al. (2009) Epistasis between Toll-like receptor-9 polymorphisms and variants in NOD2 and IL23R modulates susceptibility to Crohn's disease. Am J Gastroenterol 104: 1723-1733.
23. Dema B, Martinez A, Fernandez-Arquero M, Maluenda C, Polanco I, et al. (2009) The IL6-174G/C polymorphism is associated with celiac disease susceptibility in girls. Hum Immunol 70: 191-194.
24. Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, et al. (2010) Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 42: 1118-1125.
25. Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, et al. (2010) Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet 42: 508-514.
26. Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, et al. (2011) Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476: 214-219.