Pharmacophore models and development of spirocyclic ligands for σ 1 receptors

Current Pharmaceutical Design

Volumn 18, Issue 7, 2012, Pages 930-937

  Wünsch, Bernhard ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

1; Affinity relationships; C H bond arylation; Fluorinated PET tracer; Ligands; Pharmacophore models; Pyrazole bioisosteres; Receptor ligands; Spirocyclic 1; Structure 1; Thiophene bioisosteres

Indexed keywords

AMINO ACID; CYCLOHEXANE; FLUORINE 18; PIPERIDINE; SIGMA RECEPTOR LIGAND; SIGMA1 RECEPTOR LIGAND; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG SELECTIVITY; DRUG STRUCTURE; LIGAND BINDING; NEUROIMAGING; PHARMACOPHORE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; RECEPTOR BINDING;

ANIMALS; DRUG DESIGN; HUMANS; LIGANDS; RECEPTORS, SIGMA; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84857126465     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161212799436548     Document Type: Article

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