Enantioselective σ1 receptor binding and biotransformation of the spirocyclic PET tracer 1′-benzyl-3-(3-fluoropropyl)-3H-spiro[[2] benzofuran-1,4′-piperidine]

Chirality

Volumn 23, Issue 2, 2011, Pages 148-154

  Wiese, Christian ^a   Maestrup, Eva Große ^a   Schepmann, Dirk ^a   Grimme, Stefan ^a   Humpf, Hans Ulrich ^a   Brust, Peter ^b   Wünsch, Bernhard ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b Institut fur Interdisziplinare Isotopenforschung   (Germany)

Author keywords

1 receptor ligands; CD spectroscopy; enantioselective metabolism; enantioselective receptor binding; PET tracer; resolution

Indexed keywords

1' BENZYL 3 (3 FLUOROPROPYL) 3H SPIRO([2]BENZOFURAN 1,4' PIPERIDINE); RECEPTOR; SIGMA1 RECEPTOR; TRACER; UNCLASSIFIED DRUG; WMS 1813;

ANIMAL TISSUE; ARTICLE; DRUG METABOLISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG TRANSFORMATION; ENANTIOSELECTIVITY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

ANIMALS; BENZOFURANS; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; FLUORINE RADIOISOTOPES; GUINEA PIGS; MASS SPECTROMETRY; MICROSOMES, LIVER; PENTAZOCINE; PIPERIDINES; POSITRON-EMISSION TOMOGRAPHY; RADIOACTIVE TRACERS; RATS; RATS, WISTAR; RECEPTORS, SIGMA; SPIRO COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78650928857     PISSN: 08990042     EISSN: 1520636X     Source Type: Journal    
DOI: 10.1002/chir.20893     Document Type: Article

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