Cyclic mechanical load causes global translational arrest in articular chondrocytes: A process which is partially dependent upon PKR phosphorylation

European Cells and Materials

Volumn 22, Issue , 2011, Pages 178-189

  Lomas, Cara ^a   Tang, Xiaodi D ^a   Chanalaris, Anastasios ^a   Saklatvala, Jeremy ^a   Vincent, Tonia L ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Cartilage; Chondrocytes; Mechanical load; Protein synthesis

Indexed keywords

COLLAGEN TYPE 2; CONNECTIVE TISSUE GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INITIATION FACTOR 2ALPHA; PROTEIN KINASE; PROTEIN KINASE R; PROTEIN KINASE R LIKE ENDOPLASMIC RETICULUM KINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 3; UNCLASSIFIED DRUG; ELONGATION FACTOR 2 KINASE; FIBROBLAST GROWTH FACTOR RECEPTOR; MESSENGER RNA; PERK KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; SCLEROPROTEIN; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; IMMUNOBLOTTING; MECHANICAL STRESS; NONHUMAN; PROTEIN PROCESSING; PROTEIN SYNTHESIS INHIBITION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSLATION REGULATION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; SWINE;

ANIMALS; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; EIF-2 KINASE; ELONGATION FACTOR 2 KINASE; EXTRACELLULAR MATRIX PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, FIBROBLAST GROWTH FACTOR; RNA, MESSENGER; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; SWINE;

EID: 84857124537     PISSN: 14732262     EISSN: None     Source Type: Journal    
DOI: 10.22203/eCM.v022a14     Document Type: Article

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