Respiratory syncytial virus glycoprotein G interacts with DC-SIGN and L-SIGN To activate ERK1 and ERK2

Journal of Virology

Volumn 86, Issue 3, 2012, Pages 1339-1347

  Johnson, Teresa R ^a   McLellan, Jason S ^a   Graham, Barney S ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CD209 ANTIGEN; CD299 ANTIGEN; LYMPHOCYTE ANTIGEN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; THROMBOSPONDIN; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ANTIGEN EXPRESSION; ARTICLE; CELL STRAIN 3T3; CELLULAR IMMUNITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOMODULATION; INNATE IMMUNITY; INTRACELLULAR SIGNALING; LYMPHOCYTE ACTIVATION; MOLECULAR INTERACTION; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY SYNCYTIAL VIRUS INFECTION; SURFACE PLASMON RESONANCE; VIRUS NEUTRALIZATION;

CATIONS, DIVALENT; CELL ADHESION MOLECULES; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LECTINS, C-TYPE; PHOSPHORYLATION; PROTEIN BINDING; RECEPTORS, CELL SURFACE; RESPIRATORY SYNCYTIAL VIRUSES; VIRAL FUSION PROTEINS;

RESPIRATORY SYNCYTIAL VIRUS; RICE STRIPE VIRUS;

EID: 84857082116     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.06096-11     Document Type: Article

References (61)

1. Aizaki H, et al. 2008. Critical role of virion-associated cholesterol and sphingolipid in hepatitis C virus infection. J. Virol. 82:5715-5724.
2. Alvarez CP, Lasala F, Carrillo J, Muniz O, Delgado R. 2002. C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans. J. Virol. 76:6841- 6844.
3. Barr FE, Pedigo H, Johnson TR, Shepherd VL. 2000. Surfactant protein-A enhances uptake of respiratory synctial virus by monocytes and U937 macrophages. Am. J. Respir. Cell Mol. Biol. 23:586-592.
4. Bont L, et al. 2002. Natural reinfection with respiratory syncytial virus does not boost virus-specific T-cell immunity. Pediatr. Res. 52:363-367.
5. Caparros E, et al. 2006. DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine production. Blood 107: 3950-3958.
6. Carter GC, et al. 2009. HIV entry in macrophages is dependent on intact lipid rafts. Virology 386:192-202.
7. Chen QL, et al. 2010. Activation of p38 MAPK pathway by hepatitis C virus E2 in cells transiently expressing DC-SIGN. Cell Biochem. Biophys. 56:49-58.
8. Chi B, et al. 2006. Alpha and lambda interferon together mediate suppression of CD4 T cells induced by respiratory syncytial virus. J. Virol. 80:5032-5040.
9. Collins PL, Graham BS. 2008. Viral and host factors in human respiratory syncytial virus pathogenesis. J. Virol. 82:2040-2055.
10. Cormier EG, et al. 2004. L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus. Proc. Natl. Acad. Sci. U. S. A. 101:14067-14072.
11. Davis CW, et al. 2006. West Nile virus discriminates between DC-SIGN and DC-SIGNR for cellular attachment and infection. J. Virol. 80: 1290-1301.
12. de Graaff PM, et al. 2005. Respiratory syncytial virus infection of monocyte-derived dendritic cells decreases their capacity to activate CD4 T cells. J. Immunol. 175:5904-5911.
13. Feldman SA, Audet S, Beeler JA. 2000. The fusion glycoprotein of human respiratory syncytial virus facilitates virus attachment and infectivity via an interaction with cellular heparan sulfate. J. Virol. 74:6442- 6447.
14. Feldman SA, Hendry RM, Beeler JA. 1999. Identification of a linear heparin binding domain for human respiratory syncytial virus attachment glycoprotein G. J. Virol. 73:6610-6617.
15. Freitas MS, et al. 2011. Measuring the strength of interaction between the Ebola fusion peptide and lipid rafts: implications for membrane fusion and virus infection. PLoS One 6:e15756.
16. Geijtenbeek TBH, den Dunnen J, Gringhuis SI. 2009. Pathogen recognition by DC-SIGN shapes adaptive immunity. Future Microbiol. 4:879-890.
17. Geijtenbeek TBH, Gringhuis SI. 2009. Signalling through C-type lectin receptors: shaping immune responses. Nat. Rev. Immunol. 9:465- 479.
18. Geijtenbeek TBH, et al. 2000. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 100:587-597.
19. Geijtenbeek TBH, et al. 2003. Mycobacteria target DC-SIGN to suppress dendritic cell function. J. Exp. Med. 197:7-17.
20. Ghildyal R, et al. 1999. Surfactant protein A binds to the fusion glycoprotein of respiratory syncytial virus and neutralizes virion infectivity. J. Infect. Dis. 180:2009-2013.
21. Gringhuis SI, et al. 2009. Carbohydrate-specific signaling through theDC-SIGN signalsome tailors immunity to Mycobacterium tuberculosis, HIV-1, and Helicobacter pylori. Nat. Immunol. 10:1081-1088.
22. Gringhuis SI, et al. 2010. HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells. Nat. Immunol. 11: 419-426.
23. Guerrero-Plata A, et al. 2006. Differential response of dendritic cells to human metapneumovirus and respiratory syncytial virus. Am. J. Respir. Cell Mol. Biol. 34:320-329.
24. Hallak LK, Collins PL, Knudson W, Peeples ME. 2000. Iuronic acidcontaining glycosaminoglycans on target cells are required for efficient respiratory syncytial virus infection. Virology 271:264-275.
25. Hickling TP, et al. 2000. Lung surfactant protein A provides a route of entry for respiratory syncytial virus into host cells. Viral Immunol. 13: 125-135.
26. Hobson L, Everard ML. 2008. Persistence of respiratory syncytial virus in human dendritic cells and influence of nitric oxide. Clin. Exp. Immunol. 151:359-366.
27. Hornung V, et al. 2004. Replication-dependent potent IFN-_ induction in human plasmacytoid dendritic cells by a single-stranded RNA virus. J. Immunol. 173:5935-5943.
28. Jeffers SA, et al. 2004. CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. Proc. Natl. Acad. Sci. U. S. A. 101: 15748-15753.
29. Johnson TR, Johnson CN, Corbett KS, Edwards GC, Graham BS. 2011. Primary human mDC1, mDC2, and pDC dendritic cells are differentially infected and activated by respiratory syncytial virus. PLoS One 6:e16458.
30. Jones A, Morton I, Hobson L, Evans GS, Everard ML. 2006. Differentiation and immune function of human dendritic cells following infection by respiratory syncytial virus. Clin. Exp. Immunol. 143:513-522.
31. Kurt-Jones EA, et al. 2000. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat. Immunol. 1:398-401.
32. Lambrecht BN, Hammad H. 2009. Biology of lung dendritic cells at the origin of asthma. Immunity 31:412- 424.
33. LeVine AM, et al. 2004. Surfactant protein-D enhances phagocytosis and pulmonary clearance of respiratory syncytial virus. Am. J. Respir. Cell Mol. Biol. 31:193-199.
34. Liu CF, Rivere M, Huang HJ, Puzo G, Wang JY. 2010. Surfactant protein D inhibits mite-induced alveolar macrophage and dendritic cell activations through TLR signalling and DC-SIGN expression. Clin. Exp. Allergy 40:111-122.
35. Looney RJ, Falsey AR, Walsh EE, Campbell D. 2002. Effect of aging on cytokine production in response to respiratory syncytial virus infection. J. Infect. Dis. 185:682- 685.
36. Lozach PY, et al. 2005. Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN)-mediated enhancement of dengue virus infection is independent of DC-SIGN internalization signals. J. Biol. Chem. 280:23698-23708.
37. McCurdy LH, Graham BS. 2003. Role of plasma membrane lipid microdomains in respiratory syncytial virus filament formation. J. Virol. 77:1747-1756.
38. Mittal R, Bulgheresi S, Emami C, Prasadaro NV. 2009. Enterobacter sakazakii targets DC-SIGN to induce immunosuppressive responses in dendritic cells by modulating MAPKs. J. Immunol. 183:6588-6599.
39. Murphy BR, et al. 1986. Serum and nasal-wash immunoglobulin G and A antibody response of infants and children to respiratory syncytial virus F and G glycoproteins following primary infection. J. Clin. Microbiol. 23: 1009-1014.
40. Ono A. 2010. Relationships between plasma membrane microdomains and HIV-1 assembly. Biol. Cell 102:335-350.
41. Pleschka S. 2008. RNA viruses and the mitogenic Raf/MEK/ERK signal transduction cascade. Biol. Chem. 389:1273-1282.
42. Preston FM, Beier PL, Pope JH. 1992. Infectious respiratory syncytial virus (RSV) effectively inhibits the proliferative T cell response to inactivated RSV in vitro. J. Infect. Dis. 165:819-825.
43. Roberts N. 1982. Different effects of influenza virus, respiratory syncytial virus, and Sendai virus on human lymphocytes and macrophages. Infect. Immun. 35:1142-1146.
44. Roberts SR, Lichtenstein DL, Ball LA, Wertz GW. 1994. The membraneassociated and secreted forms of the respiratory syncytial virus attachment glycoproteinGare synthesized from alternative initiation codons. J. Virol. 68:4538-4546.
45. Sakuntabhai A, et al. 2005. A variant in the CD209 promoter is associated with severity of dengue disease. Nat. Genet. 37:507-513.
46. Schlender J, et al. 2005. Inhibition of Toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus. J. Virol. 79:5507-5515.
47. Shahrabadi MS, Lee PWK. 1988. Calcium requirement for syncytium formation in HEp-2 cells by respiratory syncytial virus. J. Clin. Microbiol. 26:139-141.
48. Shan M, et al. 2007. HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells. PLoS Pathog. 3:1637-1650.
49. Sharma NR, et al. 2010. Reciprocal regulation of AKT and MAP kinase dictates virus-host cell fusion. J. Virol. 84:4366-4382.
50. Silva BM, et al. 2011. The dengue virus nonstructural protein 1 (NS1) increases NF- k B transcriptional activity in HepG2 cells. Arch. Virol. 156:1275-1279.
51. Singleton R, Etchart N, Hou S, Hyland L. 2003. Inability to evoke a long-lasting protective immune response to respiratory syncytial virus infection in mice correlates with ineffective nasal antibody responses. J. Virol. 77:11303-11311.
52. Snyder GA, Colonna M, Sun PD. 2005. The structure of DC-SIGNR with a portion of its repeat domain lends insights to modeling of the receptor tetramer. J. Mol. Biol. 347:979-989.
53. Snyder GA, et al. 2005. Characterization of DC-SIGN/R interaction with human immunodeficiency virus type 1 gp120 and ICAM molecules favors the receptor's role as an antigen-capturing rather than an adhesion receptor. J. Virol. 79:4589-4598.
54. Svajger U, Anderluh M, Jeras M, Obermajer N. 2010. C-type lectin DC-SIGN: an adhesion, signaling and antigen-uptake molecule that guides dendritic cells in immunity. Cell. Signal. 22:1397-1405.
55. Swedan S, Musiyenko A, Barik S. 2009. Respiratory syncytial virus nonstructural proteins decrease levels of multiple members of the cellular interferon pathways. J. Virol. 83:9682-9693.
56. Tassaneetrithep B, et al. 2003. DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells. J. Exp. Med. 197:823- 829.
57. Tripp RA, et al. 2001. CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein. Nat. Immunol. 2:732-738.
58. Weichhart T, Saemann MD. 2008. The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications. Ann. Rheum. Dis. 67(Suppl. III):iii70-iii74.
59. Welliver RC, Kaul TN, Sun M, Ogra PL. 1984. Defective regulation of immune responses in respiratory syncytial virus infection. J. Immunol. 133:1925-1930.
60. Zeituni AE, Jotwani R, Carrion J, Cutler CW. 2009. Targeting of DCSIGN on human dendritic cells by a minor fimbriated Porphyromonas gingivalis strains elicits a distinct effector T cell response. J. Immunol. 183:5694-5704.
61. Zimmermann N, et al. 2000. Murine eotaxin-2: a constitutive eosinophil chemokine induced by allergen challenge and IL-4 overexpression. J. Immunol. 165:5839-5846.