Molecular analysis of population structure and antibiotic resistance of Klebsiella isolates from a three-year surveillance program in Florence hospitals, Italy

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 31, Issue 3, 2012, Pages 371-378

  Donnarumma, F ^a   Indorato, C ^a   Mastromei, G ^a   Goti, E ^a   Nicoletti, P ^a   Pecile, P ^a   Fanci, R ^a   Bosi, A ^a   Casalone, E ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMPICILLIN; ANTIBIOTIC AGENT; AZTREONAM; CARBAPENEM; CEFAZOLIN; CEFEPIME; CEFTAZIDIME; ERTAPENEM; IMIPENEM; LEVOFLOXACIN; MEROPENEM; PIPERACILLIN PLUS TAZOBACTAM; SULTAMICILLIN; TRIMETHOPRIM;

AMPLIFIED FRAGMENT LENGTH POLYMORPHISM; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; CONTROLLED STUDY; GENETIC VARIABILITY; HOSPITAL; HOSPITAL INFECTION; HUMAN; ITALY; KLEBSIELLA OXYTOCA; KLEBSIELLA PNEUMONIAE; MAJOR CLINICAL STUDY; NEWBORN INTENSIVE CARE; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; POPULATION STRUCTURE; PRIORITY JOURNAL;

AMPLIFIED FRAGMENT LENGTH POLYMORPHISM ANALYSIS; CARBAPENEMS; DISEASE OUTBREAKS; DNA, BACTERIAL; DRUG RESISTANCE, MULTIPLE, BACTERIAL; HUMANS; ITALY; KLEBSIELLA; KLEBSIELLA INFECTIONS; MOLECULAR TYPING;

EID: 84857062829     PISSN: 09349723     EISSN: 14354373     Source Type: Journal    
DOI: 10.1007/s10096-011-1319-6     Document Type: Article

References (39)

1. Riley LW (2004) Hospital infections: gram-negative bacteria. In: Molecular epidemiology of infectious diseases: principle and practices. ASM Press, Washington, DC
2. VD Rosenthal D Maki S Jamulitrat EA Medeiros SK Todi DY Gomez HH Leblebicioglu IA Khader MGM Novales R Berba FMR Wong A Barkat OR Pino L Dueñas Z Mitrev H Bijie V Gurskis SS Kanj T Mapp RF Hidalgo NB Jaballah L Raka A Gikas A Ahmed TA le Thu ME Guzman-Siritt 2010 International Nosocomial Infection Control Consortium (INICC) report, data summary for 2003-2008, issued June 2009 AJIC 38 95 104
3. M Cartelle TM del Mar S Pertega A Beceiro MA Dominguez D Velasco F Molina R Villanueva G Bou 2004 Risk factors for colonization and infection in a hospital outbreak caused by a strain of Klebsiella pneumoniae with reduced susceptibility to expanded-spectrum cephalosporins J Clin Microbiol 42 4242 4249 15365018 10.1128/JCM.42.9.4242-4249.2004 1:CAS:528:DC%2BD2cXosVyhsrs%3D (Pubitemid 39296151)
4. I Kühn A Iversen LG Burman B Olsson-Liljequist A Franklin M Finn F Aarestrup AM Seyfarth AR Blanch X Vilanova H Taylor J Caplin MA Moreno L Dominguez IA Herrero R Möllby 2003 Comparison of enterococcal populations in animals, humans, and the environment-a European study Int J Food Microbiol 88 133 145 14596986 10.1016/S0168-1605(03)00176-4 (Pubitemid 37329492)
5. MB Macrae KP Shannon DM Rayner AM Kaiser PN Hoffman GL French 2001 A simultaneous outbreak on a neonatal unit of two strains of multiply antibiotic resistant Klebsiella pneumoniae controllable only by ward closure J Hosp Infect 49 183 192 11716635 10.1053/jhin.2001.1066 1:STN:280:DC%2BD3MnntVyrtg%3D%3D (Pubitemid 33072151)
6. R Podschun U Ullmann 1998 Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity Factors Clin Microbiol Rev 11 589 603 9767057 1:STN:280:DyaK1cvktVemtQ%3D%3D (Pubitemid 28497563)
7. 2-Lactamase production in nosocomial infections Ann Intern Med 140 26 32 14706969 (Pubitemid 38055918)
8. C Pena M Pujol C Ardanuy A Ricart R Pallares J Linares J Ariza F Gudiol 1998 Epidemiology and successful control of a large outbreak due to Klebsiella pneumoniae producing extended spectrum beta-lactamases Antimicrob Agents Chemother 42 53 58 9449260 1:CAS:528:DyaK1cXisVOmtw%3D%3D (Pubitemid 28053326)
9. PA Bradford S Bratu C Urban M Visalli N Mariano D Landman JJ Rahal S Brooks S Cebular J Quale 2004 Emergence carbapenem-resistant Klebsiella species possessing the class carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM- beta-lactamases in New York City Clin Infect Dis 39 55 60 15206053 10.1086/421495 1:CAS:528:DC%2BD2cXmtlSgtr0%3D (Pubitemid 38879549)
10. MJ Schwaber Y Carmeli 2008 Carbapenem-resistant Enterobacteriaceae: a potential threat JAMA 300 2911 2913 19109119 10.1001/jama.2008.896 1:CAS:528:DC%2BD1MXmtlGhsw%3D%3D
11. L Poirel C Hèritier V Tolun P Nordmann 2004 Emergences of oxacillinases-mediated resistance to imipinem in Klebsiella pneumoniae Antimicrob Agents Chemoter 48 15 22 10.1128/AAC.48.1.15-22.2004 1:CAS:528:DC%2BD2cXlsVKlug%3D%3D (Pubitemid 38040171)
12. A Queenam K Bush 2007 Carbapenemases: the versatile β-lactamases Clin Microbiol Rev 20 440 458 10.1128/CMR.00001-07 (Pubitemid 47175013)
13. G Patel S Huprikar SH Factor SG Jenkins SG Calfee 2008 Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies Infect Control Hosp Epidemiol 29 1099 1106 18973455 10.1086/592412
14. W Lledo M Hernandez E Lopez, et al. 2009 Guidance for control of infections with carbapenem-resistant or carbapenemase-producing Enterobacteriaceae in acute care facilities MMWR 58 256 260
15. HC Maltezou P Giakkoupi A Maragos M Bolikas V Raftopoulos H Papahatzaki G Vrouhos V Liakou AC Vatopoulos 2009 Outbreak of infections due to KPC-2-producing Klebsiella pneumoniae in a hospital in Crete (Greece) J Infect 58 213 219 19246099 10.1016/j.jinf.2009.01.010 1:STN:280:DC%2BD1M7pt1Cjug%3D%3D
16. C Wendt S Schütt AH Dalpke M Konrad M Mieth B Trierweiler-Hauke MA Weigand S Zimmermann K Biehler D Jonas 2010 First outbreak of Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae in Germany Eur J Clin Microbiol Infect Dis 29 563 570 20213255 10.1007/s10096-010-0896-0 1:STN:280:DC%2BC3c3lvVWkuw%3D%3D
17. F Donnarumma S Sergi C Indorato G Mastromei R Monnanni P Nicoletti P Pecile D Cecconi R Mannino S Bencini R Fanci A Bosi E Casalone 2010 Molecular characterization of acinetobacter isolates collected in Intensive care units of six hospitals in Florence, Italy, during a 3-year surveillance program: a population structure analysis J Clin Microbiol 48 1297 1304 20181903 10.1128/JCM.01916-09 1:CAS:528:DC%2BC3cXmt1Kguro%3D
18. S Sergi F Donnarumma G Mastromei E Goti P Nicoletti P Pecile D Cecconi R Mannino R Fanci A Bosi B Bartolozzi E Casalone 2009 Molecular surveillance and population structure analysis of methicillin-susceptible and methicillin-resistant Staphylococcus aureus in high-risk wards J Clin Microbiol 47 3246 3254 19656984 10.1128/JCM.00624-09 1:CAS:528:DC%2BD1MXhsVeru77K
19. CLSI (2009) Performance standards for antimicrobial susceptibility testing, 19th informational supplement. Clinical and Laboratory Standards Institute, Wayne, PA
20. P Vos R Hogers M Bleeker M Reijans T van de Lee M Hornes A Friters J Pot J Paleman M Kuiper M Zabeau 1995 AFLP: a new technique for DNA fingerprinting Nucl Acids Res 23 4407 4414 7501463 10.1093/nar/23.21.4407 1:CAS:528: DyaK2MXpslensbo%3D
21. PHM Savelkoul HJM Aarts J de Haas L Dijkshoorn B Duim M Otsen JLW Rademaker L Schouls JA Lenstra 1999 Amplified-fragment length polymorphism analysis: the state of an art J Clin Microbiol 37 3083 3091 10488158 1:CAS:528:DyaK1MXmsFeksbw%3D (Pubitemid 29455186)
22. MA Gaston PR Hunter 1989 Efficient selection of tests for bacteriological typing schemes J Clin Pathol 42 763 766 2668344 10.1136/jcp.42.7.763 1:STN:280:DyaL1MzktV2luw%3D%3D (Pubitemid 19170793)
23. L Excoffier PE Smouse JM Quattro 1992 Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data Genetics 131 479 491 1644282 1:CAS:528:DyaK38XlsVCntro%3D
24. C Dalmastri A Fiore C Alisi A Bevivino S Tabacchioni G Giuliano AR Sprocati L Segre E Mahenthiralingam L Chiarini P Vandamme 2003 A rhizospheric Burkholderia cepacia complex population: genotypic and phenotypic diversity of Burkholderia cenocepacia and Burkholderia ambifaria FEMS Microbiol Ecol 46 179 187 19719571 10.1016/S0168-6496(03)00211-3 1:CAS:528:DC%2BD3sXosFSltL4%3D (Pubitemid 37338503)
25. Wright S (1978) Evolution and the genetics of populations, vol. 4. Variability within and among natural populations. University of Chicago Press, Chicago, IL
26. L Excoffier G Laval S Schneider 2005 Arlequin version 31: an integrated software package for population genetics data analysis Evol Bioinforma Online 1 47 50 1:CAS:528:DC%2BD28XjsFSltg%3D%3D
27. JK Rasheed C Jay B Metchock F Berkowitz L Weigel J Crellin C Steward B Hill AA Medeiros FC Tenover 1997 Evolution of extended-spectrum beta-lactam resistance (SHV-8) in a strain of Escherichia coli during multiple episodes of bacteremia Antimicrob Agents Chemother 41 647 653 9056008 1:CAS:528: DyaK2sXhsFKnt7Y%3D (Pubitemid 27098419)
28. H Yigit AM Queenan GJ Anderson A Domenech-Sanchez JW Biddle CD Steward S Alberti K Bush FC Tenover 2001 Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae Antimicrob Agents Chemother 45 1151 1161 11257029 10.1128/AAC.45.4.1151-1161.2001 1:CAS:528:DC%2BD3MXit1Omsrc%3D (Pubitemid 32230996)
29. MJ Ellington J Kistler DM Livermore N Woodford 2007 Multiplex PCR for rapid detection of genes encoding aquired metallo-β-lactamases J Antimicrob Chemoter 59 321 322 10.1093/jac/dkl481 1:CAS:528:DC%2BD2sXjt1Churk%3D (Pubitemid 47072076)
30. GF Weldhagen 2004 Rapid detection and sequence-specific differentiation of extended-spectrum β-lactamase GES-2 from Pseudomonas aeruginosa by use of a real time PCR assay Antimicrob Agents Chemother 48 4059 4062 15388481 10.1128/AAC.48.10.4059-4062.2004 1:CAS:528:DC%2BD2cXosVygtLo%3D (Pubitemid 39304650)
31. T Giani MM D'Andrea P Pecile L Borgianni P Nicoletti F Tonelli A Bartoloni GM Rossolini 2009 Emergence in Italy of Klebsiella pneumoniae sequence Type 258 producing KPC-3 carbapenemase J Clin Microbiol 47 3793 3794 19759220 10.1128/JCM.01773-09
32. S Brisse J Verhoef 2001 Phylogenetic diversity of Klebsiella pneumoniae and Klebsiella oxytoca clinical isolates revealed by randomly amplified polymorphic DNA, gyrA and parC genes sequencing and automated ribotyping Int J Syst Evol Microbiol 51 915 924 11411715 10.1099/00207713-51-3-915 1:CAS:528:DC%2BD3MXks1Kiu7w%3D (Pubitemid 32499295)
33. M Ayan C Kuzucu R Durmaz E Aktas Z Cizmeci 2003 Analysis of three outbreaks due to Klebsiella species in a neonatal intensive care unit Infect Control Hosp Epidemiol 24 495 500 12887237 10.1086/502245 (Pubitemid 36919268)
34. WC van der Zwet AM Kaiser RM van Elburg J Berkhof WPF Fetter GA Parlevliet CMJE Vandenbroucke-Grauls 2005 Nosocomial infections in a Dutch neonatal intensive care unit: surveillance study with definitions for infection specifically adapted for neonates J Hosp Infect 61 300 311 16221510 10.1016/j.jhin.2005.03.014 (Pubitemid 43009075)
35. A Leavitt I Chmelnitsky R Colodner I Ofek Y Carmeli N-V Shiri 2009 Ertapenem resistance among extended-spectrum-β-lactamase-producing Klebsiella pneumoniae isolates J Clin Microbiol 47 969 974 19213695 10.1128/JCM.00651-08 1:CAS:528:DC%2BD1MXlvVamsb0%3D
36. SE Mc Gettigan K Andreacchio PH Edelstein 2009 Specificity of ertapenem susceptibility screening for detection of Klebsiella pneumoniae carbapenemases J Clin Microbiol 47 785 786 10.1128/JCM.02143-08
37. S Pournaras E Protonotariou E Voulgari I Kristo E Dimitroulia D Vitti M Tsalidou AN Maniatis A Tsakris D Sofianou 2009 Clonal spread of KPC-2 carbapenemase-producing Klebsiella pneumoniae strains in Greece J Antimicrob Chemother 64 348 352 19525514 10.1093/jac/dkp207 1:CAS:528:DC%2BD1MXosFSrtb0%3D
38. N Woodford JWT Dallow RLR Hill MFI Palepou R Pike ME Ward M Warner DM Livermore 2007 Ertapenem resistance among Klebsiella and Enterobacter submitted in the UK to a reference laboratory Int J Antimicrob Agents 29 456 459 17293088 10.1016/j.ijantimicag.2006.11.020 1:CAS:528:DC%2BD2sXislehsb8%3D (Pubitemid 46349596)
39. TM Coque A Oliver JC Perez-Diaz F Baquero R Canton 2002 Genes encoding TEM-4, SHV-2, and CTX-M-10 extended-spectrum beta-lactamases are carried by multiple Klebsiella pneumoniae clones in a single hospital (Madrid, 1989 to 2000) Antimicrob Agents Chemother 46 500 510 11796363 10.1128/AAC.46.2.500-510. 2002 1:CAS:528:DC%2BD38XosFyhtQ%3D%3D (Pubitemid 34087201)