IFN-γ, IL-21, and IL-10 co-expression in evolving autoimmune vitiligo lesions of smyth line chickens

Journal of Investigative Dermatology

Volumn 132, Issue 3 PART 1, 2012, Pages 642-649

  Shi, Fengying ^a   Erf, Gisela F ^a  

^a UNIVERSITY OF ARKANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CELL LOSS; CHICKEN; DISEASE COURSE; FEATHER; LEUKOCYTE; MACROPHAGE; MELANOCYTE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMYTH LINE VITILIGO; T LYMPHOCYTE; TH17 CELL; TH2 CELL; VITILIGO;

EID: 84857062083     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2011.377     Document Type: Article

References (49)

1. Abbas A, Lichtman A, Pillai S (eds) (2010) Cellular and Molecular Immunology. Saunders Elsevier: Philadelphia, 566 pp
2. Abdul-Careem MF, Hunter DB, Shanmuganathan S et al (2008) Cellular and cytokine responses in feathers of chickens vaccinated against Marek0s disease. Vet Immunol Immunopathol 126:362-6
3. Austin LM, Boissy RE, Jacobson BS et al (1992) The detection of melanocyte autoantibodies in the Smyth chicken model for vitiligo. Clin Immunol Immunopathol 64:112-20
4. Bassiouny DA, Shaker O (2011) Role of interleukin-17 in the pathogenesis of vitiligo. Clin Exp Dermatol 36:292-7
5. Boissy RE, Lamont SJ, Smyth JR Jr (1984) Persistence of abnormal melanocytes in immunosuppressed chickens of the autoimmune ''DAM'' line. Cell Tissue Res 235:663-8
6. Boissy RE, Liu YY, Medrano EE et al (1991) Structural aberration of the rough endoplasmic reticulum and melanosome compartmentalization in longterm cultures of melanocytes from vitiligo patients. J Invest Dermatol 97:395-404
7. Boissy RE, Moellmann G, Trainer AT et al (1986) Delayed-amelanotic (DAM or Smyth) chicken: Melanocyte dysfunction in vivo and in vitro. J Invest Dermatol 86:149-56 (Pubitemid 16132517)
8. Boissy RE, Nordlund JJ (2011) Vitiligo: Current medical and scientific understanding. G Ital Dermatol Venereol 146:69-75
9. Boissy RE, Smyth JR Jr, Fite KV (1983) Progressive cytologic changes during the development of delayed feather amelanosis and associated choroidal defects in the DAM chicken line. A vitiligo model. Am J Pathol 111:197-212 (Pubitemid 13083995)
10. Cho BR (1975) Horizontal transmission of turkey herpesvirus to chickens. IV. Viral maturation in the feather follicle epithelium. Avian Dis 19:136-41
11. Cui J, Arita Y, Bystryn JC (1993) Cytolytic antibodies to melanocytes in vitiligo. J Invest Dermatol 100:812-5 (Pubitemid 23151245)
12. Elsaesser H, Sauer K, Brooks DG (2009) IL-21 is required to control chronic viral infection. Science 324:1569-72
13. Erf GF (2010) Animal model. In: Vitiligo. (Picardo M, Taieb A eds). Springer: Heidelberg, 205-18
14. Erf GF, Bersi TK, Wang X et al (2001) Herpesvirus connection in the expression of autoimmune vitiligo in Smyth line chickens. Pigment Cell Res 14:40-6 (Pubitemid 32228354)
15. Erf GF, Trejo-Skalli AV, Smyth JR Jr (1995) T cells in regenerating feathers of Smyth line chickens with vitiligo. Clin Immunol Immunopathol 76:120-6
16. Erf G, Wijesekera H, Lockhart B (2005) Antioxidant capacity and oxidative stress in the local environment of feather-melanocytes in vitiliginous Smyth line chickens. Pigment Cell Res 18:69
17. Frohlich A, Kisielow J, Schmitz I et al (2009) IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science 324:1576-80
18. Gilhar A, Zelickson B, Ulman Y et al (1995) In vivo destruction of melanocytes by the IgG fraction of serum from patients with vitiligo. J Invest Dermatol 105:683-6
19. Gobel TWF, Chen CH, Shrimpf J et al (1994) Characterization of avian natural killer cells and their intracellular CD3 protein complex. Eur J Immunol 24:1685-91 (Pubitemid 24203779)
20. Grimes PE, Morris R, vaniss-Aghajani E et al (2004) Topical tacrolimus therapy for vitiligo: Therapeutic responses and skin messenger RNA expression of proinflammatory cytokines. J Am Acad Dermatol 51: 52-61 (Pubitemid 38887475)
21. Hamal KR, Wideman RF, Anthony NB et al (2010) Differential gene expression of proinflammatory chemokines and cytokines in lungs of ascites-resistant and -susceptible broiler chickens following intravenous cellulose microparticle injection. Vet Immunol Immunopathol 133:250-5
22. Harning R, Cui J, Bystryn JC (1991) Relation between the incidence and level of pigment cell antibodies and disease activity in vitiligo. J Invest Dermatol 97:1078-80
23. Kelchtermans H, Billiau A, Matthys P (2008) How interferon-gamma keeps autoimmune diseases in check. Trends Immunol 29:479-86
24. Lamont SJ, Smyth JR Jr (1981) Effect of bursectomy on development of a spontaneous postnatal amelanosis. Clin Immunol Immunopathol 21:407-11 (Pubitemid 12168478)
25. Lauw FN, Pajkrt D, Hack CE et al (2000) Proinflammatory effects of IL-10 during human endotoxemia. J Immunol 165:2783-9 (Pubitemid 30660729)
26. Le Gal FA, Avril MF, Bosq J et al (2001) Direct evidence to support the role of antigen-specific CD8(+) T cells in melanoma-associated vitiligo. J Invest Dermatol 117:1464-70 (Pubitemid 34032775)
27. Le Poole I, Van den Wijngaard RM, Westerhof W et al (1996) Presence of T cells and macrophages in inflammatory vitiligo skin parallels melanocyte disappearance. Am J Pathol 148:1219-28 (Pubitemid 26108257)
28. Li Y, Yee C (2008) IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes. Blood 111:229-35
29. Moretti S, Fabbri P, Baroni G et al (2009) Keratinocyte dysfunction in vitiligo epidermis: Cytokine microenvironment and correlation to keratinocyte apoptosis. Histol Histopathol 24:849-57
30. Moretti S, Spallanzani A, Amato L et al (2002) New insights into the pathogenesis of vitiligo: Imbalance of epidermal cytokines at sites of lesions. Pigment Cell Res 15:87-92 (Pubitemid 34536320)
31. Nurieva R, Yang XO, Martinez G et al (2007) Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448:480-3 (Pubitemid 47123514)
32. Schallreuter KU, Moore J, Wood JM et al (1999) In vivo and in vitro evidence for hydrogen peroxide (H2O2) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase. J Investig Dermatol Symp Proc 4:91-6 (Pubitemid 29491263)
33. Seyedalinaghi SA, Karami N, Hajiabdolbaghi M et al (2009) Vitiligo in a patient associated with human immunodeficiency virus infection and repigmentation under antiretroviral therapy. J Eur Acad Dermatol Venereol 23:840-1
34. Shi CS, Kehrl JH (2010) TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy. Sci Signal 3:ra42
35. Shi F, Plumlee BL, Erf GF (2009) Autoinflammatory/autoimmune vitiligo in Smyth line chickens: Immune system-and melanocyte-related activities in feathers and in feather melanocytes isolated by laser capture microdissection. Pigment Cell Melanoma Res 22:495-516 (abstract)
36. Shibata Y, Foster LA, Kurimoto M et al (1998) Immunoregulatory roles of IL-10 in innate immunity: IL-10 inhibits macrophage production of IFN-g-inducing factors but enhances NK cell production of IFN-g. J Immunol 161:4283-8 (Pubitemid 28469012)
37. Shresta S, Smyth JR Jr, Erf GF (1997) Profiles of pulp infiltrating lymphocytes at various times throughout feather regeneration in Smyth line chickens with vitiligo. Autoimmunity 25:193-201 (Pubitemid 27445330)
38. Smyth JR Jr (1989) The Smyth chicken: A model for autoimmune amelanosis. Poult Biol 2:1-19
39. Son YM, Kwak CW, Lee YJ et al (2010) Ginsenoside Re enhances survival of human CD4+ T cells through regulation of autophagy. Int Immunopharmacol 10:626-31
40. Spolski R, Kim HP, Zhu W et al (2009) IL-21 mediates suppressive effects via its induction of IL-10. J Immunol 182:2859-67
41. Spritz R (2010) Shared genetic relationships underlying generalized vitiligo and autoimmune thyroid disease. Thyroid 20:745-54
42. Tilg H, van MC, van den EA et al (2002) Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon gamma. Gut 50:191-5 (Pubitemid 34087930)
43. Tsuboi H, Yonemoto K, Katsuoka K (2006) Vitiligo with inflammatory raised borders with hepatitis C virus infection. J Dermatol 33:577-8 (Pubitemid 44154800)
44. Wang X (2001) The Role of Cell-Mediated Immunity in Smyth Line Autoimmune Vitiligo. PhD dissertation, University of Arkansas, Fayetteville, AR
45. Wang X, Erf GF (2003) Melanocyte-specific cell mediated immune response in vitiliginous Smyth line chickens. J Autoimmun 21:149-60 (Pubitemid 36993727)
46. Wang X, Erf GF (2004) Apoptosis in feathers of Smyth line chickens with autoimmune vitiligo. J Autoimmun 22:21-30 (Pubitemid 38050210)
47. Wick G, Andersson L, Hala K et al (2006) Avian models with spontaneous autoimmune diseases. Adv Immunol 92:71-117 (Pubitemid 44834532)
48. Wong ML, Medrano JF (2005) Real-time PCR for mRNA quantitation. Biotechniques 39:75-85
49. Yi JS, Du M, Zajac AJ (2009) A vital role for interleukin-21 in the control of a chronic viral infection. Science 324:1572-6