The antitumor effect of mesenchymal stem cells transduced with a lentiviral vector expressing cytosine deaminase in a rat glioma model

Journal of Cancer Research and Clinical Oncology

Volumn 138, Issue 2, 2012, Pages 347-357

  Fei, Song ^a   Qi, Xing ^a   Kedong, Song ^b   Guangchun, Ji ^a   Jian, Liu ^a   Wei, Qin ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b DALIAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Cytosine deaminase; Gene therapy; Glioma; Lentiviral vector; MSCs

Indexed keywords

CYTOSINE DEAMINASE; LENTIVIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER GROWTH; CELL ENGINEERING; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG EFFICACY; EXPRESSION VECTOR; GENETIC ENGINEERING; GLIOMA; HISTOPATHOLOGY; MESENCHYMAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; RAT; STEM CELL GENE THERAPY; SURVIVAL TIME; TUMOR CELL DESTRUCTION; TUMOR VOLUME;

ANIMALS; APOPTOSIS; BRAIN NEOPLASMS; CELL LINE, TUMOR; CYTOSINE DEAMINASE; FLUCYTOSINE; GENE THERAPY; GENETIC VECTORS; GLIOMA; GREEN FLUORESCENT PROTEINS; LENTIVIRUS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; RATS; RATS, SPRAGUE-DAWLEY; TRANSDUCTION, GENETIC;

EID: 84857055800     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-011-1104-z     Document Type: Article

References (27)

1. Aboody KS, Brown A, Rainov NG et al (2000) Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci USA 97: 12846-12851
2. Aboody KS, Najbauer J, Schmidt NO et al (2006) Targeting of melanoma brain metastases using engineered neural stem/ progenitor cells. Neuro Oncol 8: 119-126 (Pubitemid 46542656)
3. Aboody KS, Najbauer J, Danks MK (2008) Stem and progenitor cellmediated tumor selective gene therapy. Gene Ther 15(10): 739-752 (Pubitemid 351627357)
4. Amano S, Li S, Gu C et al (2009) Use of genetically engineered bone marrow-derived mesenchymal stem cells for glioma gene therapy. Int J Oncol 35(6): 1265-1270
5. Aoki T (2005) Chemoradiotherapies for malignant gliomas. Nippon Rinsho 63(Suppl 9): 472-477
6. Barresi V, Belluardo N, Sipione S et al (2003) Transplantation of prodrug-converting neural progenitor cells for brain tumor therapy. Cancer Gene Ther 10(5): 396-402 (Pubitemid 36528783)
7. Benedetti S, Pirola B, Pollo B et al (2000) Gene therapy of experimental brain tumors using neural progenitor cells. Nat Med 6: 447-450 (Pubitemid 30208163)
8. Connolly JB (2002) Lentiviruses in gene therapy clinical research. Gene Ther 9: 1730-1734
9. Danks MK, Yoon KJ, Bush RA et al (2007) Tumor-targeted enzyme/ prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma. Cancer Res 67(1): 22-25 (Pubitemid 46142755)
10. Davis FG, McCarthy BJ, Berger MS (1999) Centralized databases available for describing primary brain tumor incidence, survival, and treatment: central brain tumor registry of the United States; surveillance, epidemiology, and end results; and national cancer data base. Neuro-Oncol 1(3): 205-211
11. Ehtesham M, Kabos P, Gutierrez MA et al (2002a) Induction of glioblastoma apoptosis using neural stem cell-mediated delivery of tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res 62(24): 7170-7174 (Pubitemid 36025232)
12. Ehtesham M, Kabos P, Kabosova A et al (2002b) The use of interleukin 12-secreting neural stem cells for the treatment of intracranial glioma. Cancer Res 62(20): 5657-5663 (Pubitemid 35204717)
13. Geraerts M, Eggermont K, Hernandez-Acosta P et al (2006) Lentiviral vectors mediate efficient and stable gene transfer in adult neural stem cells in vivo. Hum Gene Ther 17(6): 635-650 (Pubitemid 43967867)
14. Herrlinger U, Woiciechowski C, Sena-Esteves M et al (2000) Neural precursor cells for delivery of replication-conditional HSV-1 vectors to intracerebral gliomas. Mol Ther 1: 347-357
15. Huber BE, Austin EA, Richards CA et al (1994) Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. Proc Natl Acad Sci USA 91: 8302-8306
16. Huszthy PC, Giroglou T, Tsinkalovsky O et al (2009) Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy. PLoS One 4(7): e6314
17. Inada T, Ichikawa A, Kubota T et al (1997) 5-FU-induced apoptosis correlates with efficacy against human gastric and colon cancer xenografts in nude mice. Anticancer Res 17(3C): 1965-1971 (Pubitemid 27322311)
18. Kim SK, Kim SU, Park IH et al (2006) Human neural stem cells target experimental intracranial medulloblastoma and deliver a therapeutic gene leading to tumor regression. Clin Cancer Res 12: 5550-5556 (Pubitemid 44497273)
19. Lee DH, Ahn Y, Kim SU et al (2009) Targeting rat brainstem glioma using human neural stem cells and human mesenchymal stem cells. Clin Cancer Res 15(15): 4925-4934
20. Li S, Gao Y, Tokuyama T et al (2007) Genetically engineered neural stem cells migrate and suppress glioma cell growth at distant intracranial sites. Cancer Lett 251(2): 220-227 (Pubitemid 46669798)
21. Lv SQ, Zhang KB, Zhang EE et al (2009) Antitumor efficiency of the cytosine deaminase/5-fluorocytosine suicide gene therapy system on malignant gliomas: an in vivo study. Med Sci Monit 15(1): BR13-BR20
22. Miletic H, Fischer Y, Litwak S et al (2007) Bystander killing of malignant glioma by bone marrow-derived tumor-infiltratingprogenitor cells expressing a suicide gene. Mol Ther 15(7): 1373-1381 (Pubitemid 46965333)
23. Mitchell P, Ellison DW, Mendelow AD (2005) Surgery for malignant gliomas: mechanistic reasoning and slippery statistics. Lancet Neurol 4(7): 413-422 (Pubitemid 40834272)
24. Nakamura K, Ito Y, Kawano Y et al (2004) Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model. Gene Ther 11(14): 1155-1164 (Pubitemid 39117311)
25. Shimato S, Natsume A, Takeuchi H et al (2007) Human neural stem cells target and deliver therapeutic gene to experimental leptomeningeal medulloblastoma. Gene Ther 14: 1132-1142 (Pubitemid 47086743)
26. Song F, Xing Q, Ji GC et al (2009) Transfection of mouse bonemarrow mesenchymal stem cells with Lipofectamine-mediated cytosine deaminase genes. J Clin Rehab Tissue Eng Res 13(49): 9775-9778
27. Tsao MN, Mehta MP, Whelan TJ et al (2005) The American society for therapeutic radiology and oncology (ASTRO) evidencebased review of the role of radiosurgery for malignant glioma. Int J Radiat Oncol Biol Phys 63(1): 47-55 (Pubitemid 41583541)