Pharmacogenomics of antidepressant induced mania: A review and meta-analysis of the serotonin transporter gene (5HTTLPR) association

Journal of Affective Disorders

Volumn 136, Issue 1-2, 2012, Pages

  Biernacka, Joanna M ^a   McElroy, Susan L ^b,c,d   Crow, Scott ^e   Sharp, Alexis ^a   Benitez, Joachim ^f   Veldic, Marin ^a   Kung, Simon ^a   Cunningham, Julie M ^a   Post, Robert M ^d   Mrazek, David ^a   Frye, Mark A ^a,d  

^a MAYO CLINIC   (United States)

^b HOPE   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d Bipolar Collaborative Network   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

^f ALBERT LEA EYE CLINIC   (United States)

Author keywords

Antidepressant; Bipolar disorder; Pharmacogenomics; SLC6A4

Indexed keywords

ANTIDEPRESSANT AGENT; SEROTONIN TRANSPORTER;

BIPOLAR DISORDER; CASE CONTROL STUDY; DEPRESSION; DISEASE ASSOCIATION; DRUG INDUCED DISEASE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MANIA; META ANALYSIS; PHARMACOGENOMICS; PRIORITY JOURNAL; PROMOTER REGION; PSYCHOPHARMACOTHERAPY; REVIEW;

ADULT; ANTIDEPRESSIVE AGENTS; BIPOLAR DISORDER; DEPRESSION; FEMALE; HUMANS; MALE; PHARMACOGENETICS; POLYMORPHISM, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; YOUNG ADULT;

EID: 84857055178     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2011.05.038     Document Type: Review

References (56)

1. L. Altshuler, T. Suppes, D. Black, W. Nolen, G. Leverich, and P.J. Keck Lower switch rate in depressed patients with bipolar II than bipolar I disorder treated adjunctively with second-generation antidepressants Am. J. Psychiatry 2006 313 315 (Pubitemid 44480853)
2. R.J. Baldessarini, L. Leahy, S. Arcona, D. Gause, W. Zhang, and J. Hennen Patterns of psychotropic drug prescription for U.S. patients with diagnoses of bipolar disorders Psychiatr. Serv. 58 2007 85 91
3. F. Baumer, M. Howe, K. Gallelli, D. Simeonova, J. Hallmayer, and K. Chang A pilot study of antidepressant-induced mania in pediatric bipolar disorder: characteristics, risk factors, and the serotonin transporter gene Biol. Psychiatry 2006 1005 1012 (Pubitemid 44584215)
4. D.J. Bond, M.M. Noronha, M. Kauer-Sant'Anna, R.W. Lam, and L.N. Yatham Antidepressant-associated mood elevations in bipolar II disorder compared with bipolar I disorder and major depressive disorder: a systematic review and meta-analysis J. Clin. Psychiatry 69 2008 1589 1601
5. J.R. Calabrese, P.E.J. Keck, W. Macfadden, M. Minkwitz, T.A. Ketter, R.H. Weisler, A.J. Cutler, R. McCoy, E. Wilson, and J. Mullen A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depression Am. J. Psychiatry 162 2005 1351 1360 (Pubitemid 40905587)
6. A. de Aguiar Ferreira, F.S. Neves, F.F. da Rocha, G.S. Silva, M.A. Romano-Silva, D.M. Miranda, L. De Marco, and H. Correa The role of 5-HTTLPR polymorphism in antidepressant-associated mania in bipolar disorder J. Affect. Disord. 112 2009 267 272
7. V. De Luca, E. Mundo, J. Trakalo, G.W.H. Wong, and J.L. Kennedy Investigation of polymorphism in the MDR1 gene and antidepressant-induced mania Pharmacogenomics J. 3 2003 297 299 (Pubitemid 37428194)
8. R. DerSimonian, and N. Laird Meta-analysis in clinical trials Control. Clin. Trials 7 1986 177 188 (Pubitemid 17189972)
9. R.P. Ebstein The molecular genetic architecture of human personality: beyond self-report questionnaires Mol. Psychiatry 11 2006 427 445
10. M.A. Frye, M.J. Gitlin, and L.L. Altshuler Unmet needs in bipolar depression Depress. Anxiety 19 2004 199 208 (Pubitemid 39014139)
11. M.A. Frye, L.N. Yatham, J. Calabrese, C. Bowden, and T.A. Ketter The incidence and time course of subsyndromal symptoms in patients with bipolar I disorder: an evaluation of 2 placebo-controlled maintenance trials J. Clin. Psychiatry 67 2006 1721 1728 (Pubitemid 44955152)
12. M.A. Frye, H. Grunze, T. Suppes, S.L. McElroy, P.E. Keck Jr.; J. Walden, G.S. Leverich, L.L. Altshuler, S. Nakelsky, S. Hwang, J. Mintz, and R.M. Post A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression Am. J. Psychiatry 164 2007 1242 1249 (Pubitemid 47292414)
13. M.A. Frye, G. Helleman, S.L. McElroy, L.L. Altshuler, D.O. Black, P.E. Keck Jr.; W.A. Nolen, R. Kupka, G.S. Leverich, H. Grunze, J. Mintz, R.M. Post, and T. Suppes Correlates of treatment-emergent mania associated with antidepressant treatment in bipolar depression Am. J. Psychiatry 166 2009 164 172
14. H.A. Garriock, J.B. Kraft, S.I. Shyn, E.J. Peters, J.S. Yokoyama, G.D. Jenkins, M.S. Reinalda, S.L. Slager, P.J. McGrath, and S.P. Hamilton A genomewide association study of citalopram response in major depressive disorder Biol. Psychiatry 67 2009 133 138
15. H.J. Gijsman, J.R. Geddes, J.M. Rendell, W.A. Nolen, and G. Goodwin Antidepressants for bipolar depression: a systematic review of randomized, controlled trials Am. J. Psychiatry 161 2004 1537 1547 (Pubitemid 39201448)
16. J. Goldberg, and J. Whiteside The association between substance abuse and antidepressant-induced mania in bipolar disorder: a preliminary study J. Clin. Psychiatry 2002 791 795
17. F.K. Goodwin, and K.R. Jamison Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression 2007 Oxford University Press, Inc New York
18. S. Horstmann, and E.B. Binder Pharmacogenomics of antidepressant drugs Pharmacol. Ther. 124 2009 57 73
19. X. Hu, G. Oroszi, J. Chun, T.L. Smith, D. Goldman, and M.A. Schuckit An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk Alcohol. Clin. Exp. Res. 29 2005 8 16 (Pubitemid 40129206)
20. M. Ising, S. Lucae, E.B. Binder, T. Bettecken, M. Uhr, S. Ripke, M.A. Kohli, J.M. Hennings, S. Horstmann, S. Kloiber, A. Menke, B. Bondy, R. Rupprecht, K. Domschke, B.T. Baune, V. Arolt, A.J. Rush, F. Holsboer, and B. Muller-Myhsok A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression Arch. Gen. Psychiatry 66 2009 966 975
21. L.L. Judd, H.S. Akiskal, P.J. Schettler, J. Endicott, J. Maser, D.A. Solomon, A.C. Leon, J.A. Rice, and M.B. Keller The long-term natural history of the weekly symptomatic status of bipolar I disorder Arch. Gen. Psychiatry 59 2002 530 537 (Pubitemid 34602935)
22. M. Kato, and A. Serretti Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder Mol. Psychiatry 15 2010 473 500
23. T. Ketter Switch Rate in Bipolar Disorder T. Ketter, International Conference in Bipolar Disorders, Pittsburgh, PA 2005
24. E. Kraepelin Manic-Depressive Insanity and Paranoia 1921 Ayer Company, Publishers, Inc. Salem, New Hampshire
25. K.P. Lesch, D. Bengel, A. Heils, S.Z. Sabol, B.D. Greenberg, S. Petri, J. Benjamin, C.R. Muller, D.H. Hamer, and D.L. Murphy Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region Science 274 1996 1527 1531 (Pubitemid 26403928)
26. D.C. Lott, S.J. Kim, E.H. Cook, and H. de Wit Serotonin transporter genotype and acute subjective response to amphetamine Am. J. Addict. 15 2006 327 335 (Pubitemid 44373578)
27. E.A. Lovejoy, A.C. Scott, C.E. Fiskerstrand, V.J. Bubb, and J.P. Quinn The serotonin transporter intronic VNTR enhancer correlated with a predisposition to affective disorders has distinct regulatory elements within the domain based on the primary DNA sequence of the repeat unit Eur. J. Neurosci. 17 2003 417 420 (Pubitemid 36459521)
28. N.S. Luddington, A. Mandadapu, M. Husk, and R.S. El-Mallakh Clinical implications of genetic variation in the serotonin transporter promoter region: a review Prim. Care Companion J. Clin. Psychiatry 11 2009 93 102
29. L. Mandelli, E. Marino, A. Pirovano, R. Calati, R. Zanardi, C. Colombo, and A. Serretti Interaction between SERTPR and stressful life events on response to antidepressant treatment Eur. Neuropsychopharmacol. 19 2009 64 67
30. L. Mandelli, M. Mazza, G. Martinotti, M. Di Nicola, D. Tavian, E. Colombo, S. Missaglia, D. De Ronchi, R. Colombo, L. Janiri, and A. Serretti Harm avoidance moderates the influence of serotonin transporter gene variants on treatment outcome in bipolar patients J. Affect. Disord. 119 2009 205 209
31. S. Manwani, T. Pardo, M. Albanese, B. Zablotsky, F. Goodwin, and S. Ghaemi Substance use disorder and other predictors of antidepressant-induced mania: a retrospective chart review J. Clin. Psychiatry 2006 1341 1345 (Pubitemid 44583380)
32. A. Martin, C. Young, J.F. Leckman, C. Mukonoweshuro, R. Rosenheck, and D. Leslie Age effects on antidepressant-induced manic conversion Arch. Pediatr. Adolesc. Med. 158 2004 773 780 (Pubitemid 39025076)
33. E. Masoliver, A. Menoyo, V. Perez, V. Volpini, E. Rio, and J. Perez Serotonin transporter linked promoter (polymorphism) in the serotonin transporter gene may be associated with antidepressant-induced mania in bipolar disorder Psychiatr. Genet. 2006 25 29 (Pubitemid 44481216)
34. S.L. McElroy, R. Kotwal, R. Kaneria, and P.E. Keck Jr. Antidepressants and suicidal behavior in bipolar disorder Bipolar Disord. 8 2006 596 617 (Pubitemid 44567142)
35. S.L. McElroy, R.H. Weisler, W. Chang, B. Olausson, B. Paulsson, M. Brecher, V. Agambaram, C. Merideth, A. Nordenhem, A.H. Young EMBOLDEN II (Trial D1447C00134) Investigators A double-blind, placebo-controlled study of quetiapine and paroxetine as monotherapy in adults with bipolar depression (EMBOLDEN II) J. Clin. Psychiatry 71 2010 163 174
36. C. Moreno, G. Laje, C. Blanco, H. Jiang, A.B. Schmidt, and M. Olfson National trends in the outpatient diagnosis and treatment of bipolar disorder in youth Arch. Gen. Psychiatry 64 2007 1032 1039 (Pubitemid 47360848)
37. D.A. Mrazek, A.J. Rush, J.M. Biernacka, D.J. O'Kane, J.M. Cunningham, E.D. Wieben, D.J. Schaid, M.S. Drews, V.L. Courson, K.A. Snyder, J.L. Black III, and R.M. Weinshilboum SLC6A4 variation and citalopram response Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B 2009 341 351
38. E. Mundo, M. Walker, T. Cate, F. Macciardi, and J. Kennedy The role of serotonin transporter protein gene in antidepressant-induced mania in bipolar disorder: preliminary findings Arch. Gen. Psychiatry 2001 539 544 (Pubitemid 32523733)
39. R.H. Perlis, S. Purcell, M. Fava, J. Fagerness, A.J. Rush, M.H. Trivedi, and J.W. Smoller Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D Study Arch. Gen. Psychiatry 64 2007 689 697 (Pubitemid 46878669)
40. A.L. Price, N.J. Patterson, R.M. Plenge, M.E. Weinblatt, N.A. Shadick, and D. Reich Principal components analysis corrects for stratification in genome-wide association studies Nat. Genet. 38 2006 904 909 (Pubitemid 44141658)
41. C. Quanbeck, M. Frye, and L. Altshuler Mania and the law in California: understanding the criminalization of the mentally ill Am. J. Psychiatry 160 2003 1245 1250 (Pubitemid 41070939)
42. A. Rousseva, C. Henry, D. van den Bulke, G. Fournier, J. Laplanche, and M. Leboyer Antidepressant-induced mania, rapid cycling, and the serotonin transporter gene polymorphism Pharmacogenomics J. 2003 101 104 (Pubitemid 36675710)
43. G.S. Sachs, A.A. Nierenberg, J.R. Calabrese, L.B. Marangell, S.R. Wisniewski, L. Gyulai, E.S. Friedman, C.L. Bowden, M.D. Fossey, M.J. Ostacher, T.A. Ketter, J. Patel, P. Hauser, D. Rapport, J.M. Martinez, M.H. Allen, D.J. Miklowitz, M.W. Otto, E.B. Dennehy, and M.E. Thase Effectiveness of adjunctive antidepressant treatment for bipolar depression N. Engl. J. Med. 356 2007 1711 1722 (Pubitemid 46658703)
44. A. Serretti, P. Artioli, R. Zanardi, C. Lorenzi, D. Rossini, C. Cusin, A. Arnoldi, and M. Catalano Genetic features of antidepressant induced mania and hypo-mania in bipolar disorder Psychopharmacology 174 2004 504 511 (Pubitemid 39119339)
45. A. Serretti, L. Mandelli, C. Lorenzi, S. Landoni, R. Calati, and C. Insacco Temperament and character in mood disorders: influence of DRD4, SERTPR, TPH and MAO-A polymorphisms Neuropsychobiology 2006 9 16 (Pubitemid 43254171)
46. A. Serretti, M. Kato, D. De Ronchi, and T. Kinoshita Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients Mol. Psychiatry 12 2007 247 257 (Pubitemid 46328503)
47. H. Tang, T. Quertermous, B. Rodriguez, S.L.R. Kardia, X. Zhu, A. Brown, J.S. Pankow, M.A. Province, S.C. Hunt, E. Boerwinkle, N.J. Schork, and N.J. Risch Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies Am. J. Hum. Genet. 76 2005 268 275 (Pubitemid 40129553)
48. C. Tian, P.K. Gregersen, and M.F. Seldin Accounting for ancestry: population substructure and genome-wide association studies Hum. Mol. Genet. 17 2008 R143 R150
49. M. Tohen, E. Vieta, J. Calabrese, T.A. Ketter, G. Sachs, C. Bowden, P.B. Mitchell, F. Centorrino, R. Risser, R.W. Baker, A.R. Evans, K. Beymer, S. Dube, G.D. Tollefson, and A. Breier Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression Arch. Gen. Psychiatry 60 2003 1079 1088 (Pubitemid 37429647)
50. L. Tondo, G. Vazquez, and R.J. Baldessarini Mania associated with antidepressant treatment: comprehensive meta-analytic review Acta Psychiatr. Scand. 121 2009 404 414
51. C.J. Truman, J.F. Goldberg, S.N. Ghaemi, C.F. Baldassano, S.R. Wisniewski, E.B. Dennehy, M.E. Thase, and G.S. Sachs Self-reported history of manic/hypomanic switch associated with antidepressant use: data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) J. Clin. Psychiatry 68 2007 1472 1479 (Pubitemid 350073393)
52. H.M. Visser, and R.C. Van Der Mast Bipolar disorder, antidepressants and induction of hypomania or mania. A systematic review World J. Biol. Psychiatry 6 2005 231 241
53. R. Weinshilboum Inheritance and drug response N. Engl. J. Med. 348 2003 529 537 (Pubitemid 36159889)
54. J.R. Wendland, B.J. Martin, M.R. Kruse, K.P. Lesch, and D.L. Murphy Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531 Mol. Psychiatry 11 2006 224 226
55. B.I. Yerevanian, R.J. Koek, J. Mintz, and H.S. Akiskal Bipolar pharmacotherapy and suicidal behavior: Part 2. The impact of antidepressants J. Affect. Disord. 103 2007 13 21 (Pubitemid 47445779)
56. G. Zai, E. Mundo, J. Strauss, G.W. Wong, and J.L. Kennedy Brain-derived neurotrophic factor (BDNF) gene not associated with antidepressant-induced mania Bipolar Disord. 9 2007 521 525 (Pubitemid 47202515)