Serotonin transporter linked promoter (polymorphism) in the serotonin transporter gene may be associated with antidepressant-induced mania in bipolar disorder

Psychiatric Genetics

Volumn 16, Issue 1, 2006, Pages 25-29

  Masoliver, Elisabet ^a   Menoyo, Ana ^a   Pérez, Victor ^a   Volpini, Victor ^b   Rio, Elisabet Del ^a   Pérez, Josefina ^a   Alvarez, Enric ^a   Baiget, Monserrat ^a  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^b Hospital de la Santa Creu I Sant Pau ^*

Author keywords

Antidepressant induced mania; Bipolar disorder; Gene; Mania; Serotonin transporter

Indexed keywords

ANTIDEPRESSANT AGENT; LITHIUM; MONOAMINE OXIDASE INHIBITOR; MOOD STABILIZER; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; VENLAFAXINE; PRIMER DNA;

ADULT; ARTICLE; BIPOLAR DISORDER; CONTROLLED STUDY; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MANIA; OUTPATIENT; PREDICTION; PRIORITY JOURNAL; PROMOTER REGION; PSYCHIATRIC DIAGNOSIS; RISK ASSESSMENT; TREATMENT RESPONSE; VARIABLE NUMBER OF TANDEM REPEAT; CASE CONTROL STUDY; CHEMICALLY INDUCED DISORDER; GENETICS; NUCLEOTIDE SEQUENCE;

ANTIDEPRESSIVE AGENTS; BASE SEQUENCE; BIPOLAR DISORDER; CASE-CONTROL STUDIES; DNA PRIMERS; HOMOZYGOTE; HUMANS; LITHIUM; MINISATELLITE REPEATS; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 33646692495     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ypg.0000180684.26288.d7     Document Type: Article

References (20)

1. Bellivier F, Henry C, Szoke A, Schurhoff F, Nosten-Bertrand M, Feingold J, et al. (1998). Serotonin transporter gene polymorphisms in patients with unipolar or bipolar depression. Neurosci Lett 255:143-146.
2. Collier DA, Stober G, Li T, Heils A, Catalano M, Di Bella D, et al. (1996). A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1:453-460.
3. Craddock N, Jones I (2001). Molecular genetics of bipolar disorder. Br J Psychiatry Suppl 41:128-133.
4. Del Zompo M, Ardau R, Palmas MA, Bocchetta A, Reina A, Piccardi MP (1999). Lithium response: association study with two candidate genes. Mol Psychiatry 4:66-67.
5. Esterling LE, Yoshikawa T, Turner G, Badner JA, Bengel D, Gershon ES, et al. (1998). Serotonin transporter (5HTT) gene and bipolar affective disorder. Am J Med Genet 81:37-40.
6. Gelernter J, Pakstis AJ, Kidd KK (1995). Linkage mapping of serotonin transporter protein gene SLC6A4 on chromosome 17. Hum Genet 95:677-680.
7. Goodwin F, Jamison JW (1990). Manic-depressive illness. New York, USA: Oxford University Press.
8. Gutierrez B, Arranz MJ, Collier D, Valles V, Guillamant R, Bertranpetit J, et al. (1998). Serotonin transporter gene and risk for bipolar affective disorder: an association study in a Spanish population. Biol Psychiatry 43:843-847.
9. Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel D, et al. (1996). Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621-2624.
10. Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL, et al. (1994). Organization of the human serotonin transporter gene. J Neural Transm 95:157-162.
11. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Patri S, et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1530.
12. Lotrich FE, Pollock BG, Ferrell RE (2003). Polymorphism of the serotonin transporter. Implications for the use of selective serotonin reuptake inhibitors. Am J Pharmacogenomics 1:153-164.
13. McGuffin P, Rijsdijk F, Andrew M, Sham P, Katz R, Cardno A (2003). The heritability of bipolar affective disorder and the genetic relationship to unipolar depression. Arch Gen Psychiatry 60:497-502.
14. Mendlewicz J, Massat I, Souer D, Del-Favero J, Oruc L, Nothen MM, et al. (2004). Serotonin transporter 5HTTLPR polymorphism and affective disorders: no evidence of association in a large European multicenter study. Eur J Hum Genet 12:377-382.
15. Miller SA, Dykes DD, Polesky MF (1988). A simple salting out procedure for extracting DNA from human nucleated cells. Nucl Acids Res 16:1215.
16. Mundo M, Walker M, Cate Tasha, Macciardi F, Kennedy JL (2001). The role of serotonin transporter gene in antidepressant-induced mania in bipolar disorders. Arch Gen Psychiatry 58:539-544.
17. Rousseva A, Henry C, van den Bulke D, Fournier G, Laplanche JL, Leboyer M, et al. (2003). Antidepressant-induced mania, rapid cycling and the serotonin transporter gene polymorphism. Pharmacogenom J 3:101-104.
18. Serretti A, Lilli R, Mandelli L, Lorenzi C, Smeraldi E (2001). Serotonin transporter gene associated with lithium prophylaxis in mood disorders. Pharmacogenom J 1:71-77.
19. Serretti A, Artioli P, Zanardi R, Lorenzi C, Rossini D, Cusin C, et al. (2004a). Genetic features of antidepressant induced mania and hypomania in bipolar disorder. Psychopharmacology [published online: 10 July 2004].
20. Serretti A, Malitas PN, Mandelli L, Lorenzi C, Ploia C, Alevizos B, et al. (2004b). Further evidence for a possible association between serotonin transporter gene and lithium prophylaxis in mood disorders. Pharmacogenom J 4:267-273.