Mechanistic Determinants and Modeling of the Inhalation Pharmacokinetics of Volatile Organic Chemicals

Inhalation Toxicology: Second Edition

Volumn , Issue , 2005, Pages 439-456

  Nong, Andy ^a   Krishnan, Kannan ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84857047760     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/9781420037302-24     Document Type: Chapter

References (64)

1. Andersen, M.E., Development of physiologically based pharmacokinetic and physiologically based pharmacodynamic models for applications in toxicology and risk assessment, Toxicol. Lett., 79, 35-44, 1995.
2. Andersen, M.E., Toxicokinetic modeling and its applications in chemical risk assessment, Toxicol. Lett., 138, 9-27, 2003.
3. Andersen, M.E., Clewell, H.J., Gargas, M.L., MacNaughton, M.G., Reitz, R.H., Nolan, R.J., and McKenna, M.J., Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans, Toxicol. Appl. Pharmacol., 108, 14-27, 1991.
4. Andersen, M.E., Clewell, H.J. I., Gargas, M.L., Smith, F.A., and Reitz, R.H., Physiologically-based pharmacokinetics and risk assessment process for methylene chloride, Toxicol. Appl. Pharmacol., 87, 185-205, 1987.
5. Andersen, M.E. and Dennison, J.E., Mode of action and tissue dosimetry in current and future risk assessments, Sci. Tot. Environ., 274, 3-14, 2001.
6. Andersen, M.E. Gargas, M.L., Jones, R.A., and Jenkins, L.J., Determination of the kinetic constants for metabolism of inhaled toxicants in vivo by gas uptake measurements, Toxicol. Appl. Pharmacol., 54, 116, 1980.
7. Arms, A.D. and Travis, C.C., Reference Physiological Parameters in Pharmacokinetic Modeling. Office of Health and Environmental Assessment, EPA, EPA/600/6-88/004, 1-1-7.16, US Environmental Protection Agency, Washington, DC, 1988.
8. Basak, S.C., Mills, D., Hawkins, D.M., and El-Marsi, H.A., Prediction of tissue-air partition coefficients:A comparison of structure-based and property-based methods, SAR QSAR Environ. Res., 13, 649-665, 2002.
9. Beliveau, M., Lipscomb, J., Tardif, R., and Krishnan, K., Quantitative structure-property relationships for interspecies extrapolation of the inhalation pharmacokinetics of organic chemicals, Chem. Res. Toxicol., 18, 475-85, 2005.
10. Beliveau, M., Tardif, R., and Krishnan, K., Quantitative structure-property relationships for physiologically based pharmacokinetic modeling of volatile organic chemicals in rats. J. Toxicol. Appl. Pharmacology., 189, 221-232, 2003.
11. Brown, R.P., Delp, M.D., Lindstedt, S.L., Rhomberg, L.R., and Beliles, R.P., Physiological parameter values for physiologically based pharmacokinetic models, Toxicol. Ind. Health, 13, 407-484, 1997.
12. Caster, W.O., Poncelet, J., Simon, A.B., and Armstrong, W.B., Tissue weights of the rat. I. Normal values determined by dissection and chemical methods, Proc. Soc. Exp. Biol. Med., 91, 122-126, 1956.
13. Clewell, H.J. and Andersen, M.E., Dose species and route extrapolations using physiologically-based pharmacokinetic modeling, Drinking Water and Health, 8, 159-184, 1987.
14. Clewell, H.J. and Andersen, M.E., Physiologically-based pharmacokinetic modeling and bioactivation of xenobiotics, Toxicol. Ind. Health, 10, 1-24, 1994.
15. Clewell, H.J., Andersen, M.E., and Barton, H.A., A consistent approach for the application of pharmacokinetic modeling in cancer and noncancer risk assessment, Environ. Health Perspect., 110, 85-93, 2002.
16. D’Souza, R.W., Francis, W.R., and Andersen, M.W., Physiological model for tissue glutathione depletion and increased resynthesis after ethylene dichloride exposures, J. Pharmacol. Exp. Ther., 245, 563-568, 1988.
17. Dallas, C.E., Muralidhara, S., Chen, X.M., Ramanthan, R., Varkonyl, P., Gallo, J M., and Bruckner, J.V., Use of a physiologically based model to predict systemic uptake and respiratory elimination of perchloroethylene, Toxicol. Appl. Pharmacol., 128, 60-68, 1994.
18. Davies, B. and Morris, T., Physiological parameters in laboratory animals and humans, Pharm. Res., 10, 1093-1095, 1993.
19. DeJongh, J. and Blaauboer, B.J., Evaluation of in vitro-based simulations of toluene uptake and metabolism in rats, Toxicol. in Vitro, 11, 485-489, 1997.
20. Dennison, J.E., Andersen, M.E., and Yang, R.S., Pitfalls and related improvements of in vivo gas uptake pharmacokinetic experimental systems, Inhal. Toxicol., 17, 539-48, 2005.
21. Dedrick, R.L., Forrester, D.D., and Ho, D.H.W., In vitro-in vivo correlation of drug metabolism: Deamination of 1-β-D-arabinosyl cytosine, Biochem. Pharmacol., 21, 1-16, 1972.
22. Dedrick, R.L., Zaharko, D.S., and Lutz, R.J. Transport and binding of methotrexate in vivo, J. Pharm. Sci., 62, 882-890, 1973.
23. Delp, M.D., Manning, R.O., Bruckner, J.V., and Armstrong, R.B., Distribution of cardiac output during diurnal changes in activity in rats, Am. J. Physiol., 261, H1487-1493, 1991.
24. Easterling, M.R., Evans, M.V., and Kenyon, E.M., Comparative analysis of software for physiologically based pharmacokinetic modeling: simulation, optimization, and sensitivity analysis, Toxicol. Meth., 10, 203-229, 2000.
25. Filser, J.G. and Bolt, H.M., Inhalation pharmacokinetics based on gas uptake studies. I. Improvement of kinetic models, Arch. Toxicol., 47, 279-292, 1981.
26. Filser, J.G., Csanady, G.A., Kreuzer, P.E., and Kessler, W., Toxicokinetic models for volatile industrial chemicals and reactive metabolites, Toxicol. Lett., 82/83, 357-366, 1995.
27. Fiserova-Bergerova, V., Modeling of inhalation exopsure to vapors: uptake, distribution and elimination, Vol. 1, CRC Press Inc., Boca Raton, FL, pp.73-100, 1983.
28. Fiserova-Bergerova, V., Extrapolation of physiological parameters for physiologically based simulation models, Toxicol. Lett., 79, 77-86, 1995.
29. Fiserova-Bergerova, V. and Diaz, M.L., Determination and prediction of tissue-gas partition coefficients. Int Arch Occup Environ Health 58, 75-87, 1986.
30. Gargas, M.L., An exhaled breath chamber system for assessing rates of metabolism and rates of gastrointestinal absorption with volatile chemicals, J. Am. Coll. Toxicol., 9, 447-453, 1990.
31. Gargas, M.L. and Andersen, M.E., Determinating the kinetic constants of chlorinated ethane metabolism in the rat from rates of exhalation, Toxicol. Appl. Pharmacol., 99, 344-353, 1989.
32. Gargas, M.L., Andersen, M.E., and Clewell, H.J., A physiologically-based simulation approach for determining metabolic rate constants from gas uptake data, Toxicol. Appl. Pharmacol., 86, 341-352, 1986.
33. Gargas, M.L., Burgess, R.J, Voisard, D.E, Cason, G.H, and Andersen, M.E., Partition coefficients of low molecular weight volatile chemicals in various liquids and tissues, Toxicol. Appl. Pharmacol., 98, 87-99, 1989.
34. Gargas, M.L., Clewell, H.J., and Andersen, M.E., Gas uptake inhalation techniques and the rates of metabolism of chloromethanes, chloroethanes and chloroethylenes in the rat, Inhal. Toxicol., 2, 319, 1990.
35. Gehring, P.J., Watanabe, P.G., Park, C.N., Resolution of dose-response toxicity data for chemicals requiring metabolic activation: example-vinyl chloride,. Toxicol Appl Pharmacol., 44, 581-91, 1978.
36. International Commission on Radiation Protection (ICRP), International Commission on Radiation Protection:Report of the task group on reference man. Pergamon Press, New York, 1975.
37. Johanson, G., Modelling of respiratory exchange of polar solvents, Ann. Occup. Hyg., 35, 323-339, 1991.
38. Johanson, G. and Dynesius, B., Liquid: air partition coefficients for six commonly used glycol ethers, Br. J. Ind. Med., 45, 561-564, 1988.
39. Johanson, G. and Filser, J.G., Experimental data from closed chamber gas uptake studies in rodents suggest lower uptake rate of chemical than calculated from literature values on alveolar ventilation, Arch. Toxicol., 66, 291-295, 1992.
40. Johanson, G. and Naslund, P.H., Spreadsheet programming: A new approach in physiologically based modeling of solvent toxicokinetics, Toxicol. Lett., 41, 115-127, 1988.
41. Krishnan, K. and Andersen, M.E. Physiologically based pharmacokinetic modeling in toxicology. In Principles and methods of toxicology (A.W. Hayes, Ed.), Taylor and Francis, Philadelphia, PA, pp. 193-241, 2001.
42. Krishnan, K., Gargas, M.L., Fennell, T.R., and Andersen, M E., A physiologically-based description of ethylene oxide dosimetry in the rat, Toxicol. Ind. Health, 8, 121-140, 1992.
43. Leung, H.W. and Paustenbach, D.J., Physiologically based pharmacokinetic and pharmacodynamic modeling in health risk assessment and characterization of hazardous substances, Toxicol. Lett., 79, 55-65, 1995.
44. Lipscomb, J.C., Fisher, J.W., Confer, P.D., and Byczkowski, J.Z., In vitro to in vivo extrapolation for trichloroethylene metabolism in humans, Toxicol. Appl. Pharmacol., 152, 376-387, 1998.
45. Lipscomb, J.C., Teuschler, L.K., Swartout, J., Popken, D., Cox, T., and Kedderis, G.L., The impact of cytochrome P450 2E1-dependent metabolic variance on a risk-relevant pharmacokinetic outcome in humans, Risk Anal., 6, 1221-1238, 2003.
46. Mauderly, J.L., Measurement of respiration and respiratory responses during inhalation exposures, J. Am. Coll. Toxicol., 9, 397-406, 1990.
47. Medinsky, M.A., The application of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling to understanding the mechanism of action of hazardous substances, Toxicol. Lett., 79, 185-191, 1995.
48. Menzel, D.B., Wolpert, R.L., Boger, J.R., and Kootsey, J.M., Resources available for simulation in toxicology:specialized computers, generalized software and communication networks, Drinking Water and Health, 8, 229-254, 1987.
49. Payne, M.P. and Kenny, L.C., Comparison of models for the estimation of biological partition coefficients, J. Toxicol. Environ. Health A. 65, 897-931, 2002.
50. Poulin, P. and Krishnan, K., A biologically-based algorithm for predicting human tissue: blood partition coefficients of organic chemicals, Hum. Exp. Toxicol., 14, 273-280, 1995.
51. Poulin, P. and Krishnan, K., A tissue composition-based algorithm for predicting tissue: air partition coeffi-cients of organic chemicals, Toxicol. Appl. Pharmacol., 136, 126-130, 1996a.
52. Poulin, P. and Krishnan, K., A mechanistic algorithm for predicting blood: air partition coefficients of organic chemicals with the consideration of reversible binding in hemoglobin, Toxicol. Appl. Pharmacol., 136, 131-137, 1996b.
53. Poulin, P. and Krishnan, K., Molecular structure based prediction of the partition coefficients of organic chemicals for physiological pharmacokinetic models, Toxicol. Methods., 6, 117-137, 1996c.
54. Poulin, P. and Krishnan, K., A quantitative structure-toxicokinetic relationship model for highly metabolised chemicals, Altern. Lab. Anim., 26, 45-59, 1998.
55. Poulin, P. and Krishnan, K., Molecular structure-based prediction of the toxicokinetics of inhaled vapors in humans, Int. J. Toxicol., 18, 7-18, 1999.
56. Ramsey, J.C. and Andersen, M.E., A physiologically-based description of the inhalation pharmacokinetics of styrene in rats and humans, Toxicol. Appl. Pharmacol., 73, 159-175, 1984.
57. Reddy, M., Yang, R.S., Andersen, M.E., and Clewell, H.J., Physiological based pharmacokinetic modeling:science and applications, John Wiley and Sons, Inc., Hoboken, NJ, 2005.
58. Reitz, R.H., Gargas, M.L., Mendrala, A.L., and Schumann, A.M., In vivo and in vitro studies of perchloroethylene metabolism for physiologically based pharmacokinetic modeling in rats, mice, and humans, Toxicol. Appl. Pharmacol., 136, 289-306, 1996.
59. Tardif, R., Lapare, S., Krishnan, K. and Brodeur J., Physiologically based modeling of the toxicokinetic interaction between toluene and m-xylene in the rat, Toxicol. Appl. Pharmacol., 120, 266-73, 1993.
60. Tardif, R., Lapare, S., Charest-Tardif, G., Brodeur, J., and Krishnan, K., Physiologically-based pharmacokinetic modeling of a mixture of toluene and xylene in humans, Risk Anal. 15, 335-342, 1995.
61. Tardif, R., Charest-Tardif, G., Brodeur, J., and Krishnan, K., Physiologically based pharmacokinetic modeling of a ternary mixture of alkyl benzenes in rats and humans, Toxicol. Appl. Pharmacol., 144, 120-134, 1997.
62. Sato, A. and Nakajima, T., A vial equilibration method to evaluate the drug metabolizing enzyme activity for volatile hydrocarbons, Toxicol. Appl. Pharmacol., 47, 41-46, 1979.
63. Sato, A. and Nakajima, T., Partition coefficients of some aromatic hydrocarbons and ketones in water, blood and oil, Br. J. Ind. Med., 36, 231-234, 1979.
64. Wagner J.G., Fundamentals of Clinical Pharmacokinetics, Drug International. Hamilton, IL, 1975.