메뉴 건너뛰기




Volumn 64, Issue 3, 2012, Pages 233-237

Protective effect of a cysteine prodrug and antioxidant, L-2-oxothiazolidine-4-carboxylate, against ethanol-induced gastric lesions in rats

Author keywords

Anitoxidant; Cysteine precursor; Gastric secretion; Gastric ulcer; Glutathione; Myeloperoxidase; Sulfhydryls

Indexed keywords

2 OXO 4 THIAZOLIDINECARBOXYLIC ACID; ANTIOXIDANT; MYELOPEROXIDASE; PRODRUG; THIOL DERIVATIVE;

EID: 84857033752     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2010.08.012     Document Type: Article
Times cited : (17)

References (60)
  • 1
    • 34548629477 scopus 로고    scopus 로고
    • The ameliorative effect of cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid on cisplatin-induced nephrotoxicity in rats
    • Ali B.H., Al Moundhri M.S., Tag Eldin M., Nemmar A., Tanira M.O. The ameliorative effect of cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid on cisplatin-induced nephrotoxicity in rats. Fundam Clin Pharmacol 2007, 21:547-553.
    • (2007) Fundam Clin Pharmacol , vol.21 , pp. 547-553
    • Ali, B.H.1    Al Moundhri, M.S.2    Tag Eldin, M.3    Nemmar, A.4    Tanira, M.O.5
  • 3
    • 0023267763 scopus 로고
    • The gastric mucosal epithelia barrier: role of mucus and fibrin
    • Allen A., Sellers L.A., Bennett M.K. The gastric mucosal epithelia barrier: role of mucus and fibrin. Scand J Gastroenterol 1987, 22:6-13.
    • (1987) Scand J Gastroenterol , vol.22 , pp. 6-13
    • Allen, A.1    Sellers, L.A.2    Bennett, M.K.3
  • 4
    • 0021931148 scopus 로고
    • Properties of gastric and duodenal musus: effect of proteolysis disulfide reduction, bile, acid, ethanol and hypertonicity on mucus gel structure
    • Bell A.E., Sellers L.A., Allen A., Cunliffe W.J., Morris E.R., Ross Murphy S.B. Properties of gastric and duodenal musus: effect of proteolysis disulfide reduction, bile, acid, ethanol and hypertonicity on mucus gel structure. Gastroenterology 1985, 88:269-280.
    • (1985) Gastroenterology , vol.88 , pp. 269-280
    • Bell, A.E.1    Sellers, L.A.2    Allen, A.3    Cunliffe, W.J.4    Morris, E.R.5    Ross Murphy, S.B.6
  • 5
    • 0030807230 scopus 로고    scopus 로고
    • A trial of antioxidants N-acetylcysteine and procysteine in ARDS. The Antioxidant in ARDS Study Group
    • Bernard G.R., Wheeler A.P., Arons M.M., Morris P.E., Paz H.L., Russell J.A., et al. A trial of antioxidants N-acetylcysteine and procysteine in ARDS. The Antioxidant in ARDS Study Group. Chest 1997, 112:164-172.
    • (1997) Chest , vol.112 , pp. 164-172
    • Bernard, G.R.1    Wheeler, A.P.2    Arons, M.M.3    Morris, P.E.4    Paz, H.L.5    Russell, J.A.6
  • 6
    • 0036189671 scopus 로고    scopus 로고
    • L-2-Oxothiazolidine-4-carboxylate reverses the tumour growth-promoting effect of interleukin-2 and improves the anti-tumour efficacy of biochemotherapy in mice bearing B16 melanoma liver metastases
    • Bilbao P., del Olmo M., Alonso-Varona A., Castro B., Bilbao J., Palomares T. L-2-Oxothiazolidine-4-carboxylate reverses the tumour growth-promoting effect of interleukin-2 and improves the anti-tumour efficacy of biochemotherapy in mice bearing B16 melanoma liver metastases. Melanoma Res 2002, 12:17-26.
    • (2002) Melanoma Res , vol.12 , pp. 17-26
    • Bilbao, P.1    del Olmo, M.2    Alonso-Varona, A.3    Castro, B.4    Bilbao, J.5    Palomares, T.6
  • 7
    • 0019890658 scopus 로고
    • Gastric glutathione depletion and acute ulcerogenesis by diethylmaleate given subcutaneously to rats
    • Boyd S.C., Sasame H.A., Boyd M.R. Gastric glutathione depletion and acute ulcerogenesis by diethylmaleate given subcutaneously to rats. Life Sci 1981, 28:2987-2992.
    • (1981) Life Sci , vol.28 , pp. 2987-2992
    • Boyd, S.C.1    Sasame, H.A.2    Boyd, M.R.3
  • 8
    • 0020051148 scopus 로고
    • Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker
    • Bradley P.P., Priebat D.A., Christensen R.D., Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 1982, 78:206-209.
    • (1982) J Invest Dermatol , vol.78 , pp. 206-209
    • Bradley, P.P.1    Priebat, D.A.2    Christensen, R.D.3    Rothstein, G.4
  • 9
    • 11244327800 scopus 로고    scopus 로고
    • L-2-Oxothiazolidine-4-carboxylic acid reduces in vitro cytotoxicity of glucose degradation products
    • Breborowicz A., Witowski J., Polubinska A., Pyda M., Oreopoulos D. L-2-Oxothiazolidine-4-carboxylic acid reduces in vitro cytotoxicity of glucose degradation products. Nephrol Dial Transplant 2004, 19:3005-3011.
    • (2004) Nephrol Dial Transplant , vol.19 , pp. 3005-3011
    • Breborowicz, A.1    Witowski, J.2    Polubinska, A.3    Pyda, M.4    Oreopoulos, D.5
  • 10
    • 0016113785 scopus 로고
    • A method for the quantitative estimation of gastric barrier mucus
    • Corne S.J., Morrisey S.M., Woods R.J. A method for the quantitative estimation of gastric barrier mucus. J Physiol 1974, 242:116-117.
    • (1974) J Physiol , vol.242 , pp. 116-117
    • Corne, S.J.1    Morrisey, S.M.2    Woods, R.J.3
  • 11
    • 33646359480 scopus 로고    scopus 로고
    • Cytomodulation of interleukin-2 effect by L-2-oxothiazolidine-4-carboxylate on human malignant melanoma
    • del Olmo M., Alonso-Varona A., Castro B., Bilbao P., Palomares T. Cytomodulation of interleukin-2 effect by L-2-oxothiazolidine-4-carboxylate on human malignant melanoma. Cancer Immunol Immunother 2006, 55:948-957.
    • (2006) Cancer Immunol Immunother , vol.55 , pp. 948-957
    • del Olmo, M.1    Alonso-Varona, A.2    Castro, B.3    Bilbao, P.4    Palomares, T.5
  • 12
    • 0033951845 scopus 로고    scopus 로고
    • Comparison of N-acetylcysteine and L-2-oxothiazolidine-4-carboxylate as cysteine deliverers and glutathione precursors in human malignant melanoma transplants in mice
    • Dizdar N., Kullman A., Kågedal B. Comparison of N-acetylcysteine and L-2-oxothiazolidine-4-carboxylate as cysteine deliverers and glutathione precursors in human malignant melanoma transplants in mice. Cancer Chemother Pharmacol 2000, 45(3):192-198.
    • (2000) Cancer Chemother Pharmacol , vol.45 , Issue.3 , pp. 192-198
    • Dizdar, N.1    Kullman, A.2    Kågedal, B.3
  • 13
    • 67649726840 scopus 로고    scopus 로고
    • Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue
    • Dursun H., Bilici M., Albayrak F., Ozturk C., Saglam M.B., Alp H.H., et al. Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue. BMC Gastroenterol 2009, 9:36.
    • (2009) BMC Gastroenterol , vol.9 , pp. 36
    • Dursun, H.1    Bilici, M.2    Albayrak, F.3    Ozturk, C.4    Saglam, M.B.5    Alp, H.H.6
  • 14
    • 0023931739 scopus 로고
    • Phagocytosis of bacteria and phospholipid degradation
    • Elsbach P., Weiss J. Phagocytosis of bacteria and phospholipid degradation. Biochim Biophys Acta 1988, 947:29-52.
    • (1988) Biochim Biophys Acta , vol.947 , pp. 29-52
    • Elsbach, P.1    Weiss, J.2
  • 15
    • 27744479515 scopus 로고    scopus 로고
    • Oxidative damage in an experimentally induced gastric and gastroduodenal reflux model
    • Erbil Y., Türkoglu U., Barbaros U., Balik E., Olgac V., Kaya H., et al. Oxidative damage in an experimentally induced gastric and gastroduodenal reflux model. Surg Innov 2005, 12:219-225.
    • (2005) Surg Innov , vol.12 , pp. 219-225
    • Erbil, Y.1    Türkoglu, U.2    Barbaros, U.3    Balik, E.4    Olgac, V.5    Kaya, H.6
  • 16
    • 67650087619 scopus 로고    scopus 로고
    • L-2-Oxothiazolidine-4-carboxylate reverses glutathione oxidation and delays fatigue of skeletal muscle in vitro
    • Ferreira L.F., Gilliam L.A., Reid M.B. L-2-Oxothiazolidine-4-carboxylate reverses glutathione oxidation and delays fatigue of skeletal muscle in vitro. J Appl Physiol 2009, 107:211-216.
    • (2009) J Appl Physiol , vol.107 , pp. 211-216
    • Ferreira, L.F.1    Gilliam, L.A.2    Reid, M.B.3
  • 17
    • 0023233043 scopus 로고
    • Enprotil: a preliminary review of its pharmacodynamics and pharmacokinetic properties and therapeutic efficacy in the treatment of peptic ulcer diseases
    • Goa K.L., Monk J.P. Enprotil: a preliminary review of its pharmacodynamics and pharmacokinetic properties and therapeutic efficacy in the treatment of peptic ulcer diseases. Drugs 1987, 3:539-559.
    • (1987) Drugs , vol.3 , pp. 539-559
    • Goa, K.L.1    Monk, J.P.2
  • 18
    • 0031786731 scopus 로고    scopus 로고
    • Pharmacokinetics of 2-oxothiazolidine-4-carboxylate, a cysteine prodrug, and cysteine
    • Gwilt P.R., Radick L.E., Li X.Y., Whalen J.J., Leaf C.D. Pharmacokinetics of 2-oxothiazolidine-4-carboxylate, a cysteine prodrug, and cysteine. J Clin Pharmacol 1998, 38:945-950.
    • (1998) J Clin Pharmacol , vol.38 , pp. 945-950
    • Gwilt, P.R.1    Radick, L.E.2    Li, X.Y.3    Whalen, J.J.4    Leaf, C.D.5
  • 19
    • 0032874845 scopus 로고    scopus 로고
    • Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress
    • Hayes J.D., McLellan L.I. Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic Res 1999, 31:273-300.
    • (1999) Free Radic Res , vol.31 , pp. 273-300
    • Hayes, J.D.1    McLellan, L.I.2
  • 21
    • 0020761116 scopus 로고
    • Gastric mucosal barrier: hydrophobic lining to the lumen of the stomach
    • Hills B.A., Butler B.D., Lichtenberger L.M. Gastric mucosal barrier: hydrophobic lining to the lumen of the stomach. Am J Physiol 1983, 244:561-568.
    • (1983) Am J Physiol , vol.244 , pp. 561-568
    • Hills, B.A.1    Butler, B.D.2    Lichtenberger, L.M.3
  • 22
    • 0011024223 scopus 로고    scopus 로고
    • The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat
    • Iimuro Y., Bradford B.U., Yamashina S., Rusyn I., Nakagami M., Enomoto N., et al. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. Hepatology 2000, 31:391-398.
    • (2000) Hepatology , vol.31 , pp. 391-398
    • Iimuro, Y.1    Bradford, B.U.2    Yamashina, S.3    Rusyn, I.4    Nakagami, M.5    Enomoto, N.6
  • 23
    • 0026008324 scopus 로고
    • Exogenous surface-active phospholipids protects necturus gastric mucosa against luminal acid and barrier-breaking agents
    • Kiviluoto T., Paimela H., Mustonen H., Kivilaakso E.L. Exogenous surface-active phospholipids protects necturus gastric mucosa against luminal acid and barrier-breaking agents. Gastroenterology 1991, 100:38-46.
    • (1991) Gastroenterology , vol.100 , pp. 38-46
    • Kiviluoto, T.1    Paimela, H.2    Mustonen, H.3    Kivilaakso, E.L.4
  • 24
    • 64849084068 scopus 로고    scopus 로고
    • Gastroprotective and anti-oxidative properties of ascorbic acid on indomethacin-induced gastric injuries in rats
    • Koc M., Imik H., Odabasoglu F. Gastroprotective and anti-oxidative properties of ascorbic acid on indomethacin-induced gastric injuries in rats. Biol Trace Elem Res 2008, 126:222-236.
    • (2008) Biol Trace Elem Res , vol.126 , pp. 222-236
    • Koc, M.1    Imik, H.2    Odabasoglu, F.3
  • 26
    • 0036196986 scopus 로고    scopus 로고
    • Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury
    • Kwiecień S., Brzozowski T., Konturek S.J. Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury. J Physiol Pharmacol 2002, 53:39-50.
    • (2002) J Physiol Pharmacol , vol.53 , pp. 39-50
    • Kwiecień, S.1    Brzozowski, T.2    Konturek, S.J.3
  • 27
    • 0033947733 scopus 로고    scopus 로고
    • Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol-induced gastric lesions
    • La Casa C., Villegas I., Alarcon de la Lastra C., Motilva V., Martin Calero M.J. Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol-induced gastric lesions. J Ethnopharmacol 2000, 71:45-53.
    • (2000) J Ethnopharmacol , vol.71 , pp. 45-53
    • La Casa, C.1    Villegas, I.2    Alarcon de la Lastra, C.3    Motilva, V.4    Martin Calero, M.J.5
  • 28
    • 0023876910 scopus 로고
    • Histology of alcoholic haemorrhagic gastritis: a prospective evaluation
    • Laine L., Weinstein W.M. Histology of alcoholic haemorrhagic gastritis: a prospective evaluation. Gastroenterology 1988, 94:1254-1264.
    • (1988) Gastroenterology , vol.94 , pp. 1254-1264
    • Laine, L.1    Weinstein, W.M.2
  • 29
    • 10044224510 scopus 로고    scopus 로고
    • Blockade of airway hyperresponsiveness and inflammation in a murine model of asthma by a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid
    • Lee Y.C., Lee K.S., Park S.J., Park H.S., Lim J.S., Park K.H., et al. Blockade of airway hyperresponsiveness and inflammation in a murine model of asthma by a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid. FASEB J 2004, 18:1917-1919.
    • (2004) FASEB J , vol.18 , pp. 1917-1919
    • Lee, Y.C.1    Lee, K.S.2    Park, S.J.3    Park, H.S.4    Lim, J.S.5    Park, K.H.6
  • 30
    • 33748061638 scopus 로고    scopus 로고
    • Protective role of L-2-oxothiazolidine-4-carboxylic acid in cisplatin-induced renal injury
    • Lee S., Moon S.O., Kim W., Sung M.J., Kim D.H., Kang K.P., et al. Protective role of L-2-oxothiazolidine-4-carboxylic acid in cisplatin-induced renal injury. Nephrol Dial Transplant 2006, 21:2085-2095.
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 2085-2095
    • Lee, S.1    Moon, S.O.2    Kim, W.3    Sung, M.J.4    Kim, D.H.5    Kang, K.P.6
  • 31
    • 0031940068 scopus 로고    scopus 로고
    • Selective elevation of glutathione levels in target tissues with L-2-oxothiazolidine-4-carboxylate (OTC) protects against hyperoxia-induced lung damage in protein-energy malnourished rats: implications for a new treatment strategy
    • Levy M.A., Sikorski B., Bray T.M. Selective elevation of glutathione levels in target tissues with L-2-oxothiazolidine-4-carboxylate (OTC) protects against hyperoxia-induced lung damage in protein-energy malnourished rats: implications for a new treatment strategy. J Nutr 1998, 128:671-676.
    • (1998) J Nutr , vol.128 , pp. 671-676
    • Levy, M.A.1    Sikorski, B.2    Bray, T.M.3
  • 32
    • 0032698860 scopus 로고    scopus 로고
    • Ethanol consumption, amino acid and glutathione blood levels in patients with and without chronic liver disease
    • Loguercio C., Blanco F.D., De Girolamo V., Disalvo D., Nardi G., Parente A., et al. Ethanol consumption, amino acid and glutathione blood levels in patients with and without chronic liver disease. Alcohol Clin Exp Res 1999, 23:1780-1784.
    • (1999) Alcohol Clin Exp Res , vol.23 , pp. 1780-1784
    • Loguercio, C.1    Blanco, F.D.2    De Girolamo, V.3    Disalvo, D.4    Nardi, G.5    Parente, A.6
  • 33
    • 32244447306 scopus 로고    scopus 로고
    • Gastrointestinal inflammation: a central component of mucosal defense and repair
    • Martin G.R., Wallace J.L. Gastrointestinal inflammation: a central component of mucosal defense and repair. Exp Biol Med 2006, 231:130-137.
    • (2006) Exp Biol Med , vol.231 , pp. 130-137
    • Martin, G.R.1    Wallace, J.L.2
  • 34
    • 0020537304 scopus 로고
    • Selective modification of glutathione metabolism
    • Meister A. Selective modification of glutathione metabolism. Science 1983, 220:472-477.
    • (1983) Science , vol.220 , pp. 472-477
    • Meister, A.1
  • 35
    • 0031749131 scopus 로고    scopus 로고
    • Elevation of whole-blood glutathione in peritoneal dialysis patients by L-2-oxothiazolidine-4-carboxylate, a cysteine prodrug (Procysteine)
    • Moberly J.B., Logan J., Borum P.R., Story K.O., Webb L.E., Jassal S.V., et al. Elevation of whole-blood glutathione in peritoneal dialysis patients by L-2-oxothiazolidine-4-carboxylate, a cysteine prodrug (Procysteine). J Am Soc Nephrol 1998, 9:1093-1099.
    • (1998) J Am Soc Nephrol , vol.9 , pp. 1093-1099
    • Moberly, J.B.1    Logan, J.2    Borum, P.R.3    Story, K.O.4    Webb, L.E.5    Jassal, S.V.6
  • 37
    • 0035397383 scopus 로고    scopus 로고
    • Seriate histomorphometry of whole rat stomach: an accurate and reliable method for quantitative analysis of mucosal damage
    • Natale G., Lazzeri G., Blandizzi C., Gherardi G., Lenzi P., Pellegrini A., et al. Seriate histomorphometry of whole rat stomach: an accurate and reliable method for quantitative analysis of mucosal damage. Toxicol Appl Pharmacol 2001, 174:17-26.
    • (2001) Toxicol Appl Pharmacol , vol.174 , pp. 17-26
    • Natale, G.1    Lazzeri, G.2    Blandizzi, C.3    Gherardi, G.4    Lenzi, P.5    Pellegrini, A.6
  • 38
    • 68549105872 scopus 로고    scopus 로고
    • Pulmonary exposure to diesel exhaust particles promotes cerebral microvessel thrombosis: protective effect of a cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid
    • Nemmar A., Al-Salam S., Dhanasekaran S., Sudhadevi M., Ali B.H. Pulmonary exposure to diesel exhaust particles promotes cerebral microvessel thrombosis: protective effect of a cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid. Toxicology 2009, 263:84-92.
    • (2009) Toxicology , vol.263 , pp. 84-92
    • Nemmar, A.1    Al-Salam, S.2    Dhanasekaran, S.3    Sudhadevi, M.4    Ali, B.H.5
  • 39
    • 68149110224 scopus 로고    scopus 로고
    • Procysteine stimulates expression of key anabolic factors and reduces plantaris atrophy in alcohol-fed rats
    • Otis J.S., Guidot D.M. Procysteine stimulates expression of key anabolic factors and reduces plantaris atrophy in alcohol-fed rats. Alcohol Clin Exp Res 2009, 33:1450-1459.
    • (2009) Alcohol Clin Exp Res , vol.33 , pp. 1450-1459
    • Otis, J.S.1    Guidot, D.M.2
  • 40
    • 0035743401 scopus 로고    scopus 로고
    • Evaluation of the effects of nicorandil on experimentally induced gastric ulcers
    • Patel H.M., Santani D.D., Goswami S.G. Evaluation of the effects of nicorandil on experimentally induced gastric ulcers. Pharmacology 2001, 63:154-159.
    • (2001) Pharmacology , vol.63 , pp. 154-159
    • Patel, H.M.1    Santani, D.D.2    Goswami, S.G.3
  • 41
    • 0023632379 scopus 로고
    • Free radicals and lipid peroxidation in ethanol- or aspirin-induced gastric mucosal injury
    • Pihan G., Regillo C., Szabo S. Free radicals and lipid peroxidation in ethanol- or aspirin-induced gastric mucosal injury. Dig Dis Sci 1987, 32:1395-1401.
    • (1987) Dig Dis Sci , vol.32 , pp. 1395-1401
    • Pihan, G.1    Regillo, C.2    Szabo, S.3
  • 43
    • 85044707347 scopus 로고    scopus 로고
    • The protective effects of N-Acetl-cysteine, oxo-thiazolidine-carboxylate, acetaminophen and their combinations against sulfur mustard cytotoxicity on human skin fibroblast cell line (HF2FF)
    • Saberi M., Zaree Mahmodabady A. The protective effects of N-Acetl-cysteine, oxo-thiazolidine-carboxylate, acetaminophen and their combinations against sulfur mustard cytotoxicity on human skin fibroblast cell line (HF2FF). Iran Biomed J 2009, 13:215-221.
    • (2009) Iran Biomed J , vol.13 , pp. 215-221
    • Saberi, M.1    Zaree Mahmodabady, A.2
  • 44
    • 0021251305 scopus 로고
    • Gastroprotective effects of morniflumate, an esterified anti-inflammatory drug
    • Schiantarelli P., Cadel S., Folco G.C. Gastroprotective effects of morniflumate, an esterified anti-inflammatory drug. Arzneim Forsch 1984, 34:885-890.
    • (1984) Arzneim Forsch , vol.34 , pp. 885-890
    • Schiantarelli, P.1    Cadel, S.2    Folco, G.C.3
  • 45
    • 0014428865 scopus 로고
    • Estimation of total protein bound and nonprotein sulfhydryl groups in tissue with Ellman's reagent
    • Sedlak J., Lindsay R.H. Estimation of total protein bound and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 1968, 25:192-195.
    • (1968) Anal Biochem , vol.25 , pp. 192-195
    • Sedlak, J.1    Lindsay, R.H.2
  • 46
    • 38749127956 scopus 로고    scopus 로고
    • Antioxidant effect of alpha-lipoic acid against ethanol-induced gastric mucosal erosion in rats
    • Sehirli O., Tatlidede E., Yüksel M., Erzik C., Cetinel S., Yeĝen B.C., et al. Antioxidant effect of alpha-lipoic acid against ethanol-induced gastric mucosal erosion in rats. Pharmacology 2008, 81:173-180.
    • (2008) Pharmacology , vol.81 , pp. 173-180
    • Sehirli, O.1    Tatlidede, E.2    Yüksel, M.3    Erzik, C.4    Cetinel, S.5    Yeĝen, B.C.6
  • 48
    • 0034117836 scopus 로고    scopus 로고
    • Pentoxyfyllin accelerates gastric ulcer healing in rats: roles of tumor necrosis factor α and neutrophils during the early phase of ulcer healing
    • Shimizu N., Watanabe T., Arakawa T., Fujiwara Y., Higuchi K., Kuroki T. Pentoxyfyllin accelerates gastric ulcer healing in rats: roles of tumor necrosis factor α and neutrophils during the early phase of ulcer healing. Digestion 2000, 61:157-164.
    • (2000) Digestion , vol.61 , pp. 157-164
    • Shimizu, N.1    Watanabe, T.2    Arakawa, T.3    Fujiwara, Y.4    Higuchi, K.5    Kuroki, T.6
  • 49
    • 0022407865 scopus 로고
    • The role of surface and intracellular mucus in gastric mucosal protection against hydrogen ion. Compositional differences
    • Slomiany B.L., Piasek A., Sarosiek J., Slomiany A. The role of surface and intracellular mucus in gastric mucosal protection against hydrogen ion. Compositional differences. Scand J Gastroenterol 1985, 20:1191-1196.
    • (1985) Scand J Gastroenterol , vol.20 , pp. 1191-1196
    • Slomiany, B.L.1    Piasek, A.2    Sarosiek, J.3    Slomiany, A.4
  • 50
    • 0032406737 scopus 로고    scopus 로고
    • Anti-ulcer effects of antioxidants, quercetin, alpha-tocopherol, nifedipine and tetracycline in rats
    • Suzuki Y., Ishihara M., Segami T., Ito M. Anti-ulcer effects of antioxidants, quercetin, alpha-tocopherol, nifedipine and tetracycline in rats. Jpn J Pharmacol 1998, 78:435-441.
    • (1998) Jpn J Pharmacol , vol.78 , pp. 435-441
    • Suzuki, Y.1    Ishihara, M.2    Segami, T.3    Ito, M.4
  • 51
    • 0019825246 scopus 로고
    • Sulfhydryl compounds may mediate gastric cytoprotection
    • Szabo S., Trier J.S., Frankel P.W. Sulfhydryl compounds may mediate gastric cytoprotection. Science 1981, 214:200-202.
    • (1981) Science , vol.214 , pp. 200-202
    • Szabo, S.1    Trier, J.S.2    Frankel, P.W.3
  • 52
    • 0037251311 scopus 로고    scopus 로고
    • Accelaration of gastric ulcer healing by omeprazole in portal hypertensive rats. Is its action mediated by gastrin release and the stimulation of epithelial proliferation?
    • Takeuchi Y., Kitano S., Bandoh T., Matsumoto T., Baatar D., Kai S. Accelaration of gastric ulcer healing by omeprazole in portal hypertensive rats. Is its action mediated by gastrin release and the stimulation of epithelial proliferation?. Eur Surg Res 2003, 35:75-80.
    • (2003) Eur Surg Res , vol.35 , pp. 75-80
    • Takeuchi, Y.1    Kitano, S.2    Bandoh, T.3    Matsumoto, T.4    Baatar, D.5    Kai, S.6
  • 53
    • 33748499816 scopus 로고    scopus 로고
    • Protective effects of nedocromil sodium and sodium cromoglycate on gastroduodenal ulcers: a comparative study in rats
    • Tariq M., Al Moutaery M., Elfaki I., Arshaduddin M., Khan H.A. Protective effects of nedocromil sodium and sodium cromoglycate on gastroduodenal ulcers: a comparative study in rats. Inflammopharmacology 2006, 14:163-169.
    • (2006) Inflammopharmacology , vol.14 , pp. 163-169
    • Tariq, M.1    Al Moutaery, M.2    Elfaki, I.3    Arshaduddin, M.4    Khan, H.A.5
  • 54
    • 33750103830 scopus 로고    scopus 로고
    • Bromophenacyl bromide, a phospholipase A2 inhibitor attenuates chemically induced gastroduodenal ulcers in rats
    • Tariq M., Elfaki I., Khan H.A., Arshaduddin M., Sobki S., Al Moutaery M. Bromophenacyl bromide, a phospholipase A2 inhibitor attenuates chemically induced gastroduodenal ulcers in rats. World J Gastroenterol 2006, 13:5798-5804.
    • (2006) World J Gastroenterol , vol.13 , pp. 5798-5804
    • Tariq, M.1    Elfaki, I.2    Khan, H.A.3    Arshaduddin, M.4    Sobki, S.5    Al Moutaery, M.6
  • 56
    • 0032521146 scopus 로고    scopus 로고
    • L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease
    • Vita J.A., Frei B., Holbrook M., Gokce N., Leaf C., Keaney J.F. L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease. J Clin Invest 1998, 101:1408-1414.
    • (1998) J Clin Invest , vol.101 , pp. 1408-1414
    • Vita, J.A.1    Frei, B.2    Holbrook, M.3    Gokce, N.4    Leaf, C.5    Keaney, J.F.6
  • 57
    • 0029830408 scopus 로고    scopus 로고
    • Cooperative modulation of gastrointestinal mucosal defence by prostaglandins and nitric oxide
    • Wallace J.L. Cooperative modulation of gastrointestinal mucosal defence by prostaglandins and nitric oxide. Clin Invest Med 1996, 19:346-351.
    • (1996) Clin Invest Med , vol.19 , pp. 346-351
    • Wallace, J.L.1
  • 58
    • 0022519314 scopus 로고
    • Role of mucus in the repair of gastric epithelial damage in the rat
    • Wallace J.L., Whittle B.J.R. Role of mucus in the repair of gastric epithelial damage in the rat. Gastroenterology 1986, 91:603-611.
    • (1986) Gastroenterology , vol.91 , pp. 603-611
    • Wallace, J.L.1    Whittle, B.J.R.2
  • 59
    • 1542376929 scopus 로고    scopus 로고
    • Glutathione metabolism and its implications for health
    • Wu G., Fang Y.Z., Yang S., Lupton J.R., Turner N.D. Glutathione metabolism and its implications for health. J Nutr 2004, 134:489-492.
    • (2004) J Nutr , vol.134 , pp. 489-492
    • Wu, G.1    Fang, Y.Z.2    Yang, S.3    Lupton, J.R.4    Turner, N.D.5
  • 60
    • 60749129223 scopus 로고    scopus 로고
    • Gastroduodenal mucosal defense
    • Zhu A., Kaunitz J. Gastroduodenal mucosal defense. Curr Gastroenterol Rep 2008, 10:548-554.
    • (2008) Curr Gastroenterol Rep , vol.10 , pp. 548-554
    • Zhu, A.1    Kaunitz, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.