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Volumn 38, Issue 10, 1998, Pages 945-950

Pharmacokinetics of 2-oxothiazolidine-4-carboxylate, a cysteine prodrug, and cysteine

Author keywords

[No Author keywords available]

Indexed keywords

2 OXO 4 THIAZOLIDINECARBOXYLIC ACID; CYSTEINE; GLUTATHIONE DISULFIDE; PRODRUG;

EID: 0031786731     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1552-4604.1998.tb04391.x     Document Type: Article
Times cited : (8)

References (18)
  • 1
    • 0026500114 scopus 로고
    • Adult respiratory distress syndrome
    • McNaughton PD, Evans TW: Adult respiratory distress syndrome. Lancet 1992:339:469-472.
    • (1992) Lancet , vol.339 , pp. 469-472
    • McNaughton, P.D.1    Evans, T.W.2
  • 2
    • 0028111828 scopus 로고
    • Glutathione precursor and antioxidant activities of N-acetylcysteine and oxothiazolidine carboxylate compared in vitro studies of HIV replication
    • Raju PA, Herzenberg LA, Roederer M: Glutathione precursor and antioxidant activities of N-acetylcysteine and oxothiazolidine carboxylate compared in vitro studies of HIV replication. AIDS Res Hum Retroviruses 1994;10:961-967.
    • (1994) AIDS Res Hum Retroviruses , vol.10 , pp. 961-967
    • Raju, P.A.1    Herzenberg, L.A.2    Roederer, M.3
  • 4
    • 0027465289 scopus 로고
    • The role of oxygen radicals in human disease, with particular reference to the vascular system
    • Halliwell B: The role of oxygen radicals in human disease, with particular reference to the vascular system. Haemostasis 1993; 235:118-126.
    • (1993) Haemostasis , vol.235 , pp. 118-126
    • Halliwell, B.1
  • 5
    • 0026343403 scopus 로고
    • Glutathione deficiency produced by inhibition of its synthesis, and its reversal: Applications in research and therapy
    • Meister A: Glutathione deficiency produced by inhibition of its synthesis, and its reversal: applications in research and therapy. Pharmacol Ther 1991;51:155-194.
    • (1991) Pharmacol Ther , vol.51 , pp. 155-194
    • Meister, A.1
  • 6
    • 0023081006 scopus 로고
    • Intracellular delivery of cysteine
    • Andersen ME, Meister A: Intracellular delivery of cysteine. Methods Enzymol 1987;143:313-325.
    • (1987) Methods Enzymol , vol.143 , pp. 313-325
    • Andersen, M.E.1    Meister, A.2
  • 7
    • 0028104816 scopus 로고
    • Development of a novel glutathione repleting agent, L-2-oxothiazolidine-4-carboxylic acid (procysteine)
    • Leaf CD, Pace GW: Development of a novel glutathione repleting agent, L-2-oxothiazolidine-4-carboxylic acid (procysteine). Exp Opin Invest Drugs 1994:3:1293-1302.
    • (1994) Exp Opin Invest Drugs , vol.3 , pp. 1293-1302
    • Leaf, C.D.1    Pace, G.W.2
  • 9
    • 0028289034 scopus 로고
    • A phase I/II trial of intravenous L-2-oxothiazolidine-4-carboxylic acid (procysteine) in asymptomatic HIV-infected subjects
    • Kalyjian RC, Skowron G, Emgushov R, Chance M, Spell SA, Borum PR, et al: A phase I/II trial of intravenous L-2-oxothiazolidine-4-carboxylic acid (procysteine) in asymptomatic HIV-infected subjects. J Acquir Immune Defic Syndr 1994;7:369-374.
    • (1994) J Acquir Immune Defic Syndr , vol.7 , pp. 369-374
    • Kalyjian, R.C.1    Skowron, G.2    Emgushov, R.3    Chance, M.4    Spell, S.A.5    Borum, P.R.6
  • 10
    • 0028300284 scopus 로고
    • Determination of L-2-oxothiazolidine-4-carboxylic acid (procysteine) in human plasma by high-performance liquid chromatography
    • Webb LW, Gechman M, Story K: Determination of L-2-oxothiazolidine-4-carboxylic acid (procysteine) in human plasma by high-performance liquid chromatography. J Chromatogr B 1994;654:257-262.
    • (1994) J Chromatogr B , vol.654 , pp. 257-262
    • Webb, L.W.1    Gechman, M.2    Story, K.3
  • 11
    • 0027462812 scopus 로고
    • Homocysteine and other thiols in plasma and urine: Automated determination and sample stability
    • Fiskerstrand T, Refsum H, Kvalheim G, Ueland PM: Homocysteine and other thiols in plasma and urine: automated determination and sample stability. Clin Chem 1993;39:263-271.
    • (1993) Clin Chem , vol.39 , pp. 263-271
    • Fiskerstrand, T.1    Refsum, H.2    Kvalheim, G.3    Ueland, P.M.4
  • 13
    • 0018091195 scopus 로고
    • Application of Akaike's Information Criterion in the evaluation of linear pharmacokinetic equations
    • Yamaoka K, Nakagawa T, Uno T: Application of Akaike's Information Criterion in the evaluation of linear pharmacokinetic equations. J Pharmacokinet Biopharm 1978;6:165-175.
    • (1978) J Pharmacokinet Biopharm , vol.6 , pp. 165-175
    • Yamaoka, K.1    Nakagawa, T.2    Uno, T.3
  • 14
    • 0026075333 scopus 로고
    • L-2-oxothiazolidine-4-carboxylate acid, a cysteine prodrug: Pharmacokinetics and effects on thiols in plasma and lymphocytes in human
    • Porta P, Aebi S, Summer K, Sauterburg BH: L-2-oxothiazolidine-4-carboxylate acid, a cysteine prodrug: pharmacokinetics and effects on thiols in plasma and lymphocytes in human. JPharmacol Exp Ther 1991;257:331-334.
    • (1991) JPharmacol Exp Ther , vol.257 , pp. 331-334
    • Porta, P.1    Aebi, S.2    Summer, K.3    Sauterburg, B.H.4
  • 15
    • 0026564310 scopus 로고
    • Bidirectional mechanism of plasma transport of reduced glutathione in intact rat hepatocytes and membrane vesicles
    • Garcia-Ruiz C, Fernandez JC, Kaplowitz N: Bidirectional mechanism of plasma transport of reduced glutathione in intact rat hepatocytes and membrane vesicles. J Biol Chem 1992;267: 22256-22264.
    • (1992) J Biol Chem , vol.267 , pp. 22256-22264
    • Garcia-Ruiz, C.1    Fernandez, J.C.2    Kaplowitz, N.3
  • 16
    • 0027176789 scopus 로고
    • Elevation of cysteine and replenishment of glutathione by cysteine isopropylester and other cysteine precursors
    • Butterworth M, Upshall DG, Hobbs M, Cohen GM: Elevation of cysteine and replenishment of glutathione by cysteine isopropylester and other cysteine precursors. Biochem Pharmacol 1993; 45:1769-1774.
    • (1993) Biochem Pharmacol , vol.45 , pp. 1769-1774
    • Butterworth, M.1    Upshall, D.G.2    Hobbs, M.3    Cohen, G.M.4
  • 17
    • 0025987254 scopus 로고
    • Use of N-acetylcysteine in clinical toxicology
    • Flanagan RJ, Meredith JJ: Use of N-acetylcysteine in clinical toxicology. Am J Med 1991;Suppl 3C:131S-139S.
    • (1991) Am J Med , Issue.SUPPL. 3C
    • Flanagan, R.J.1    Meredith, J.J.2
  • 18
    • 0028258621 scopus 로고    scopus 로고
    • The utilization of N-acetylcysteine and 2-oxothiazolidine-4-carboxylate by rat hepatocytes is limited by their rate of uptake and conversion to cysteine
    • Banks MF, Stipanuk MH: The utilization of N-acetylcysteine and 2-oxothiazolidine-4-carboxylate by rat hepatocytes is limited by their rate of uptake and conversion to cysteine. J Nutr 1996; 124:378-387.
    • (1996) J Nutr , vol.124 , pp. 378-387
    • Banks, M.F.1    Stipanuk, M.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.