SKI-1 and Furin Generate Multiple RGMa Fragments that Regulate Axonal Growth

Developmental Cell

Volumn 22, Issue 2, 2012, Pages 391-402

  Tassew, Nardos G ^a,b   Charish, Jason ^a,b   Seidah, Nabil G ^c   Monnier, Philippe P ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; FIBRONECTIN; FURIN; NEOGENIN; PROPROTEIN CONVERTASE 1; REPULSIVE GUIDANCE MOLECULE A PROTEIN; SKI 1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DISULFIDE BOND; HUMAN; HUMAN CELL; MOLECULE; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN PROCESSING; SEQUENCE HOMOLOGY;

ANIMALS; AXONS; CERCOPITHECUS AETHIOPS; CLONING, MOLECULAR; COS CELLS; DNA-BINDING PROTEINS; FURIN; GENE SILENCING; GPI-LINKED PROTEINS; IMMUNOPRECIPITATION; MEMBRANE PROTEINS; MICE; NERVE TISSUE PROTEINS; PROTO-ONCOGENE PROTEINS; RNA, SMALL INTERFERING;

EID: 84857014510     PISSN: 15345807     EISSN: 18781551     Source Type: Journal    
DOI: 10.1016/j.devcel.2011.11.022     Document Type: Article

References (30)

1. Adams R.H., Lohrum M., Klostermann A., Betz H., Püschel A.W. The chemorepulsive activity of secreted semaphorins is regulated by furin-dependent proteolytic processing. EMBO J. 1997, 16:6077-6086.
2. Carvalho R.F., Beutler M., Marler K.J.M., Knöll B., Becker-Barroso E., Heintzmann R., Ng T., Drescher U. Silencing of EphA3 through a cis interaction with ephrinA5. Nat. Neurosci. 2006, 9:322-330.
3. Drescher U., Bonhoeffer F., Müller B.K. The Eph family in retinal axon guidance. Curr. Opin. Neurobiol. 1997, 7:75-80.
4. Egea J., Klein R. Bidirectional Eph-ephrin signaling during axon guidance. Trends Cell Biol. 2007, 17:230-238.
5. Endo M., Yamashita T. Inactivation of Ras by p120GAP via focal adhesion kinase dephosphorylation mediates RGMa-induced growth cone collapse. J.Neurosci. 2009, 29:6649-6662.
6. Hata K., Fujitani M., Yasuda Y., Doya H., Saito T., Yamagishi S., Mueller B.K., Yamashita T. RGMa inhibition promotes axonal growth and recovery after spinal cord injury. J.Cell Biol. 2006, 173:47-58.
7. Hattori M., Osterfield M., Flanagan J.G. Regulated cleavage of a contact-mediated axon repellent. Science 2000, 289:1360-1365.
8. Kalus I., Schnegelsberg B., Seidah N.G., Kleene R., Schachner M. The proprotein convertase PC5A and a metalloprotease are involved in the proteolytic processing of the neural adhesion molecule L1. J.Biol. Chem. 2003, 278:10381-10388.
9. Matsunaga E., Tauszig-Delamasure S., Monnier P.P., Mueller B.K., Strittmatter S.M., Mehlen P., Chédotal A. RGM and its receptor neogenin regulate neuronal survival. Nat. Cell Biol. 2004, 6:749-755.
10. Matsunaga E., Nakamura H., Chédotal A. Repulsive guidance molecule plays multiple roles in neuronal differentiation and axon guidance. J.Neurosci. 2006, 26:6082-6088.
11. Mitchell K.J., Pinson K.I., Kelly O.G., Brennan J., Zupicich J., Scherz P., Leighton P.A., Goodrich L.V., Lu X., Avery B.J., et al. Functional analysis of secreted and transmembrane proteins critical to mouse development. Nat. Genet. 2001, 28:241-249.
12. Monnier P.P., Sierra A., Macchi P., Deitinghoff L., Andersen J.S., Mann M., Flad M., Hornberger M.R., Stahl B., Bonhoeffer F., Mueller B.K. RGM is a repulsive guidance molecule for retinal axons. Nature 2002, 419:392-395.
13. Muramatsu R., Kubo T., Mori M., Nakamura Y., Fujita Y., Akutsu T., Okuno T., Taniguchi J., Kumanogoh A., Yoshida M., et al. RGMa modulates Tcell responses and is involved in autoimmune encephalomyelitis. Nat. Med. 2011, 17:488-494.
14. Nohra R., Beyeen A.D., Guo J.P., Khademi M., Sundqvist E., Hedreul M.T., Sellebjerg F., Smestad C., Oturai A.B., Harbo H.F., et al. RGMA and IL21R show association with experimental inflammation and multiple sclerosis. Genes Immun. 2010, 11:279-293.
15. Oertle T., van der Haar M.E., Bandtlow C.E., Robeva A., Burfeind P., Buss A., Huber A.B., Simonen M., Schnell L., Brösamle C., et al. Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions. J.Neurosci. 2003, 23:5393-5406.
16. Papanikolaou G., Samuels M.E., Ludwig E.H., MacDonald M.L., Franchini P.L., Dubé M.P., Andres L., MacFarlane J., Sakellaropoulos N., Politou M., et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat. Genet. 2004, 36:77-82.
17. Pasquato A., Pullikotil P., Asselin M.C., Vacatello M., Paolillo L., Ghezzo F., Basso F., Di Bello C., Dettin M., Seidah N.G. The proprotein convertase SKI-1/S1P. Invitro analysis of Lassa virus glycoprotein-derived substrates and exvivo validation of irreversible peptide inhibitors. J.Biol. Chem. 2006, 281:23471-23481.
18. Phan J., Zdanov A., Evdokimov A.G., Tropea J.E., Peters H.K., Kapust R.B., Li M., Wlodawer A., Waugh D.S. Structural basis for the substrate specificity of tobacco etch virus protease. J.Biol. Chem. 2002, 277:50564-50572.
19. Pullikotil P., Vincent M., Nichol S.T., Seidah N.G. Development of protein-based inhibitors of the proprotein of convertase SKI-1/S1P: processing of SREBP-2, ATF6, and a viral glycoprotein. J.Biol. Chem. 2004, 279:17338-17347.
20. Rajagopalan S., Deitinghoff L., Davis D., Conrad S., Skutella T., Chedotal A., Mueller B.K., Strittmatter S.M. Neogenin mediates the action of repulsive guidance molecule. Nat. Cell Biol. 2004, 6:756-762.
21. Roebroek A.J., Umans L., Pauli I.G., Robertson E.J., van Leuven F., Van de Ven W.J., Constam D.B. Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin. Development 1998, 125:4863-4876.
22. Seidah N.G., Chrétien M. Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. BrainRes. 1999, 848:45-62.
23. Seidah N.G., Mowla S.J., Hamelin J., Mamarbachi A.M., Benjannet S., Touré B.B., Basak A., Munzer J.S., Marcinkiewicz J., Zhong M., et al. Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization. Proc. Natl. Acad. Sci. USA 1999, 96:1321-1326.
24. Seiradake E., von Philipsborn A.C., Henry M., Fritz M., Lortat-Jacob H., Jamin M., Hemrika W., Bastmeyer M., Cusack S., McCarthy A.A. Structure and functional relevance of the Slit2 homodimerization domain. EMBO Rep. 2009, 10:736-741.
25. Tassew N.G., Charish J., Chestopalova L., Monnier P.P. Sustained invivo inhibition of protein domains using scFv recombinant antibodies and its application to dissect RGMa activity on retinal axon outgrowth. J.Neurosci. 2009, 29:1126-1131.
26. Tessier-Lavigne M., Goodman C.S. The molecular biology of axon guidance. Science 1996, 274:1123-1133.
27. Thanos S., Mey J. Development of the visual system of the chick. II. Mechanisms of axonal guidance. Brain Res. Brain Res. Rev. 2001, 35:205-245.
28. Zhong M., Munzer J.S., Basak A., Benjannet S., Mowla S.J., Decroly E., Chrétien M., Seidah N.G. The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. Invitro and exvivo assessment of their efficacy and selectivity. J.Biol. Chem. 1999, 274:33913-33920.
29. Zhou Z., Xie J., Lee D., Liu Y., Jung J., Zhou L., Xiong S., Mei L., Xiong W.C. Neogenin regulation of BMP-induced canonical Smad signaling and endochondral bone formation. Dev. Cell 2010, 19:90-102.
30. Zisman S., Marom K., Avraham O., Rinsky-Halivni L., Gai U., Kligun G., Tzarfaty-Majar V., Suzuki T., Klar A. Proteolysis and membrane capture of F-spondin generates combinatorial guidance cues from a single molecule. J.Cell Biol. 2007, 178:1237-1249.