The Sociodevelopmental Origins of Psychosis

Principles of Social Psychiatry: Second Edition

Volumn , Issue , 2010, Pages 193-213

  Morgan, Craig ^a   Hutchinson, Gerard ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF THE WEST INDIES   (Trinidad and Tobago)

Author keywords

Changing epidemiological landscape seminal studies of schizophrenia, determinants of outcomes of severe mental disorder (dosmed); Mechanisms, cognition and emotion models of psychosis focusing on specific symptoms; Mechanisms, gene environment interaction susceptibility linked to genotype; Migration and ethnicity evidence, discrimination and disadvantage; Social adversity across life course childhood and adulthood; Social disorder psychotic disorder emergence; Sociodevelopmental origins of psychosis; Urbanicity evidence, social contexts and structures

Indexed keywords

EID: 84856998400     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470684214.ch15     Document Type: Chapter

References (129)

1. Andreasen, N. (2000) Schizophrenia: the fundamental questions. Brain Research Reviews, 31, 106-112.
2. Krabbendam, L. and van Os, J. (2005) Schizophrenia and urbanicity: a major environmental influence - conditional on genetic risk. Schizophrenia Bulletin, 31 (4), 795-799.
3. Morgan, C. and Fisher, H. (2007) Environment and schizophrenia: environmental factors in schizophrenia: childhood trauma - a critical review. Schizophrenia Bulletin, 33 (1), 3-10.
4. Morgan, C., McKenzie, K. and Fearon, P. (2008) Society and Psychosis, Cambridge University Press, Cambridge.
5. Kendler,K. S., Neale, M. C.,Kessler,R.C. et al. (1992) Childhood parental loss and adult psychopathology in women - a twin study perspective. Archives of General Psychiatry, 49 (2), 109-116.
6. Collip, D., Myin-Germeys, I. and Van Os, J. (2008) Does the concept of 'sensitization' provide a plausible mechanism for the putative link between the environment and schizophrenia?. Schizophrenia Bulletin, 34 (2), 220-225.
7. van Os, J., Rutten, B. P. and Poulton, R. (2008) Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions. Schizophrenia Bulletin, 34 (6), 1066-1082.
8. van Winkel, R. and Stefanis, N. C. (2008) Myin- Germeys I. Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction. Schizophrenia Bulletin, 34 (6), 1095-1105.
9. Garety, P. A., Bebbington, P., Fowler, D. et al. (2007) Implications for neurobiological research of cognitive models of psychosis: a theoretical paper. Psychological Medicine, 37 (10), 1377-1391.
10. Garety, P. A., Kuipers, E., Fowler, D. et al. (2001) A cognitive model of the positive symptoms of psychosis. Psychological Medicine, 31 (2), 189-195.
11. Fisher,H. and Craig, T. (2008) Childhood adversity and psychosis, in Society and Psychosis (eds. C. Morgan, K. McKenzie and P. Fearon), Cambridge University Press, Cambridge, pp. 95-111.
12. Bebbington, P., Fowler, D., Garety, P. et al. (2008) Theories of cognition, emotion and the social world: missing links in psychosis, in Society and Psychosis (eds C. Morgan, K. McKenzie and P. Fearon), Cambridge University Press, Cambridge, pp. 219-237.
13. WHO (1974) Schizophrenia: A Multinational Study, World Health Organization, Geneva.
14. Jablensky, A., Sartorius, N., Ernberg, G. et al. (1992) Schizophrenia: manifestations, incidence and course in different cultures: aWorld Health Organization tencountry study. Psychological Medicine, 20 (suppl. 20), 1-97.
15. Crow, T. (2000) Schizophrenia as the price that Homo sapiens pays for language: a resolution of the central paradox in the origin of the species. Brain Research Reviews, 31, 118-129.
16. Crow, T. J. (2007)Howand why genetic linkage has not solved the problem of psychosis: review and hypothesis. American Journal of Psychiatry, 164 (1), 13-21.
17. Cantor-Graae, E. and Selten, J. P. (2005) Schizophrenia and migration: a meta-analysis and review. American Journal of Psychiatry, 162, 12-24.
18. McGrath, J., Saha, S., Welham, J. et al. (2004) A systematic review of the incidence of schizophrenia: the distribution of rates and the influence of sex, urbanicity, migrant status and methodology. BMC Medical, 2 (1), 13.
19. Kleinman, A. (1991) Rethinking Psychiatry: From Cultural Category to Personal Experience, The Free Press, New York.
20. McGrath, J. J. (2007) The surprisingly rich contours of schizophrenia epidemiology. Archives of General Psychiatry, 64 (1), 14-16.
21. Verdoux, H. and van Os, J. (2002) Psychotic symptoms in non-clinical populations and the continuum of psychosis. Schizophrenia Research, 54 (1-2), 59-65.
22. van Os, J., Linscott, R. J., Myin-Germeys, I. et al. (2009) A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder. Psychological Medicine, 39 (2), 179-195.
23. Dutta, R., Greene, T., Addington, J. et al. (2007) Biological, life course, and cross-cultural studies all point toward the value of dimensional and developmental ratings in the classification of psychosis. Schizophrenia Bulletin, 33 (4), 868-876.
24. Spauwen, J.,Krabbendam, L., Lieb, R. et al. (2004) Does urbanicity shift the population expression of psychosis. Journal of Psychiatric Research, 38 (6), 613-618.
25. Morgan, C., Fisher, H., Hutchinson, G. et al. (2009) Ethnicity, social disadvantage and psychotic-like experiences in a healthy population based sample. Acta Psychiatrica Scandinavica, 119 (3), 226-235.
26. Morgan, C., Kirkbride, J., Leff, J. et al. (2007) Parental separation, loss and psychosis in different ethnic groups: a case-control study. Psychological Medicine, 37 (4), 495-503.
27. Pedersen, C. B. and Mortensen, P. B. (2006) Urbanicity during upbringing and bipolar affective disorders in Denmark. Bipolar Disorders, 8, 242-247.
28. Pedersen, C. B. and Mortensen, P. B. (2001) Evidence of a dose-response relationship between urbanicity during upbringing and schizophrenia risk. Archives of General Psychiatry, 58 (11), 1039-1046.
29. Marcelis, M., Navarro-Mateu, F., Murray, R. et al. (1998) Urbanization and psychosis: a study of 1942-1978 birth cohorts in The Netherlands. Psychological Medicine, 28 (4), 871-879.
30. McGrath, J. and Scott, J. (2006) Urban birth and risk of schizophrenia: a worrying example of epidemiology where the data are stronger than the hypotheses. Epidemiologia e Psichiatria Sociale, 15, 243-246.
31. Faris, R. and Dunham, H. (1939) Mental Disorders in Urban Areas, University of Chicago Press, Chicago, Illinois.
32. Hare, E. (1956) Mental illness and social conditions in Bristol. Journal of Mental Science, 102, 349-357.
33. Durkheim, E. (1952) Suicide, The Free Press, Glencoe, Illinois.
34. Merton, R. K. (1938) Social structure and anomie. American Sociological Review, 3, 672-682.
35. Deflam, M. (2007) Anomie, in The Blackwell Encyclopedia of Sociology (ed. G. Ritzer), Blackwell Publishing, Oxford.
36. Allardyce, J. and Boydell, J. (2006) Review: the wider social environment and schizophrenia. Schizophrenia Bulletin, 32 (4), 592-598.
37. Boydell, J., van Os, J., McKenzie, K. and Murray, R. M. (2004) The association of inequality with the incidence of schizophrenia - an ecological study. Social Psychiatry and Psychiatric Epidemiology, 39 (8), 597-599.
38. Allardyce, J., Gilmour, H., Atkinson, J. et al. (2005) Social fragmentation, deprivation and urbanicity: relation to first-admission rates for psychoses. British Journal of Psychiatry, 187, 401-406.
39. Kirkbride, J. B., Fearon, P., Morgan, C. et al. (2006) Heterogeneity in incidence rates of schizophrenia and other psychotic syndromes: findings from the 3-center ÆSOP study. Archives of General Psychiatry, 63 (3), 250-258.
40. Kirkbride, J. B., Morgan, C., Fearon, P. et al. (2007) Neighbourhood-level effects on psychoses: reexamining the role of context. Psychological Medicine, 37 (10), 1413-1425.
41. Kirkbride, J. B., Boydell, J., Ploubidis, G. B. et al. (2008) Testing the association between the incidence of schizophrenia and social capital in an urban area. Psychological Medicine, 38 (8), 1083-1094.
42. van Os, J., Driessen, G., Gunther, N. and Delespaul, P. (2000) Neighbourhood variation in incidence of schizophrenia. Evidence for person-environment interaction. British Journal of Psychiatry, 176, 243-248.
43. McGrath, J., El-Saadi, O., Cardy, S. et al. (2001) Urban birth and migrant status as risk factors for psychosis: an Australian case-control study. Social Psychiatry and Psychiatric Epidemiology, 36 (11), 533-536.
44. Fearon, P. and Morgan, C. (2006) Environmental factors in schizophrenia: the role of migrant studies. Schizophrenia Bulletin, 32 (3), 405-408.
45. Kirkbride, J. B., Barker, D., Cowden, F. et al. (2008) Psychoses, ethnicity and socio-economic status. British Journal of Psychiatry, 193 (1), 18-24.
46. Bresnahan, M., Begg, M. D., Brown, A. et al. (2007) Race and risk of schizophrenia in a US birth cohort: another example of health disparity. International Journal of Epidemiology, 36 (4), 751-758.
47. Fearon, P., Kirkbride, J. B., Morgan, C. et al. (2006) Incidence of schizophrenia and other psychoses in ethnic minority groups: results from the MRC ÆSOP Study. Psychological Medicine, 36 (11), 1541-1550.
48. Morgan, C. and Hutchinson, G. (in press) The social determinants of psychosis in migrant and ethnic minority populations: a public health tragedy. Psychological Medicine, 1-5.
49. Hickling, F.W.,McKenzie, K., Mullen, R. and Murray, R. (1999) A Jamaican psychiatrist evaluates diagnoses at a London psychiatric hospital. British Journal of Psychiatry, 175, 283-285.
50. Veling, W., Selten, J. P., Veen, N. et al. (2006) Incidence of schizophrenia among ethnic minorities in the Netherlands: a four-year first-contact study. Schizophrenia Research, 86 (1-3), 189-193.
51. Sharpley, M., Hutchinson, G., McKenzie, K. and Murray, R. (2001) Understanding the excess of psychosis among the African-Caribbean population in England. British Journal of Psychiatry, 178 (suppl. 40), s60-s68.
52. McKenzie, K., Fearon, P. and Hutchinson, G. (2008) Migration, ethnicity and psychosis, in Society and Psychosis (eds C. M. Morgan, K. McKenzie and P. Fearon), Cambridge University Press, Cambridge.
53. Cooper, B. (2005) Immigration and schizophrenia: the social causation hypothesis revisited. British Journal of Psychiatry, 186, 361-363.
54. Bhugra, D., Hilwig, M., Hossein, B. et al. (1996) Firstcontact incidence rates of schizophrenia in Trinidad and one-year follow-up. British Journal of Psychiatry, 169, 587-592.
55. Hickling, F. and Rodgers-Johnson, P. (1995) The incidence of first-contact schizophrenia in Jamaica. British Journal of Psychiatry, 167, 193-196.
56. Mahy, G., Mallett, R., Leff, J. and Bhugra, D. (1999) First-contact incidence of schizophrenia in Barbados. British Journal of Psychiatry, 175, 28-33.
57. Boydell, J., van Os, J., McKenzie, K. et al. (2001) Incidence of schizophrenia in ethnic minorities in London: ecological study into interactions with environment. British Medical Journal, 323, 1336-1338.
58. Veling, W., Susser, E., van Os, J. et al. (2008) Ethnic density of neighborhoods and incidence of psychotic disorders among immigrants. The American Journal of Psychiatry, 165 (1), 66-73.
59. Veling,W., Hoek, H.W. and Mackenbach, J. P. (2008) Perceived discrimination and the risk of schizophrenia in ethnic minorities: a case-control study. Social Psychiatry and Psychiatric Epidemiology, 43 (12), 953-959.
60. Dean, K., Dazzan, P., Lloyd, T. et al. (2007) Minor physical anomalies across ethnic groups in a first episode psychosis sample. Schizophrenia Research, 89 (1-3), 86-90.
61. Morgan, C., Kirkbride, J., Hutchinson, G. et al. (2008) Cumulative social disadvantage, ethnicity and firstepisode psychosis: a case-control study. Psychological Medicine, 38 (12), 1701-1715.
62. Tienari, P. and Wahlberg, K. (2008) Family environment and psychosis, in Society and Psychosis (eds C. Morgan, K. McKenzie and P. Fearon), Cambridge University Press, Cambridge, pp. 112-126.
63. Read, J., Seymour, F. and Mosher, L. (2004) Unhappy families, in Models of Madness (eds J. Read, L. Mosher and R. Bentall), Brunner-Routledge, East Sussex, pp. 253-268.
64. Fromm-Reichmann, F. (1948) Notes on the development of treatment of schizophrenics by psycho-analytic psychotherapy. Psychiatry, 11, 263-273.
65. Bateson, G., Jackson, D., Haley, J. and Weakland, J. (1956) Toward a theory of schizophrenia. Behavioural Science, 1, 251-264.
66. Lainge, R. D. and Esterson, D. (1964) Sanity, Madness and the Family, Basic Books, New York.
67. Hirsch, S. and Leff, J. (1975) Abnormalities in the Parents of Schizophrenics, Oxford University Press, Oxford.
68. Kavanagh, N. (1992) Recent developments in expressed emotion and schizophrenia. British Journal of Psychiatry, 160, 601-620.
69. Read, J., van Os, J., Morrison, A. P. and Ross, C. A. (2005) Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications. Acta Psychiatrica Scandinavica, 112 (5), 330-350.
70. Bendall, S., Jackson, H. J., Hulbert, C. A. and McGorry, P. D. (2008) Childhood trauma and psychotic disorders: a systematic, critical reviewof the evidence. Schizophrenia Bulletin, 34 (3), 568-579.
71. Jannsen, I., Krabbendam, L., Bak, M. et al. (2004) Childhood abuse as a risk factor for psychosis. Acta Psychiatrica Scandinavica, 109, 38-45.
72. Whitfield, C. L., Dube, S. R., Felitti, V. J. and Anda, R. F. (2005) Adverse childhood experiences and hallucinations. Child Abuse and Neglect, 29, 797-810.
73. Read, J., Agar, K., Argyle, N. and Aderhold, V. (2003) Sexual and physical assault during childhood and adulthood as predictors of hallucinations, delusions and thought disorder. Psychology and Psychotherapy: Theory, Research and Practice, 76, 1-22.
74. Hammersley, P., Dias, A., Todd, G. et al. (2003) Childhood traumas and hallucinations in bipolar affective disorder. British Journal of Psychiatry, 182, 543-547.
75. Morrison, A. and Petersen, T. (2003) Trauma and metacognition as predictors of predisposition to hallucinations. Behavioural and Cognitive Psychotherapy, 31, 235-246.
76. Kelleher, I., Harley,M., Lynch, F. et al. (2008) Associations between childhood trauma, bullying and psychotic symptoms among a school-based adolescent sample. British Journal of Psychiatry, 193 (5), 378-382.
77. Spauwen, J., Krabbendam, L., Lieb, R. et al. (2006) Impact of psychological trauma on the development of psychotic symptoms: relationship with psychosis proneness.British Journal of Psychiatry, 188, 527-533.
78. Bebbington, P., Bhugra, D., Singleton, N. et al. (2004) Psychosis, victimisation and childhood disadvantage: evidence from the second British National Survey of Psychiatric Morbidity. British Journal of Psychiatry, 185, 220-226.
79. Shevlin, M., Houston, J. E., Dorahy, M. J. and Adamson, G. (2008) Cumulative traumas and psychosis: an analysis of the national comorbidity survey and the British Psychiatric Morbidity Survey. Schizophrenia Bulletin, 34 (1), 193-199.
80. Spataro, J., Mullen, P. E., Burgess, P. M. et al. (2004) Impact of child sexual abuse on mental health: prospective study in males and females. British Journal of Psychiatry, 184, 416-421.
81. Fisher, H., Morgan, C., Dazzan, P. et al. (2009) Gender differences in the association between childhood abuse and psychosis. British Journal of Psychiatry, 194 (4), 319-325.
82. Wicks, S., Hjern, A., Gunnell, D. et al. (2005) Social adversity in childhood and the risk of developing psychosis: a national cohort study. American Journal of Psychiatry, 162, 1652-1657.
83. Agid, O., Shapira, B., Zislin, J. et al. (1999) Environment and vulnerability to major psychiatric illness: a case control study of early parental loss in major depression, bipolar disorder and schizophrenia. Molecular Psychiatry, 4 (2), 163-172.
84. Mulvany, F., O'Callaghan, E., Takei, N. et al. (2001) Effect of social class at birth on risk and presentation of schizophrenia: case-control study. British Medical Journal, 323 (7326), 1398-1401.
85. Harrison, G., Gunnell, D., Glazebrook, C. et al. (2001) Association between schizophrenia and social inequality at birth: case-control study. British Journal of Psychiatry, 179, 346-350.
86. Fallon, P. (2008) Life events; their role in onset and relapse in psychosis, research utilizing semi-structured interview methods: a literature review. Journal of Psychiatric and Mental Health Nursing, 15 (5), 386-392.
87. Norman, R. M. and Malla, A. K. (1993) Stressful life events and schizophrenia. I: A review of the research. British Journal of Psychiatry, 162, 161-166.
88. Bebbington, P.,Wilkins, S., Jones, P. et al. (1993) Life events and psychosis. Initial results from the Camberwell Collaborative Psychosis Study. British Journal of Psychiatry, 162, 72-79.
89. Malla, A. K., Cortese, L., Shaw, T. S. and Ginsberg, B. (1990) Life events and relapse in schizophrenia. A one year prospective study. Social Psychiatry and Psychiatric Epidemiology, 25 (4), 221-224.
90. Johns, L. C., Cannon, M., Singleton, N. et al. (2004) Prevalence and correlates of self-reported psychotic symptoms in the British population. British Journal of Psychiatry, 185, 298-305.
91. Wiles, N. J., Zammit, S., Bebbington, P. et al. (2006) Self-reported psychotic symptoms in the general population: results from the longitudinal study of the British National Psychiatric Morbidity Survey. British Journal of Psychiatry, 188, 519-526.
92. Jones, P. B., Bebbington, P., Foerster, A. et al. (1993) Premorbid social underachievement in schizophrenia. Results from the Camberwell Collaborative Psychosis Study. British Journal of Psychiatry, 162, 65-71.
93. Kendler, K. S. and Baker, J. H. (2007) Genetic influences on measures of the environment: a systematic review. Psychological Medicine, 37 (5), 615-626.
94. Jones, P., Rodgers, B., Murray, R. and Marmot, M. (1994) Child development risk factors for adult schizophrenia in the British 1946 birth cohort. Lancet, 344 (8934), 1398-1402.
95. Selten, J. P. and Cantor-Graae, E. (in press) The denial of a psychosis epidemic. Psychological Medicine, 1-3.
96. Myin-Germeys, I. and van Os, J. (2008) Adult adversity: do early environment and genotype create lasting vulnerability for adult social adversity in psychosis., in Society and Psychosis (eds C. Morgan, K.McKenzie and P. Fearon), Cambridge University Press, Cambridge, pp. 127-142.
97. Glaser, J. P., van Os, J., Portegijs, P. J. and Myin-Germeys, I. (2006) Childhood trauma and emotional reactivity to daily life stress in adult frequent attenders of general practitioners. Journal of Psychosomatic Research, 61 (2), 229-236.
98. Myin-Germeys, I., van Os, J., Schwartz, J. E. et al. (2001) Emotional reactivity to daily life stress in psychosis. Archives of General Psychiatry, 58 (12), 1137-1144.
99. Scheper-Hughes, N. (2001) Saints, Scholars and Schizophrenics: Mental Illness in Rural Ireland, Twentieth Anniversary Edition, University of California Press, Los Angeles, California.
100. Howes, O. D. and Kapur, S. (2009) The dopamine hypothesis of schizophrenia: version III - the final common pathway. Schizophrenia Bulletin, 35 (3), 549-562.
101. Di Forti, M., Lappin, J. M. and Murray, R. M. (2007) Risk factors for schizophrenia - all roads lead to dopamine. European Neuropsychopharmacology, 17 (suppl. 2), S101-S107.
102. Walker, E., Mittal,V. and Tessner,K. (2008) Stress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia. Annual Review of Clinical Psychology, 4, 189-216.
103. Pariante, C. M., Vassilopoulou, K., Velakoulis, D. et al. (2004) Pituitary volume in psychosis. British Journal of Psychiatry, 185, 5-10.
104. Hall, F. S.,Wilkinson, L. S.,Humby, T. and Robbins, T. W. (1999) Maternal deprivation of neonatal rats produces enduring changes in dopamine function. Synapse, 32 (1), 37-43.
105. Berton, O., McClung, C. A., Dileone, R. J. et al. (2006) Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science, 311 (5762), 864-868.
106. Tidey, J. W. and Miczek, K. A. (1996) Social defeat stress selectively alters mesocorticolimbic dopamine release: an in vivo microdialysis study. Brain Research, 721 (1-2), 140-149.
107. Isovich, E., Engelmann, M., Landgraf, R. and Fuchs, E. (2001) Social isolation after a single defeat reduces striatal dopamine transporter binding in rats. European Journal of Neuroscience, 13 (6), 1254-1256.
108. Morgan, D., Grant, K. A., Gage, H. D. et al. (2002) Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration. Nature Neuroscience, 5 (2), 169-174.
109. Pruessner, J. C., Champagne, F., Meaney, M. J. and Dagher, A. (2004) Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: a positron emission tomography study using [11C]raclopride. Journal of Neuroscience, 24 (11), 2825-2831.
110. De Bellis, M. D., Lefter, L., Trickett, P. K. and PutnamJr, F. W. (1994) Urinary catecholamine excretion in sexually abused girls. Journal of the American Academy of Child and Adolescent Psychiatry, 33 (3), 320-327.
111. Heim, C., Newport, D. J., Heit, S. et al. (2000) Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. Journal of the American Medical Association, 284 (5), 592-597.
112. De Bellis, M. D., Chrousos, G. P., Dorn, L. D. et al. (1994) Hypothalamic-pituitary-adrenal axis dysregulation in sexually abused girls. Journal of Clinical Endocrinology and Metabolism, 78 (2), 249-255.
113. Morrison,A.,Read, J. and Turkington,D. (2005) Trauma and psychosis: theoretical and clinical implications. Acta Psychiatrica Scandinavica, 112 (5), 327-329.
114. Selten, J. P. and Cantor-Graae, E. (2005) Social defeat: risk factor for schizophrenia. British Journal of Psychiatry, 187, 101-102.
115. Weaver, I. C., Cervoni, N., Champagne, F. A. et al. (2004) Epigenetic programming by maternal behavior. Nature Neuroscience, 7 (8), 847-854.
116. Meaney, M. J. and Szyf, M. (2005) Environmental programming of stress responses throughDNAmethylation: life at the interface between a dynamic environment and a fixed genome. Dialogues in Clinical NeuroSciences, 7 (2), 103-123.
117. Caspi, A., Sugden, K., Moffitt, T. E. et al. (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301 (5631), 386-389.
118. Caspi, A., Moffitt, T. E., Cannon, M. et al. (2005) Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction. Biological Psychiatry, 57 (10), 1117-1127.
119. Stefanis, N. C., Henquet, C., Avramopoulos, D. et al. (2007) COMT Val158Met moderation of stress-induced psychosis. Psychological Medicine, 37 (11), 1651-1656.
120. Tienari, P., Wynne, L. C., Sorri, A. et al. (2004) Genotype-environment interaction in schizophreniaspectrum disorder. British Journal of Psychiatry, 184, 216-222.
121. van Os, J., Hanssen, M., Bak, M. et al. (2003) Do urbanicity and familial liability coparticipate in causing psychosis. American Journal of Psychiatry, 160 (3), 477-482.
122. Risch, N., Herrell, R., Lehner, T. et al. (2009) Interaction between the serotonin transporter gene (5- HTTLPR), stressful life events, and risk of depression: a meta-analysis. Journal of the American Medical Association, 301 (23), 2462-2471.
123. Bentall, R. P. and Fernyhough, C. (2008) Social predictors of psychotic experiences: specificity and psychological mechanisms. Schizophrenia Bulletin, 34 (6), 1012-1020.
124. Freeman, D., Garety, P. A. and Kuipers, E. (2001) Persecutory delusions: developing the understanding of belief maintenance and emotional distress. Psychological Medicine, 31 (7), 1293-1306.
125. Sharpley, M. S. and Peters, E. R. (1999) Ethnicity, class and schizotypy. Social Psychiatry and Psychiatric Epidemiology, 34 (10), 507-512.
126. Demjaha, A., Morgan, K., Morgan, C. et al. (2006) Symptom dimensions and ethnicity in the ÆSOP first onset psychosis study. Schizophrenia Research, 81, 233-1233.
127. Thornicroft, G. (2006) Shunned: Discrimination Against People with Mental Illness, Oxford University Press, Oxford.
128. Kleinman, A., Das, V. and Lock, M. (eds) (1997) Social Suffering, University of California Press, Los Angeles, California.
129. Oh, G. and Petronis, A. (2008) Environmental studies of schizophrenia through the prism of epigenetics. Schizophrenia Bulletin, 34 (6), 1122-1129.