Connective tissue growth factor gene expression and decline in renal function in lupus nephritis

Experimental and Therapeutic Medicine

Volumn 3, Issue 4, 2012, Pages 713-718

  Tachaudomdach, Chiraporn ^a   Kantachuvesiri, Surasak ^b   Changsirikulchai, Siribha ^c   Wimolluck, Surangkana ^b   Pinpradap, Koset ^b   Kitiyakara, Chagriya ^b  

^a Mahidol University   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

^c Faculty of Medicine Srinakharinwirot University   (Thailand)

Author keywords

Connective tissue growth factor; Cytokines; Fibrosis; Gene expression; Kidney disease; Kidney failure; Lupus nephritis; Systemic lupus erythematosus

Indexed keywords

AZATHIOPRINE; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; CORTICOSTEROID; CYCLOPHOSPHAMIDE; MESSENGER RNA; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTICLE; CHRONIC KIDNEY DISEASE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DETERIORATION; DISEASE COURSE; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; KIDNEY DYSFUNCTION; KIDNEY FAILURE; LUPUS ERYTHEMATOSUS NEPHRITIS; MALE; MEASUREMENT; MULTIPLEX POLYMERASE CHAIN REACTION; NUCLEOTIDE SEQUENCE; PREDICTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 84856987531     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2012.473     Document Type: Article

References (29)

1. D'Cruz DP, Khamashta MA and Hughes GR: Systemic lupus erythematosus. Lancet 17: 587-596, 2007.
2. Markowitz GS and D'Agati VD: Classification of lupus nephritis. Curr Opin Nephrol Hypertens 18: 220-225, 2009.
3. Boor P, Ostendorf T and Floege J: Renal fibrosis: novel insights into mechanisms and therapeutic targets. Nat Rev Nephrol 6: 643-656, 2010.
4. Garcia-Sanchez O, Lopez-Hernandez FJ and Lopez-Novoa JM: An integrative view on the role of TGF-beta in the progressive tubular deletion associated with chronic kidney disease. Kidney Int 77: 950-955, 2010.
5. Zeisberg M and Neilson EG: Mechanisms of tubulointerstitial fibrosis. J Am Soc Nephrol 21: 1819-1834, 2010.
6. Goldschmeding R, Aten J, Ito Y, Blom I, Rabelink T and Weening JJ: Connective tissue growth factor: just another factor in renal fibrosis? Nephrol Dial Transplant 15: 296-299, 2000.
7. Hill GS, Delahousse M, Nochy D, et al: Outcome of relapse in lupus nephritis: roles of reversal of renal fibrosis and response of inflammation to therapy. Kidney Int 61: 2176-2186, 2002.
8. Michael Z, Gary BYM, Pablo C, et al: Collagen and fibrosis. J Urol 67: 176-184, 2005.
9. Phanish MK, Winn SK and Dockrell ME: Connective tissue growth factor-(CTGF, CCN2) - a marker, mediator and therapeutic target for renal fibrosis. Nephron Exp Nephrol 114: 83-92, 2010.
10. Chen XM, Qi W and Pollock CA: CTGF and chronic kidney fibrosis. Front Biosci 1: 132-141, 2009.
11. Gupta S, Clarkson MR, Duggan J and Brady HR: Connective tissue growth factor: potential role in glomerulosclerosis and tubulointerstitial fibrosis. Kidney Int 58: 1389-1399, 2000.
12. Weening JJ, D'Agati VD, Schwartz MM, et al: The classification of glomerulonephritis in systemic lupus erythematosus revisited. J Am Soc Nephrol 15: 241-250, 2004.
13. Austin HA, Muenz LR, Joyce KM, Antonovych TT and Balow JE: Diffuse proliferative lupus nephritis: identification of specific pathologic features affecting renal outcome. Kidney Int 25: 689-695, 1984.
14. National Kidney Foundation: K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 39: S1-266, 2002.
15. Levey AS, Stevens LA, Schmid CH, et al: A new equation to estimate glomerular filtration rate. Ann Intern Med 5: 604-612, 2009.
16. Li YL, Ye F, Hu Y, Lu WG and Xie X: Identification of suitable reference genes for gene expression studies of human serous ovarian cancer by real-time polymerase chain reaction. Anal Biochem 394: 110-116, 2009.
17. Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408, 2001.
18. Bao L, Zhou J, Holers VM and Quigg RJ: Excessive matrix accumulation in the kidneys of MRL/lpr lupus mice is dependent on complement activation. J Am Soc Nephrol 14: 2516-2525, 2003.
19. Igarashi A, Okochi H, Bradham DM and Grotendorst GR: Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair. Mol Biol Cell 4: 637-645, 1993.
20. Murphy M, Godson C, Cannon S, et al: Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells. J Biol Chem 274: 5830-5834, 1999.
21. Furness PN: Extracellular matrix and the kidney. J Clin Pathol 49: 355-359, 1996.
22. Vleming LJ, Baelde JJ, Westendorp RG, Daha MR, van Es LA and Bruijn JA: Progression of chronic renal disease in humans is associated with the deposition of basement membrane components and decorin in the interstitial extracellular matrix. Clin Nephrol 44: 211-219, 1995.
23. Bakker RC, Koop K, Sijpkens YW, et al: Early interstitial accumulation of collagen type I discriminates chronic rejection from chronic cyclosporine nephrotoxicity. J Am Soc Nephrol 14: 2142-2149, 2003.
24. Sonnylal S, Shi-Wen X, Leoni P, et al: Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis. Arthritis Rheum 62: 1523-1532, 2010.
25. Yokoi H, Mukoyama M, Nagae T, et al: Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis. J Am Soc Nephrol 15: 1430-1440, 2004.
26. Ito Y, Aten J, Bende RJ, et al: Expression of connective tissue growth factor in human renal fibrosis. Kidney Int 53: 853-861, 1998.
27. Suzuki D, Toyoda M, Umezono T, et al: Glomerular expression of connective tissue growth factor mRNA in various renal diseases. Nephrology 8: 92-97, 2003.
28. Kobayashi T, Okada H, Inoue T, Kanno Y and Suzuki H: Tubular expression of connective tissue growth factor correlates with interstitial fibrosis in type 2 diabetic nephropathy. Nephrol Dial Transplant 21: 548-549, 2006.
29. Adler SG, Schwartz S, Williams ME, et al: Phase 1 study of anti-CTGF monoclonal antibody in patients with diabetes and microalbuminuria. Clin J Am Soc Nephrol 5: 1420-1428, 2010.