"Seizing" the opportunity to understand antifibrinolytic drugs;Saisir la chance de comprendre les antifibrinolytiques

Canadian Journal of Anesthesia

Volumn 59, Issue 1, 2012, Pages 1-5

  Lecker, Irene ^a   Orser, Beverley A ^b,c   Mazer, C David ^b,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^d ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; AMINOCAPROIC ACID; ANTIFIBRINOLYTIC AGENT; APROTININ; LYSINE DERIVATIVE; TRANEXAMIC ACID;

APACHE; CARDIOPULMONARY BYPASS; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DOSE COMPARISON; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; HEART ARREST; HEART SURGERY; HUMAN; KIDNEY DYSFUNCTION; NEUROLOGIC DISEASE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; REVIEW; RISK ASSESSMENT; RISK FACTOR; SEIZURE; UNSPECIFIED SIDE EFFECT;

CARDIAC SURGICAL PROCEDURES; FEMALE; HUMANS; MALE; POSTOPERATIVE COMPLICATIONS; SEIZURES; TRANEXAMIC ACID;

EID: 84856970834     PISSN: 0832610X     EISSN: 14968975     Source Type: Journal    
DOI: 10.1007/s12630-011-9621-4     Document Type: Review

References (17)

1. CRASH-2 Trial Collaborators H Shakur I Roberts R Bautista, et al. 2010 Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial Lancet 376 23 32 20554319 10.1016/S0140-6736(10)61479-1 1:CAS:528:DC%2BC3cXosVWnurk%3D
2. JM Murkin F Falter J Granton B Young C Burt M Chu 2010 High-dose tranexamic acid is associated with nonischemic clinical seizures in cardiac surgical patients Anesth Analg 110 350 353 19996135 10.1213/ANE.0b013e3181c92b23 1:CAS:528:DC%2BC3cXpsFeiuw%3D%3D
3. DA Fergusson PC Hebert CD Mazer, et al. 2008 A comparison of aprotinin and lysine analogues in high-risk cardiac surgery N Engl J Med 358 2319 2331 18480196 10.1056/NEJMoa0802395 1:CAS:528:DC%2BD1cXmsVOhs74%3D (Pubitemid 351749156)
4. Manji RA, Grocott HP, Leake J, et al. Seizures following cardiac surgery: the impact of tranexamic acid and other risk factors. Can J Anesth 2012; 59: this issue. DOI: 10.1007/s12630-011-9618-z.
5. O Kaabachi M Eddhif K Rais MA Zaabar 2011 Inadvertent intrathecal injection of tranexamic acid Saudi J Anaesth 5 90 92 21655027 10.4103/1658-354X.76504
6. Society of Thoracic Surgeons Blood Conservation Guideline Task Force VA Ferraris JR Brown GJ Despotis, et al. 2011 2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines Ann Thorac Surg 91 944 982 21353044 10.1016/j.athoracsur.2010.11.078
7. Henry DA, Carless PA, Moxey AJ, et al. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 2011; 3: CD001886.
8. Health Canada. Health Canada Decision on Trasylol (aprotinin). Information Update September 2011. Available from URl: http://www.hc-sc.gc.ca/ ahc-asc/media/advisories-avis/-2011/2011-124-eng.php. (accessed October, 2011).
9. NP Dowd JM Karski DC Cheng, et al. 2002 Pharmacokinetics of tranexamic acid during cardiopulmonary bypass Anesthesiology 97 390 399 12151929 10.1097/00000542-200208000-00016 1:CAS:528:DC%2BD38XmslOktb4%3D (Pubitemid 34847752)
10. Bokesch PM, Szabo G, Wojdyga R, et al. A phase 2 prospective, randomized, double-blind trial comparing the effects of tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery with cardiopulmonary bypass (CONSERV-2 Trial). J Thorac Cardiovasc Surg 2011; doi: 10.1016/j.jtcvs.2011.06. 001.
11. GR Hunter GB Young 2011 Seizures after cardiac surgery J Cardiothorac Vasc Anesth 25 299 305 21036061 10.1053/j.jvca.2010.08.004
12. I Laccheo E Ablah R Heinrichs T Sadler L Baade K Liow 2008 Assessment of quality of life among the elderly with epilepsy Epilepsy Behav 12 257 261 17988950 10.1016/j.yebeh.2007.09.003
13. GW Roach M Kanchuger CM Mangano, et al. 1996 Adverse cerebral outcomes after coronary bypass surgery. Multicenter Study of Perioperative Ischemia Research Group and the Ischemia Research and Education Foundation Investigators N Engl J Med 335 1857 1863 8948560 10.1056/NEJM199612193352501 1:STN:280:DyaK2s%2Fps1ygtw%3D%3D (Pubitemid 26419192)
14. M Sander CD Spies V Martiny C Rosenthal KD Wernecke C von Heymann 2010 Mortality associated with administration of high-dose tranexamic acid and aprotinin in primary open-heart procedures: a retrospective analysis Crit Care 14 R148 20682059 10.1186/cc9216
15. K Martin J Knorr T Breuer, et al. 2011 Seizures after open heart surgery: comparison of epsilon-aminocaproic acid and tranexamic acid J Cardiothorac Vasc Anesth 25 20 25 21272777 10.1053/j.jvca.2010.10.007 1:CAS:528: DC%2BC3MXhtlSqsL0%3D
16. AC Iplikcioglu MZ Berkman 2003 The effect of short-term antifibrinolytic therapy on experimental vasospasm Surg Neurol 59 10 16 12633948 10.1016/S0090-3019(02)00867-4 discussion 16-7 (Pubitemid 36299097)
17. R Furtmuller MG Schlag M Berger, et al. 2002 Tranexamic acid, a widely used antifibrinolytic agent, causes convulsions by a gamma-aminobutyric acid(A) receptor antagonistic effect J Pharmacol Exp Ther 301 168 173 11907171 10.1124/jpet.301.1.168 1:CAS:528:DC%2BD38Xis1Kru7c%3D (Pubitemid 34256345)