Tranexamic acid, a widely used antifibrinolytic agent, causes convulsions by a γ-aminobutyric acidA receptor antagonistic effect

Journal of Pharmacology and Experimental Therapeutics

Volumn 301, Issue 1, 2002, Pages 168-173

  Furtmüller, Roman ^a   Schlag, Michael G ^b   Berger, Michael ^a   Hopf, Rudolf ^c   Huck, Sigismund ^a   Sieghart, Werner ^a   Redl, Heinz ^c  

^a UNIVERSITY OF VIENNA   (Austria)

^b BAXTER INNOVATIONS GMBH   (Austria)

^c LUDWIG BOLTZMANN INSTITUTE FOR EXPERIMENTAL AND CLINICAL TRAUMATOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; CHLORIDE ION; MUSCIMOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; TRANEXAMIC ACID;

ARTICLE; BINDING SITE; BRAIN CORTEX; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CONVULSION; DOSE RESPONSE; DRUG ACTIVITY; DRUG BINDING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; ION CURRENT; KIDNEY CELL; PRIORITY JOURNAL; RECEPTOR BINDING; SPINAL CORD;

ANIMALS; ANTIFIBRINOLYTIC AGENTS; BINDING, COMPETITIVE; BRAIN CHEMISTRY; CELL LINE; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; GABA AGONISTS; GABA ANTAGONISTS; HINDLIMB; HUMANS; MALE; MEMBRANE POTENTIALS; MEMBRANES; MUSCIMOL; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, GABA-A; RECEPTORS, N-METHYL-D-ASPARTATE; SEIZURES; SPINAL CORD; TRANEXAMIC ACID;

EID: 0036196828     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.301.1.168     Document Type: Article

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