Identification of continuous epitopes of HuD antibodies related to paraneoplastic diseases/small cell lung cancer

Journal of Neuroimmunology

Volumn 243, Issue 1-2, 2012, Pages 25-33

  Trier, Nicole Hartwig ^a,b   Hansen, Paul Robert ^b   Vedeler, Christian A ^c   Somnier, Finn Engeborg ^a   Houen, Gunnar ^a  

^a STATENS SERUM INSTITUT   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

Epitope mapping; HuD; Monoclonal antibody; Small cell lung cancer; Solid phase peptide synthesis

Indexed keywords

EPITOPE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY HUD; ONCOPROTEIN; PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTIBODY SCREENING; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; GENE IDENTIFICATION; GENE INTERACTION; GENE LOCATION; GENE SYNTHESIS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOMIC FRAGMENT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LUNG SMALL CELL CANCER; MAJOR CLINICAL STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MOTIF;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; EPITOPES; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; HUMANS; LUNG NEOPLASMS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PARANEOPLASTIC SYNDROMES; SMALL CELL LUNG CARCINOMA; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84856970615     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2011.12.020     Document Type: Article

References (31)

1. Akamatsu W., Fujihara H., Mitsuhashi T., Yano M., Shibata S., Hayakawa Y., Okano H.J., Sakakibara S., Takano H., Takano T., Takahashi T., Noda T., Okano H. The RNA-binding protein HuD regulates neuronal cell identity and maturation. Proc. Natl. Acad. Sci. U. S. A. 2005, 102(12):4625-4630.
2. Atherton, Sheppard Solid Phase Peptide Synthesis: A Practical Approach 1989, Oxford University Press, USA.
3. Barami K., Iversen K., Furneaux H., Goldman S.A. Hu protein as an early marker of neuronal phenotypic differentiation by subependymal zone cells of the adult songbird forebrain. J. Neurobiol. 1995, 28(1):82-101.
4. Bolognani F., Tanner D.C., Merhege M., Deschenes-Furry J., Jasmin B., Perrone-Bizzozero N.I. In vivo post-transcriptional regulation of GAP-43 mRNA by overexpression of the RNA-binding protein HuD. J. Neurochem. 2006, 96(3):790-801.
5. Bolognani F., Contente-Cuomo T., Perrone-Bizzozero N.I. Novel recognition motifs and biological functions of the RNA-binding protein HuD revealed by genome-wide identification of its targets. Nucleic Acids Res. 2010, 38(1):117-130.
6. Chung S., Jiang L., Cheng S., Furneaux H. Purification and properties of HuD, a neuronal RNA-binding protein. J. Biol. Chem. 1996, 271(19):11518-11524.
7. D'Alessandro V., Muscarella L.A., La T.A., Bisceglia M., Parrella P., Scaramuzzi G., Storlazzi C.T., Trombetta D., Kok K., De C.A., Sperandeo M., Zelante L., Carella M., Vendemiale G. Molecular analysis of the HuD gene in neuroendocrine lung cancers. Lung Cancer 2010, 67(1):69-75.
8. Dalmau J., Furneaux H.M., Gralla R.J., Kris M.G., Posner J.B. Detection of the anti-Hu antibody in the serum of patients with small cell lung cancer-a quantitative western blot analysis. Ann. Neurol. 1990, 27(5):544-552.
9. Dalmau J., Furneaux H.M., Rosenblum M.K., Graus F., Posner J.B. Detection of the anti-Hu antibody in specific regions of the nervous system and tumor from patients with paraneoplastic encephalomyelitis/sensory neuronopathy. Neurology 1991, 41(11):1757-1764.
10. Dalmau J., Graus F., Rosenblum M.K., Posner J.B. Anti-Hu-associated paraneoplastic encephalomyelitis/sensory neuronopathy. A clinical study of 71 patients. Medicine (Baltimore) 1992, 71(2):59-72.
11. Dalmau J., Graus F., Cheung N.K., Rosenblum M.K., Ho A., Canete A., Delattre J.Y., Thompson S.J., Posner J.B. Major histocompatibility proteins, anti-Hu antibodies, and paraneoplastic encephalomyelitis in neuroblastoma and small cell lung cancer. Cancer 1995, 75(1):99-109.
12. Darnell R.B., Posner J.B. Paraneoplastic syndromes involving the nervous system. N. Engl. J. Med. 2003, 349(16):1543-1554.
13. DeLuca I., Blachere N.E., Santomasso B., Darnell R.B. Tolerance to the neuron-specific paraneoplastic HuD antigen. PLoS One 2009, 4(6):e5739.
14. Graus F., Cordon-Cardo C., Posner J.B. Neuronal antinuclear antibody in sensory neuronopathy from lung cancer. Neurology 1985, 35(4):538-543.
15. Graus F., Keime-Guibert F., Rene R., Benyahia B., Ribalta T., Ascaso C., Escaramis G., Delattre J.Y. Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients. Brain 2001, 124(Pt 6):1138-1148.
16. Kazarian M., Calbo J., Proost N., Carpenter C.L., Berns A., Laird-Offringa I.A. Immune response in lung cancer mouse model mimics human anti-Hu reactivity. J. Neuroimmunol. 2009, 217(1-2):38-45.
17. King P.H., Redden D., Palmgren J.S., Nabors L.B., Lennon V.A. Hu antigen specificities of ANNA-I autoantibodies in paraneoplastic neurological disease. J. Autoimmun. 1999, 13(4):435-443.
18. Ma W.J., Cheng S., Campbell C., Wright A., Furneaux H. Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. J. Biol. Chem. 1996, 271(14):8144-8151.
19. Ma W.J., Chung S., Furneaux H. The Elav-like proteins bind to AU-rich elements and to the poly(A) tail of mRNA. Nucleic Acids Res. 1997, 25(18):3564-3569.
20. Manley G.T., Smitt P.S., Dalmau J., Posner J.B. Hu antigens: reactivity with Hu antibodies, tumor expression, and major immunogenic sites. Ann. Neurol. 1995, 38(1):102-110.
21. Marusich M.F., Furneaux H.M., Henion P.D., Weston J.A. Hu neuronal proteins are expressed in proliferating neurogenic cells. J. Neurobiol. 1994, 25(2):143-155.
22. Petersen N.H., Hansen P.R., Houen G. Fast and efficient characterization of an anti-gliadin monoclonal antibody epitope related to celiac disease using resin-bound peptides. J. Immunol. Methods 2011, 365(2011):174-182.
23. Rauer S., Andreou I. Tumor progression and serum anti-HuD antibody concentration in patients with paraneoplastic neurological syndromes. Eur. Neurol. 2002, 47(4):189-195.
24. Rubinstein N.D., Mayrose I., Halperin D., Yekutieli D., Gershoni J.M., Pupko T. Computational characterization of B-cell epitopes. Mol. Immunol. 2008, 45(12):3477-3489.
25. Sillevis Smitt P.A., Manley G.T., Posner J.B. Immunization with the paraneoplastic encephalomyelitis antigen HuD does not cause neurologic disease in mice. Neurology 1995, 45(10):1873-1878.
26. Sodeyama N., Ishida K., Jaeckle K.A., Zhang L., Azuma A., Yamada M., Mizusawa H., Wada Y. Pattern of epitopic reactivity of the anti-Hu antibody on HuD with and without paraneoplastic syndrome. J. Neurol. Neurosurg. Psychiatry 1999, 66(1):97-99.
27. Storstein A., Monstad S.E., Haugen M., Mazengia K., Veltman D., Lohndal E., Aarseth J., Vedeler C. Onconeural antibodies: improved detection and clinical correlations. J. Neuroimmunol. 2011, 232(1-2):166-170.
28. Szabo A., Dalmau J., Manley G., Rosenfeld M., Wong E., Henson J., Posner J.B., Furneaux H.M. HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal. Cell 1991, 67(2):325-333.
29. Tanner D.C., Qiu S., Bolognani F., Partridge L.D., Weeber E.J., Perrone-Bizzozero N.I. Alterations in mossy fiber physiology and GAP-43 expression and function in transgenic mice overexpressing HuD. Hippocampus 2008, 18(8):814-823.
30. Van Der Geld Y.M., Simpelaar A., Van Der Zee R., Tervaert J.W., Stegeman C.A., Limburg P.C., Kallenberg C.G. Antineutrophil cytoplasmic antibodies to proteinase 3 in Wegener's granulomatosis: epitope analysis using synthetic peptides. Kidney Int. 2001, 59(1):147-159.
31. Wakamatsu Y., Weston J.A. Sequential expression and role of Hu RNA-binding proteins during neurogenesis. Development 1997, 124(17):3449-3460.